Detrimental and Beneficial Effect of Autophagy and a Potential Therapeutic Target after Ischemic Stroke

mTOR and Beclin1: Two key autophagy-related molecules and their roles in myocardial ischemia/reperfusion injury

(2019) Binhao Shi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of miR-497 improves functional outcome after ischemic stroke by enhancing neuronal autophagy in young and aged rats

(2019) Xudong Chen et al.   NEUROCHEMISTRY INTERNATIONAL

Nucleic Acid Therapies for Ischemic Stroke

(2019) Nils Henninger et al.   Neurotherapeutics

Crosstalk Between Autophagy and Cerebral Ischemia

(2019) Yulin Sun et al.   Frontiers in Neuroscience

Novel therapeutic strategies for stroke: The role of autophagy

(2019) Seyed Fazel Nabavi et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

(2019) Ruth Scherz‐Shouval et al.   EMBO JOURNAL

The relation between PI3K/AKT signalling pathway and cancer

(2019) Saeed Noorolyai et al.   GENE

The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods

(2019) Kai Hou et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

The Role of Astragaloside IV against Cerebral Ischemia/Reperfusion Injury: Suppression of Apoptosis via Promotion of P62-LC3-Autophagy

(2019) Yi Zhang et al.   MOLECULES

The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1α in cerebral ischemia-reperfusion injury

(2019) Yang Hou et al.   Drug Design Development and Therapy

Tetrahydroxystilbene Glucoside Suppresses NAPDH Oxidative Stress to Mitigate Apoptosis and Autophagy Induced by Cerebral Ischemia/Reperfusion Injury in Mice

(2019) Feng Yu et al.   Evidence-based Complementary and Alternative Medicine

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway

(2019) Jianqing Pan et al.   BIOSCIENCE REPORTS

Hyperbaric oxygen alleviated cognitive impairments in mice induced by repeated cerebral ischemia-reperfusion injury via inhibition of autophagy

(2019) Chunxia Chen et al.   LIFE SCIENCES

Remote limb ischemic postconditioning protects against cerebral ischemia-reperfusion injury by activating AMPK-dependent autophagy

(2018) Hao Guo et al.   BRAIN RESEARCH BULLETIN

Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism

(2018) Rong Ke et al.   CELL BIOLOGY INTERNATIONAL

Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway

(2018) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats

(2018) Jing Yu et al.   EXPERIMENTAL NEUROLOGY

Oxymatrine attenuates cognitive deficits through SIRT1-mediated autophagy in ischemic stroke

(2018) Shuhu Zhou et al.   JOURNAL OF NEUROIMMUNOLOGY

Electroacupuncture Ameliorates Cognitive Impairment and Spontaneous Low-Frequency Brain Activity in Rats with Ischemic Stroke

(2018) Tao Wen et al.   Journal of Stroke & Cerebrovascular Diseases

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

(2018) Zhi-Gang Mei et al.   Neural Regeneration Research

Remote ischemic postconditioning protects the brain from focal ischemia/reperfusion injury by inhibiting autophagy through the mTOR/p70S6K pathway

(2018) Guo-zhong Chen et al.   NEUROLOGICAL RESEARCH

The effect of normobaric oxygen in patients with acute stroke: a systematic review and meta-analysis

(2018) Jiayue Ding et al.   NEUROLOGICAL RESEARCH

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Electroacupunture contributes to recovery of neurological deficits in experimental stroke by activating astrocytes

(2018) Haijun Zhao et al.   RESTORATIVE NEUROLOGY AND NEUROSCIENCE

Electroacupuncture Ameliorates Cognitive Impairment and Spontaneous Low-Frequency Brain Activity in Rats with Ischemic Stroke

(2018) Tao Wen et al.   Journal of Stroke & Cerebrovascular Diseases

SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway

(2018) Meng Zhang et al.   Aging and Disease

Mild Therapeutic Hypothermia Protects the Brain from Ischemia/Reperfusion Injury through Upregulation of iASPP

(2018) Xiangrong Liu et al.   Aging and Disease

An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning

(2018) Ciprian Hentia et al.   Brain and Behavior

Possible Involvement of PTEN Signaling Pathway in the Anti-apoptotic Effect of Electroacupuncture Following Ischemic Stroke in Rats

(2018) Ying Xing et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Electroacupuncture Alleviated Neuronal Apoptosis Following Ischemic Stroke in Rats via Midkine and ERK/JNK/p38 Signaling Pathway

(2018) Ying Xing et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning

(2018) Na Lu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

AMPK: Potential Therapeutic Target for Ischemic Stroke

(2018) Shuai Jiang et al.   Theranostics

Pioglitazone Protects Against Renal Ischemia-Reperfusion Injury via the AMP-Activated Protein Kinase-Regulated Autophagy Pathway

(2018) Wenlin Chen et al.   Frontiers in Pharmacology

Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK/mTOR/ULK1 signaling

(2018) Luopei Wang et al.   PHYTOMEDICINE

A division of labor in mTORC1 signaling and autophagy

(2018) Sascha Martens   Science Signaling

Neuroprotective Autophagic Flux Induced by Hyperbaric Oxygen Preconditioning is Mediated by Cystatin C

(2018) Zongping Fang et al.   Neuroscience Bulletin

Mechanisms Involved in the Neuroprotection of Electroacupuncture Therapy for Ischemic Stroke

