Irisin and Autophagy: First Update

Aggravated ulcerative colitis caused by intestinal Metrnl deficiency is associated with reduced autophagy in epithelial cells

(2020) Sai-long Zhang et al.   ACTA PHARMACOLOGICA SINICA

Irisin Improves Autophagy of Aged Hepatocytes via Increasing Telomerase Activity in Liver Injury

(2020) Jianbin Bi et al.   Oxidative Medicine and Cellular Longevity

Human Liver Memory CD8+ T Cells Use Autophagy for Tissue Residence

(2020) Leo Swadling et al.   Cell Reports

Irisin activates Opa1-induced mitophagy to protect cardiomyocytes against apoptosis following myocardial infarction

(2020) Ting Xin et al.   Aging-US

Effect of HIIT with Tabata Protocol on Serum Irisin, Physical Performance, and Body Composition in Men

(2020) Eugenia Murawska-Cialowicz et al.   International Journal of Environmental Research and Public Health

Role of interleukin-6 in inhibiting hepatic autophagy markers in exercised mice

(2020) Ana P. Pinto et al.   CYTOKINE

Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration

(2019) David Lee et al.   Cells

Role of Myokines in Regulating Skeletal Muscle Mass and Function

(2019) Jong Han Lee et al.   Frontiers in Physiology

The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain

(2019) Viviane José de Oliveira Bristot et al.   Frontiers in Neuroscience

Irisin ameliorates angiotensin II-induced cardiomyocyte apoptosis through autophagy

(2019) Ruli Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LIF, a Novel Myokine, Protects Against Amyloid-Beta-Induced Neurotoxicity via Akt-Mediated Autophagy Signaling in Hippocampal Cells

(2019) Hye Jeong Lee et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway

(2019) Qingxue Li et al.   Food Science & Nutrition

GRK2 regulates mitochondrial bioenergetics and impairs myostatin-mediated autophagy in muscle cells

(2019) Leandro Henrique Manfredi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Urotensin II Induces Mice Skeletal Muscle Atrophy Associated with Enhanced Autophagy and Inhibited Irisin Precursor (Fibronectin Type III Domain Containing 5) Expression in Chronic Renal Failure

(2019) Ya-Jing Pan et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway

(2019) Xiao Ye et al.   PEPTIDES

Maximizing Longevity and Healthspan: Multiple Approaches All Converging on Autophagy

(2019) Akshay Bareja et al.   Frontiers in Cell and Developmental Biology

IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma

(2018) Fucan Xia et al.   Autophagy

Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

(2018) Michelle R. Marasco et al.   DIABETES

IL-7 suppresses macrophage autophagy and promotes liver pathology in Schistosoma japonicum -infected mice

(2018) Jifeng Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: A cross sectional and a prospective case-control study nested in the Normative Aging Study

(2018) Ayse Sahin-Efe et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells

(2018) F. De Meneck et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Aerobic endurance training improves nonalcoholic fatty liver disease (NAFLD) features via miR-33 dependent autophagy induction in high fat diet fed mice

(2018) Parvin Ghareghani et al.   Obesity Research & Clinical Practice

Autophagy Is a Promoter for Aerobic Exercise Performance during High Altitude Training

(2018) Ying Zhang et al.   Oxidative Medicine and Cellular Longevity

TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival

(2018) Lele Zhu et al.   Nature Communications

Autophagy regulates DUOX1 localization and superoxide production in airway epithelial cells during chronic IL-13 stimulation

(2018) John D. Dickinson et al.   Redox Biology

Autophagy induction: a critical event for the modulation of cell death/survival and inflammatory responses by adipokines

(2018) Pil-Hoon Park   ARCHIVES OF PHARMACAL RESEARCH

Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

(2018) Ru-Li Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases

(2018) Luana G. Leal et al.   Frontiers in Physiology

Autophagy in Metabolic Age-Related Human Diseases

(2018) Manon Moulis et al.   Cells

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2018) Hyeonwoo Kim et al.   CELL

