R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases

Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination

(2020) Aminat S. Musah et al.   JOURNAL OF NEUROSCIENCE

Neuron-oligodendroglia interactions: Activity-dependent regulation of cellular signaling

(2020) Michael A. Thornton et al.   NEUROSCIENCE LETTERS

Nodes of Ranvier during development and repair in the CNS

(2020) Catherine Lubetzki et al.   Nature Reviews Neurology

Mechanisms for the maintenance and regulation of axonal energy supply

(2019) Kelly Anne Chamberlain et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases

(2019) Na Suo et al.   GLIA

Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood

(2019) Akihiro Ishii et al.   GLIA

Diversity in the oligodendrocyte lineage: Plasticity or heterogeneity?

(2019) Sarah Foerster et al.   GLIA

Molecular Control of Oligodendrocyte Development

(2019) Benayahu Elbaz et al.   TRENDS IN NEUROSCIENCES

Charcot-Marie-Tooth: From Molecules to Therapy

(2019) Jonathan Morena et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Myelin in the Central Nervous System: Structure, Function, and Pathology

(2019) Christine Stadelmann et al.   PHYSIOLOGICAL REVIEWS

Neuregulin-1/ErbB network: An emerging modulator of nervous system injury and repair

(2019) Hardeep Kataria et al.   PROGRESS IN NEUROBIOLOGY

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

(2019) Simon Faissner et al.   NATURE REVIEWS DRUG DISCOVERY

Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory

(2018) Fucheng Luo et al.   EXPERIMENTAL NEUROLOGY

R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System

(2018) Miriam Sanz-Rodriguez et al.   JOURNAL OF NEUROSCIENCE

Applying the 2017 McDonald diagnostic criteria for multiple sclerosis – Authors' reply

(2018) Alan J Thompson et al.   LANCET NEUROLOGY

Glycogen synthase kinases: Moonlighting proteins with theranostic potential in cancer

(2018) Siddavaram Nagini et al.   SEMINARS IN CANCER BIOLOGY

mTORC1 Activation by Loss of Tsc1 in Myelinating Glia Causes Downregulation of Quaking and Neurofascin 155 Leading to Paranodal Domain Disorganization

(2018) Qian Shi et al.   Frontiers in Cellular Neuroscience

Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development

(2018) Sueli Marques et al.   DEVELOPMENTAL CELL

RAS variant signalling

(2018) Stephanie P. Mo et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Multiple sclerosis - a review

(2018) R. Dobson et al.   EUROPEAN JOURNAL OF NEUROLOGY

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

Neuregulin-1 promotes remyelination and fosters a pro-regenerative inflammatory response in focal demyelinating lesions of the spinal cord

(2017) Hardeep Kataria et al.   GLIA

Oligodendroglia: metabolic supporters of neurons

(2017) Thomas Philips et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2–MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner

(2017) Miki Furusho et al.   JOURNAL OF NEUROSCIENCE

Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination

(2017) Lauren E. McLane et al.   JOURNAL OF NEUROSCIENCE

Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination

(2017) Chao Weng et al.   Molecular Medicine Reports

Prevalence and clinical features of neuromyelitis optica spectrum disorders in northern Japan

(2017) Hideki Houzen et al.   NEUROLOGY

The Axonal Cytoskeleton and the Assembly of Nodes of Ranvier

(2017) Aniket Ghosh et al.   NEUROSCIENTIST

All Wrapped Up: Environmental Effects on Myelination

(2017) Thomas A. Forbes et al.   TRENDS IN NEUROSCIENCES

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity—Diverse effects on cell growth, metabolism and cancer

(2016) James A. McCubrey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myelination

(2016) J.L. Salzer et al.   CURRENT BIOLOGY

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease

(2016) Andreia Barateiro et al.   CURRENT PHARMACEUTICAL DESIGN

Intracellular signaling pathway regulation of myelination and remyelination in the CNS

(2016) Jenna M. Gaesser et al.   EXPERIMENTAL NEUROLOGY

Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching

(2016) Rane A. Harrison et al.   JOURNAL OF MOLECULAR BIOLOGY

The Activators of Cyclin-Dependent Kinase 5 p35 and p39 Are Essential for Oligodendrocyte Maturation, Process Formation, and Myelination

(2016) F. Luo et al.   JOURNAL OF NEUROSCIENCE

Strength of ERK1/2 MAPK Activation Determines Its Effect on Myelin and Axonal Integrity in the Adult CNS

(2016) Akihiro Ishii et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

(2016) Aiman S. Saab et al.   NEURON

The roles of extracellular related-kinases 1 and 2 signaling in CNS myelination

(2016) David Gonsalvez et al.   NEUROPHARMACOLOGY

Oligodendrocyte heterogeneity in the mouse juvenile and adult central nervous system

(2016) S. Marques et al.   SCIENCE

Dual regulatory switch through interactions of Tcf7l2/Tcf4 with stage-specific partners propels oligodendroglial maturation

(2016) Chuntao Zhao et al.   Nature Communications

How to make an oligodendrocyte

(2015) S. A. Goldman et al.   DEVELOPMENT

Dynamics and Mechanisms of CNS Myelination

(2015) Kathryn K. Bercury et al.   DEVELOPMENTAL CELL

Canonical Wnt signaling in the oligodendroglial lineage-puzzles remain

(2015) Fuzheng Guo et al.   GLIA

Translational Control of Myelin Basic Protein Expression by ERK2 MAP Kinase Regulates Timely Remyelination in the Adult Brain

(2015) K. Michel et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte Development and Plasticity

(2015) Dwight E. Bergles et al.   Cold Spring Harbor Perspectives in Biology

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Myelination of the Nervous System: Mechanisms and Functions

(2014) Klaus-Armin Nave et al.   Annual Review of Cell and Developmental Biology

Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination

(2014) Andreia Barateiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

(2014) Nicolas Snaidero et al.   CELL

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

(2014) JinXiang Dai et al.   GLIA

Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain

(2014) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

Role of ERK1/2 MAPK Signaling in the Maintenance of Myelin and Axonal Integrity in the Adult CNS

(2014) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Cyclin-Dependent Kinase 5 Mediates Adult OPC Maturation and Myelin Repair through Modulation of Akt and GsK-3  Signaling

(2014) F. Luo et al.   JOURNAL OF NEUROSCIENCE

The role of myelin and oligodendrocytes in axonal energy metabolism

(2013) Aiman S Saab et al.   CURRENT OPINION IN NEUROBIOLOGY

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cell Proliferation

(2013) A. W. Wong et al.   JOURNAL OF NEUROSCIENCE

Adenomatous Polyposis Coli Regulates Oligodendroglial Development

(2013) J. Lang et al.   JOURNAL OF NEUROSCIENCE

Signaling through ERK1/2 Controls Myelin Thickness during Myelin Repair in the Adult Central Nervous System

(2013) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

R-RAS2 overexpression in tumors of the human central nervous system

(2013) Sylvia Gutierrez-Erlandsson et al.   Molecular Cancer

Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

(2013) Felipe Ortega et al.   NATURE CELL BIOLOGY

Limited TCF7L2 Expression in MS Lesions

(2013) Alexander Lürbke et al.   PLoS One

Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro

(2012) Junhua Xiao et al.   JOURNAL OF NEUROCHEMISTRY

ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination

(2012) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

(2012) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

(2012) Romain M. Larive et al.   MOLECULAR BIOLOGY OF THE CELL

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Canonical Wnt Signalling Requires the BMP Pathway to Inhibit Oligodendrocyte Maturation

(2011) Keith Feigenson et al.   ASN Neuro

Tcf7l2 is Tightly Controlled During Myelin Formation

(2011) Hui Fu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

GSK3β negatively regulates oligodendrocyte differentiation and myelination in vivo

(2011) Kasum Azim et al.   GLIA

Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

(2011) Hebe M. Guardiola-Diaz et al.   GLIA

Wnt/ -Catenin Signaling Is an Essential and Direct Driver of Myelin Gene Expression and Myelinogenesis

(2011) M. Tawk et al.   JOURNAL OF NEUROSCIENCE

The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing of Oligodendrocyte Differentiation

(2011) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

(2011) Stephen P J Fancy et al.   NATURE NEUROSCIENCE

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

(2011) S. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

(2010) Emily P. Harrington et al.   ANNALS OF NEUROLOGY

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

(2009) S. P.J. Fancy et al.   GENES & DEVELOPMENT

A Genome-Wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development

(2009) H. Fu et al.   JOURNAL OF NEUROSCIENCE

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

(2009) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

Wnt signaling is sufficient to perturb oligodendrocyte maturation

(2009) Keith Feigenson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction

(2009) Feng Ye et al.   NATURE NEUROSCIENCE

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Wnt-mediated self-renewal of neural stem/progenitor cells

(2008) M. Y. S. Kalani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA