Induction of Adipose Tissue Browning as a Strategy to Combat Obesity

Targeting Abdominal Obesity and Its Complications with Dietary Phytoestrogens

(2020) Alina Kuryłowicz et al.   Nutrients

Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling

(2020) Suocheng Hui et al.   INTERNATIONAL JOURNAL OF OBESITY

Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity

(2020) Alana E. O’Mara et al.   JOURNAL OF CLINICAL INVESTIGATION

ASK1 inhibits browning of white adipose tissue in obesity

(2020) Fabrizio C. Lucchini et al.   Nature Communications

Exercise Reverses the Alterations in Gut Microbiota Upon Cold Exposure and Promotes Cold-Induced Weight Loss

(2020) Yan Meng et al.   Frontiers in Physiology

Do Bariatric Surgeries Enhance Brown/Beige Adipose Tissue Thermogenesis?

(2020) Mohammed K. Hankir et al.   Frontiers in Endocrinology

Role of c-Jun N-terminal Kinase (JNK) in Obesity and Type 2 Diabetes

(2020) Justin Hou Ming Yung et al.   Cells

CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling

(2020) Yasuo Oguri et al.   CELL

The Impact of Single-Cell Genomics on Adipose Tissue Research

(2020) Alana Deutsch et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of resveratrol on expression of genes involved thermogenesis in mice and humans

(2019) João Marcus Oliveira Andrade et al.   BIOMEDICINE & PHARMACOTHERAPY

FGF21 as Modulator of Metabolism in Health and Disease

(2019) Caterina Tezze et al.   Frontiers in Physiology

Adipose tissue browning in mice and humans

(2019) Carsten T Herz et al.   JOURNAL OF ENDOCRINOLOGY

Meta-omics analysis of elite athletes identifies a performance-enhancing microbe that functions via lactate metabolism

(2019) Jonathan Scheiman et al.   NATURE MEDICINE

Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

(2019) Lingyan Wu et al.   Cell Death & Disease

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

(2019) Anying Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp1 controls brown/beige adipocyte differentiation and thermogenesis through regulating β3-AR desensitization

(2019) Pei Liu et al.   Nature Communications

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes

(2019) Prashant Rajbhandari et al.   eLife

Antibiotic-induced Disruption of Intestinal Microbiota Contributes to Failure of Vertical Sleeve Gastrectomy

(2018) Cyrus Jahansouz et al.   ANNALS OF SURGERY

Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity

(2018) Hyun Cheol Roh et al.   Cell Metabolism

Deconstructing Adipogenesis Induced by β3-Adrenergic Receptor Activation with Single-Cell Expression Profiling

(2018) Rayanne B. Burl et al.   Cell Metabolism

Green tea supplementation upregulates uncoupling protein 3 expression in severe obese women adipose tissue but does not promote weight loss

(2018) Driele Cristina Gomes Quinhoneiro et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Inflammation of brown/beige adipose tissues in obesity and metabolic disease

(2018) F. Villarroya et al.   JOURNAL OF INTERNAL MEDICINE

Exercise-induced ‘browning’ of adipose tissues

(2018) Peter Aldiss et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Dietary Curcumin Intervention Targets Mouse White Adipose Tissue Inflammation and Brown Adipose Tissue UCP1 Expression

(2018) Zhuolun Song et al.   Obesity

A direct tissue-grafting approach to increasing endogenous brown fat

(2018) Nicole R. Blumenfeld et al.   Scientific Reports

AMP-Activated Protein Kinase (AMPK) Regulates Energy Metabolism through Modulating Thermogenesis in Adipose Tissue

(2018) Lingyan Wu et al.   Frontiers in Physiology

Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1

(2018) Dianxin Liu et al.   Molecular Metabolism

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

The Peroxisome Proliferator-Activated Receptor α (PPARα) Agonist Pemafibrate Protects against Diet-Induced Obesity in Mice

(2018) Masaya Araki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity

(2018) Ryutaro Ikegami et al.   Cell Reports

Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice

(2018) Chelsea Hepler et al.   eLife

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Parathyroid hormone induces a browning program in human white adipocytes

(2018) Oana C. Hedesan et al.   INTERNATIONAL JOURNAL OF OBESITY

Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes

(2018) A. Kaisanlahti et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway

(2018) Guihong Qi et al.   Acta Pharmaceutica Sinica B

NGS Reveals Molecular Pathways Affected by Obesity and Weight Loss-Related Changes in miRNA Levels in Adipose Tissue

(2017) Alina Kuryłowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction

(2017) Mark Nøhr et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes

(2017) Mandana Pahlavani et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

(2017) Roksana M Pirzgalska et al.   NATURE MEDICINE

The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe

(2017) Haruka Kimura et al.   Scientific Reports

Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat

(2017) Lu Yao et al.   Cell Reports

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice

(2017) Liang Xu et al.   EBioMedicine

Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 level in mice

(2016) Tomoya Sakamoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardiac Cachexia: Perspectives for Prevention and Treatment

(2016) Marina Politi Okoshi et al.   Arquivos Brasileiros de Cardiologia

Browning and thermogenic programing of adipose tissue

(2016) Florian W. Kiefer   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms

(2016) Padmamalini Baskaran et al.   BRITISH JOURNAL OF PHARMACOLOGY

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

(2016) Marika Ziętak et al.   Cell Metabolism

AMPK/α-Ketoglutarate Axis Dynamically Mediates DNA Demethylation in the Prdm16 Promoter and Brown Adipogenesis

(2016) Qiyuan Yang et al.   Cell Metabolism

PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer

(2016) Serkan Kir et al.   Cell Metabolism

Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

(2016) Emilio P. Mottillo et al.   Cell Metabolism

FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues

(2016) Christian Schlein et al.   Cell Metabolism

A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis

(2016) Kana Ohyama et al.   DIABETES

PPARγ Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

(2016) Sun-Sil Choi et al.   DIABETES

Single-cell transcriptomics and functional target validation of brown adipocytes show their complex roles in metabolic homeostasis

(2016) Jennifer M. Spaethling et al.   FASEB JOURNAL

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

(2016) Lili Ding et al.   HEPATOLOGY

Eicosapentaenoic Acid Potentiates Brown Thermogenesis through FFAR4-dependent Up-regulation of miR-30b and miR-378

(2016) Jiyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Browning and Higher Mitochondrial Function in Periadrenal But Not SC Fat in Pheochromocytoma

(2016) Laurent Vergnes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects

(2016) L.M. Laiglesia et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes

(2016) Jameel Lone et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Nutrigenomic regulation of adipose tissue development — role of retinoic acid: A review

(2016) Bo Wang et al.   MEAT SCIENCE

Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity

(2016) Yong Chen et al.   Nature Communications

Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathway in vivo and in vitro

(2016) Endong Zhu et al.   Oncotarget

Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women

(2016) Shinsuke Nirengi et al.   SpringerPlus

GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice

(2016) Michella S. Coelho et al.   PLoS One

Curcumin promotes browning of white adipose tissue in a norepinephrine-dependent way

(2015) Shan Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic activation of pattern recognition receptors suppresses brown adipogenesis of multipotent mesodermal stem cells and brown pre-adipocytes

(2015) Jiyoung Bae et al.   Biochemistry and Cell Biology

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Pharmacologic Effects of FGF21 Are Independent of the “Browning” of White Adipose Tissue

(2015) Murielle M. Véniant et al.   Cell Metabolism

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1  signaling network

(2015) H. Zhang et al.   EMBO REPORTS

Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1

(2015) S Wang et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues

(2015) Alina Kurylowicz et al.   Journal of Translational Medicine

Fenofibrate (PPARalpha agonist) induces beige cell formation in subcutaneous white adipose tissue from diet-induced male obese mice

(2015) Tamiris Lima Rachid et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training

(2015) Jakob G. Knudsen et al.   Obesity

Diet-induced obesity causes insulin resistance in mouse brown adipose tissue

(2015) Carla Roberts-Toler et al.   Obesity

Efficacy of Berberine in Patients with Non-Alcoholic Fatty Liver Disease

(2015) Hong-Mei Yan et al.   PLoS One

Serum FGF21 levels are associated with brown adipose tissue activity in humans

(2015) Mark J.W. Hanssen et al.   Scientific Reports

Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice

(2014) Meritxell Rosell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes

(2014) Ming Zhao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

A Smooth Muscle-Like Origin for Beige Adipocytes

(2014) Jonathan Z. Long et al.   Cell Metabolism

Prdm16 Is Required for the Maintenance of Brown Adipocyte Identity and Function in Adult Mice

(2014) Matthew J. Harms et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Irisin: ‘fat’ or artefact

