Exosome in Cardiovascular Diseases: A Complex World Full of Hope

Myocardial infarction-induced microRNA-enriched exosomes contribute to cardiac Nrf2 dysregulation in chronic heart failure

(2018) Changhai Tian et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cardiac-specific delivery by cardiac tissue-targeting peptide-expressing exosomes

(2018) Hyoeun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardioprotection by cardiac progenitor cell-secreted exosomes: role of pregnancy-associated plasma protein-A

(2018) Lucio Barile et al.   CARDIOVASCULAR RESEARCH

Biologically active constituents of the secretome of human W8B2+ cardiac stem cells

(2018) Shuai Nie et al.   Scientific Reports

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide

(2018) Adam Vandergriff et al.   Theranostics

miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN

(2018) Xiang Nie et al.   Molecular Therapy-Nucleic Acids

Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction

(2018) Xu Wang et al.   Journal of the American Heart Association

Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum

(2017) Yue-Ting Tang et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Overexpression of Exosomal Cardioprotective miRNAs Mitigates Hypoxia-Induced H9c2 Cells Apoptosis

(2017) Jinwei Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine

(2017) Francisco Vizoso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxia-Induced Changes in the Fibroblast Secretome, Exosome, and Whole-Cell Proteome Using Cultured, Cardiac-Derived Cells Isolated from Neonatal Mice

(2017) Jake Cosme et al.   JOURNAL OF PROTEOME RESEARCH

Potential Role of Exosomes in Mending a Broken Heart: Nanoshuttles Propelling Future Clinical Therapeutics Forward

(2017) Julie A. Dougherty et al.   Stem Cells International

Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction

(2016) Romain Gallet et al.   EUROPEAN HEART JOURNAL

Exosomal transfer of miR-30a between cardiomyocytes regulates autophagy after hypoxia

(2016) Yan Yang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury

(2016) Esther Sok Hwee Cheow et al.   MOLECULAR & CELLULAR PROTEOMICS

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4

(2016) J Xiao et al.   Cell Death & Disease

Pretreatment of Cardiac Stem Cells With Exosomes Derived From Mesenchymal Stem Cells Enhances Myocardial Repair

(2016) Zhiwei Zhang et al.   Journal of the American Heart Association

Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

(2016) Dinh Ha et al.   Acta Pharmaceutica Sinica B

Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection

(2015) Bin Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium

(2015) Yingjie Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise

(2015) Pankaj Chaturvedi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

(2015) Gregor Fuhrmann et al.   JOURNAL OF CONTROLLED RELEASE

A critical role of cardiac fibroblast-derived exosomes in activating renin angiotensin system in cardiomyocytes

(2015) Linmao Lyu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glucose Starvation in Cardiomyocytes Enhances Exosome Secretion and Promotes Angiogenesis in Endothelial Cells

(2015) Nahuel A. Garcia et al.   PLoS One

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Extracellular vesicles from human cardiac progenitor cells inhibit cardiomyocyte apoptosis and improve cardiac function after myocardial infarction

(2014) L. Barile et al.   CARDIOVASCULAR RESEARCH

Reproducibility and efficiency of serum-derived exosome extraction methods

(2014) Josselin Caradec et al.   CLINICAL BIOCHEMISTRY

Cardiac fibroblast–derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

(2014) Claudia Bang et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells

(2014) Xiaohong Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

(2014) Yuliang Feng et al.   PLoS One

The Complex Ultrastructure of the Endolysosomal System

(2014) J. Klumperman et al.   Cold Spring Harbor Perspectives in Biology

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Cardiac myocyte exosomes: stability, HSP60, and proteomics

(2013) Z. A. Malik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

(2013) B. W. M. van Balkom et al.   BLOOD

Circulating cardio-enriched microRNAs are associated with long-term prognosis following myocardial infarction

(2013) Olof Gidlöf et al.   BMC Cardiovascular Disorders

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction

(2013) YQ Li et al.   Clinics

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

(2013) Julie Halkein et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury

(2012) Xiaohui Wang et al.   CARDIOVASCULAR RESEARCH

miR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium

(2012) Yan Huang et al.   FASEB JOURNAL

Ultrastructural Evidence of Exosome Secretion by Progenitor Cells in Adult Mouse Myocardium and Adult Human Cardiospheres

(2012) Lucio Barile et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mechanism of TNF-α autocrine effects in hypoxic cardiomyocytes: Initiated by hypoxia inducible factor 1α, presented by exosomes

(2012) Xian Yu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Syndecan–syntenin–ALIX regulates the biogenesis of exosomes

(2012) Maria Francesca Baietti et al.   NATURE CELL BIOLOGY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

The Majority of MicroRNAs Detectable in Serum and Saliva Is Concentrated in Exosomes

(2012) Alessia Gallo et al.   PLoS One

Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells

(2012) Anders Waldenström et al.   PLoS One

Identification of nucleotide patterns enriched in secreted RNAs as putative cis-acting elements targeting them to exosome nano-vesicles

(2011) Arsen O Batagov et al.   BMC GENOMICS

Exosomes From Human CD34 + Stem Cells Mediate Their Proangiogenic Paracrine Activity

(2011) Susmita Sahoo et al.   CIRCULATION RESEARCH

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

Identification of targeting peptides for ischemic myocardium by in vivo phage display

(2011) Sachiko Kanki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Heart regeneration

(2011) Michael A. Laflamme et al.   NATURE

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

Biomarkers in acute myocardial infarction

(2010) Daniel Chan et al.   BMC Medicine

Circulating microRNA: a novel potential biomarker for early diagnosis of acute myocardial infarction in humans

(2010) Guo-Kun Wang et al.   EUROPEAN HEART JOURNAL

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE