Review
Biochemistry & Molecular Biology
Verena Moosbrugger-Martinz, Corinne Leprince, Marie-Claire Mechin, Michel Simon, Stefan Blunder, Robert Gruber, Sandrine Dubrac
Summary: The discovery of loss-of-function mutations in the filaggrin gene has shed new light on the understanding of skin conditions such as ichthyosis vulgaris and atopic dermatitis. However, there is still much to learn about how filaggrin deficiency contributes to atopic dermatitis and the factors that lead to reduced filaggrin levels. This review re-evaluates the roles of filaggrin in the epidermis and atopic dermatitis, providing insights into its importance for keratinocyte alignment, maintenance of epidermal texture, and cellular abnormalities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chunying Xiao, Zhongbin Sun, Jixin Gao, Yaxing Bai, Chen Zhang, Bingyu Pang, Hongjiang Qiao, Meng Fu, Erle Dang, Gang Wang
Summary: This study demonstrated the critical role of skin barrier protein FLG in the pathogenesis of atopic dermatitis, with CPT-induced dermatitis being more severe in Flg(-/-) mice compared to wild-type mice. Additionally, emollients MPS and ceramide partially restored epidermal function and alleviated skin inflammation in the Flg(-/-) mouse model of AD induced by CPT.
Article
Medicine, General & Internal
Annalisa Astolfi, Francesca Cipriani, Daria Messelodi, Matilde De Luca, Valentina Indio, Costanza Di Chiara, Arianna Giannetti, Lorenza Ricci, Iria Neri, Annalisa Patrizi, Giampaolo Ricci, Andrea Pession
Summary: This study revealed that children with atopic dermatitis carrying FLG mutations are at higher risk of developing severe food allergies, such as anaphylaxis. Peanut and hazelnut were identified as high-risk foods for patients with FLG mutations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Petra Pavel, Stefan Blunder, Verena Moosbrugger-Martinz, Peter M. Elias, Sandrine Dubrac
Summary: Atopic dermatitis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Alterations of the epidermal barrier and lipid abnormalities play crucial roles in the development and inflammation of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Haengdueng Jeong, Nakyum Lee, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Yeseul Oh, KeLun Zhang, Hye Li Kim, James R. Goldenring, Kyung-Min Lim, Chang Ook Park, Ki Taek Nam
Summary: Rab-25 plays an important role in maintaining skin barrier function and keratinization in atopic dermatitis (AD).
Article
Allergy
Anna Maria Andersson, Julie Solberg, Anders Koch, Lone Skov, Ivone Jakasa, Sanja Kezic, Jacob Pontoppidan Thyssen
Summary: This study analyzed biomarkers in children with atopic dermatitis using tape strips and skin biopsies, finding that cytokine profiles in lesional skin were associated with disease severity, food allergy, and filaggrin gene mutations. Levels of TARC, CTACK, IL-8, and IL-18 in tape strips correlated significantly with AD severity, while skin biopsy data did not show significant correlations. Sampling the stratum corneum with non-invasive tape strips may be useful for identifying biomarkers associated with disease severity, food allergy, and filaggrin mutations.
Article
Dermatology
Hila Emmert, Hansjoerg Baurecht, Frederieke Thielking, Dora Stoelzl, Elke Rodriguez, Inken Harder, Ehrhardt Proksch, Stephan Weidinger
Summary: This study revealed significant differences in lipid composition between body sites and between AD patients and healthy individuals, as well as correlations between skin microbiome and skin lipid alterations in AD.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Allergy
Jessica W. Hui-Beckman, Elena Goleva, Evgeny Berdyshev, Donald Y. M. Leung
Summary: Atopic dermatitis (AD) and food allergy (FA) are closely related and one-third of AD children develop concomitant FA. Epithelial barrier dysfunction is important in both diseases. Genetic factors such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms are associated with increased risk. In addition, several environmental exposures lead to reduced filaggrin and contribute to skin barrier dysfunction. Staphylococcus aureus colonization appears to contribute to AD and FA as well as activating the type 2 immune response. Comprehensive multiomic studies have identified distinct atopic endotypes with unique characteristics, providing an opportunity for improved diagnosis and prevention of atopy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Allergy
Tammy Gonzalez, Mariana L. Stevens, Asel Baatyrbek Kyzy, Rosario Alarcon, Hua He, John W. Kroner, Daniel Spagna, Brittany Grashel, Elaine Sidler, Lisa J. Martin, Jocelyn M. Biagini Myers, Gurjit K. Khurana Hershey, Andrew B. Herr
Summary: In the first US early-life cohort of children with atopic dermatitis, the presence of staphylococcal biofilms on skin lesions was found to be associated with increased disease severity, suggesting a pathogenic role forS aureus biofilms in atopic dermatitis development. Additionally, the balance between S epidermidis and S aureus, as well as their biofilm propensity, may have important implications for atopic dermatitis.
Article
Chemistry, Multidisciplinary
Bum Soo Lee, Ye-Ryeong Cho, Minju Jeong, Yoon Seo Jang, Jin-Chul Kim, Sanguine Byun, Ki Hyun Kim
Summary: This study investigated the inhibitory effects of Cornus walteri on atopic dermatitis (AD). The results showed that Cornus walteri reduced the secretion of AD-related chemokines and upregulated filaggrin. Phytochemical analysis led to the identification of six potential bioactive constituents in Cornus walteri, and three of them significantly inhibited the expression of eotaxin-3. These findings suggest that Cornus walteri and its active compounds have potential as therapeutic agents for treating AD.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Nahoko Zeze, Makiko Kido-Nakahara, Gaku Tsuji, Eriko Maehara, Yuki Sato, Sawako Sakai, Kei Fujishima, Akiko Hashimoto-Hachiya, Masutaka Furue, Takeshi Nakahara
Summary: Atopic dermatitis is a skin disorder characterized by inflammation, barrier disruption, and intense itch. This study investigates the involvement of the extracellular signal-regulated kinase (ERK) pathway in the pathogenesis of atopic dermatitis. The results suggest that the ERK pathway plays a role in the development of atopic dermatitis and may be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Liu Tang, Xiaoqin Cao, Xiaolei Li, Hong Ding
Summary: The study showed that topical application of conjugated linoleic acid (CLA) significantly improved skin lesions, itching, and inflammation in a murine model of AD. CLA modulated skin barrier function and inflammation response, providing protective effects against AD lesional skin.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Veterinary Sciences
Rosanna Marsella, Kim Ahrens, Rachel Wilkes
Summary: Skin barrier dysfunction is important in atopic dermatitis and may be related to differences in cell growth behavior rather than tight junction protein differences. Atopic keratinocytes have lower TEER than normal keratinocytes, indicating higher epithelial permeability.
VETERINARY SCIENCES
(2022)
Review
Dermatology
Thomas Luger, Masayuki Amagai, Brigitte Dreno, Marie-Ange Dagnelie, Wilson Liao, Kenji Kabashima, Tamara Schikowski, Ehrhardt Proksch, Peter M. Elias, Michel Simon, Eric Simpson, Erin Grinich, Matthias Schmuth
Summary: AD is a chronic inflammatory skin disorder characterized by eczematous and pruritic skin lesions, with increasing prevalence worldwide in recent decades. Studies have shown that genetic defects affecting structural proteins of the skin barrier, as well as exposure to environmental allergens and pollutants, contribute to the development of AD. Research on epidermal barrier function, inflammation, lipid metabolism, and bacterial communities is crucial for understanding the complex etiology of AD and developing new therapies.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Immunology
Hyang Jeon, Geunyeong Kim, Ayesha Kashif, Min Hwa Hong, Ji-Sook Lee, Yujin Hong, Beom Seok Park, Eun Ju Yang, In Sik Kim
Summary: Atopic dermatitis is a chronic disease characterized by skin inflammation and barrier dysfunction, with house dust mites being key allergens. A study on Der p 38, a novel mite allergen, has shown that it triggers atopic dermatitis by reducing skin barrier proteins and increasing inflammatory cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Gursimran K. Dhamrait, Kunjal Panchal, Naomi J. Fleury, Tamara N. Abel, Mathew K. Ancliffe, Rachael C. Crew, Kevin Croft, Bernadette O. Fernandez, Magdalena Minnion, Prue H. Hart, Robyn M. Lucas, Peter J. Mark, Martin Feelisch, Richard B. Weller, Vance Matthews, Shelley Gorman
Letter
Cardiac & Cardiovascular Systems
Richard B. Weller
Article
Biochemistry & Molecular Biology
Milena T. Pelegrino, Richard B. Weller, Andre Paganotti, Amedea B. Seabra
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2020)
Article
Construction & Building Technology
Yi Jin, Fan Wang, Megan Carpenter, Richard B. Weller, Dominic Tabor, Sarah R. Payne
BUILDING AND ENVIRONMENT
(2020)
Review
Environmental Sciences
Lars Alfredsson, Bruce K. Armstrong, D. Allan Butterfield, Rajiv Chowdhury, Frank R. de Gruijl, Martin Feelisch, Cedric F. Garland, Prue H. Hart, David G. Hoel, Ramune Jacobsen, Pelle G. Lindqvist, David J. Llewellyn, Henning Tiemeier, Richard B. Weller, Antony R. Young
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Letter
Peripheral Vascular Disease
Richard B. Weller, Martin Feelisch, Peter Kotanko
JOURNAL OF HYPERTENSION
(2020)
Review
Virology
Joana C. Pieretti, Olga Rubilar, Richard B. Weller, Gonzalo R. Tortella, Amedea B. Seabra
Summary: Nitric oxide plays a key role in the immune system and has shown potential in treating human coronavirus infections, including COVID-19. Through inhalation and the use of NO donors combined with nanomaterials, sustained release of NO can be achieved, enhancing its benefits and minimizing side effects.
Review
Cardiac & Cardiovascular Systems
Shelley Gorman, Richard B. Weller
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2020)
Article
Dermatology
M. Cherrie, T. Clemens, C. Colandrea, Z. Feng, D. J. Webb, R. B. Weller, C. Dibben
Summary: Research indicates that higher ambient UVA exposure is associated with lower COVID-19-specific mortality, suggesting potential population health benefits and novel treatments.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Cell Biology
Kyle T. Mincham, Kunjal Panchal, Prue H. Hart, Robyn M. Lucas, Martin Feelisch, Richard B. Weller, Vance B. Matthews, Deborah H. Strickland, Shelley Gorman
Summary: Eating a high-fat diet can impact the proportions of HSPCs and cDCs in BAT and bone marrow; compared to a low-fat diet, a high-fat diet significantly reduces myeloid progenitors in iBAT.
IMMUNOLOGY AND CELL BIOLOGY
(2021)
Article
Construction & Building Technology
Yi Jin, Fan Wang, Sarah R. Payne, Richard B. Weller
Summary: Dry indoor air in winter is the main cause of dry skin in older occupants, impacting their well-being. HVAC design standards do not consider specific humidity levels to prevent dry skin. A study comparing younger and older people's comfort and skin condition in winter found that older occupants prefer warmer temperatures and that stratum corneum hydration can be used as an indicator for minimum humidity levels to reduce dry skin risk.
INDOOR AND BUILT ENVIRONMENT
(2022)
Article
Peripheral Vascular Disease
Richard B. Weller, Iain M. Macintyre, Vanessa Melville, Michael Farrugia, Martin Feelisch, David J. Webb
Summary: Latitude and season are correlated with ultraviolet radiation exposure and blood pressure. This study tested the effectiveness of low-dose daily UVA phototherapy for mild hypertension and found that it did not effectively control blood pressure but caused a transient fall.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Meeting Abstract
Dermatology
M. Cherrie, T. Clemens, C. Colandrea, Z. Feng, D. Webb, C. Dibben, R. Weller
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Meeting Abstract
Dermatology
C. Flohr, P. Beattie, M. Cork, S. Brown, T. Burton, K. Gholam, C. Griffiths, J. Ingram, A. Irvine, S. Langan, A. Manca, L. Newell, G. Ogg, T. Patton, N. Reynolds, M. Redding, A. Proctor, D. Wall, M. Wan, R. Weller, D. Boisfer, R. Woolf, W. Abdelrahman, A. Shahid, C. Broderick, S. Baron, M. Ardern-Jones
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Cell Biology
Milena T. Pelegrino, Andre Paganotti, Amedea B. Seabra, Richard B. Weller
HISTOCHEMISTRY AND CELL BIOLOGY
(2020)