(2014) A.B. Crujeiras et al.   CLINICAL ENDOCRINOLOGY

Browning of White Adipose Cells by Intermediate Metabolites: An Adaptive Mechanism to Alleviate Redox Pressure

(2014) A. Carriere et al.   DIABETES

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

(2014) João Marcus Oliveira Andrade et al.   EUROPEAN JOURNAL OF NUTRITION

The Effects of Temperature and Seasons on Subcutaneous White Adipose Tissue in Humans: Evidence for Thermogenic Gene Induction

(2014) Philip A. Kern et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Berberine activates thermogenesis in white and brown adipose tissue

(2014) Zhiguo Zhang et al.   Nature Communications

BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells

(2013) Manuela Elsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Brown adipose tissue: development, metabolism and beyond

(2013) Tim J. Schulz et al.   BIOCHEMICAL JOURNAL

White-to-brown transdifferentiation of omental adipocytes in patients affected by pheochromocytoma

(2013) Andrea Frontini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Retinoic acid has different effects on UCP1 expression in mouse and human adipocytes

(2013) Maria Murholm et al.   BMC CELL BIOLOGY

EBF2 Determines and Maintains Brown Adipocyte Identity

(2013) Sona Rajakumari et al.   Cell Metabolism

Anatomical Locations of Human Brown Adipose Tissue: Functional Relevance and Implications in Obesity and Type 2 Diabetes

(2013) H. Sacks et al.   DIABETES

Orexin Restores Aging-Related Brown Adipose Tissue Dysfunction in Male Mice

(2013) Dyan Sellayah et al.   ENDOCRINOLOGY

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Green tea catechins prevent obesity through modulation of peroxisome proliferator-activated receptors

(2013) JingQi Yan et al.   Science China-Life Sciences

Small-Molecule Hormones: Molecular Mechanisms of Action

(2013) Monika Puzianowska-Kuznicka et al.   International Journal of Endocrinology

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Systemic  -Adrenergic Stimulation of Thermogenesis Is Not Accompanied by Brown Adipose Tissue Activity in Humans

(2012) M. J. Vosselman et al.   DIABETES

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

(2012) Marica Bordicchia et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Relevance of brown adipose tissue in infancy and adolescence

(2012) Vicente Gilsanz et al.   PEDIATRIC RESEARCH

Curcumin Prevents High Fat Diet Induced Insulin Resistance and Obesity via Attenuating Lipogenesis in Liver and Inflammatory Pathway in Adipocytes

(2012) Weijuan Shao et al.   PLoS One

Orexin Is Required for Brown Adipose Tissue Development, Differentiation, and Function

(2011) Dyan Sellayah et al.   Cell Metabolism

The Effects of Capsaicin and Capsiate on Energy Balance: Critical Review and Meta-analyses of Studies in Humans

(2011) M.-J. Ludy et al.   CHEMICAL SENSES

The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis

(2011) R. Hursel et al.   Obesity Reviews

Challenges in β3-adrenoceptor agonist drug development

(2011) Jonathan R. S. Arch   Therapeutic Advances in Endocrinology and Metabolism

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Cold-Induced Adaptive Thermogenesis in Lean and Obese

(2010) Sander L.J. Wijers et al.   Obesity

Transdifferentiation properties of adipocytes in the adipose organ

(2009) Saverio Cinti   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

(2009) Jesse J Smith et al.   BMC Systems Biology

GABA A receptors in the lateral hypothalamus as mediators of satiety and body weight regulation

(2009) Christine I. Turenius et al.   BRAIN RESEARCH

Transcriptional control of brown adipocyte development and physiological function--of mice and men

(2009) P. Seale et al.   GENES & DEVELOPMENT

Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

(2009) Natasa Petrovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metabolic and Behavioral Compensations in Response to Caloric Restriction: Implications for the Maintenance of Weight Loss

(2009) Leanne M. Redman et al.   PLoS One

Associations between Sleep Loss and Increased Risk of Obesity and Diabetes

(2008) Kristen L. Knutson et al.   Annals of the New York Academy of Sciences

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

(2008) I. Murano et al.   JOURNAL OF ANATOMY

Prolonged AICAR-induced AMP-kinase activation promotes energy dissipation in white adipocytes: novel mechanisms integrating HSL and ATGL

(2008) Mandeep P. Gaidhu et al.   JOURNAL OF LIPID RESEARCH

Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue

(2008) Sachiko Nomura et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE