Journal
CELL CALCIUM
Volume 88, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceca.2020.102208
Keywords
Piezo1; TRPV4; Orai1; Ca2+ overload; pancreatitis; drug target
Categories
Funding
- U.K. Medical Research Council
- National Institute for Health Research
- Hampson Trust
- European Union Innovative Medicines Initiative
- GlaxoSmithKline PLC
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Pancreatic trauma and high parenchymal pressure have been found to open Piezo1 plasma membrane Ca2+ channels to such an extent that transient receptor potential vanilloid type 4 channels also open to further Ca2+ entry, overloading the cell with Ca2+ to induce acute pancreatitis (Swain et al, J Clin Invest, 2020). Elucidation of this mechanism is an important step in understanding pancreatitis and opens up new possibilities for prevention and treatment.
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