The Epigenetic Connection Between the Gut Microbiome in Obesity and Diabetes

Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome

(2019) Abeer Mahmoud et al.   Nutrients

Regulation of DNA methylation and 2-OG/TET signaling by choline alleviated cardiac hypertrophy in spontaneously hypertensive rats

(2019) Longzhu Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Importance of probiotics in the prevention and treatment of colorectal cancer

(2019) Majid Eslami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Beneficial effects of ginger on prevention of obesity through modulation of gut microbiota in mice

(2019) Jing Wang et al.   EUROPEAN JOURNAL OF NUTRITION

Role for Diet in Normal Gut Barrier Function: Developing Guidance within the Framework of Food Labeling Regulations

(2019) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

Gut Microbiota Composition Is Associated With the Global DNA Methylation Pattern in Obesity

(2019) Bruno Ramos-Molina et al.   Frontiers in Genetics

The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children

(2018) Sanna Vähämiko et al.   EUROPEAN JOURNAL OF NUTRITION

Disruption of Epithelial HDAC3 in Intestine Prevents Diet-Induced Obesity in Mice

(2018) Jordan Whitt et al.   GASTROENTEROLOGY

Microbiota effects on cancer: from risks to therapies

(2018) Domenica Rea et al.   Oncotarget

Probiotic Species in the Modulation of Gut Microbiota: An Overview

(2018) Md. Abul Kalam Azad et al.   Biomed Research International

The Microbiological Memory, an Epigenetic Regulator Governing the Balance Between Good Health and Metabolic Disorders

(2018) Christian A. Devaux et al.   Frontiers in Microbiology

Stability of the human faecal microbiome in a cohort of adult men

(2018) Raaj S. Mehta et al.   Nature Microbiology

Loss of HDAC6 alters gut microbiota and worsens obesity

(2018) Arnon D. Lieber et al.   FASEB JOURNAL

Is maternal microbial metabolism an early-life determinant of health?

(2018) Kymberleigh A. Romano et al.   LAB ANIMAL

Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid

(2018) Samantha Yuille et al.   PLoS One

Necrotizing enterocolitis: The intestinal microbiome, metabolome and inflammatory mediators

(2018) Josef Neu et al.   Seminars in Fetal & Neonatal Medicine

Coordinate regulation of long non-coding RNAs and protein-coding genes in germ-free mice

(2018) Joseph Dempsey et al.   BMC GENOMICS

Temporal development of the gut microbiome in early childhood from the TEDDY study

(2018) Christopher J. Stewart et al.   NATURE

Tackling malignant melanoma epigenetically: histone lysine methylation

(2018) Elias Orouji et al.   Clinical Epigenetics

Altered Gut Microbiota and Compositional Changes in Firmicutes and Proteobacteria in Mexican Undernourished and Obese Children

(2018) Eder Orlando Méndez-Salazar et al.   Frontiers in Microbiology

A microbial signature for Crohn's disease

(2017) Victoria Pascal et al.   GUT

Crosstalk between the microbiome and epigenome: messages from bugs

(2017) Yufeng Qin et al.   JOURNAL OF BIOCHEMISTRY

Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4

(2017) Kazuaki Nakata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC6-mediated acetylation of lipid droplet–binding protein CIDEC regulates fat-induced lipid storage

(2017) Hui Qian et al.   JOURNAL OF CLINICAL INVESTIGATION

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

(2017) Aafke W. F. Janssen et al.   JOURNAL OF LIPID RESEARCH

Adiposity in Juvenile Psoriatic Arthritis

(2017) Aaida Samad et al.   JOURNAL OF RHEUMATOLOGY

Microbiome, trimethylamine N-oxide, and cardiometabolic disease

(2017) W.H. Wilson Tang et al.   Translational Research

Choline, Other Methyl-Donors and Epigenetics

(2017) Steven Zeisel   Nutrients

Gut dysbiosis following C-section instigates higher colonisation of toxigenic Clostridium perfringens in infants

(2017) R. Nagpal et al.   Beneficial Microbes

Leaky Gut As a Danger Signal for Autoimmune Diseases

(2017) Qinghui Mu et al.   Frontiers in Immunology

Role of Gut Microbiota in Rheumatoid Arthritis

(2017) Yuichi Maeda et al.   Journal of Clinical Medicine

Engineering CRISPR–Cpf1 crRNAs and mRNAs to maximize genome editing efficiency

(2017) Bin Li et al.   Nature Biomedical Engineering

Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome

(2016) Xiaolei Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Imbalance of Fecal Microbiota at Newly Diagnosed Type 1 Diabetes in Chinese Children

(2016) Xin-Hua Xiao et al.   CHINESE MEDICAL JOURNAL

Altered fecal short chain fatty acid composition in children with a history of Hirschsprung-associated enterocolitis

(2016) Farokh R. Demehri et al.   JOURNAL OF PEDIATRIC SURGERY

Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants

(2016)   LANCET

Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues

(2016) Kimberly A. Krautkramer et al.   MOLECULAR CELL

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Antibiotics, birth mode, and diet shape microbiome maturation during early life

(2016) Nicholas A. Bokulich et al.   Science Translational Medicine

Revised Estimates for the Number of Human and Bacteria Cells in the Body

(2016) Ron Sender et al.   PLOS BIOLOGY

Trimethylamine N-Oxide: The Good, the Bad and the Unknown

(2016) Manuel Velasquez et al.   Toxins

Sensitive Quantitative Analysis of the Meconium Bacterial Microbiota in Healthy Term Infants Born Vaginally or by Cesarean Section

(2016) Ravinder Nagpal et al.   Frontiers in Microbiology

Gut Microbiota of Obese, Type 2 Diabetic Individuals is Enriched in Faecalibacterium prausnitzii, Akkermansia muciniphila and Peptostreptococcus anaerobius after Weight Loss

(2016) Marlene Remely et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents

(2015) Qibin Qi et al.   DIABETES

Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes

(2015) Aimon K. Alkanani et al.   DIABETES

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity

(2015) Injae Hwang et al.   FASEB JOURNAL

FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3

(2015) Liqing Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

The Plant Microbiome at Work

(2015) Klaus Schlaeppi et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization and Comparison of Protein and Peptide Profiles and their Biological Activities of Improved Common Bean Cultivars (Phaseolus vulgaris L.) from Mexico and Brazil

(2015) Luis Mojica et al.   PLANT FOODS FOR HUMAN NUTRITION

Intestinal Microbiota Composition Modulates Choline Bioavailability from Diet and Accumulation of the Proatherogenic Metabolite Trimethylamine- N -Oxide

(2015) Kymberleigh A. Romano et al.   mBio

Long noncoding RNA expression profiles in gut tissues constitute molecular signatures that reflect the types of microbes

(2015) Lunxi Liang et al.   Scientific Reports

The effects of long-term daily folic acid and vitamin B12 supplementation on genome-wide DNA methylation in elderly subjects

(2015) Dieuwertje E. G. Kok et al.   Clinical Epigenetics

Influences of diet and the gut microbiome on epigenetic modulation in cancer and other diseases

(2015) Bidisha Paul et al.   Clinical Epigenetics

Impact of oxidative stress during pregnancy on fetal epigenetic patterns and early origin of vascular diseases

(2015) J. G. Ortega Avila et al.   NUTRITION REVIEWS

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity

(2014) Vita Rovite et al.   MOLECULAR BIOLOGY REPORTS

Gut Microbiota as an Epigenetic Regulator: Pilot Study Based on Whole-Genome Methylation Analysis

(2014) Himanshu Kumar et al.   mBio

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

A Gnotobiotic Mouse Model Demonstrates That Dietary Fiber Protects against Colorectal Tumorigenesis in a Microbiota- and Butyrate-Dependent Manner

(2014) D. R. Donohoe et al.   Cancer Discovery

Microbiota and epigenetic regulation of inflammatory mediators in type 2 diabetes and obesity

(2014) M. Remely et al.   Beneficial Microbes

Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin Secretion

(2014) Tasnim Dayeh et al.   PLoS Genetics

More than just a gut instinct–the potential interplay between a baby's nutrition, its gut microbiome, and the epigenome

(2013) Mona Mischke et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Transglucosidase improves the gut microbiota profile of type 2 diabetes mellitus patients: a randomized double-blind, placebo-controlled study

(2013) Makoto Sasaki et al.   BMC GASTROENTEROLOGY

Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study

(2013) Mora Murri et al.   BMC Medicine

The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options

(2013) L Fani et al.   INTERNATIONAL JOURNAL OF OBESITY

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

(2013) Shin Yoshimoto et al.   NATURE

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Is butyrate the link between diet, intestinal microbiota and obesity-related metabolic diseases?

(2013) L. K. Brahe et al.   Obesity Reviews

Human Gut Microbiota Changes Reveal the Progression of Glucose Intolerance

(2013) Xiuying Zhang et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory properties of the intestinal microbiome effecting the development and treatment of diabetes

(2013) Joann Romano-Keeler et al.   Current Opinion in Endocrinology Diabetes and Obesity

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

Human gut microbiome viewed across age and geography

(2012) Tanya Yatsunenko et al.   NATURE

Association between Inflammatory and Obesity Markers in a Swiss Population-Based Sample (CoLaus Study)

(2012) Pedro Marques-Vidal et al.   Obesity Facts

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

(2012) Krista S. Crider et al.   Advances in Nutrition

Molecular monitoring of the development of intestinal microbiota in Japanese infants

(2012) H. Tsuji et al.   Beneficial Microbes

Acetate supplementation increases brain histone acetylation and inhibits histone deacetylase activity and expression

(2011) Mahmoud L. Soliman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

MicroRNAs 103 and 107 regulate insulin sensitivity

(2011) Mirko Trajkovski et al.   NATURE

The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

(2011) Lei Chen et al.   Nature Reviews Endocrinology

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

(2011) Christopher T. Brown et al.   PLoS One

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

(2011) A. Davalos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bifidobacterium lactisattenuates onset of inflammation in a murine model of colitis

(2011) David Philippe   WORLD JOURNAL OF GASTROENTEROLOGY

Folate Production by Probiotic Bacteria

(2011) Maddalena Rossi et al.   Nutrients

Lack of Commensal Flora in Helicobacter pylori–Infected INS-GAS Mice Reduces Gastritis and Delays Intraepithelial Neoplasia

(2010) Jennifer L. Lofgren et al.   GASTROENTEROLOGY

Toward defining the autoimmune microbiome for type 1 diabetes

(2010) Adriana Giongo et al.   ISME Journal

Quantification of Folic Acid in Human Feces After Administration of Bifidobacterium Probiotic Strains

(2010) G. Paolo Strozzi et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

A human gut microbial gene catalogue established by metagenomic sequencing

(2010) Junjie Qin et al.   NATURE

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

(2010) Nadja Larsen et al.   PLoS One

Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa

(2010) C. De Filippo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Succession of microbial consortia in the developing infant gut microbiome

(2010) J. E. Koenig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns

(2010) M. G. Dominguez-Bello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study

(2009) Cheng-Chieh Lin et al.   BMC PUBLIC HEALTH

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

The core gut microbiome, energy balance and obesity

(2009) Peter J. Turnbaugh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

(2009) Shaoguang Wu et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla

(2009) M. A. Mahowald et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies

(2008) Stephanie-May Ruchat et al.   ACTA DIABETOLOGICA