Nucleic Acid Therapies for Ischemic Stroke

Heart Disease and Stroke Statistics—2018 Update: A Report From the American Heart Association

(2018) Emelia J. Benjamin et al.   CIRCULATION

EP News: Clinical

(2018) N.A. Mark Estes   HEART RHYTHM

Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention

(2018) Francesco Panza et al.   JOURNAL OF ALZHEIMERS DISEASE

microRNA-21 Confers Neuroprotection Against Cerebral Ischemia-Reperfusion Injury and Alleviates Blood-Brain Barrier Disruption in Rats via the MAPK Signaling Pathway

(2018) Xiaofeng Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Balancing risks versus benefits of anticoagulants in stroke prevention

(2018) Charlotte Cordonnier   LANCET NEUROLOGY

Upregulation of miR-215 exerts neuroprotection effects against ischemic injury via negative regulation of Act1/IL-17RA signaling

(2018) Hongxue Sun et al.   NEUROSCIENCE LETTERS

MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset

(2018) Götz Thomalla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging

(2018) Gregory W. Albers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

(2018) Raul G. Nogueira et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treatments to Promote Neural Repair after Stroke

(2018) Steven C. Cramer   Journal of Stroke

Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

(2017) Ionica Pirici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Atrial fibrillation, cognition and dementia: A review

(2017) Summer Aldrugh et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL

(2017) Arturo I. Machuca-Parra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-1906, a Novel Regulator of Toll-Like Receptor 4, Ameliorates Ischemic Injury after Experimental Stroke in Mice

(2017) Xiaomeng Xu et al.   JOURNAL OF NEUROSCIENCE

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2017) Simon I Hay et al.   LANCET

MicroRNA-15a/16-1 Antagomir Ameliorates Ischemic Brain Injury in Experimental Stroke

(2017) Xinxin Yang et al.   STROKE

Stroke Recovery and Rehabilitation Research

(2017) Steven C. Cramer et al.   STROKE

MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats

(2017) Hongqi Xin et al.   STROKE

The FOCUS, AFFINITY and EFFECTS trials studying the effect(s) of fluoxetine in patients with a recent stroke: statistical and health economic analysis plan for the trials and for the individual patient data meta-analysis

(2017) Catriona Graham et al.   Trials

Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 LevelsCLINICAL PERSPECTIVE

(2017) Hernan A. Bazan et al.   Circulation-Cardiovascular Genetics

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping:in vitroproof of concept

(2016) Julie W. Rutten et al.   BRAIN

Emerging Therapeutic Options for Lowering of Lipoprotein(a): Implications for Prevention of Cardiovascular Disease

(2016) Michael B. Boffa   Current Atherosclerosis Reports

Pre-existing anti-PEG antibodies are associated with severe immediate allergic reactions to pegnivacogin, a PEGylated aptamer

(2016) Thomas J. Povsic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

(2016) Nancy J. Ganson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia

(2016) P. Barton Duell et al.   Journal of Clinical Lipidology

Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials

(2016) Peter M Rothwell et al.   LANCET

Effect of the REG1 anticoagulation system versus bivalirudin on outcomes after percutaneous coronary intervention (REGULATE-PCI): a randomised clinical trial

(2016) A Michael Lincoff et al.   LANCET

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial

(2016) Kevin N Sheth et al.   LANCET NEUROLOGY

Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial

(2016) Serge Bracard et al.   LANCET NEUROLOGY

Incidence and Predictors of Early Recanalization After Intravenous Thrombolysis

(2016) Pierre Seners et al.   STROKE

Challenges and Opportunities of Endovascular Stroke Therapy

(2015) Mayank Goyal et al.   ANNALS OF NEUROLOGY

Mipomersen, an Antisense Oligonucleotide to Apolipoprotein B-100, Reduces Lipoprotein(a) in Various Populations With HypercholesterolemiaSignificance

(2015) Raul D. Santos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipoprotein (a) as a risk factor for ischemic stroke: A meta-analysis

(2015) Alexander H. Nave et al.   ATHEROSCLEROSIS

Angiogenesis-regulating microRNAs and Ischemic Stroke

(2015) Ke-Jie Yin et al.   Current Vascular Pharmacology

Monogenic causes of stroke: now and the future

(2015) Rhea Y. Y. Tan et al.   JOURNAL OF NEUROLOGY

In Vivo Inhibition of miR-155 Promotes Recovery after Experimental Mouse Stroke

(2015) E. Caballero-Garrido et al.   JOURNAL OF NEUROSCIENCE

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study

(2015) Sotirios Tsimikas et al.   LANCET

Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study

(2015) Valery L. Feigin et al.   NEUROEPIDEMIOLOGY

Lipid and lipoprotein measurements and the risk of ischemic vascular events: Framingham Study

(2015) A. Pikula et al.   NEUROLOGY

Thrombectomy within 8 Hours after Symptom Onset in Ischemic Stroke

(2015) Tudor G. Jovin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stent-Retriever Thrombectomy after Intravenous t-PA vs. t-PA Alone in Stroke

(2015) Jeffrey L. Saver et al.   NEW ENGLAND JOURNAL OF MEDICINE

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endovascular Therapy for Ischemic Stroke with Perfusion-Imaging Selection

(2015) Bruce C.V. Campbell et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke

(2015) Olvert A. Berkhemer et al.   NEW ENGLAND JOURNAL OF MEDICINE

The National Institutes of Health StrokeNet

(2015) Joseph P. Broderick et al.   STROKE

Tissue-type plasminogen activator-binding RNA aptamers inhibiting low-density lipoprotein receptor family-mediated internalisation

(2015) Kenneth A. Bøtkjær et al.   THROMBOSIS AND HAEMOSTASIS

Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Disease Risk in Adults: Synopsis of the 2013 American College of Cardiology/American Heart Association Cholesterol Guideline

(2014) Neil J. Stone et al.   ANNALS OF INTERNAL MEDICINE

Incidence, Prevalence, Costs, and Impact on Disability of Common Conditions Requiring Rehabilitation in the United States: Stroke, Spinal Cord Injury, Traumatic Brain Injury, Multiple Sclerosis, Osteoarthritis, Rheumatoid Arthritis, Limb Loss, and Back Pain

(2014) Vincent Y. Ma et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Shared Decision Making in Atrial Fibrillation

(2014) Luke Seaburg et al.   CIRCULATION

Lack of Concordance Between Empirical Scores and Physician Assessments of Stroke and Bleeding Risk in Atrial Fibrillation

(2014) Benjamin A. Steinberg et al.   CIRCULATION

MicroRNAs Expression and Function in Cerebral Ischemia Reperfusion Injury

(2014) Yu Di et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Discrimination and Net Reclassification of Cardiovascular Risk With Lipoprotein(a)

(2014) Peter Willeit et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Embolic strokes of undetermined source: the case for a new clinical construct

(2014) Robert G Hart et al.   LANCET NEUROLOGY

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack

(2014) Walter N. Kernan et al.   STROKE

miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke

(2014) Sofie Sølvsten Sørensen et al.   Translational Stroke Research

Trial of ORG 10172 in Acute Stroke Treatment (TOAST) Classification and Vascular Territory of Ischemic Stroke Lesions Diagnosed by Diffusion‐Weighted Imaging

(2014) Jong‐Won Chung et al.   Journal of the American Heart Association

Estimates of Current and Future Incidence and Prevalence of Atrial Fibrillation in the U.S. Adult Population

(2013) Susan Colilla et al.   AMERICAN JOURNAL OF CARDIOLOGY

Risk–Benefit Profile of Long-Term Dual- Versus Single-Antiplatelet Therapy Among Patients With Ischemic Stroke

(2013) Meng Lee et al.   ANNALS OF INTERNAL MEDICINE

Lipoprotein Apheresis in Patients With Maximally Tolerated Lipid-Lowering Therapy, Lipoprotein(a)-Hyperlipoproteinemia, and Progressive Cardiovascular Disease

(2013) Josef Leebmann et al.   CIRCULATION

microRNAs: Innovative Targets for Cerebral Ischemia and Stroke

(2013) Yi-Bing Ouyang et al.   CURRENT DRUG TARGETS

Clinical course of atrial fibrillation in older adults: the importance of cardiovascular events beyond stroke

(2013) J. P. Piccini et al.   EUROPEAN HEART JOURNAL

miR-363-5p regulates endothelial cell properties and their communication with hematopoietic precursor cells

(2013) Ana Costa et al.   Journal of Hematology & Oncology

Lipoprotein(a): resurrected by genetics

(2013) F. Kronenberg et al.   JOURNAL OF INTERNAL MEDICINE

The MicroRNA-17-92 Cluster Enhances Axonal Outgrowth in Embryonic Cortical Neurons

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Inflammation and stroke

(2013) Yi-Bing Ouyang   NEUROSCIENCE LETTERS

Genetic Associations with Valvular Calcification and Aortic Stenosis

(2013) George Thanassoulis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage: A challenge for neuroprotection

(2013) Julien Puyal et al.   PROGRESS IN NEUROBIOLOGY

Stroke Treatment Academic Industry Roundtable

(2013) Jeffrey L. Saver et al.   STROKE

Tumour angiogenesis regulation by the miR-200 family

(2013) Chad V. Pecot et al.   Nature Communications

Apolipoprotein B Synthesis Inhibition With Mipomersen in Heterozygous Familial Hypercholesterolemia

(2012) Evan A. Stein et al.   CIRCULATION

A Phase 2, randomized, partially blinded, active-controlled study assessing the efficacy and safety of variable anticoagulation reversal using the REG1 system in patients with acute coronary syndromes: results of the RADAR trial

(2012) Thomas J. Povsic et al.   EUROPEAN HEART JOURNAL

CADASIL Mutations and shRNA Silencing of NOTCH3 Affect Actin Organization in Cultured Vascular Smooth Muscle Cells

(2012) Saara Tikka et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Lipoprotein(a) as a Potential Causal Genetic Risk Factor of Cardiovascular Disease

(2012) Sotirios Tsimikas et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

(2012) Anna Helgadottir et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation

(2012) Dirk M Hermann et al.   LANCET NEUROLOGY

Infarct Volume Is a Pivotal Biomarker After Intra-Arterial Stroke Therapy

(2012) Albert J. Yoo et al.   STROKE

Final Infarct Volume Is a Stronger Predictor of Outcome Than Recanalization in Patients With Proximal Middle Cerebral Artery Occlusion Treated With Endovascular Therapy

(2012) Syed F. Zaidi et al.   STROKE

Practice-Level Variation in Warfarin Use Among Outpatients With Atrial Fibrillation (from the NCDR PINNACLE Program)

(2011) Paul S. Chan et al.   AMERICAN JOURNAL OF CARDIOLOGY

Bleeding and Stroke Risk in a Real-world Prospective Primary Prevention Cohort of Patients With Atrial Fibrillation

(2011) Daniela Poli et al.   CHEST

Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles

(2011) Nicole A. Terpolilli et al.   CIRCULATION RESEARCH

Atorvastatin decreases lipoprotein(a): A meta-analysis of randomized trials

(2011) Hisato Takagi et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Cell-specific effects of miR-221/222 in vessels: Molecular mechanism and therapeutic application

(2011) Xiaojun Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial

(2011) François Chollet et al.   LANCET NEUROLOGY

Rapidly Regulating Platelet Activity In Vivo With an Antidote Controlled Platelet Inhibitor

(2011) Shahid M Nimjee et al.   MOLECULAR THERAPY

Rivaroxaban versus Warfarin in Nonvalvular Atrial Fibrillation

(2011) Manesh R. Patel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The von Willebrand Inhibitor ARC1779 Reduces Cerebral Embolization After Carotid Endarterectomy

(2011) Hugh S. Markus et al.   STROKE

Effect of Mipomersen, an Apolipoprotein B Synthesis Inhibitor, on Low-Density Lipoprotein Cholesterol in Patients With Familial Hypercholesterolemia

(2010) Fatima Akdim et al.   AMERICAN JOURNAL OF CARDIOLOGY

Underuse of Oral Anticoagulants in Atrial Fibrillation: A Systematic Review

(2010) Isla M. Ogilvie et al.   AMERICAN JOURNAL OF MEDICINE

Risk of Bleeding With Single, Dual, or Triple Therapy With Warfarin, Aspirin, and Clopidogrel in Patients With Atrial Fibrillation

(2010) Morten L. Hansen et al.   ARCHIVES OF INTERNAL MEDICINE

Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)

(2010) et al.   EUROPEAN HEART JOURNAL

Efficacy and Safety of Mipomersen, an Antisense Inhibitor of Apolipoprotein B, in Hypercholesterolemic Subjects Receiving Stable Statin Therapy

(2010) Fatima Akdim et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial

(2010) Frederick J Raal et al.   LANCET

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

(2010) Andrew N. Clarkson et al.   NATURE

MiR-210 – micromanager of the hypoxia pathway

(2010) Xin Huang et al.   TRENDS IN MOLECULAR MEDICINE

Deficiency of von Willebrand factor protects mice from ischemic stroke

(2009) C. Kleinschnitz et al.   BLOOD

Classification of Stroke Subtypes

(2009) P. Amarenco et al.   CEREBROVASCULAR DISEASES

Genetically Elevated Lipoprotein(a) and Increased Risk of Myocardial Infarction

(2009) Pia R. Kamstrup   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lipoprotein(a) Concentration and the Risk of Coronary Heart Disease, Stroke, and Nonvascular Mortality

(2009)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain and Blood microRNA Expression Profiling of Ischemic Stroke, Intracerebral Hemorrhage, and Kainate Seizures

(2009) Da-Zhi Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779

(2009) J. L. DIENER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic

(2009) Zheng Gang Zhang et al.   LANCET NEUROLOGY

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

(2009) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

(2009) Robert Clarke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

A Structural Explanation for the Antithrombotic Activity of ARC1172, a DNA Aptamer that Binds von Willebrand Factor Domain A1

(2009) Ren-Huai Huang et al.   STRUCTURE

Phase 1b Randomized Study of Antidote-Controlled Modulation of Factor IXa Activity in Patients With Stable Coronary Artery Disease

(2008) Mark Y. Chan et al.   CIRCULATION

Magnetic Resonance Imaging Investigation of Axonal Remodeling and Angiogenesis after Embolic Stroke in Sildenafil-Treated Rats

(2008) Guangliang Ding et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Normobaric Hyperoxia and Delayed tPA Treatment in a Rat Embolic Stroke Model

(2008) Nils Henninger et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A randomized, repeat-dose, pharmacodynamic and safety study of an antidote-controlled factor IXa inhibitor

(2008) M. Y. CHAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

(2008) Werner Hacke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms Underlying Improved Recovery of Neurological Function After Stroke in the Rodent After Treatment With Neurorestorative Cell-Based Therapies

(2008) M. Chopp et al.   STROKE