Mechanisms of progressive fibrosis in connective tissue disease (CTD)-associated interstitial lung diseases (ILDs)

Pirfenidone: Molecular Mechanisms and Potential Clinical Applications in Lung Disease

(2020) Saleela M Ruwanpura et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pro-fibrotic effects of IL-17A and elevated IL-17RA in IPF and RA-ILD support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease

(2019) Jie Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Integrating Genomics into Management of Fibrotic Interstitial Lung Disease

(2019) Ayodeji Adegunsoye et al.   CHEST

Telomere Length and Genetic Variant Associations with Interstitial Lung Disease Progression and Survival

(2019) Chad A. Newton et al.   EUROPEAN RESPIRATORY JOURNAL

Performance of candidate serum biomarkers for systemic sclerosis-interstitial lung disease

(2019) Muriel Elhai et al.   Arthritis & Rheumatology

The Aging Lung and Idiopathic Pulmonary Fibrosis

(2019) Swati Gulati et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis

(2019) Gabriela Kania et al.   Nature Reviews Rheumatology

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pulmonary Complications of Rheumatoid Arthritis

(2019) Hamish Farquhar et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Tracking Impact of Interstitial Lung Disease in Systemic Sclerosis in a Complete Nationwide Cohort

(2019) Anna-Maria Hoffmann-Vold et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Potential of Nintedanib in Treatment of Progressive Fibrosing Interstitial Lung Diseases

(2019) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Alteration of human macrophage phenotypes by the anti-fibrotic drug nintedanib

(2019) Nessrine Bellamri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Telomerase and Telomeres in Interstitial Lung Diseases: From Molecules to Clinical Implications

(2019) Nissim Arish et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature

(2019) Olivier Bonhomme et al.   RHEUMATOLOGY

Telomeropathy in Chronic Hypersensitivity Pneumonitis

(2019) Demosthenes Bouros et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Progressive fibrosing interstitial lung disease associated with systemic autoimmune diseases

(2019) Aryeh Fischer et al.   CLINICAL RHEUMATOLOGY

New trajectories in the treatment of interstitial lung disease

(2019) Julie Morisset et al.   CURRENT OPINION IN PULMONARY MEDICINE

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Mechanisms of lung disease development in rheumatoid arthritis

(2019) Dan Wang et al.   Nature Reviews Rheumatology

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

(2019) Kevin R. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: a double-blind, randomised, placebo-controlled, phase 2 trial

(2019) Toby M Maher et al.   Lancet Respiratory Medicine

Endotype–phenotyping may predict a treatment response in progressive fibrosing interstitial lung disease

(2019) Anna-Maria Hoffmann-Vold et al.   EBioMedicine

Activated human T lymphocytes inhibit TGFβ-induced fibroblast to myofibroblast differentiation via prostaglandins D2 and E2

(2018) Shannon H. Lacy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The controversial role of mast cells in fibrosis

(2018) Peter Bradding et al.   IMMUNOLOGICAL REVIEWS

Aged polymorphonuclear leukocytes cause fibrotic interstitial lung disease in the absence of regulation by B cells

(2018) Jung Hwan Kim et al.   NATURE IMMUNOLOGY

Clinical spectrum and prognostic factors of possible UIP pattern on high-resolution CT in patients who underwent surgical lung biopsy

(2018) Yasuhiro Kondoh et al.   PLoS One

Fibroblast-matrix interplay: Nintedanib and pirfenidone modulate the effect of IPF fibroblast-conditioned matrix on normal fibroblast phenotype

(2018) Gali Epstein Shochet et al.   RESPIROLOGY

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres

(2018) Juan Manuel Povedano et al.   eLife

The lung in rheumatoid arthritis - focus on interstitial lung disease

(2018) Paolo Spagnolo et al.   Arthritis & Rheumatology

Impaired CMV Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres

(2018) Iulia Popescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hypersensitivity Pneumonitis: Radiologic Phenotypes are Associated with Distinct Survival Time and Pulmonary Function Trajectory

