Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

Dynamics Intrinsic to Cystic Fibrosis Transmembrane Conductance Regulator Function and Stability

(2013) P. A. Chong et al.   Cold Spring Harbor Perspectives in Medicine

The CFTR Ion Channel: Gating, Regulation, and Anion Permeation

(2013) T.-C. Hwang et al.   Cold Spring Harbor Perspectives in Medicine

Cystic Fibrosis Transmembrane Conductance Regulator: A Molecular Model Defines the Architecture of the Anion Conduction Path and Locates a “Bottleneck” in the Pore

(2012) Yohei Norimatsu et al.   BIOCHEMISTRY

CFTR,SPINK1,CTRCandPRSS1variants in chronic pancreatitis: is the role of mutatedCFTRoverestimated?

(2012) Jonas Rosendahl et al.   GUT

New Model of Cystic Fibrosis Transmembrane Conductance Regulator Proposes Active Channel-like Conformation

(2012) James Dalton et al.   Journal of Chemical Information and Modeling

The Power Stroke Driven by ATP Binding in CFTR As Studied by Molecular Dynamics Simulations

(2012) Tomoka Furukawa-Hagiya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Dynamics Simulations of the Bacterial ABC Transporter SAV1866 in the Closed Form

(2012) Jean-François St-Pierre et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis

(2012) David C Whitcomb et al.   NATURE GENETICS

Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis

(2012) Lei Sun et al.   NATURE GENETICS

Molecular Mechanism of Pancreatic and Salivary Gland Fluid and HCO3− Secretion

(2012) Min Goo Lee et al.   PHYSIOLOGICAL REVIEWS

Dynamic modulation of ANO1/TMEM16A HCO3- permeability by Ca2+/calmodulin

(2012) J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic fibrosis modifier genes related to Pseudomonas aeruginosa infection

(2011) J E Park et al.   GENES AND IMMUNITY

Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens

(2011) Bernhard Steiner et al.   HUMAN MUTATION

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2011) Mark F. Rosenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recommendations for the classification of diseases as CFTR-related disorders

(2011) C. Bombieri et al.   Journal of Cystic Fibrosis

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

(2011) Fred A Wright et al.   NATURE GENETICS

A new role for bicarbonate in mucus formation

(2010) Eric Y. T. Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Dynamic Regulation of CFTR Bicarbonate Permeability by [Cl−]i and Its Role in Pancreatic Bicarbonate Secretion

(2010) Hyun Woo Park et al.   GASTROENTEROLOGY

Type of CFTR Mutation Determines Risk of Pancreatitis in Patients With Cystic Fibrosis

(2010) Chee Y. Ooi et al.   GASTROENTEROLOGY

Combined Bicarbonate Conductance-Impairing Variants in CFTR and SPINK1 Variants Are Associated With Chronic Pancreatitis in Patients Without Cystic Fibrosis

(2010) Alexander Schneider et al.   GASTROENTEROLOGY

Idiopathic chronic pancreatitis in India: phenotypic characterisation and strong genetic susceptibility due to SPINK1 and CFTR gene mutations

(2010) S. Midha et al.   GUT

On the functional significance of soft modes predicted by coarse-grained models for membrane proteins

(2010) Ivet Bahar   JOURNAL OF GENERAL PHYSIOLOGY

On the mechanism of CFTR inhibition by a thiazolidinone derivative

(2010) Zoia Kopeikin et al.   JOURNAL OF GENERAL PHYSIOLOGY

Independent Contribution of Common CFTR Variants to Chronic Pancreatitis

(2010) Rafael de Cid et al.   PANCREAS

CFTR Gene Mutation in Patients with Apparently Idiopathic Pancreatitis: Lack of Phenotype-Genotype Correlation

(2010) Anne-Laure Pelletier et al.   PANCREATOLOGY

Asymmetric Switching in a Homodimeric ABC Transporter: A Simulation Study

(2010) Jussi Aittoniemi et al.   PLoS Computational Biology

Alcohol Consumption, Cigarette Smoking, and the Risk of Recurrent Acute and Chronic Pancreatitis

(2009) Dhiraj Yadav   ARCHIVES OF INTERNAL MEDICINE

Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore

(2009) Christopher Alexander et al.   BIOCHEMISTRY

The very low penetrance of cystic fibrosis for the R117H mutation: a reappraisal for genetic counselling and newborn screening

(2009) C Thauvin-Robinet et al.   JOURNAL OF MEDICAL GENETICS

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Multicenter Approach to Recurrent Acute and Chronic Pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)

(2008) David C. Whitcomb et al.   PANCREATOLOGY

Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function

(2008) A. W. R. Serohijos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA