RAS variant signalling

K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions

(2018) Jean K. Chung et al.   BIOPHYSICAL JOURNAL

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

(2018) Chiara Ambrogio et al.   CELL

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

K-Ras Populates Conformational States Differently from Its Isoform H-Ras and Oncogenic Mutant K-RasG12D

(2018) Jillian A. Parker et al.   STRUCTURE

Differential Effector Engagement by Oncogenic KRAS

(2018) Tina L. Yuan et al.   Cell Reports

The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects

(2017) Christian W. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiplexed in vivo homology-directed repair and tumor barcoding enables parallel quantification of Kras variant oncogenicity

(2017) Ian P. Winters et al.   Nature Communications

A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution

(2017) Grace R. Anderson et al.   Cell Reports

The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants

(2017) Jillian A. Parker et al.   Cold Spring Harbor Perspectives in Medicine

Ras and the Plasma Membrane: A Complicated Relationship

(2017) Yong Zhou et al.   Cold Spring Harbor Perspectives in Medicine

Quantification of spatiotemporal patterns of Ras isoform expression during development

(2017) Anna U. Newlaczyl et al.   Scientific Reports

Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis

(2016) Priyanka Prakash et al.   BIOPHYSICAL JOURNAL

Pathogenetics of the RASopathies

(2016) William E. Tidyman et al.   HUMAN MOLECULAR GENETICS

RAS isoforms and mutations in cancer at a glance

(2016) G. Aaron Hobbs et al.   JOURNAL OF CELL SCIENCE

Loss of wild-type Kras promotes activation of all Ras isoforms in oncogenic Kras-induced leukemogenesis

(2016) G Kong et al.   LEUKEMIA

Inhibition of RAS function through targeting an allosteric regulatory site

(2016) Russell Spencer-Smith et al.   Nature Chemical Biology

Recent advances in RASopathies

(2015) Yoko Aoki et al.   JOURNAL OF HUMAN GENETICS

Differential Reprogramming of Isogenic Colorectal Cancer Cells by Distinct Activating KRAS Mutations

(2015) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

Inhibition of acid sphingomyelinase depletes cellular phosphatidylserine and mislocalizes K-Ras from the plasma membrane

(2015) Kwang-jin Cho et al.   MOLECULAR AND CELLULAR BIOLOGY

Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

(2015) J. C. Hunter et al.   MOLECULAR CANCER RESEARCH

Comparative analysis of KRAS codon 12, 13, 18, 61 and 117 mutations using human MCF10A isogenic cell lines

(2015) Britta Stolze et al.   Scientific Reports

Absolute Quantification of Endogenous Ras Isoform Abundance

(2015) Craig J. Mageean et al.   PLoS One

Rare codons capacitate Kras-driven de novo tumorigenesis

(2014) Nicole L.K. Pershing et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutation-Specific RAS Oncogenicity Explains NRAS Codon 61 Selection in Melanoma

(2014) C. E. Burd et al.   Cancer Discovery

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Signal Integration by Lipid-Mediated Spatial Cross Talk between Ras Nanoclusters

(2013) Yong Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

(2013) M. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction

(2012)   BIOPHYSICAL JOURNAL

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Rare Codons Regulate KRas Oncogenesis

(2012) Benjamin L. Lampson et al.   CURRENT BIOLOGY

Explaining the preponderance of Kras mutations in human cancer: An isoform-specific function in stem cell expansion

(2011) Margaret P. Quinlan et al.   CELL CYCLE

Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

(2011) Stephan Fath et al.   PLoS One

Ras nanoclusters: Combining digital and analog signaling

(2010) Angus Harding et al.   CELL CYCLE

Structural Basis for Conformational Dynamics of GTP-bound Ras Protein

(2010) Fumi Shima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Ras membrane orientation and nanodomain localization generate isoform diversity

(2010) D. Abankwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras acylation, compartmentalization and signaling nanoclusters (Review)

(2009) Yoav I. Henis et al.   MOLECULAR MEMBRANE BIOLOGY

Activated Kras, but Not Hras or Nras, May Initiate Tumors of Endodermal Origin via Stem Cell Expansion

(2008) M. P. Quinlan et al.   MOLECULAR AND CELLULAR BIOLOGY

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

(2008) Kevin M Haigis et al.   NATURE GENETICS

Kras regulatory elements and exon 4A determine mutation specificity in lung cancer

(2008) Minh D To et al.   NATURE GENETICS

Mapping the Nucleotide and Isoform-Dependent Structural and Dynamical Features of Ras Proteins

(2008) Alemayehu A. Gorfe et al.   STRUCTURE