The Genetics and Epigenetics of Atopic Dermatitis—Filaggrin and Other Polymorphisms
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Title
The Genetics and Epigenetics of Atopic Dermatitis—Filaggrin and Other Polymorphisms
Authors
Keywords
Atopic dermatitis, Genetics, Epigenetics, Epidermal barrier, Filaggrin, Polymorphism
Journal
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
Volume 51, Issue 3, Pages 315-328
Publisher
Springer Nature
Online
2015-09-18
DOI
10.1007/s12016-015-8508-5
References
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Note: Only part of the references are listed.- Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin
- (2014) Teruhiko Makino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Molecular Biology of Atopic Dermatitis
- (2014) Zhanglei Mu et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- The Changing Geoepidemiology of Food Allergies
- (2014) Patrick S. C. Leung et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- The role of commensal bacteria in the regulation of sensitization to food allergens
- (2014) Severine Cao et al. FEBS LETTERS
- Mechanisms of abnormal lamellar body secretion and the dysfunctional skin barrier in patients with atopic dermatitis
- (2014) Peter M. Elias et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- An Integrated Epigenetic and Transcriptomic Analysis Reveals Distinct Tissue-Specific Patterns of DNA Methylation Associated with Atopic Dermatitis
- (2014) Elke Rodríguez et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Epigenetics in immune development and in allergic and autoimmune diseases
- (2014) David Martino et al. JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Thymic Stromal Lymphopoietin Variation, Filaggrin Loss of Function, and the Persistence of Atopic Dermatitis
- (2014) David J. Margolis et al. JAMA Dermatology
- Eczema phenotypes are associated with multiple vitamin D pathway genes in Chinese children
- (2013) S. S. Wang et al. ALLERGY
- Immunology of atopic eczema: overcoming the Th1/Th2 paradigm
- (2013) K. Eyerich et al. ALLERGY
- Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis
- (2013) I.-J. Wang et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Promoter demethylation contributes to TSLP overexpression in skin lesions of patients with atopic dermatitis
- (2013) Y. Luo et al. CLINICAL AND EXPERIMENTAL DERMATOLOGY
- Epigenetics of allergy
- (2013) Giovanna Tezza et al. EARLY HUMAN DEVELOPMENT
- A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis
- (2013) Takashi Sasaki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects
- (2013) Sean P. Saunders et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis
- (2013) Jorge Esparza-Gordillo et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin
- (2013) Laurence Pellerin et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The multifunctional role of filaggrin in allergic skin disease
- (2013) Maeve A. McAleer et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Filaggrin-2 variation is associated with more persistent atopic dermatitis in African American subjects
- (2013) David J. Margolis et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Maternal and cord blood miR-223 expression associates with prenatal tobacco smoke exposure and low regulatory T-cell numbers
- (2013) Gunda Herberth et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Asthma, allergy, and responses to methyl donor supplements and nutrients
- (2013) Sunita Sharma et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The role of IL-22 and Th22 cells in human skin diseases
- (2013) Hideki Fujita JOURNAL OF DERMATOLOGICAL SCIENCE
- Cytochrome P450-mediated metabolism of vitamin D
- (2013) Glenville Jones et al. JOURNAL OF LIPID RESEARCH
- Roles of NLRP10 in innate and adaptive immunity
- (2013) Anna Damm et al. MICROBES AND INFECTION
- High-density genotyping study identifies four new susceptibility loci for atopic dermatitis
- (2013) David Ellinghaus et al. NATURE GENETICS
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review
- (2013) Susan B Brown et al. NUTRITION REVIEWS
- Atopic dermatitis: a candidate for disease-modifying strategy
- (2012) T. Bieber et al. ALLERGY
- Interleukin-18 Gene Polymorphisms in Egyptian Patients with Allergic Diseases
- (2012) Gehan H. Ibrahim et al. American Journal of Rhinology & Allergy
- Common Methodologies in the Evaluation of Food Allergy: Pitfalls and Prospects of Food Allergy Prevalence Studies
- (2012) Shang-an Shu et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Clinical Spectrum of Food Allergies: a Comprehensive Review
- (2012) Marco H.-K. Ho et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Maternal Exposure to Polycyclic Aromatic Hydrocarbons and 5’-CpG Methylation of Interferon-γ in Cord White Blood Cells
- (2012) Wan-yee Tang et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- The 420K LEKTI variant alters LEKTI proteolytic activation and results in protease deregulation: implications for atopic dermatitis
- (2012) P. Fortugno et al. HUMAN MOLECULAR GENETICS
- Human β-defensin 1 (DEFB1) allele and genotype frequencies probably impact on ethnic susceptibility to atopic dermatitis
- (2012) Ernesto Prado Montes de Oca et al. INTERNATIONAL JOURNAL OF DERMATOLOGY
- Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency
- (2012) Sanja Kezic et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort
- (2012) David J. Margolis et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- IL-33 and ST2 in Atopic Dermatitis: Expression Profiles and Modulation by Triggering Factors
- (2012) Terhi Savinko et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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- (2012) Jessica C. Kiefte-de Jong et al. JOURNAL OF NUTRITION
- Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
- (2012) Tomomitsu Hirota et al. NATURE GENETICS
- Commensal bacteria–derived signals regulate basophil hematopoiesis and allergic inflammation
- (2012) David A Hill et al. NATURE MEDICINE
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- (2011) Y. Liang et al. ALLERGY
- The role of vitamin D in the immunopathogenesis of allergic skin diseases
- (2011) A. A. Benson et al. ALLERGY
- Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year
- (2011) D. Hinz et al. ALLERGY
- Association of serum interleukin-18 and other biomarkers with disease severity in adults with atopic dermatitis
- (2011) Kenzen Kou et al. ARCHIVES OF DERMATOLOGICAL RESEARCH
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- (2011) Alexia Hulin et al. CARDIOVASCULAR RESEARCH
- The role of thymic stromal lymphopoietin in the immunopathogenesis of atopic dermatitis
- (2011) S. P. Jariwala et al. CLINICAL AND EXPERIMENTAL ALLERGY
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- (2011) A. Amberbir et al. CLINICAL AND EXPERIMENTAL ALLERGY
- Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy
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- (2011) Cheng-Che E. Lan et al. EXPERIMENTAL DERMATOLOGY
- Association of polymorphisms in the promoter region of FCER1A gene with atopic dermatitis, chronic uticaria, asthma, and serum immunoglobulin E levels in a Han Chinese population
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- Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response
- (2011) Donald Y.M. Leung et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Specificity protein 1 is pivotal in the skin’s antiviral response
- (2011) Lianghua Bin et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Early complementary feeding and risk of food sensitization in a birth cohort
- (2011) Christine L.M. Joseph et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Epigenetic regulation in murine offspring as a novel mechanism for transmaternal asthma protection induced by microbes
- (2011) Stephanie Brand et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis
- (2011) Anna De Benedetto et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Gut microbiota, probiotics, and vitamin D: Interrelated exposures influencing allergy, asthma, and obesity?
- (2011) Ngoc P. Ly et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy
- (2011) Sara J. Brown et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Association Screening in the Epidermal Differentiation Complex (EDC) Identifies an SPRR3 Repeat Number Variant as a Risk Factor for Eczema
- (2011) Ingo Marenholz et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- SNPing at the Epidermal Barrier
- (2011) David P. Kelsell et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Genetic Variants in Interferon Regulatory Factor 2 (IRF2) Are Associated with Atopic Dermatitis and Eczema Herpeticum
- (2011) Pei-Song Gao et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect
- (2011) Sara J. Brown et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- One Remarkable Molecule: Filaggrin
- (2011) Sara J. Brown et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Association of SPINK5 gene polymorphisms with atopic dermatitis in Northeast China
- (2011) L.P. Zhao et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Polymorphisms in the TLR6 gene associated with the inverse association between childhood acute lymphoblastic leukemia and atopic disease
- (2011) K G E Miedema et al. LEUKEMIA
- Naturally occurring FCER1A N222K mutation – Its ethnicity-dependent distribution and a role in atopic dermatitis
- (2011) Daniel P. Potaczek et al. MOLECULAR IMMUNOLOGY
- Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population
- (2011) Liang-Dan Sun et al. NATURE GENETICS
- Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease
- (2011) Gosia Trynka et al. NATURE GENETICS
- Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
- (2011) Lavinia Paternoster et al. NATURE GENETICS
- The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
- (2011) Taylor A Doherty et al. NATURE MEDICINE
- Filaggrin Mutations Associated with Skin and Allergic Diseases
- (2011) Alan D. Irvine et al. NEW ENGLAND JOURNAL OF MEDICINE
- Maternal dietary patterns during pregnancy and risk of wheeze and eczema in Japanese infants aged 16-24 months: The Osaka Maternal and Child Health Study
- (2011) Yoshihiro Miyake et al. PEDIATRIC ALLERGY AND IMMUNOLOGY
- A Parsimonious Model for Gene Regulation by miRNAs
- (2011) S. Djuranovic et al. SCIENCE
- The role of epigenetic dysregulation in the epidemic of allergic disease
- (2011) Susan Prescott et al. Clinical Epigenetics
- Common IL-31 Gene Haplotype Associated with Non-atopic Eczema is Not Implicated in Epidermolysis Bullosa Pruriginosa
- (2010) JA McGrath et al. ACTA DERMATO-VENEREOLOGICA
- Atopy, asthma, and lung function in relation to folate and vitamin B12 in adults
- (2010) B. H. Thuesen et al. ALLERGY
- Innate Immunity in Atopic Dermatitis
- (2010) Andreas Wollenberg et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- FcεRIα gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients
- (2010) Y. Niwa et al. International Journal of Immunogenetics
- Raman profiles of the stratum corneum define 3 filaggrin genotype–determined atopic dermatitis endophenotypes
- (2010) Gráinne M. O'Regan et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Genetic variants in thymic stromal lymphopoietin are associated with atopic dermatitis and eczema herpeticum
- (2010) Pei-Song Gao et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4
- (2010) Enikö Sonkoly et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Nutrients and foods for the primary prevention of asthma and allergy: Systematic review and meta-analysis
- (2010) Ulugbek Nurmatov et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- An association of TLR2-16934A>T polymorphism and severity/phenotype of atopic dermatitis
- (2010) DP Potaczek et al. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
- Genomewide Association Studies and Assessment of the Risk of Disease
- (2010) Teri A. Manolio NEW ENGLAND JOURNAL OF MEDICINE
- T Regulatory Cells in Cord Blood—FOXP3 Demethylation as Reliable Quantitative Marker
- (2010) Jing Liu et al. PLoS One
- Parents’ smoking habit and prevalence of atopic eczema in 6-7 and 13-14 year-old schoolchildren in Spain. ISAAC Phase III
- (2009) M. Morales Suárez-Varela et al. ALLERGOLOGIA ET IMMUNOPATHOLOGIA
- Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk
- (2009) J. M. Mahachie John et al. ALLERGY
- Impaired TLR-2 expression and TLR-2-mediated cytokine secretion in macrophages from patients with atopic dermatitis
- (2009) M. Niebuhr et al. ALLERGY
- Effect of Supplemental Folic Acid in Pregnancy on Childhood Asthma: A Prospective Birth Cohort Study
- (2009) M. J. Whitrow et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases
- (2009) Y Wang et al. CLINICAL GENETICS
- Deltex1 Is a Target of the Transcription Factor NFAT that Promotes T Cell Anergy
- (2009) Huey-Wen Hsiao et al. IMMUNITY
- Locus 1q21 Gene Expression Changes in Atopic Dermatitis Skin Lesions: Deregulation of Small Proline-Rich Region 1A
- (2009) Jerzy Jarzab et al. INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
- T-box 21 transcription factor is responsible for distorted TH2 differentiation in human peripheral CD4+ T cells
- (2009) Osamu Kaminuma et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Higher serum folate levels are associated with a lower risk of atopy and wheeze
- (2009) Elizabeth C. Matsui et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease
- (2009) Elke Rodríguez et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Filaggrin mutations that confer risk of atopic dermatitis confer greater risk for eczema herpeticum
- (2009) Pei-Song Gao et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Bidirectional Modulation of Adipogenesis by the Secreted Protein Ccdc80/DRO1/URB
- (2009) Frédéric Tremblay et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Filaggrin in the frontline: role in skin barrier function and disease
- (2009) A. Sandilands et al. JOURNAL OF CELL SCIENCE
- Single nucleotide polymorphisms and the haplotype in the DEFB1 gene are associated with atopic dermatitis in a Korean population
- (2009) Eugene Kim et al. JOURNAL OF DERMATOLOGICAL SCIENCE
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- (2009) S. Hoffjan et al. JOURNAL OF DERMATOLOGICAL SCIENCE
- Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
- (2009) Anaïs Briot et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Eczema Genetics: Current State of Knowledge and Future Goals
- (2009) Sara J. Brown et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A common variant on chromosome 11q13 is associated with atopic dermatitis
- (2009) Jorge Esparza-Gordillo et al. NATURE GENETICS
- Relation of DNA Methylation of 5′-CpG Island of ACSL3 to Transplacental Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Childhood Asthma
- (2009) Frederica Perera et al. PLoS One
- Molecular Identification and Expression Analysis of Filaggrin-2, a Member of the S100 Fused-Type Protein Family
- (2009) Zhihong Wu et al. PLoS One
- GARP (LRRC32) is essential for the surface expression of latent TGF- on platelets and activated FOXP3+ regulatory T cells
- (2009) D. Q. Tran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism
- (2008) M. Niebuhr et al. ALLERGY
- DNA methylation controls Foxp3 gene expression
- (2008) Julia K. Polansky et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Filaggrin mutations, atopic eczema, hay fever, and asthma in children
- (2008) Stephan Weidinger et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis
- (2008) Salima Mrabet-Dahbi et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- The burden of disease associated with filaggrin mutations: A population-based, longitudinal birth cohort study
- (2008) John Henderson et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
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- (2008) Thomas Bieber NEW ENGLAND JOURNAL OF MEDICINE
- Multilevel Regulation of Gene Expression by MicroRNAs
- (2008) E. V. Makeyev et al. SCIENCE
- Genome-Wide Scan on Total Serum IgE Levels Identifies FCER1A as Novel Susceptibility Locus
- (2008) Stephan Weidinger et al. PLoS Genetics
- Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic Eczema
- (2007) Sara J. Brown et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
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