Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2–MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner

(2017) Miki Furusho et al.   JOURNAL OF NEUROSCIENCE

ERK1/2 Activation in Preexisting Oligodendrocytes of Adult Mice Drives New Myelin Synthesis and Enhanced CNS Function

(2016) M. A. Jeffries et al.   JOURNAL OF NEUROSCIENCE

Strength of ERK1/2 MAPK Activation Determines Its Effect on Myelin and Axonal Integrity in the Adult CNS

(2016) Akihiro Ishii et al.   JOURNAL OF NEUROSCIENCE

The roles of extracellular related-kinases 1 and 2 signaling in CNS myelination

(2016) David Gonsalvez et al.   NEUROPHARMACOLOGY

A new mechanism of nervous system plasticity: activity-dependent myelination

(2015) R. Douglas Fields   NATURE REVIEWS NEUROSCIENCE

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue

(2014) Nicolas Snaidero et al.   CELL

IL-17A activates ERK1/2 and enhances differentiation of oligodendrocyte progenitor cells

(2014) Jane M. Rodgers et al.   GLIA

Interaction of mTOR and Erk1/2 signaling to regulate oligodendrocyte differentiation

(2014) JinXiang Dai et al.   GLIA

Oligodendrocyte Precursor Cell-Intrinsic Effect of Rheb1 Controls Differentiation and Mediates mTORC1-Dependent Myelination in Brain

(2014) Y. Zou et al.   JOURNAL OF NEUROSCIENCE

Role of ERK1/2 MAPK Signaling in the Maintenance of Myelin and Axonal Integrity in the Adult CNS

(2014) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Conditional Ablation of Raptor or Rictor Has Differential Impact on Oligodendrocyte Differentiation and CNS Myelination

(2014) K. K. Bercury et al.   JOURNAL OF NEUROSCIENCE

Mammalian Target of Rapamycin Promotes Oligodendrocyte Differentiation, Initiation and Extent of CNS Myelination

(2014) S. E. Wahl et al.   JOURNAL OF NEUROSCIENCE

Balanced mTORC1 Activity in Oligodendrocytes Is Required for Accurate CNS Myelination

(2014) F. Lebrun-Julien et al.   JOURNAL OF NEUROSCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development

(2013) Teresa L. Wood et al.   ASN Neuro

Sustained Activation of ERK1/2 MAPK in Oligodendrocytes and Schwann Cells Enhances Myelin Growth and Stimulates Oligodendrocyte Progenitor Expansion

(2013) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Oligodendroglial Expression of TrkB Independently Regulates Myelination and Progenitor Cell Proliferation

(2013) A. W. Wong et al.   JOURNAL OF NEUROSCIENCE

Signaling through ERK1/2 Controls Myelin Thickness during Myelin Repair in the Adult Central Nervous System

(2013) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

Extracellular signal-regulated kinase 1/2 signaling promotes oligodendrocyte myelination in vitro

(2012) Junhua Xiao et al.   JOURNAL OF NEUROCHEMISTRY

ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of Myelination

(2012) A. Ishii et al.   JOURNAL OF NEUROSCIENCE

Fibroblast Growth Factor Receptor Signaling in Oligodendrocytes Regulates Myelin Sheath Thickness

(2012) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

Impaired adult myelination in the prefrontal cortex of socially isolated mice

(2012) Jia Liu et al.   NATURE NEUROSCIENCE

A Critical Period for Social Experience-Dependent Oligodendrocyte Maturation and Myelination

(2012) M. Makinodan et al.   SCIENCE

Myelin Regeneration: A Recapitulation of Development?

(2011) Stephen P.J. Fancy et al.   Annual Review of Neuroscience

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

(2011) William A. Tyler et al.   GLIA

Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

(2011) Hebe M. Guardiola-Diaz et al.   GLIA

Fibroblast Growth Factor Signaling Is Required for the Generation of Oligodendrocyte Progenitors from the Embryonic Forebrain

(2011) M. Furusho et al.   JOURNAL OF NEUROSCIENCE

The ERK2 Mitogen-Activated Protein Kinase Regulates the Timing of Oligodendrocyte Differentiation

(2011) S. L. Fyffe-Maricich et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelination

(2010) Emily P. Harrington et al.   ANNALS OF NEUROLOGY

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

(2009) Lakshmi Srinivasan et al.   CELL

A role for the MAPK/ERK pathway in oligodendroglial differentiation in vitro: stage specific effects on cell branching

(2009) V. Younes-Rapozo et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

(2009) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway

(2008) Ashlee Van't Veer et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Initiation of Oligodendrocyte Progenitor Cell Migration by a PDGF-A Activated Extracellular Regulated Kinase (ERK) Signaling Pathway

(2008) Emma E. Frost et al.   NEUROCHEMICAL RESEARCH

White matter in learning, cognition and psychiatric disorders

(2008) R. Douglas Fields   TRENDS IN NEUROSCIENCES