Critical thresholds: key to unlocking the door to the prevention and specific treatments for acute pancreatitis

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-onset Chronic Pancreatitis

(2020) Atsushi Masamune et al.   GASTROENTEROLOGY

Brake adjustment: Ca2+ entry pathway provides a novel target for acute pancreatitis therapy

(2020) Richard T. Waldron et al.   Annals of Translational Medicine

TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation

(2020) Sandip M. Swain et al.   JOURNAL OF CLINICAL INVESTIGATION

Parenchymal pressure injury Ca2+ entry mechanism in pancreatitis

(2020) Robert Sutton   CELL CALCIUM

Hypertriglyceridaemia-associated acute pancreatitis: diagnosis and impact on severity

(2019) Ruwen Zhang et al.   HPB

Chronic pancreatitis

(2019) Sarah J. Schwarzenberg et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Organ Failure due to Systemic Injury in Acute Pancreatitis

(2019) Pramod K. Garg et al.   GASTROENTEROLOGY

Impaired TFEB-Mediated Lysosomal Biogenesis Promotes the Development of Pancreatitis in Mice and Is Associated with Human Pancreatitis

(2019) Shaogui Wang et al.   Autophagy

The Orai Ca 2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis

(2019) Richard T. Waldron et al.   JOURNAL OF PHYSIOLOGY-LONDON

Recent Insights Into the Pathogenic Mechanism of Pancreatitis

(2019) Anna S. Gukovskaya et al.   PANCREAS

Simvastatin induces autophagic flux to restore cerulein-impaired phagosome-lysosome fusion in acute pancreatitis

(2019) Honit Piplani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

(2019) Matthias Sendler et al.   GASTROENTEROLOGY

Management of severe acute pancreatitis

(2019) O Joe Hines et al.   BMJ-British Medical Journal

Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice

(2018) Li Wen et al.   GASTROENTEROLOGY

American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis

(2018) Seth D. Crockett et al.   GASTROENTEROLOGY

Cathepsin B-Mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice

(2018) Matthias Sendler et al.   GASTROENTEROLOGY

Calcium signalling in the acinar environment of the exocrine pancreas: physiology and pathophysiology

(2018) Oleksiy Gryshchenko et al.   JOURNAL OF PHYSIOLOGY-LONDON

Necrotic amplification loop in acute pancreatitis: pancreatic stellate cells and nitric oxide are important players in the development of the disease

(2018) Péter Hegyi   JOURNAL OF PHYSIOLOGY-LONDON

The Importance of Aquaporin 1 in Pancreatitis and Its Relation to the CFTR Cl- Channel

(2018) Viktória Venglovecz et al.   Frontiers in Physiology

Biology, role and therapeutic potential of circulating histones in acute inflammatory disorders

(2018) Peter Szatmary et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Global epidemiology and holistic prevention of pancreatitis

(2018) Maxim S. Petrov et al.   Nature Reviews Gastroenterology & Hepatology

The Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells

(2017) Aurelia Lugea et al.   GASTROENTEROLOGY

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

(2017) Anna S. Gukovskaya et al.   GASTROENTEROLOGY

Ca2+ tunnelling through the ER lumen as a mechanism for delivering Ca2+ entering via store-operated Ca2+ channels to specific target sites

(2017) Ole H Petersen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Alcohol Consumption and Cigarette Smoking are Important Modifiers of the Association Between Acute Pancreatitis and the PRSS1-PRSS2 Locus in Men

(2017) Alexey V. Polonikov et al.   PANCREAS

BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues

(2016) Liang Song et al.   GASTROENTEROLOGY

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

(2016) Damian J Mole et al.   NATURE MEDICINE

Prospective Study of Alcohol Drinking, Smoking, and Pancreatitis

(2016) Veronica Wendy Setiawan et al.   PANCREAS

Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition

(2016) David C. Whitcomb et al.   PANCREATOLOGY

Pancreatic adenocarcinoma up-regulated factor (PAUF) enhances the accumulation and functional activity of myeloid-derived suppressor cells (MDSCs) in pancreatic cancer

(2016) Jinhoi Song et al.   Oncotarget

Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis

(2016) Soma Kumar et al.   JAMA Pediatrics

Genetic mutations in SPINK1, CFTR, CTRC genes in acute pancreatitis

(2015) Dorota Koziel et al.   BMC GASTROENTEROLOGY

Pancreatic stellate cell

(2015) Minote Apte et al.   CURRENT OPINION IN GASTROENTEROLOGY

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models

(2015) Li Wen et al.   GASTROENTEROLOGY

Alcohol Disrupts Levels and Function of the Cystic Fibrosis Transmembrane Conductance Regulator to Promote Development of Pancreatitis

(2015) József Maléth et al.   GASTROENTEROLOGY

Impaired Autophagy Induces Chronic Atrophic Pancreatitis in Mice via Sex- and Nutrition-Dependent Processes

(2015) Kalliope N. Diakopoulos et al.   GASTROENTEROLOGY

Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

(2015) Rajarshi Mukherjee et al.   GUT

TLR4-mediated NF-κB signaling pathway mediates HMGB1-induced pancreatic injury in mice with severe acute pancreatitis

(2015) GANG LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

(2015) Colin W Steele et al.   JOURNAL OF PATHOLOGY

The clinical relevance of obesity in acute pancreatitis: Targeted systematic reviews

(2015) Rakesh Premkumar et al.   PANCREATOLOGY

Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress

(2015) Laura Antonucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D Receptor-Mediated Stromal Reprogramming Suppresses Pancreatitis and Enhances Pancreatic Cancer Therapy

(2014) Mara H. Sherman et al.   CELL

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections

(2014) Pawan Noel et al.   GUT

Insulin Protects Pancreatic Acinar Cells from Palmitoleic Acid-induced Cellular Injury

(2014) Aysha Samad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

(2014) Jessica LaRusch et al.   PLoS Genetics

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

(2013) Hong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

IAP/APA evidence-based guidelines for the management of acute pancreatitis

(2013)   PANCREATOLOGY

Central role of mitochondrial injury in the pathogenesis of acute pancreatitis

(2012) J. Maléth et al.   Acta Physiologica

Natural History Following the First Attack of Acute Pancreatitis

(2012) Dhiraj Yadav et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Autophagy and pancreatitis

(2012) Anna S. Gukovskaya et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Determinant-Based Classification of Acute Pancreatitis Severity

(2012) E. Patchen Dellinger et al.   ANNALS OF SURGERY

Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus

(2012) Peter A Banks et al.   GUT

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

(2012) David C Whitcomb et al.   NATURE GENETICS

Smoking and the Course of Recurrent Acute and Chronic Alcoholic Pancreatitis

(2012) Vinciane Rebours et al.   PANCREAS

Effect of type of alcoholic beverage in causing acute pancreatitis

(2011) O. Sadr Azodi et al.   BRITISH JOURNAL OF SURGERY

Alcohol Abuse, Endoplasmic Reticulum Stress and Pancreatitis

(2011) Stephen J. Pandol et al.   DIGESTIVE DISEASES

Trypsin Reduces Pancreatic Ductal Bicarbonate Secretion by Inhibiting CFTR Cl− Channels and Luminal Anion Exchangers

(2011) Petra Pallagi et al.   GASTROENTEROLOGY

A Conservative and Minimally Invasive Approach to Necrotizing Pancreatitis Improves Outcome

(2011) Hjalmar C. van Santvoort et al.   GASTROENTEROLOGY

Lipotoxicity Causes Multisystem Organ Failure and Exacerbates Acute Pancreatitis in Obesity

(2011) S. Navina et al.   Science Translational Medicine

The islet-acinar axis of the pancreas: more than just insulin

(2010) Savio G. Barreto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Type of CFTR Mutation Determines Risk of Pancreatitis in Patients With Cystic Fibrosis

(2010) Chee Y. Ooi et al.   GASTROENTEROLOGY

Pathophysiological relevance of apical large-conductance Ca2+-activated potassium channels in pancreatic duct epithelial cells

(2010) V. Venglovecz et al.   GUT

Alcohol-induced acute pancreatitis: The ‘critical mass’ concept

(2010) Savio G. Barreto et al.   MEDICAL HYPOTHESES

Galanin in the Pathogenesis of Acute Pancreatitis

(2010) Savio George Barreto et al.   PANCREAS

Galanin, a Potent Inhibitor of Pancreatic Bicarbonate Secretion, Is Involved in the Induction and Progression of Cerulein-Induced Experimental Acute Pancreatitis

(2010) Péter Hegyi et al.   PANCREAS

The efficacy of combining feG and galantide in mild caerulein-induced acute pancreatitis in mice

(2010) Savio G. Barreto et al.   PEPTIDES

Galanin potentiates supramaximal caerulein-stimulated pancreatic amylase secretion via its action on somatostatin secretion

(2009) Savio G. Barreto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis

(2009) Dhiraj Yadav   ARCHIVES OF INTERNAL MEDICINE

Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis

(2009) Olga A. Mareninova et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma Concentrations of High-Mobility Group Box Protein 1, Soluble Receptor for Advanced Glycation End-Products and Circulating DNA in Patients with Acute Pancreatitis

(2009) Á.K. Kocsis et al.   PANCREATOLOGY

The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice

(2009) Savio G. Barreto et al.   PEPTIDES

Pancreatic stellate cells express Toll-like receptors

(2008) Atsushi Masamune et al.   JOURNAL OF GASTROENTEROLOGY

Individual susceptibility to alcoholic pancreatitis

(2008) Minoti V Apte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Acute pancreatitis severity is exacerbated by intestinal ischemia-reperfusion conditioned mesenteric lymph

(2008) Richard S. Flint et al.   SURGERY