Regulatory roles of circRNAs in adipogenesis and lipid metabolism: emerging insights into lipid‐related diseases

UCP1-independent thermogenesis

(2020) Anna Roesler et al.   BIOCHEMICAL JOURNAL

Maternal obesity alters circRNA expression and the potential role of mmu_circRNA_0000660 via sponging miR_693 in offspring liver at weaning age

(2020) Qiutong Chen et al.   GENE

Translation and functional roles of circular RNAs in human cancer

(2020) Ming Lei et al.   Molecular Cancer

Circular RNA Profiling Reveals Exosomal circ_0006156 as a Novel Biomarker in Papillary Thyroid Cancer

(2020) Guojun Wu et al.   Molecular Therapy-Nucleic Acids

Comprehensive Analysis of the Characteristics and Differences in Adult and Newborn Brown Adipose Tissue (BAT): Newborn BAT Is a More Active/Dynamic BAT

(2020) Junyu Liu et al.   Cells

Insights into the regulatory role of circRNA in angiogenesis and clinical implications

(2020) Yan Liu et al.   ATHEROSCLEROSIS

Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head

(2020) Gaoyang Chen et al.   BONE

Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression

(2020) Wei Chen et al.   CANCER LETTERS

Salvianolic acid B plays an anti-obesity role in high fat diet-induced obese mice by regulating the expression of mRNA, circRNA, and lncRNA

(2019) Tian An et al.   PeerJ

Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals

(2019) Peifeng Ji et al.   Cell Reports

CircFunBase: a database for functional circular RNAs

(2019) Xianwen Meng et al.   Database-The Journal of Biological Databases and Curation

Targeting pericyte–endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction

(2019) Chang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Analysis of Differentially Expressed mRNA, lncRNA and circRNA and Their ceRNA Networks in the Longissimus Dorsi Muscle of Two Different Pig Breeds

(2019) Jing Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles Long RNA Sequencing Reveals Abundant mRNA, circRNA, and lncRNA in Human Blood as Potential Biomarkers for Cancer Diagnosis

(2019) Yuchen Li et al.   CLINICAL CHEMISTRY

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

Widespread and Functional RNA Circularization in Localized Prostate Cancer

(2019) Sujun Chen et al.   CELL

Genome‐wide identification and comparison of mRNA s, lnc RNA s and circ RNA s in porcine intramuscular, subcutaneous, retroperitoneal and mesenteric adipose tissues

(2019) X. Liu et al.   ANIMAL GENETICS

Age‐induced oxidative stress impairs adipogenesis and thermogenesis in brown fat

(2019) Xianwei Cui et al.   FEBS Journal

Circbank: a comprehensive database for circRNA with standard nomenclature

(2019) Ming Liu et al.   RNA Biology

The Therapeutic Potential of Nanobodies

(2019) Ivana Jovčevska et al.   BIODRUGS

Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells

(2019) Yuezhu Zhang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1

(2019) Yiyi Zhu et al.   EXPERIMENTAL CELL RESEARCH

Kidney-secreted erythropoietin lowers lipidemia via activating JAK2-STAT5 signaling in adipose tissue

(2019) Jinxiang Li et al.   EBioMedicine

Circular RNA expression profiles in the porcine liver of two distinct phenotype pig breeds

(2018) Minjie Huang et al.   ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice

(2018) Jun Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification and Characterization of CircRNAs of Two Pig Breeds as a New Biomarker in Metabolism-Related Diseases

(2018) Ai Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis and Hepatocellular Carcinoma

(2018) Omar Massoud et al.   Clinics in Liver Disease

Long noncoding RNA H19 interacts with polypyrimidine tract-binding protein 1 to reprogram hepatic lipid homeostasis

(2018) Chune Liu et al.   HEPATOLOGY

Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers

(2018) Midori Honma et al.   INTERNATIONAL JOURNAL OF OBESITY

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

(2018) Maolei Zhang et al.   ONCOGENE

circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

(2018) Xing-Ya Guo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

circRNA disease: a manually curated database of experimentally supported circRNA-disease associations

(2018) Zheng Zhao et al.   Cell Death & Disease

CircR2Disease: a manually curated database for experimentally supported circular RNAs associated with various diseases

(2018) Chunyan Fan et al.   Database-The Journal of Biological Databases and Curation

A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer

(2018) Dong Hang et al.   Cancer Medicine

TRCirc: a resource for transcriptional regulation information of circRNAs

(2018) Zhidong Tang et al.   BRIEFINGS IN BIOINFORMATICS

Long non-coding RNAs regulation in adipogenesis and lipid metabolism: Emerging insights in obesity

(2018) Chen Chen et al.   CELLULAR SIGNALLING

CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway

(2018) Peifei Li et al.   DIGESTIVE DISEASES AND SCIENCES

Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA–lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma

(2018) Rui Zhao et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

A genome-wide landscape of mRNAs, lncRNAs, and circRNAs during subcutaneous adipogenesis in pigs

(2018) Xin Liu et al.   Journal of Animal Science and Biotechnology

A comprehensive review of circRNA: from purification and identification to disease marker potential

(2018) Sheng Xu et al.   PeerJ

CIRCpedia v2: An Updated Database for Comprehensive Circular RNA Annotation and Expression Comparison

(2018) Rui Dong et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway

(2018) Haiyang Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7

(2018) Haiyang Zhang et al.   ONCOGENE

Biogenesis of circular RNAs and their roles in cardiovascular development and pathology

(2017) Mengyang Li et al.   FEBS Journal

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

PDGFRα Regulated by miR-34a and FoxO1 Promotes Adipogenesis in Porcine Intramuscular Preadipocytes through Erk Signaling Pathway

(2017) Yun-Mei Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway

(2017) Haiyan Pan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

(2017) Jian Zheng et al.   Journal of Hematology & Oncology

CircRNA: functions and properties of a novel potential biomarker for cancer

(2017) Shujuan Meng et al.   Molecular Cancer

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

CSCD: a database for cancer-specific circular RNAs

(2017) Siyu Xia et al.   NUCLEIC ACIDS RESEARCH

circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis

(2017) Xing-Ya Guo et al.   Oxidative Medicine and Cellular Longevity

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

MiR-30c-5p ameliorates hepatic steatosis in leptin receptor-deficient (db/db) mice via down-regulating FASN

(2017) Jiahui Fan et al.   Oncotarget

Circular RNA Profiling and Bioinformatic Modeling Identify Its Regulatory Role in Hepatic Steatosis

(2017) Xing-Ya Guo et al.   Biomed Research International

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

(2017) Yuwei Jiang et al.   eLife

Lower Expression of SLC27A1 Enhances Intramuscular Fat Deposition in Chicken via Down-Regulated Fatty Acid Oxidation Mediated by CPT1A

(2017) Fengfang Qiu et al.   Frontiers in Physiology

The complexity of the translation ability of circRNAs

(2016) Javier T. Granados-Riveron et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Knockdown of Plakophilin 2 Downregulates miR-184 Through CpG Hypermethylation and Suppression of the E2F1 Pathway and Leads to Enhanced Adipogenesis In VitroNovelty and Significance

(2016) Priyatansh Gurha et al.   CIRCULATION RESEARCH

Metabolic interplay between white, beige, brown adipocytes and the liver

(2016) Ludger Scheja et al.   JOURNAL OF HEPATOLOGY

White Adipose Tissue Browning: A Double-edged Sword

(2016) Abdikarim Abdullahi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression

(2016) Lei Yu et al.   PLoS One

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Transcriptional regulation of hepatic lipogenesis

(2015) Yuhui Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread noncoding circular RNAs in plants

(2015) Chu-Yu Ye et al.   NEW PHYTOLOGIST

deepBase v2.0: identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs from deep-sequencing data

(2015) Ling-Ling Zheng et al.   NUCLEIC ACIDS RESEARCH

CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

(2015) Dawood B. Dudekula et al.   RNA Biology

Regulation of circRNA biogenesis

(2015) Ling-Ling Chen et al.   RNA Biology

Metazoan tRNA introns generate stable circular RNAs in vivo

(2015) Zhipeng Lu et al.   RNA

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miR-140-5p regulates adipocyte differentiation by targeting transforming growth factor-β signaling

(2015) Xin Zhang et al.   Scientific Reports

Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease

(2015) Jiexia Ding et al.   Scientific Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

CIRI: an efficient and unbiased algorithm for de novo circular RNA identification

(2015) Yuan Gao et al.   GENOME BIOLOGY

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Biogenesis of Circular RNAs

(2014) Quentin Vicens et al.   CELL

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6

(2014) Chen Chen et al.   CELLULAR SIGNALLING

A compound heterozygous mutation in GPD1 causes hepatomegaly, steatohepatitis and hypertriglyceridemia

(2014) Mugdha Joshi et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The global burden of liver disease: The major impact of China

(2014) Fu-Sheng Wang et al.   HEPATOLOGY

A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3

(2014) Sacha Ferdinandusse et al.   HUMAN MOLECULAR GENETICS

A View of Pre-mRNA Splicing from RNase R Resistant RNAs

(2014) Hitoshi Suzuki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

circBase: a database for circular RNAs

(2014) Petar Glažar et al.   RNA

TIPping the balance in adipogenesis

(2014) Yuan Gao et al.   Adipocyte

Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte

(2013) Huijin Fan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein–RNA interaction networks from large-scale CLIP-Seq data

(2013) Jun-Hao Li et al.   NUCLEIC ACIDS RESEARCH

Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60

(2013) Yuan Gao et al.   Nature Communications

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Obesity resistance and increased hepatic expression of catabolism-related mRNAs inCnot3+/−mice

(2011) Masahiro Morita et al.   EMBO JOURNAL

Adipocyte-specific Inactivation of Acyl-CoA Synthetase Fatty Acid Transport Protein 4 (Fatp4) in Mice Causes Adipose Hypertrophy and Alterations in Metabolism of Complex Lipids under High Fat Diet

(2011) Lena-Solveig Lenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTC124 improves readthrough and increases enzymatic activity of the CPT1A R160X nonsense mutation

(2011) Lu Tan et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin

(2011) Jiong Zhao et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptome-wide discovery of circular RNAs in Archaea

(2011) Miri Danan et al.   NUCLEIC ACIDS RESEARCH

The pig: a model for human infectious diseases

(2011) François Meurens et al.   TRENDS IN MICROBIOLOGY

Transcriptional Control of Brown Fat Development

(2010) Shingo Kajimura et al.   Cell Metabolism

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation

(2010) Josep M. Orellana-Gavaldà et al.   HEPATOLOGY

A role ofmiR-27in the regulation of adipogenesis

(2009) Qun Lin et al.   FEBS Journal

Initiation of myoblast to brown fat switch by a PRDM16–C/EBP-β transcriptional complex

(2009) Shingo Kajimura et al.   NATURE

New developments in adipogenesis

(2009) Martina I. Lefterova et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE