UCP1-independent thermogenesis

Cold acclimation enhances UCP1 content, lipolysis, and triacylglycerol re-synthesis, but not mitochondrial uncoupling and fat oxidation in rat white adipocytes

(2019) Diane M. Sepa-Kishi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure

(2019) Tobias Fromme et al.   Scientific Reports

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

(2019) Naja Z. Jespersen et al.   Molecular Metabolism

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis

(2019) Sai P. Pydi et al.   Nature Communications

Selective activation of Gs signaling in adipocytes causes striking metabolic improvements in mice

(2019) Lei Wang et al.   Molecular Metabolism

Adipocyte Gs but not Gi signaling regulates whole-body glucose homeostasis

(2019) Alexandre Caron et al.   Molecular Metabolism

Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α

(2019) Chen-Cheng Lee et al.   MOLECULAR CELL

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

(2019) Takeshi Yoneshiro et al.   NATURE

Uncoupling protein 1 and the capacity for non-shivering thermogenesis are components of the glucose homeostatic system

(2019) Stefanie F. Maurer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue

(2019) Anying Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct detection of brown adipose tissue thermogenesis in UCP1−/− mice by hyperpolarized 129Xe MR thermometry

(2019) Michael A. Antonacci et al.   Scientific Reports

Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status

(2019) M. Peleli et al.   Redox Biology

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

(2018) Mueez U Din et al.   Cell Metabolism

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

(2018) Katharina Braun et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Sarcolipin Makes Heat, but Is It Adaptive Thermogenesis?

(2018) Kevin L. Campbell et al.   Frontiers in Physiology

Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1

(2018) Dianxin Liu et al.   Molecular Metabolism

Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight

(2018) Michael Rosenbaum et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

(2018) Rubén Cereijo et al.   Cell Metabolism

Accumulation of succinate controls activation of adipose tissue thermogenesis

(2018) Evanna L. Mills et al.   NATURE

Brown Adipose Tissue Energy Metabolism in Humans

(2018) André C. Carpentier et al.   Frontiers in Endocrinology

Intact innervation is essential for diet-induced recruitment of brown adipose tissue

(2018) Alexander W. Fischer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

New Advances in Adaptive Thermogenesis: UCP1 and Beyond

(2018) Edward T. Chouchani et al.   Cell Metabolism

Thermal stress induces glycolytic beige fat formation via a myogenic state

(2018) Yong Chen et al.   NATURE

Induction of lipogenesis in white fat during cold exposure in mice: link to lean phenotype

(2017) P Flachs et al.   INTERNATIONAL JOURNAL OF OBESITY

Quantifying enzyme activity in living cells

(2017) Agnes Zotter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction

(2017) Lawrence Kazak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping of human brown adipose tissue in lean and obese young men

(2017) Brooks P. Leitner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

(2017) Denis P. Blondin et al.   Nature Communications

Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice

(2017) Nicholas Douris et al.   Molecular Metabolism

Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice

(2016) Marika Zietak et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Creatine transporter deficiency leads to increased whole body and cellular metabolism

(2016) Marla K. Perna et al.   AMINO ACIDS

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

(2016) Shogo Wada et al.   GENES & DEVELOPMENT

Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function

(2016) Naresh C. Bal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1

(2016) Edward T. Chouchani et al.   NATURE

Sarcolipin and uncoupling protein 1 play distinct roles in diet-induced thermogenesis and do not compensate for one another

(2016) Leslie A. Rowland et al.   Obesity

Sarcolipin knockout mice fed a high-fat diet exhibit altered indices of adipose tissue inflammation and remodeling

(2016) Rebecca E.K. MacPherson et al.   Obesity

Proteomic Analysis of Human Brown Adipose Tissue Reveals Utilization of Coupled and Uncoupled Energy Expenditure Pathways

(2016) Sebastian Müller et al.   Scientific Reports

A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat

(2015) Lawrence Kazak et al.   CELL

Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress

(2015) Leslie A. Rowland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New genetic loci link adipose and insulin biology to body fat distribution

(2015) Dmitry Shungin et al.   NATURE

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

(2014) Jakob D Wikstrom et al.   EMBO JOURNAL

Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans

(2014) Denis P. Blondin et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

Brown and beige fat: development, function and therapeutic potential

(2013) Matthew Harms et al.   NATURE MEDICINE

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Mechanism of Fatty-Acid-Dependent UCP1 Uncoupling in Brown Fat Mitochondria

(2012) Andriy Fedorenko et al.   CELL

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals

(2012) Naresh C Bal et al.   NATURE MEDICINE

Chronic cold acclimation increases thermogenic capacity, non-shivering thermogenesis and muscle citrate synthase activity in both wild-type and brown adipose tissue deficient mice

(2011) P.M. Mineo et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Inactivation of the Mitochondrial Carrier SLC25A25 (ATP-Mg2+/PiTransporter) Reduces Physical Endurance and Metabolic Efficiency in Mice

(2011) Rea P. Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice

(2010) Carola W. Meyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cold tolerance of UCP1-ablated mice: A skeletal muscle mitochondria switch toward lipid oxidation with marked UCP3 up-regulation not associated with increased basal, fatty acid- or ROS-induced uncoupling or enhanced GDP effects

(2010) Irina G. Shabalina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Adipose Acyl-CoA Synthetase-1 Directs Fatty Acids toward β-Oxidation and Is Required for Cold Thermogenesis

(2010) Jessica M. Ellis et al.   Cell Metabolism

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

Gene expression in human brown adipose tissue

(2010) Svensson   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sympathetic and sensory innervation of brown adipose tissue

(2010) T J Bartness et al.   INTERNATIONAL JOURNAL OF OBESITY

Brown fat thermogenesis and body weight regulation in mice: relevance to humans

(2010) L P Kozak et al.   INTERNATIONAL JOURNAL OF OBESITY

Uncoupling Protein 1 Decreases Superoxide Production in Brown Adipose Tissue Mitochondria

(2010) Rebecca Oelkrug et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Coefficients for Active Transport and Thermogenesis of Ca2+-ATPase Isoforms

(2009) Signe Kjelstrup et al.   BIOPHYSICAL JOURNAL

Molecular Mechanisms of Hepatic Steatosis and Insulin Resistance in the AGPAT2-Deficient Mouse Model of Congenital Generalized Lipodystrophy

(2009) Víctor A. Cortés et al.   Cell Metabolism

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Creatine kinase regulation by reversible phosphorylation in frog muscle

(2009) Christopher A. Dieni et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Deficiency of the intestinal enzyme acyl CoA:monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding

(2009) Chi-Liang Eric Yen et al.   NATURE MEDICINE

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

(2008) Yuguang Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity

(2008) Rea Anunciado-Koza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a novelsn-glycerol-3-phosphate acyltransferase isoform, GPAT4, as the enzyme deficient inAgpat6−/−mice

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals

(2007) Masahiro Watanabe et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS