The Role of PGC-1α/UCP2 Signaling in the Beneficial Effects of Physical Exercise on the Brain

Energy Compensation in Response to Aerobic Exercise Training in Overweight Adults

(2018) Kyle D Flack et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Electrically evoked local muscle contractions cause an increase in hippocampal BDNF

(2018) Takahiro Maekawa et al.   Applied Physiology Nutrition and Metabolism

Exercise training and endothelial function in patients with type 2 diabetes: a meta-analysis

(2018) Shanhu Qiu et al.   Cardiovascular Diabetology

Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control

(2018) Louise Lang Lehrskov et al.   Cell Metabolism

Sedentary behaviour and risk of all-cause, cardiovascular and cancer mortality, and incident type 2 diabetes: a systematic review and dose response meta-analysis

(2018) Richard Patterson et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Aquarobic exercises improve the serum blood irisin and brain-derived neurotrophic factor levels in elderly women

(2018) Ji-Hyeon Kim et al.   EXPERIMENTAL GERONTOLOGY

Improvement of cognitive functions in response to a regular Nordic walking training in elderly women – A change dependent on the training experience

(2018) A. Gmiąt et al.   EXPERIMENTAL GERONTOLOGY

Central irisin administration affords antidepressant-like effect and modulates neuroplasticity-related genes in the hippocampus and prefrontal cortex of mice

(2018) Aline Siteneski et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model

(2018) Yuan-Hao Chen et al.   Scientific Reports

Energy Constraint as a Novel Mechanism Linking Exercise and Health

(2018) Herman Pontzer   PHYSIOLOGY

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Physical activity and sedentary behavior in people with major depressive disorder: A systematic review and meta-analysis

(2017) Felipe Schuch et al.   JOURNAL OF AFFECTIVE DISORDERS

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of Cyclophosphamide and/or Doxorubicin in a Murine Model of Postchemotherapy Cognitive Impairment

(2017) Timothy J Flanigan et al.   TOXICOLOGICAL SCIENCES

The Alteration of Irisin—Brain-Derived Neurotrophic Factor Axis Parallels Severity of Distress Disorder in Bronchial Asthma Patients

(2017) Magdolna E. Szilasi et al.   Frontiers in Neuroscience

Alteration of the irisin–brain-derived neurotrophic factor axis contributes to disturbance of mood in COPD patients

(2017) Csaba Papp et al.   International Journal of Chronic Obstructive Pulmonary Disease

Exercise training with dietary restriction enhances circulating irisin level associated with increasing endothelial progenitor cell number in obese adults: an intervention study

(2017) Junhao Huang et al.   PeerJ

Exercise Plays a Preventive Role Against Alzheimer's Disease

(2017) Zsolt Radak et al.   JOURNAL OF ALZHEIMERS DISEASE

Effects of resistance exercise on endothelial progenitor cell mobilization in women

(2017) Fernando Ribeiro et al.   Scientific Reports

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness

(2016) Chitoku Toda et al.   CELL

Physical exercise mitigates doxorubicin-induced brain cortex and cerebellum mitochondrial alterations and cellular quality control signaling

(2016) I. Marques-Aleixo et al.   MITOCHONDRION

The potential of endurance exercise-derived exosomes to treat metabolic diseases

(2016) Adeel Safdar et al.   Nature Reviews Endocrinology

Designing Environments to Enhance Physical and Psychological Benefits of Physical Activity: A Multidisciplinary Perspective

(2016) Eric Brymer et al.   SPORTS MEDICINE

Sedentary Time and Its Association With Risk for Disease Incidence, Mortality, and Hospitalization in Adults

(2015) Aviroop Biswas et al.   ANNALS OF INTERNAL MEDICINE

Central and Peripheral Irisin Differentially Regulate Blood Pressure

(2015) Weizhen Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Fndc5overexpression facilitated neural differentiation of mouse embryonic stem cells

(2015) Mahboobeh Forouzanfar et al.   CELL BIOLOGY INTERNATIONAL

Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry

(2015) Mark P. Jedrychowski et al.   Cell Metabolism

Enhanced expression of FNDC5 in human embryonic stem cell-derived neural cells along with relevant embryonic neural tissues

(2015) Fatemeh Ahmadi Ghahrizjani et al.   GENE

The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

(2015) Dong Liu et al.   JOURNAL OF NEUROCHEMISTRY

Physical activity and cognition in adolescents: A systematic review

(2015) Irene Esteban-Cornejo et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway

(2015) Aderbal Silva Aguiar et al.   NEUROCHEMICAL RESEARCH

Effect of carnosine, methylprednisolone and their combined application on irisin levels in the plasma and brain of rats with acute spinal cord injury

(2015) Serdal Albayrak et al.   NEUROPEPTIDES

Physical exercise improves brain cortex and cerebellum mitochondrial bioenergetics and alters apoptotic, dynamic and auto(mito)phagy markers

(2015) I. Marques-Aleixo et al.   NEUROSCIENCE

Dose–response association of moderate-to-vigorous physical activity with cardiovascular biomarkers and all-cause mortality: Considerations by individual sports, exercise and recreational physical activities

(2015) Paul D. Loprinzi   PREVENTIVE MEDICINE

A runner’s high depends on cannabinoid receptors in mice

(2015) Johannes Fuss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relationship Between Sedentary Behavior and Cardiovascular Risk

(2015) Robert V. Same et al.   Current Cardiology Reports

Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways

(2014) Ruo-ming Wu et al.   ACTA PHARMACOLOGICA SINICA

The identification of irisin in human cerebrospinal fluid: influence of adiposity, metabolic markers, and gestational diabetes

(2014) Milan K. Piya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats

(2014) Ferenc Torma et al.   BRAIN RESEARCH BULLETIN

Effects of exercise on mitochondrial function, neuroplasticity and anxio-depressive behavior of mice

(2014) A.S. Aguiar et al.   NEUROSCIENCE

Hippocampal UCP2 is essential for cognition and resistance to anxiety but not required for the benefits of exercise

(2014) D. Wang et al.   NEUROSCIENCE

Irisin as a muscle-derived hormone stimulating thermogenesis – A critical update

(2014) Tobias Hofmann et al.   PEPTIDES

Exercise for anxiety disorders: systematic review

(2013) Kaushadh Jayakody et al.   BRITISH JOURNAL OF SPORTS MEDICINE

BDNF (I)rising from Exercise

(2013) Baoji Xu   Cell Metabolism

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Resistance to Exercise-Induced Weight Loss

(2013) EDWARD L. MELANSON et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

The Antidepressant-like Effect of Physical Activity on a Voluntary Running Wheel

(2013) MAURICIO P. CUNHA et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Pharmacological concentrations of irisin increase cell proliferation without influencing markers of neurite outgrowth and synaptogenesis in mouse H19-7 hippocampal cell lines

(2013) Hyun-Seuk Moon et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin-immunoreactivity in neural and non-neural cells of the rodent

(2013) S.L. Dun et al.   NEUROSCIENCE

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Fitness vs. Fatness on All-Cause Mortality: A Meta-Analysis

(2013) Vaughn W. Barry et al.   PROGRESS IN CARDIOVASCULAR DISEASES

BDNF mediates adaptive brain and body responses to energetic challenges

(2013) Krisztina Marosi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Early Exercise Affects Mitochondrial Transcription Factors Expression after Cerebral Ischemia in Rats

(2012) Qi Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis

(2012) D. M. Thomas et al.   Obesity Reviews

Association of Sedentary Time with Mortality Independent of Moderate to Vigorous Physical Activity

(2012) Annemarie Koster et al.   PLoS One

Ucp2 Induced by Natural Birth Regulates Neuronal Differentiation of the Hippocampus and Related Adult Behavior

(2012) Julia Simon-Areces et al.   PLoS One

Sedentary Activity Associated With Metabolic Syndrome Independent of Physical Activity

(2011) A. Bankoski et al.   DIABETES CARE

Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling

(2011) Aderbal S. Aguiar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Quantity and Quality of Exercise for Developing and Maintaining Cardiorespiratory, Musculoskeletal, and Neuromotor Fitness in Apparently Healthy Adults

(2011) Carol Ewing Garber et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Changes in Diet and Lifestyle and Long-Term Weight Gain in Women and Men

(2011) Dariush Mozaffarian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mitochondrial UCP5 is neuroprotective by preserving mitochondrial membrane potential, ATP levels, and reducing oxidative stress in MPP+ and dopamine toxicity

(2010) Ken Hon-Hung Kwok et al.   FREE RADICAL BIOLOGY AND MEDICINE

Appropriate Physical Activity Intervention Strategies for Weight Loss and Prevention of Weight Regain for Adults

(2010) JOSEPH E. DONNELLY et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Physical activities and future risk of Parkinson disease

(2010) Q. Xu et al.   NEUROLOGY

Fat or Fit: What Is More Important?

(2009) V. Hainer et al.   DIABETES CARE

Fitness and Fatness as Mortality Predictors in Healthy Older Men: The Veterans Exercise Testing Study

(2009) P. McAuley et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Brain Uncoupling Protein UCP4 Attenuates Mitochondrial Toxin-Induced Cell Death: Role of Extracellular Signal-Regulated Kinases in Bioenergetics Adaptation and Cell Survival

(2009) Zelan Wei et al.   NEUROTOXICITY RESEARCH

Physical activity, fitness and fatness: relations to mortality, morbidity and disease risk factors. A systematic review

(2009) M. Fogelholm   Obesity Reviews

The Runner's High: Opioidergic Mechanisms in the Human Brain

(2008) H. Boecker et al.   CEREBRAL CORTEX

Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition

(2008) Fernando Gomez-Pinilla et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial UCP4 attenuates MPP+- and dopamine-induced oxidative stress, mitochondrial depolarization, and ATP deficiency in neurons and is interlinked with UCP2 expression

(2008) Andrew Chi-Yuen Chu et al.   FREE RADICAL BIOLOGY AND MEDICINE

The exercise redox paradigm in the Down’s syndrome: improvements in motor function and increases in blood oxidative status in young adults

(2008) Aderbal S. Aguiar et al.   JOURNAL OF NEURAL TRANSMISSION

Exercise-Induced Synaptogenesis in the Hippocampus Is Dependent on UCP2-Regulated Mitochondrial Adaptation

(2008) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE