Regulation and mechanisms of extracellular vesicle biogenesis and secretion

Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling

(2018) Frederik Johannes Verweij et al.   JOURNAL OF CELL BIOLOGY

Biogenesis and function of ESCRT-dependent extracellular vesicles

(2018) Thomas Juan et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lipids in exosomes: Current knowledge and the way forward

(2017) Tore Skotland et al.   PROGRESS IN LIPID RESEARCH

Pathogen-derived extracellular vesicles coordinate social behaviour and host manipulation

(2017) Yifat Ofir-Birin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cellular Functions and Molecular Mechanisms of the ESCRT Membrane-Scission Machinery

(2017) Liliane Christ et al.   TRENDS IN BIOCHEMICAL SCIENCES

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Proteomic insights into extracellular vesicle biology – defining exosomes and shed microvesicles

(2016) David W. Greening et al.   Expert Review of Proteomics

Microvesicles provide a mechanism for intercellular communication by embryonic stem cells during embryo implantation

(2016) Laura M. Desrochers et al.   Nature Communications

Y-box protein 1 is required to sort microRNAs into exosomes in cells and in a cell-free reaction

(2016) Matthew J Shurtleff et al.   eLife

The Enrichment of Survivin in Exosomes from Breast Cancer Cells Treated with Paclitaxel Promotes Cell Survival and Chemoresistance

(2016) Bridget Kreger et al.   Cancers

Tumor-derived microvesicles in the tumor microenvironment: How vesicle heterogeneity can shape the future of a rapidly expanding field

(2015) James W. Clancy et al.   BIOESSAYS

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

(2015) C Mazzeo et al.   CELL DEATH AND DIFFERENTIATION

Heparanase activates the syndecan-syntenin-ALIX exosome pathway

(2015) Bart Roucourt et al.   CELL RESEARCH

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

(2015) Valentina Marchesin et al.   JOURNAL OF CELL BIOLOGY

Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications

(2015) Sweta Rani et al.   MOLECULAR THERAPY

Differential fates of biomolecules delivered to target cells via extracellular vesicles

(2015) Masamitsu Kanada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

(2015) James W. Clancy et al.   Nature Communications

Extracellular microvesicles and invadopodia mediate non-overlapping modes of tumor cell invasion

(2015) Alanna E. Sedgwick et al.   Scientific Reports

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Exosomes and other extracellular vesicles in host-pathogen interactions

(2014) J. S. Schorey et al.   EMBO REPORTS

Biology and proteomics of extracellular vesicles: harnessing their clinical potential

(2014) Crislyn D'Souza-Schorey et al.   Expert Review of Proteomics

Regulation of exosome release by glycosphingolipids and flotillins

(2014) Santosh Phuyal et al.   FEBS Journal

Extracellular Vesicles as Enhancers of Virus Vector–Mediated Gene Delivery

(2014) Zachary Fitzpatrick et al.   HUMAN GENE THERAPY

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular RNA mediates and marks cancer progression

(2014) Jasmina S. Redzic et al.   SEMINARS IN CANCER BIOLOGY

Syntenin-ALIX exosome biogenesis and budding into multivesicular bodies are controlled by ARF6 and PLD2

(2014) Rania Ghossoub et al.   Nature Communications

Nontemplated Nucleotide Additions Distinguish the Small RNA Composition in Cells from Exosomes

(2014) Danijela Koppers-Lalic et al.   Cell Reports

Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells

(2014) Mario Leonardo Squadrito et al.   Cell Reports

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

(2013) Kirsi Rilla et al.   EXPERIMENTAL CELL RESEARCH

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion

(2013) Sabrina Schlienger et al.   MOLECULAR BIOLOGY OF THE CELL

Influence of microRNA deregulation on chaperone-mediated autophagy and α-synuclein pathology in Parkinson's disease

(2013) L Alvarez-Erviti et al.   Cell Death & Disease

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Extracellular Vesicles – Biomarkers and Effectors of the Cellular Interactome in Cancer

(2013) Janusz Rak   Frontiers in Pharmacology

Large Oncosomes in Human Prostate Cancer Tissues and in the Circulation of Mice with Metastatic Disease

(2012) Dolores Di Vizio et al.   AMERICAN JOURNAL OF PATHOLOGY

Production of Plasma Membrane Vesicles with Chloride Salts and Their Utility as a Cell Membrane Mimetic for Biophysical Characterization of Membrane Protein Interactions

(2012) Nuala Del Piccolo et al.   ANALYTICAL CHEMISTRY

Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns

(2012) Ming-Lin Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types

(2012) Jasenka Guduric-Fuchs et al.   BMC GENOMICS

Tumor-derived microvesicles: shedding light on novel microenvironment modulators and prospective cancer biomarkers

(2012) C. D'Souza-Schorey et al.   GENES & DEVELOPMENT

Genetically Engineered Microvesicles Carrying Suicide mRNA/Protein Inhibit Schwannoma Tumor Growth

(2012) Arda Mizrak et al.   MOLECULAR THERAPY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

(2012) B Li et al.   ONCOGENE

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-1289 and “Zipcode”-like Sequence Enrich mRNAs in Microvesicles

(2012) Mehmet Fatih Bolukbasi et al.   Molecular Therapy-Nucleic Acids

The Genomic and Proteomic Content of Cancer Cell-Derived Exosomes

(2012) Meredith C. Henderson et al.   Frontiers in Oncology

Multivesicular Body Morphogenesis

(2011) Phyllis I. Hanson et al.   Annual Review of Cell and Developmental Biology

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

(2011) R Alonso et al.   CELL DEATH AND DIFFERENTIATION

Brain Tumor Microvesicles: Insights into Intercellular Communication in the Nervous System

(2011) Kristan E. van der Vos et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A–C

(2010) Chieh Hsu et al.   JOURNAL OF CELL BIOLOGY

Microvesicles: mediators of extracellular communication during cancer progression

(2010) V. Muralidharan-Chari et al.   JOURNAL OF CELL SCIENCE

Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes

(2010) Jung Eun Park et al.   MOLECULAR & CELLULAR PROTEOMICS

TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/multivesicular body pathways

(2009) Claudio Marcelo Fader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ADP-Ribosylation Factor 6 Regulates Tumorigenic and Invasive Properties In vivo

(2009) V. Muralidharan-Chari et al.   CANCER RESEARCH

Oncosome Formation in Prostate Cancer: Association with a Region of Frequent Chromosomal Deletion in Metastatic Disease

(2009) Dolores Di Vizio et al.   CANCER RESEARCH

ARF6-Regulated Shedding of Tumor Cell-Derived Plasma Membrane Microvesicles

(2009) Vandhana Muralidharan-Chari et al.   CURRENT BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivesicular Endosome Biogenesis in the Absence of ESCRTs

(2009) Susanne Stuffers et al.   TRAFFIC

MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways

(2009) Sonja I. Buschow et al.   TRAFFIC

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Endocytic Trafficking of Rac Is Required for the Spatial Restriction of Signaling in Cell Migration

(2008) Andrea Palamidessi et al.   CELL

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE