Journal
EXPERIMENTAL DERMATOLOGY
Volume 27, Issue 4, Pages 427-432Publisher
WILEY
DOI: 10.1111/exd.13276
Keywords
atopic dermatitis; interleukin-12 receptor 2; microRNAs; miR-151a; T helper cells
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Funding
- National Natural Scientific Foundation of China [81402600, 81371737]
- Guangdong Natural Scientific Foundation [2014A030313708, 2014A030313710]
- Shenzhen Research Grant [JCYJ20150403110829622, CXZZ20140416144209739, KQCX20120803145850990]
- China Postdoctoral Science Foundation [2014M562195]
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MicroRNAs (miRNAs) have been reported to circulate in the blood in a highly stable and cell-free form. Dysregulated expression of miRNAs has been detected in various pathological conditions including atopic dermatitis. In our study, human blood plasma miRNAs were identified by high-throughput sequencing and compared among patients of atopic dermatitis and healthy controls. We found that miR-151a was differentially expressed in the plasma of atopic dermatitis patients. MiR-151a regulates the expression of IL12RB2 by targeting two loci in the 3 untranslated region of the Il12rb2 gene. Moreover, IL12RB2 was remarkably downregulated in Jurkat cells overexpressing miR-151a. Jurkat cells treated with phytohemagglutinin also showed reduced expression of IFN-, interleukin-2 (IL-2) and IL-12. Together, these results suggest that miR-151a is involved in the pathogenesis of atopic dermatitis by regulating IL12RB2.
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