Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite–derived phospholipase

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals

(2015) Sumithra Subramaniam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Bee venom processes human skin lipids for presentation by CD1a

(2015) Elvire A. Bourgeois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

(2015) Lavinia Paternoster et al.   NATURE GENETICS

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

(2015) Richard W Birkinshaw et al.   NATURE IMMUNOLOGY

Biology of CD1- and MR1-Restricted T Cells

(2014) Mariolina Salio et al.   Annual Review of Immunology

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

(2014) Luzheng Xue et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis

(2014) Lisa A. Beck et al.   NEW ENGLAND JOURNAL OF MEDICINE

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human CD1a Deficiency Is Common and Genetically Regulated

(2013) C. Seshadri et al.   JOURNAL OF IMMUNOLOGY

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

(2013) Annemieke de Jong et al.   NATURE IMMUNOLOGY

Citrus Allergy from Pollen to Clinical Symptoms

(2013) Rosa Anna Iorio et al.   PLoS One

Role for lysosomal phospholipase A2 in iNKT cell-mediated CD1d recognition

(2013) C. Paduraru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioactive Lysophosphatidylcholine 16:0 and 18:0 Are Elevated in Lungs of Asthmatic Subjects

(2013) Mark Yoder et al.   Allergy Asthma & Immunology Research

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis

(2012) Julia K. Gittler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mechanisms of IFN-γ–induced apoptosis of human skin keratinocytes in patients with atopic dermatitis

(2012) Ana Rebane et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

(2012) Patricia T. Illing et al.   NATURE

Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity

(2012) Sebastian Zeissig et al.   NATURE MEDICINE

Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes

(2011) D. Gutowska-Owsiak et al.   BRITISH JOURNAL OF DERMATOLOGY

IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

(2011) Danuta Gutowska-Owsiak et al.   EXPERIMENTAL DERMATOLOGY

Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities

(2011) Mayte Suárez-Fariñas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy

(2011) J. Strid et al.   SCIENCE

High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells

(2010) Claudia de Lalla et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Distinct enzymatic and cellular characteristics of two secretory phospholipases A2 in the filamentous fungus Aspergillus oryzae

(2010) Tomoyuki Nakahama et al.   FUNGAL GENETICS AND BIOLOGY

An update on the genetics of atopic dermatitis: Scratching the surface in 2009

(2010) Kathleen C. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Changes in the Ceramide Profile of Atopic Dermatitis Patients

(2010) Junko Ishikawa et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

(2010) Annemieke de Jong et al.   NATURE IMMUNOLOGY

The evolved functions of CD1 during infection

(2009) Anne Kasmar et al.   CURRENT OPINION IN IMMUNOLOGY

Secreted phospholipases A2: A proinflammatory connection between macrophages and mast cells in the human lung

(2009) Francescopaolo Granata et al.   IMMUNOBIOLOGY

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

(2009) Tiffany C. Scharschmidt et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Meta-analysis of filaggrin polymorphisms in eczema and asthma: Robust risk factors in atopic disease

(2009) Elke Rodríguez et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis

(2009) Eva Gros et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lung mast cells are a source of secreted phospholipases A2

(2009) Massimo Triggiani et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A possible mechanism underlying the ceramide deficiency in atopic dermatitis: Expression of a deacylase enzyme that cleaves the N-acyl linkage of sphingomyelin and glucosylceramide

(2009) Genji Imokawa   JOURNAL OF DERMATOLOGICAL SCIENCE

Recognition of Lyso-Phospholipids by Human Natural Killer T Lymphocytes

(2009) Lisa M. Fox et al.   PLOS BIOLOGY

Anti-lymphocyte function associated antigen-1 inhibits T-helper 2 function of human allergen-specific CD4+ T cells

(2008) M.R. Ardern-Jones et al.   BRITISH JOURNAL OF DERMATOLOGY

Practice of venom immunotherapy in the United Kingdom: a national audit and review of literature

(2008) L. Diwakar et al.   CLINICAL AND EXPERIMENTAL ALLERGY

A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR

(2008) Kwok S. Wun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Global Expression Profiling in Atopic Eczema Reveals Reciprocal Expression of Inflammatory and Lipid Genes

(2008) Annika M. Sääf et al.   PLoS One