Genetic and Epigenetic Aspects of Atopic Dermatitis

Belinostat resolves skin barrier defects in atopic dermatitis by targeting the dysregulated miR-335:SOX6 axis

(2020) Wen Chiy Liew et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Epigenetic Connection Between the Gut Microbiome in Obesity and Diabetes

(2020) Manvi Sharma et al.   Frontiers in Genetics

MicroRNAs in atopic dermatitis: A systematic review

(2020) Xin Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genetics and Epigenetics of Atopic Dermatitis: An Updated Systematic Review

(2020) Maria J Martin et al.   Genes

Disease-associated KIF3A variants alter gene methylation and expression impacting skin barrier and atopic dermatitis risk

(2020) Mariana L. Stevens et al.   Nature Communications

Blocking histone deacetylase activity as a novel target for epithelial barrier defects in allergic rhinitis

(2019) Brecht Steelant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Role of the Environmental Risk Factors in the Pathogenesis and Clinical Outcome of Atopic Dermatitis

(2019) Domenico Bonamonte et al.   Biomed Research International

Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

(2019) Mari Løset et al.   DERMATOLOGY

Corrigendum: Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I

(2019) A. Wollenberg et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

MicroRNA‑146a as a potential regulator involved in the pathogenesis of atopic dermatitis

(2019) Fenggen Yan et al.   Molecular Medicine Reports

Atopic Dermatitis in Adults

(2019) Jonathan I. Silverberg   MEDICAL CLINICS OF NORTH AMERICA

Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development

(2019) Louis Legoff et al.   Cells

Identification and interaction analysis of key genes and microRNAs in atopic dermatitis by bioinformatics analysis

(2018) H. M. Li et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Trans- and inter-generational epigenetic inheritance in allergic diseases

(2018) Toril Mørkve Knudsen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

(2018) A. Wollenberg et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Atopic dermatitis

(2018) Stephan Weidinger et al.   Nature Reviews Disease Primers

Analysis of the Association of Polymorphisms rs5743708 in TLR2 and rs4986790 in TLR4 with Atopic Dermatitis Risk

(2018) Yuan Zhang et al.   IMMUNOLOGICAL INVESTIGATIONS

Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis

(2018) Eishika Dissanayake et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MiR-151a is involved in the pathogenesis of atopic dermatitis by regulating interleukin-12 receptor β2

(2017) Xiao-Fan Chen et al.   EXPERIMENTAL DERMATOLOGY

Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

(2017) Kyu-Seon Oh et al.   IMMUNITY

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis

(2017) Elisabet Johansson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of regulatory T cells and genes involved in their differentiation in pathogenesis of selected inflammatory and neoplastic skin diseases. Part III: Polymorphisms of genes involved in Tregs’ activation and function

(2017) Bogusław Nedoszytko et al.   Postepy Dermatologii i Alergologii

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

(2017) Gaku Tsuji et al.   Cell Death & Disease

Epigenetics and allergy: from basic mechanisms to clinical applications

(2017) Daniel P Potaczek et al.   Epigenomics

Association of a Single Nucleotide Polymorphism in a Late Cornified Envelope-like Proline-rich 1 Gene (LELP1) with Atopic Dermatitis

(2016) M Trzeciak et al.   ACTA DERMATO-VENEREOLOGICA

Prevalence and odds of Staphylococcus aureuscarriage in atopic dermatitis: a systematic review and meta-analysis

(2016) J.E.E. Totté et al.   BRITISH JOURNAL OF DERMATOLOGY

Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond

(2016) W.H.I. McLean   BRITISH JOURNAL OF DERMATOLOGY

Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells

(2016) Claire S. Leitch et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients

(2016) A. Wollenberg et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Atopic dermatitis

(2016) Stephan Weidinger et al.   LANCET

Trying to understand the genetics of atopic dermatitis

(2016) Susanne Stemmler et al.   MOLECULAR AND CELLULAR PROBES

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

(2016) Rachael Jarrett et al.   Science Translational Medicine

Unravelling the complex genetic background of atopic dermatitis: from genetic association results towards novel therapeutic strategies

(2015) Sabine Hoffjan et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

MicroRNA-155 may be involved in the pathogenesis of atopic dermatitis by modulating the differentiation and function of T helper type 17 (Th17) cells

(2015) L. Ma et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The Genetics and Epigenetics of Atopic Dermatitis—Filaggrin and Other Polymorphisms

(2015) Yunsheng Liang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Update on epigenetics in allergic disease

(2015) Hani Harb et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Genomic imprinting in psoriasis and atopic dermatitis: A review

(2015) Catherine M. Nguyen et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Human Breast Milk miRNA, Maternal Probiotic Supplementation and Atopic Dermatitis in Offspring

(2015) Melanie Rae Simpson et al.   PLoS One

A polymorphism in the TH2 locus control region is associated with changes in DNA methylation and gene expression

(2014) M. Schieck et al.   ALLERGY

Filaggrin-insufficiency in keratinocytes influences responsiveness of allergen-specific T cells to cognate antigen and compounds barrier function deficiency

(2014) Ishita Marwah et al.   CLINICAL IMMUNOLOGY

The role of commensal bacteria in the regulation of sensitization to food allergens

(2014) Severine Cao et al.   FEBS LETTERS

Impact of 5-aza-2′-deoxycytidine and epigallocatechin-3-gallate for induction of human regulatory T cells

(2014) Jan Kehrmann et al.   IMMUNOLOGY

The frequencies of haplotypes defined by three polymorphisms of theIL-31gene: −1066, −2057, and IVS2+12 in Polish patients with atopic dermatitis

(2014) Małgorzata Sokołowska-Wojdyło et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes

(2014) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Integrated Epigenetic and Transcriptomic Analysis Reveals Distinct Tissue-Specific Patterns of DNA Methylation Associated with Atopic Dermatitis

(2014) Elke Rodríguez et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

(2014) Bodo C Melnik et al.   Journal of Translational Medicine

Association of polymorphisms in the toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan

(2014) G. F. Gimalova et al.   MOLECULAR BIOLOGY

Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis

(2014) Bogusław Nedoszytko et al.   Postepy Dermatologii i Alergologii

The Epigenetics Heretic

(2014) J. Kaiser   SCIENCE

Farm exposure and time trends in early childhood may influence DNA methylation in genes related to asthma and allergy

(2013) S. Michel et al.   ALLERGY

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis

(2013) I.-J. Wang et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Promoter demethylation contributes to TSLP overexpression in skin lesions of patients with atopic dermatitis

(2013) Y. Luo et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

The association ofGM-CSF-677A/C promoter gene polymorphism with the occurrence and severity of atopic dermatitis in a Polish population

(2013) Aleksandra Wilkowska et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases

(2013) Thomas X. Lu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNAs: Essential players in the regulation of inflammation

(2013) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers

(2013) Gunda Herberth et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Increased regulatory T-cell numbers are associated with farm milk exposure and lower atopic sensitization and asthma in childhood

(2013) Anna Lluis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model

(2012) M. Gschwandtner et al.   ALLERGY

Maternal Exposure to Polycyclic Aromatic Hydrocarbons and 5’-CpG Methylation of Interferon-γ in Cord White Blood Cells

(2012) Wan-yee Tang et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The DNA Methylation Inhibitor 5-Azacytidine Increases Regulatory T Cells and Alleviates Airway Inflammation in Ovalbumin-Sensitized Mice

(2012) Cheng-Jang Wu et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

(2012) Hiroshi Kawasaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Epigenetic Regulation of Gene Expression in Keratinocytes

(2012) Vladimir A. Botchkarev et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants

(2012) A.H. Ziyab et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Wet-Wrap Treatment in Children with Atopic Dermatitis: A Practical Guideline

(2012) Arjan C. A. Devillers et al.   PEDIATRIC DERMATOLOGY

MicroRNA-155 Modulates Treg and Th17 Cells Differentiation and Th17 Cell Function by Targeting SOCS1

(2012) Rui Yao et al.   PLoS One

Demethylation of the FCER1G promoter leads to FcεRI overexpression on monocytes of patients with atopic dermatitis

(2011) Y. Liang et al.   ALLERGY

Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year

(2011) D. Hinz et al.   ALLERGY

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes

(2011) D. Gutowska-Owsiak et al.   BRITISH JOURNAL OF DERMATOLOGY

Effects of Helicobacter pylori, geohelminth infection and selected commensal bacteria on the risk of allergic disease and sensitization in 3-year-old Ethiopian children

(2011) A. Amberbir et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

(2011) M. Trzeciak et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Therapeutic effects of recombinantSalmonella typhimuriumharboring CCL22 miRNA on atopic dermatitis-like skin in mice

(2011) Won Suck Yoon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Filaggrin knockdown and Toll-like receptor 3 (TLR3) stimulation enhanced the production of thymic stromal lymphopoietin (TSLP) from epidermal layers

(2011) Kyung Ho Lee et al.   EXPERIMENTAL DERMATOLOGY

IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

(2011) Danuta Gutowska-Owsiak et al.   EXPERIMENTAL DERMATOLOGY

Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes

(2011) Stephanie Brand et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

MicroRNA-21 Limits In Vivo Immune Response-Mediated Activation of the IL-12/IFN-  Pathway, Th1 Polarization, and the Severity of Delayed-Type Hypersensitivity

(2011) T. X. Lu et al.   JOURNAL OF IMMUNOLOGY

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

(2011) Sara J. Brown et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

(2010) Enikö Sonkoly et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Interleukin-13promoter gene polymorphism -1112C/T is associated with the systemic form of mastocytosis

(2009) B. Nedoszytko et al.   ALLERGY

Prenatal Tobacco Smoke Exposure Affects Global and Gene-specific DNA Methylation

(2009) Carrie V. Breton et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells

(2009) Bianca Schaub et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells

(2009) Osamu Kaminuma et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association between the –1154 G/A promoter polymorphism of the vascular endothelial growth factor gene and atopic dermatitis

(2009) M Zablotna et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis

(2009) M Trzeciak et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Impairment of T helper and T regulatory cell responses at birth

(2008) B. Schaub et al.   ALLERGY

Comparative Study of Regulatory T Cell Function of HumanCD25+CD4+T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood

(2008) Wakae Fujimaki et al.   Clinical & Developmental Immunology

MicroRNAs: novel regulators in skin inflammation

(2008) E. Sonkoly et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Multilevel Regulation of Gene Expression by MicroRNAs

(2008) E. V. Makeyev et al.   SCIENCE

MicroRNAs and immunity: Novel players in the regulation of normal immune function and inflammation

(2008) Enikö Sonkoly et al.   SEMINARS IN CANCER BIOLOGY