(2018) Ying Xing et al.   Frontiers in Neuroscience

miR-30d-5p Plays an Important Role in Autophagy and Apoptosis in Developing Rat Brains After Hypoxic–Ischemic Injury

(2017) Fengyan Zhao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Identification of IL-17A-derived neural cell type and dynamic changes of IL-17A in serum/CSF of mice with ischemic stroke

(2017) Shujuan Li et al.   NEUROLOGICAL RESEARCH

Protective effect of electroacupuncture on neurons autophagy in perfusion period of cerebral ischemia

(2017) Zuo Ting et al.   NEUROSCIENCE LETTERS

Dexmedetomidine Protects Mouse Brain from Ischemia-Reperfusion Injury via Inhibiting Neuronal Autophagy through Up-Regulating HIF-1α

(2017) Cong Luo et al.   Frontiers in Cellular Neuroscience

Sodium hydrosulfide attenuates cerebral ischemia/reperfusion injury by suppressing overactivated autophagy in rats

(2017) Wen-Wu Jiang et al.   FEBS Open Bio

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

(2017) Meiling Wu et al.   Annals of Clinical and Translational Neurology

Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome

(2016) Zhui Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

(2016) Mayank Goyal et al.   LANCET

Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke

(2016) Peng-yue Zhang et al.   Neural Regeneration Research

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Autophagy Upregulation and Apoptosis Downregulation in DAHP and Triptolide Treated Cerebral Ischemia

(2015) Yang Yang et al.   MEDIATORS OF INFLAMMATION

Ischemic Preconditioning Mediates Neuroprotection against Ischemia in Mouse Hippocampal CA1 Neurons by Inducing Autophagy

(2015) Chunlin Gao et al.   PLoS One

Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways

(2014) Ya-Dan Wen et al.   Autophagy

p65/RelA binds and activates thebeclin 1promoter

(2014) Tamara Copetti et al.   Autophagy

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy

(2014) Teng Jiang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Advances in research of the neuroprotective mechanisms of cerebral ischemic postconditioning

(2014) Xu-Dong Ma et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries

(2014) Venkata Prasuja Nakka et al.   MOLECULAR NEUROBIOLOGY

Ischemic Preconditioning Provides Neuroprotection by Induction of AMP-Activated Protein Kinase-Dependent Autophagy in a Rat Model of Ischemic Stroke

(2014) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Autophagy: a double-edged sword for neuronal survival after cerebral ischemia

(2014) Kangyong Liu et al.   Neural Regeneration Research

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy

(2014) Peng Wang et al.   NEUROCHEMICAL RESEARCH

Autophagy Activation Contributes to the Neuroprotection of Remote Ischemic Perconditioning Against Focal Cerebral Ischemia in Rats

(2014) Jingyuan Su et al.   NEUROCHEMICAL RESEARCH

Neuronal autophagy in cerebral ischemia – a potential target for neuroprotective strategies?

(2014) Bożena Gabryel et al.   Pharmacological Reports

Chronic Oxidative Stress Increases Growth and Tumorigenic Potential of MCF-7 Breast Cancer Cells

(2014) Prathap Kumar S. Mahalingaiah et al.   PLoS One

The protective roles of autophagy in ischemic preconditioning

(2013) Wen-jun Yan et al.   ACTA PHARMACOLOGICA SINICA

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

NF-κB-mediated induction of autophagy in cardiac ischemia/reperfusion injury

(2013) Min Zeng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ischemia preconditioning is neuroprotective in a rat cerebral ischemic injury model through autophagy activation and apoptosis inhibition

(2013) D.Y. Xia et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

(2013) Ramon Rodrigo et al.   CNS & Neurological Disorders-Drug Targets

The regulatory role of NF-κB in autophagy-like cell death after focal cerebral ischemia in mice

(2013) W.-L. Li et al.   NEUROSCIENCE

Autophagy in the brain of neonates following hypoxia–ischemia shows sex- and region-specific effects

(2013) S.N. Weis et al.   NEUROSCIENCE

Regulation of autophagy by stress-responsive transcription factors

(2013) Federico Pietrocola et al.   SEMINARS IN CANCER BIOLOGY

Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

(2012) Pei Wang et al.   Autophagy

A Double-Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury

(2012) Kai Wei et al.   CNS Neuroscience & Therapeutics

Intranasal Ginsenoside Rb1 Targets the Brain and Ameliorates Cerebral Ischemia/Reperfusion Injury in Rats

(2011) Tingting Lu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats

(2011) Wenjun Yan et al.   BRAIN RESEARCH

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

(2011) A. Avivar-Valderas et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks

(2011) S. Alers et al.   MOLECULAR AND CELLULAR BIOLOGY

Why Starving Cells Eat Themselves

(2011) D. G. Hardie   SCIENCE

Role of 5′-Adenosine Monophosphate-Activated Protein Kinase in Cell Survival and Death Responses in Neurons

(2010) Petronela Weisová et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy Signaling Through Reactive Oxygen Species

(2010) Ju Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Hyperbaric oxygen preconditioning reduces ischemia–reperfusion injury by stimulating autophagy in neurocyte

(2010) Yong-Chun Wang et al.   BRAIN RESEARCH

Transient Focal Ischemia Induces Extensive Temporal Changes in Rat Cerebral MicroRNAome

(2009) Ashuthosh Dharap et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death

(2007) A. Rami et al.   NEUROBIOLOGY OF DISEASE