CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia-reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery

(2015) P. Opfermann et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The safety and tolerability of oral AZD5069, a selective CXCR2 antagonist, in patients with moderate-to-severe COPD

(2015) A.M. Kirsten et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections

(2014) S M Dauphinee et al.   GENES AND IMMUNITY

CCR2 knockout exacerbates cerulein-induced chronic pancreatitis with hyperglycemia via decreased GLP-1 receptor expression and insulin secretion

(2013) Yuji Nakamura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes

(2013) Oliver Soehnlein et al.   EMBO Molecular Medicine

Resolution of inflammation: an integrated view

(2013) Almudena Ortega-Gómez et al.   EMBO Molecular Medicine

Cerulein-Induced Chronic Pancreatitis Does Not Require Intra-Acinar Activation of Trypsinogen in Mice

(2013) Raghuwansh P. Sah et al.   GASTROENTEROLOGY

Genetic Risk Factors for Pancreatic Disorders

(2013) David C. Whitcomb   GASTROENTEROLOGY

Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic Cancer

(2013) Ilya Gukovsky et al.   GASTROENTEROLOGY

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

(2013) Hong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

NFATc3 Regulates Trypsinogen Activation, Neutrophil Recruitment, and Tissue Damage in Acute Pancreatitis in Mice

(2012) Darbaz Awla et al.   GASTROENTEROLOGY

Deletion of IκBα Activates RelA to Reduce Acute Pancreatitis in Mice Through Up-regulation of Spi2A

(2012) Patrick Neuhöfer et al.   GASTROENTEROLOGY

Activation of Nuclear Factor-κB in Acinar Cells Increases the Severity of Pancreatitis in Mice

(2012) Haojie Huang et al.   GASTROENTEROLOGY

Intra-acinar Trypsinogen Activation Mediates Early Stages of Pancreatic Injury but Not Inflammation in Mice With Acute Pancreatitis

(2011) Rajinder Dawra et al.   GASTROENTEROLOGY

TLR4 but not TLR2 regulates inflammation and tissue damage in acute pancreatitis induced by retrograde infusion of taurocholate

(2011) Darbaz Awla et al.   INFLAMMATION RESEARCH

Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis

(2011) Aree Abdulla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil-derived matrix metalloproteinase-9 is a potent activator of trypsinogen in acinar cells in acute pancreatitis

(2011) Darbaz Awla et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini

(2010) Lidiya S. Orlichenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of alcoholic pancreatitis

(2010) Minoti V Apte et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL