Transgenerational Inheritance of Environmentally Induced Epigenetic Alterations during Mammalian Development

Maternal obesity influences expression and DNA methylation of the adiponectin and leptin systems in human third-trimester placenta

(2019) Perrine Nogues et al.   Clinical Epigenetics

Histone H1, the forgotten histone

(2019) Kevin Brockers et al.   Epigenomics

Cellular functions of long noncoding RNAs

(2019) Run-Wen Yao et al.   NATURE CELL BIOLOGY

RNA profiling of human testicular cells identifies syntenic lncRNAs associated with spermatogenesis

(2019) A D Rolland et al.   HUMAN REPRODUCTION

Developmental dynamics of lncRNAs across mammalian organs and species

(2019) Ioannis Sarropoulos et al.   NATURE

A hidden human proteome encoded by ‘non-coding’ genes

(2019) Shaohua Lu et al.   NUCLEIC ACIDS RESEARCH

The histone variant H2A.Z in gene regulation

(2019) Benedetto Daniele Giaimo et al.   Epigenetics & Chromatin

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prenatal Exposure to Bisphenol A, E, and S Induces Transgenerational Effects on Male Reproductive Functions in Mice

(2019) Mingxin Shi et al.   TOXICOLOGICAL SCIENCES

X Inactivation and Escape: Epigenetic and Structural Features

(2019) He Fang et al.   Frontiers in Cell and Developmental Biology

Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice

(2019) Carlos Diaz-Castillo et al.   Scientific Reports

Environmental Influences on the Epigenome: Exposure- Associated DNA Methylation in Human Populations

(2018) Elizabeth M. Martin et al.   Annual Review of Public Health

Profiling of testis-specific long noncoding RNAs in mice

(2018) Seong Hyeon Hong et al.   BMC GENOMICS

Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus

(2018) Xiaoling Weng et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Transgenerational effects of prenatal restricted diet on gene expression and histone modifications in the rat

(2018) Joanna Nowacka-Woszuk et al.   PLoS One

DNA methylation and potential multigenerational epigenetic effects linked to uranium chronic low-dose exposure in gonads of males and females rats

(2018) G. Elmhiri et al.   TOXICOLOGY LETTERS

The Role of Xist in X-Chromosome Dosage Compensation

(2018) Anna Sahakyan et al.   TRENDS IN CELL BIOLOGY

Protein arginine methylation: an emerging regulator of the cell cycle

(2018) Anita E. Raposo et al.   Cell Division

Intrauterine hyperglycemia exposure results in intergenerational inheritance via DNA methylation reprogramming on F1 PGCs

(2018) Jun Ren et al.   Epigenetics & Chromatin

Small de novo CNVs as biomarkers of parental exposure to low doses of ionizing radiation of caesium-137

(2018) Emília Oliveira Alves Costa et al.   Scientific Reports

Gestational exposure to chlordecone promotes transgenerational changes in the murine reproductive system of males

(2018) Aurore Gely-Pernot et al.   Scientific Reports

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

(2018) Peter W. S. Hill et al.   NATURE

Smoking induces coordinated DNA methylation and gene expression changes in adipose tissue with consequences for metabolic health

(2018) Pei-Chien Tsai et al.   Clinical Epigenetics

Chronic exposure to arsenic, LINE-1 hypomethylation, and blood pressure: a cross-sectional study in Bangladesh

(2017) Khaled Hossain et al.   Environmental Health

Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats

(2017) Kushaan Dumasia et al.   Epigenetics

The Dark Side of the Epitranscriptome: Chemical Modifications in Long Non-Coding RNAs

(2017) Roland Jacob et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia

(2017) Shashi P. Singh et al.   JOURNAL OF IMMUNOLOGY

Histone chaperone networks shaping chromatin function

(2017) Colin M. Hammond et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging roles of linker histones in regulating chromatin structure and function

(2017) Dmitry V. Fyodorov et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Strategies and Challenges in Identifying Function for Thousands of sORF-Encoded Peptides in Meiosis

(2017) Ina Hollerer et al.   PROTEOMICS

Transgenerational transmission of environmental information in C. elegans

(2017) Adam Klosin et al.   SCIENCE

Roles of histone H3.5 in human spermatogenesis and spermatogenic disorders

(2017) K. Shiraishi et al.   Andrology

Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers

(2017) Margaux McBirney et al.   PLoS One

The effects of paternal high-fat diet exposure on offspring metabolism with epigenetic changes in the mouse adiponectin and leptin gene promoters

(2016) Hisashi Masuyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Prenatal Air Pollution Exposures, DNA Methyl Transferase Genotypes, and Associations with Newborn LINE1 and Alu Methylation and Childhood Blood Pressure and Carotid Intima-Media Thickness in the Children’s Health Study

(2016) Carrie V. Breton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Sperm is epigenetically programmed to regulate gene transcription in embryos

(2016) Marta Teperek et al.   GENOME RESEARCH

Resetting Epigenetic Memory by Reprogramming of Histone Modifications in Mammals

(2016) Hui Zheng et al.   MOLECULAR CELL

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos

(2016) Xiaoyu Liu et al.   NATURE

Allelic reprogramming of the histone modification H3K4me3 in early mammalian development

(2016) Bingjie Zhang et al.   NATURE

Unique features of long non-coding RNA biogenesis and function

(2016) Jeffrey J. Quinn et al.   NATURE REVIEWS GENETICS

Exposure to the widely used herbicide atrazine results in deregulation of global tissue-specific RNA transcription in the third generation and is associated with a global decrease of histone trimethylation in mice

(2016) Chunxiang Hao et al.   NUCLEIC ACIDS RESEARCH

Non-coding RNAs as regulators in epigenetics

(2016) Jian-Wei Wei et al.   ONCOLOGY REPORTS

Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches

(2016) Julia Beermann et al.   PHYSIOLOGICAL REVIEWS

Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation

(2016) Albert Jeltsch et al.   RNA Biology

The DNA methyltransferase DNMT3C protects male germ cells from transposon activity

(2016) Joan Barau et al.   SCIENCE

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

(2016) B. R. Nelson et al.   SCIENCE

Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming

(2016) C. Eguizabal et al.   STEM CELLS

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

(2016) Justin S. Becker et al.   TRENDS IN GENETICS

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

(2016) T Mansell et al.   Translational Psychiatry

siRNA Silencing EZH2 Reverses Cisplatin-resistance of Human Non-small Cell Lung and Gastric Cancer Cells

(2015) Wen Zhou et al.   Asian Pacific Journal of Cancer Prevention

Brain-Derived Neurotrophic Factor Epigenetic Modifications Associated with Schizophrenia-like Phenotype Induced by Prenatal Stress in Mice

(2015) Erbo Dong et al.   BIOLOGICAL PSYCHIATRY

SOX17 Is a Critical Specifier of Human Primordial Germ Cell Fate

(2015) Naoko Irie et al.   CELL

Multigenerational Undernutrition Increases Susceptibility to Obesity and Diabetes that Is Not Reversed after Dietary Recuperation

(2015) Anandwardhan A. Hardikar et al.   Cell Metabolism

The interplay of histone modifications - writers that read

(2015) T. Zhang et al.   EMBO REPORTS

Transgenerational inheritance of heart disorders caused by paternal bisphenol A exposure

(2015) Marta Lombó et al.   ENVIRONMENTAL POLLUTION

Maternal prenatal depressive symptoms predict infantNR3C11F andBDNFIV DNA methylation

(2015) EC Braithwaite et al.   Epigenetics

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Nuclear receptors in transgenerational epigenetic inheritance

(2015) Lilla Ozgyin et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Disruption of histone methylation in developing sperm impairs offspring health transgenerationally

(2015) K. Siklenka et al.   SCIENCE

DNA methylation is stable during replication and cell cycle arrest

(2015) Amy R. Vandiver et al.   Scientific Reports

Exercise training and DNA methylation in humans

(2014) S. Voisin et al.   Acta Physiologica

Transgenerational Epigenetic Inheritance: Myths and Mechanisms

(2014) Edith Heard et al.   CELL

Regulatory Principles of Pluripotency: From the Ground State Up

(2014) Jamie A. Hackett et al.   Cell Stem Cell

The Gpr1/Zdbf2 locus provides new paradigms for transient and dynamic genomic imprinting in mammals

(2014) R. Duffie et al.   GENES & DEVELOPMENT

H2A.B facilitates transcription elongation at methylated CpG loci

(2014) Y. Chen et al.   GENOME RESEARCH

The evolution of lncRNA repertoires and expression patterns in tetrapods

(2014) Anamaria Necsulea et al.   NATURE

Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice

(2014) Katharina Gapp et al.   NATURE NEUROSCIENCE

Pesticide Methoxychlor Promotes the Epigenetic Transgenerational Inheritance of Adult-Onset Disease through the Female Germline

(2014) Mohan Manikkam et al.   PLoS One

Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1

(2014) D. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3K27me and PRC2 transmit a memory of repression across generations and during development

(2014) L. J. Gaydos et al.   SCIENCE

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Regulatory network decoded from epigenomes of surface ectoderm-derived cell types

(2014) Rebecca F. Lowdon et al.   Nature Communications

Early life stress in fathers improves behavioural flexibility in their offspring

(2014) Katharina Gapp et al.   Nature Communications

Perinatal nicotine-induced transgenerational asthma

(2013) Virender K. Rehan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dissecting Quantitative Traits in Mice

(2013) Richard Mott et al.   Annual Review of Genomics and Human Genetics

Ancestral dichlorodiphenyltrichloroethane (DDT) exposure promotes epigenetic transgenerational inheritance of obesity

(2013) Michael K Skinner et al.   BMC Medicine

DNA repair mechanisms in dividing and non-dividing cells

(2013) Teruaki Iyama et al.   DNA REPAIR

Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population

(2013) Lars Lind et al.   ENVIRONMENT INTERNATIONAL

Environmental risk factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies

(2013) Mark J Nieuwenhuijsen et al.   Environmental Health

Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content

(2013) Tod Fullston et al.   FASEB JOURNAL

Transgenerational effects of prenatal bisphenol A on social recognition

(2013) Jennifer T. Wolstenholme et al.   HORMONES AND BEHAVIOR

A tripartite transcription factor network regulates primordial germ cell specification in mice

(2013) Erna Magnúsdóttir et al.   NATURE CELL BIOLOGY

Parental olfactory experience influences behavior and neural structure in subsequent generations

(2013) Brian G Dias et al.   NATURE NEUROSCIENCE

PIWI-interacting RNAs: from generation to transgenerational epigenetics

(2013) Maartje J. Luteijn et al.   NATURE REVIEWS GENETICS

Structure and function of long noncoding RNAs in epigenetic regulation

(2013) Tim R Mercer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stability, delivery and functions of human sperm RNAs at fertilization

(2013) Edward Sendler et al.   NUCLEIC ACIDS RESEARCH

Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

(2013) Mohan Manikkam et al.   PLoS One

Maternal Stress Induces Epigenetic Signatures of Psychiatric and Neurological Diseases in the Offspring

(2013) Fabiola C. R. Zucchi et al.   PLoS One

A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis

(2013) B. J. Lesch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Species-specific differences in X chromosome inactivation in mammals

(2013) Takashi Sado et al.   REPRODUCTION

Hydrocarbons (jet fuel JP-8) induce epigenetic transgenerational inheritance of obesity, reproductive disease and sperm epimutations

(2013) Rebecca Tracey et al.   REPRODUCTIVE TOXICOLOGY

The influence of endocrine disruptors on growth and development of children

(2013) Sara A. DiVall   Current Opinion in Endocrinology Diabetes and Obesity

Distinct roles of KAP1, HP1 and G9a/GLP in silencing of the two-cell-specific retrotransposon MERVL in mouse ES cells

(2013) Irina A Maksakova et al.   Epigenetics & Chromatin

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review

(2012) Marijke de Cock et al.   ACTA PAEDIATRICA

Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression

(2012) Jennifer T. Wolstenholme et al.   ENDOCRINOLOGY

Low-Level Environmental Cadmium Exposure Is Associated with DNA Hypomethylation in Argentinean Women

(2012) Mohammad Bakhtiar Hossain et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Smoking induces differential miRNA expression in human spermatozoa: A potential transgenerational epigenetic concern?

(2012) Emma L. Marczylo et al.   Epigenetics

Oocyte-specific linker histone H1foo is an epigenomic modulator that decondenses chromatin and impairs pluripotency

(2012) Koji Hayakawa et al.   Epigenetics

The Dynamics of Genome-wide DNA Methylation Reprogramming in Mouse Primordial Germ Cells

(2012) Stefanie Seisenberger et al.   MOLECULAR CELL

A nuclear Argonaute promotes multigenerational epigenetic inheritance and germline immortality

(2012) Bethany A. Buckley et al.   NATURE

The ontogeny of cKIT+ human primordial germ cells proves to be a resource for human germ line reprogramming, imprint erasure and in vitro differentiation

(2012) Sofia Gkountela et al.   NATURE CELL BIOLOGY

Pesticide and insect repellent mixture (permethrin and DEET) induces epigenetic transgenerational inheritance of disease and sperm epimutations

(2012) Mohan Manikkam et al.   REPRODUCTIVE TOXICOLOGY

Germline DNA Demethylation Dynamics and Imprint Erasure Through 5-Hydroxymethylcytosine

(2012) J. A. Hackett et al.   SCIENCE

Epigenetically Heritable Alteration of Fly Development in Response to Toxic Challenge

(2012) Shay Stern et al.   Cell Reports

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

(2011) Mohammad M. Karimi et al.   Cell Stem Cell

HP1  links histone methylation marks to meiotic synapsis in mice

(2011) Y. Takada et al.   DEVELOPMENT

Structure and function of active chromatin and DNase I hypersensitive sites

(2011) Peter N. Cockerill   FEBS Journal

Associations between congenital cryptorchidism in newborn boys and levels of dioxins and PCBs in placenta

(2011) H. E. Virtanen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Cryptorchidism and endocrine disrupting chemicals

(2011) Helena E. Virtanen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Centromeres: unique chromatin structures that drive chromosome segregation

(2011) Jolien S. Verdaasdonk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair

(2011) A. C. Nottke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repetitive Elements May Comprise Over Two-Thirds of the Human Genome

(2011) A. P. Jason de Koning et al.   PLoS Genetics

Epigenetic Transmission of the Impact of Early Stress Across Generations

(2010) Tamara B. Franklin et al.   BIOLOGICAL PSYCHIATRY

Epigenetic effects on the mouse mandible: common features and discrepancies in remodeling due to muscular dystrophy and response to food consistency

(2010) Sabrina Renaud et al.   BMC EVOLUTIONARY BIOLOGY

Paternally Induced Transgenerational Environmental Reprogramming of Metabolic Gene Expression in Mammals

(2010) Benjamin R. Carone et al.   CELL

Conserved and Divergent Roles of FGF Signaling in Mouse Epiblast Stem Cells and Human Embryonic Stem Cells

(2010) Boris Greber et al.   Cell Stem Cell

Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals

(2010) François Cuzin et al.   Essays in Biochemistry

Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiation

(2010) Melissa Krebs et al.   EXPERIMENTAL LUNG RESEARCH

Dynamic changes in the human methylome during differentiation

(2010) L. Laurent et al.   GENOME RESEARCH

Environmental epigenetics

(2010) V Bollati et al.   HEREDITY

Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2

(2010) Aditi Kanhere et al.   MOLECULAR CELL

KAP1 controls endogenous retroviruses in embryonic stem cells

(2010) Helen M. Rowe et al.   NATURE

Epigenetic memory in induced pluripotent stem cells

(2010) K. Kim et al.   NATURE

Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring

(2010) Sheau-Fang Ng et al.   NATURE

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

(2010) Urszula Brykczynska et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epigenetics of Royalty

(2010) Alexandra Chittka et al.   PLOS BIOLOGY

In Utero Exposure to Diethylstilbestrol (DES) or Bisphenol-A (BPA) Increases EZH2 Expression in the Mammary Gland: An Epigenetic Mechanism Linking Endocrine Disruptors to Breast Cancer

(2010) Leo F. Doherty et al.   Hormones & Cancer

A C. elegans LSD1 Demethylase Contributes to Germline Immortality by Reprogramming Epigenetic Memory

(2009) David J. Katz et al.   CELL

Naive and Primed Pluripotent States

(2009) Jennifer Nichols et al.   Cell Stem Cell

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Hypermethylation of Homeobox A10 byin UteroDiethylstilbestrol Exposure: An Epigenetic Mechanism for Altered Developmental Programming

(2009) Jason G. Bromer et al.   ENDOCRINOLOGY

Common themes in siRNA-mediated epigenetic silencing pathways

(2009) Andre Verdel et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Arginine Methylation Regulates Telomere Length and Stability

(2009) T. R. H. Mitchell et al.   MOLECULAR AND CELLULAR BIOLOGY

Intracisternal A particle genes: Distribution in the mouse genome, active subtypes, and potential roles as species-specific mediators of susceptibility to cancer

(2009) Chunhua Qin et al.   MOLECULAR CARCINOGENESIS

Distinctive chromatin in human sperm packages genes for embryo development

(2009) Saher Sue Hammoud et al.   NATURE

A three-dimensional view of the molecular machinery of RNA interference

(2009) Martin Jinek et al.   NATURE

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

Transgenerational effects of the endocrine disruptor vinclozolin on the methylation pattern of imprinted genes in the mouse sperm

(2009) Christelle Stouder et al.   REPRODUCTION

Balancing Work and Life: A Conversation with Konrad Hochedlinger

(2009) Majlinda Lako et al.   STEM CELLS

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Crosstalk among Histone Modifications

(2008) Tamaki Suganuma et al.   CELL

Transgenerational epigenetic inheritance in health and disease

(2008) Nadia C Whitelaw et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

RNA Induction and Inheritance of Epigenetic Cardiac Hypertrophy in the Mouse

(2008) Kay D. Wagner et al.   DEVELOPMENTAL CELL

The Chromatin of Active Genes Is Not in a Permanently Open Conformation

(2008) Nelly Sapojnikova et al.   JOURNAL OF MOLECULAR BIOLOGY

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

(2008) Petra Hajkova et al.   NATURE

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Transgenerational Epigenetic Programming of the Brain Transcriptome and Anxiety Behavior

(2008) Michael K. Skinner et al.   PLoS One

Direct Evidence Revealing Structural Elements Essential for the High Binding Ability of Bisphenol A to Human Estrogen-Related Receptor-γ

(2007) Hiroyuki Okada et al.   ENVIRONMENTAL HEALTH PERSPECTIVES