Interleukin 7 receptor activates PI3K/Akt/mTOR signaling pathway via downregulation of Beclin-1 in lung cancer

(2018) Ming Jian et al.   MOLECULAR CARCINOGENESIS

Irisin a Novel Metabolic Biomarker: Present Knowledge and Future Directions

(2018) Ilse Yessabel Martinez Munoz et al.   International Journal of Endocrinology

Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

(2017) Amelia K. Linnemann et al.   FASEB JOURNAL

Interleukin-6 downregulated vascular smooth muscle cell contractile proteins via ATG4B-mediated autophagy in thoracic aortic dissection

(2017) Zhao An et al.   HEART AND VESSELS

Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway

(2017) Olivia C. Küster et al.   JOURNAL OF ALZHEIMERS DISEASE

Decorin-evoked paternally expressed gene 3 (PEG3) is an upstream regulator of the transcription factor EB (TFEB) in endothelial cell autophagy

(2017) Thomas Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decorin-inducible Peg3 Evokes Beclin 1-mediated Autophagy and Thrombospondin 1-mediated Angiostasis

(2017) Annabel Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury

(2017) Hao Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circulating irisin levels are lower in patients with either stable coronary artery disease (CAD) or myocardial infarction (MI) versus healthy controls, whereas follistatin and activin A levels are higher and can discriminate MI from CAD with similar to CK-MB accuracy

(2017) Athanasios D. Anastasilakis et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise

(2017) Osvaldo C. Moreira et al.   Oxidative Medicine and Cellular Longevity

Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations

(2017) Christoph Hoffmann et al.   Cold Spring Harbor Perspectives in Medicine

Metabolic memory: Evolving concepts

(2017) Anoop Misra et al.   Journal of Diabetes

Activating Autophagy by Aerobic Exercise in Mice

(2017) Altea Rocchi et al.   Jove-Journal of Visualized Experiments

Levels of metabolic markers in drug-naive prediabetic and type 2 diabetic patients

(2016) Amal Akour et al.   ACTA DIABETOLOGICA

Effects of aerobic training on markers of autophagy in the elderly

(2016) Yubisay Mejías-Peña et al.   AGE

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes

(2016) Yuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mammalian Autophagy: How Does It Work?

(2016) Carla F. Bento et al.   Annual Review of Biochemistry

RUFY4: Immunity piggybacking on autophagy?

(2016) Seigo Terawaki et al.   Autophagy

A novel tumor-promoting mechanism of IL6 and the therapeutic efficacy of tocilizumab: Hypoxia-induced IL6 is a potent autophagy initiator in glioblastoma via the p-STAT3-MIR155-3p-CREBRF pathway

(2016) Hao Xue et al.   Autophagy

Skeletal muscle as a gene regulatory endocrine organ

(2016) Kristian Karstoft et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

FNDC5 Alleviates Hepatosteatosis by Restoring AMPK/mTOR-Mediated Autophagy, Fatty Acid Oxidation, and Lipogenesis in Mice

(2016) Tong-Yan Liu et al.   DIABETES

Zależne od czasu zmiany stężenia irisiny u pacjentów z jawną niedoczynnością tarczycy

(2016) Ariadna Zybek-Kocik et al.   Endokrynologia Polska

Anti-diabetic activity of recombinant irisin in STZ-induced insulin-deficient diabetic mice

(2016) Huikun Duan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The regulation of autophagy during exercise in skeletal muscle

(2016) Anna Vainshtein et al.   JOURNAL OF APPLIED PHYSIOLOGY

Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition

(2016) Jeong-sun Ju et al.   Journal of Physiological Sciences

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

(2016) Li Mo et al.   MOLECULAR ENDOCRINOLOGY

Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy

(2016) Haiying Li et al.   Oxidative Medicine and Cellular Longevity

Expression of decorin in intestinal tissues of mice with inflammatory bowel disease and its correlation with autophagy

(2016) Huazhou Zhao et al.   Experimental and Therapeutic Medicine

FoxO1-mediated autophagy is required for NK cell development and innate immunity

(2016) Shuo Wang et al.   Nature Communications

IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia

(2016) Aizhang Xu et al.   Cell and Bioscience

Association of Serum Irisin Concentrations with Presence and Severity of Coronary Artery Disease

(2016) Wen Deng   MEDICAL SCIENCE MONITOR

Decorin-mediated inhibition of the migration of U87MG glioma cells involves activation of autophagy and suppression of TGF-β signaling

(2016) Ting Yao et al.   FEBS Open Bio

Acute Endurance Exercise Induces Nuclear p53 Abundance in Human Skeletal Muscle

(2016) Bill Tachtsis et al.   Frontiers in Physiology

Up-Regulated Expression of LAMP2 and Autophagy Activity during Neuroendocrine Differentiation of Prostate Cancer LNCaP Cells

(2016) Cecilia Morell et al.   PLoS One

Irisin levels in the progression of diabetes in sedentary women

(2015) Iffet Dağdelen Duran et al.   CLINICAL BIOCHEMISTRY

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Irisin improves fatty acid oxidation and glucose utilization in type 2 diabetes by regulating the AMPK signaling pathway

(2015) C Xin et al.   INTERNATIONAL JOURNAL OF OBESITY

RUN and FYVE domain–containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4

(2015) Seigo Terawaki et al.   JOURNAL OF CELL BIOLOGY

Autophagy as a Potential Target for Sarcopenia

(2015) Jingjing Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Irisin in Response to Exercise in Humans With and Without Metabolic Syndrome

(2015) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating irisin and glucose metabolism in overweight/obese women: effects of α-lipoic acid and eicosapentaenoic acid

(2015) A. E. Huerta et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Irisin: A true, circulating hormone

(2015) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Resistance exercise induces a greater irisin response than endurance exercise

(2015) Yoshifumi Tsuchiya et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Myostatin Activates the Ubiquitin-Proteasome and Autophagy-Lysosome Systems Contributing to Muscle Wasting in Chronic Kidney Disease

(2015) Dong-Tao Wang et al.   Oxidative Medicine and Cellular Longevity

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

IL-6 Inhibits Starvation-induced Autophagy via the STAT3/Bcl-2 Signaling Pathway

(2015) Beibei Qin et al.   Scientific Reports

Circulating Irisin Levels Are Positively Associated with Metabolic Risk Factors in Sedentary Subjects

(2015) María Moreno et al.   PLoS One

Metformin promotes irisin release from murine skeletal muscle independently of AMP-activated protein kinase activation

(2014) D.-J. Li et al.   Acta Physiologica

Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise

(2014) Anthony M. J. Sanchez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Bcl-2 family members: Dual regulators of apoptosis and autophagy

(2014) Beth Levine et al.   Autophagy

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Skeletal Muscle: A Brief Review of Structure and Function

(2014) Walter R. Frontera et al.   CALCIFIED TISSUE INTERNATIONAL

Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer

(2014) Y. S. Gallot et al.   CANCER RESEARCH

A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis

(2014) G. Zadra et al.   EMBO Molecular Medicine

Disuse deterioration of human skeletal muscle challenged by resistive exercise superimposed with vibration: evidence from structural and proteomic analysis

(2014) Michele Salanova et al.   FASEB JOURNAL

The effect of Irisin on antioxidant system in liver

(2014) Saime Batirel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events

(2014) K N Aronis et al.   INTERNATIONAL JOURNAL OF OBESITY

Irisin: A potentially candidate marker for myocardial infarction

(2014) Tuncay Kuloglu et al.   PEPTIDES

A comprehensive immunohistochemical examination of the distribution of the fat-burning protein irisin in biological tissues

(2014) Suleyman Aydin et al.   PEPTIDES

Association of Serum Irisin with Metabolic Syndrome in Obese Chinese Adults

(2014) Bing Yan et al.   PLoS One

Autophagic Cellular Responses to Physical Exercise in Skeletal Muscle

(2014) Bjorn T. Tam et al.   SPORTS MEDICINE

Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index

(2014) María Pardo et al.   International Journal of Endocrinology

Sequence-based protein stabilization in the absence of glycosylation

(2014) Nikki Y. Tan et al.   Nature Communications

Autophagy in Kidney Health and Disease

(2013) Zhibo Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Irisin as a predictor of glucose metabolism in children: sexually dimorphic effects

(2013) Nasser M. Al-Daghri et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Myostatin induces atrophy of trout myotubes through inhibiting the TORC1 signaling and promoting Ubiquitin–Proteasome and Autophagy-Lysosome degradative pathways

(2013) Iban Seiliez et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Skeletal Muscle-derived Myonectin Activates the Mammalian Target of Rapamycin (mTOR) Pathway to Suppress Autophagy in Liver

(2013) Marcus M. Seldin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulatory Coordination between Two Major Intracellular Homeostatic Systems

(2013) Karol Dokladny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome

(2013) Kyung Hee Park et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance

(2013) José María Moreno-Navarrete et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Relationship between circulating irisin, renal function and body composition in type 2 diabetes

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Promotion of autophagy at the maturation step by IL-6 is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity

(2013) Xue-zhong Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cardiac, skeletal muscle and serum irisin responses to with or without water exercise in young and old male rats: Cardiac muscle produces more irisin than skeletal muscle

(2013) Suna Aydin et al.   PEPTIDES

Decorin causes autophagy in endothelial cells via Peg3

(2013) S. Buraschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy

(2013) C Bentzinger et al.   Skeletal Muscle

AGER/RAGE-mediated autophagy promotes pancreatic tumorigenesis and bioenergetics through the IL6-pSTAT3 pathway

(2012) Rui Kang et al.   Autophagy

Interleukin-6

(2012) Nikki A. Delk et al.   Autophagy

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

The major isoforms of Bim contribute to distinct biological activities that govern the processes of autophagy and apoptosis in interleukin-7 dependent lymphocytes

(2012) Shannon M. Ruppert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy and cardiovascular aging

(2012) Sreejayan Nair et al.   CELL CYCLE

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Myostatin induces autophagy in skeletal muscle in vitro

(2011) Jen Y. Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Single bout of running exercise changes LC3-II expression in rat cardiac muscle

(2011) Yuji Ogura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

microRNA-101 is a potent inhibitor of autophagy

(2011) Lisa B Frankel et al.   EMBO JOURNAL

Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction: Regulatory effects of hydroxytyrosol

(2011) Zhihui Feng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy: cellular defense to excessive inflammation

(2011) Eun-Kyeong Jo et al.   MICROBES AND INFECTION

Interleukin 4 induces the apoptosis of mouse microglial cells by a caspase-dependent mechanism

(2011) Javier A. Soria et al.   NEUROBIOLOGY OF DISEASE

An Exploratory Analysis of the Effects of a Weight Loss Plus Exercise Program on Cellular Quality Control Mechanisms in Older Overweight Women

(2011) Stephanie E. Wohlgemuth et al.   REJUVENATION RESEARCH

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Muscles and their myokines

(2010) B. K. Pedersen   JOURNAL OF EXPERIMENTAL BIOLOGY

Autophagy in liver diseases

(2010) Pierre-Emmanuel Rautou et al.   JOURNAL OF HEPATOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

The Absence of Interleukin-6 Enhanced Arsenite-Induced Renal Injury by Promoting Autophagy of Tubular Epithelial Cells with Aberrant Extracellular Signal-Regulated Kinase Activation

(2009) Akihiko Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin Resistance and Adipocytokines

(2009) Stergios Polyzos et al.   CURRENT MOLECULAR MEDICINE

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

(2009) Stephanie Eva Wohlgemuth et al.   EXPERIMENTAL GERONTOLOGY

ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy

(2009) Ian G. Ganley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

The role of exercise and PGC1α in inflammation and chronic disease

(2008) Christoph Handschin et al.   NATURE