(2018) Margaret L. Salisbury et al.   CHEST

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production

(2018) Lindsay J. Celada et al.   Science Translational Medicine

Sarcoidosis

(2018) S. Salah et al.   JOURNAL FRANCAIS D OPHTALMOLOGIE

Short telomere syndromes cause a primary T cell immunodeficiency

(2018) Christa L. Wagner et al.   JOURNAL OF CLINICAL INVESTIGATION

MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease

(2018) Pierre-Antoine Juge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pneumocystosis revealing immunodeficiency secondary toTERCmutation

(2017) Raphael Borie et al.   EUROPEAN RESPIRATORY JOURNAL

Shared genetic predisposition in rheumatoid arthritis-interstitial lung disease and familial pulmonary fibrosis

(2017) Pierre-Antoine Juge et al.   EUROPEAN RESPIRATORY JOURNAL

SIRT3 deficiency promotes lung fibrosis by augmenting alveolar epithelial cell mitochondrial DNA damage and apoptosis

(2017) Renea P. Jablonski et al.   FASEB JOURNAL

Triple Angiokinase Inhibitor Nintedanib Directly Inhibits Tumor Cell Growth and Induces Tumor Shrinkage via Blocking Oncogenic Receptor Tyrosine Kinases

(2017) Frank Hilberg et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Short-term Automated Quantification of Radiologic Changes in the Characterization of Idiopathic Pulmonary Fibrosis Versus Nonspecific Interstitial Pneumonia and Prediction of Long-term Survival

(2017) Federica De Giacomi et al.   JOURNAL OF THORACIC IMAGING

Idiopathic pulmonary fibrosis

(2017) Luca Richeldi et al.   LANCET

Pirfenidone suppresses MAPK signalling pathway to reverse epithelial-mesenchymal transition and renal fibrosis

(2017) Zhenzhen Li et al.   NEPHROLOGY

Exploration of the MUC5B promoter variant and ILD risk in patients with autoimmune myositis

(2017) Cheilonda Johnson et al.   RESPIRATORY MEDICINE

Progressive Decline of Lung Function in Rheumatoid Arthritis-Associated Interstitial Lung Disease

(2017) Jorge A. Zamora-Legoff et al.   Arthritis & Rheumatology

CCL2 in the Circulation Predicts Long-Term Progression of Interstitial Lung Disease in Patients With Early Systemic Sclerosis: Data From Two Independent Cohorts

(2017) Minghua Wu et al.   Arthritis & Rheumatology

The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study

(2017) Brett Ley et al.   Lancet Respiratory Medicine

Immune Mechanisms in Pulmonary Fibrosis

(2016) Saeed Kolahian et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Tissue remodelling in pulmonary fibrosis

(2016) Lars Knudsen et al.   CELL AND TISSUE RESEARCH

Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial

(2016) Dinesh Khanna et al.   LANCET

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial

(2016) Donald P Tashkin et al.   Lancet Respiratory Medicine

Therapeutic management of patients with rheumatoid arthritis and associated interstitial lung disease: case report and literature review

(2016) Andrea Picchianti Diamanti et al.   Therapeutic Advances in Respiratory Disease

Incidences and Risk Factors of Organ Manifestations in the Early Course of Systemic Sclerosis: A Longitudinal EUSTAR Study

(2016) Veronika K. Jaeger et al.   PLoS One

Epigenetics in idiopathic pulmonary fibrosis

(2015) Argyrios Tzouvelekis et al.   Biochemistry and Cell Biology

Telomere Length in Interstitial Lung Diseases

(2015) Reinier Snetselaar et al.   CHEST

Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease

(2015) Joshua J. Solomon et al.   EUROPEAN RESPIRATORY JOURNAL

Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis

(2015) Qing-Qing Zhu et al.   MEDICINE

Telomere dysfunction causes alveolar stem cell failure

(2015) Jonathan K. Alder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interstitial Lung Disease in Scleroderma

(2015) Sara R. Schoenfeld et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

(2015) Juan M. Povedano et al.   Cell Reports

Neutrophil extracellular traps promote differentiation and function of fibroblasts

(2014) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis

(2014) Talmadge E. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low-dose oral imatinib in the treatment of systemic sclerosis interstitial lung disease unresponsive to cyclophosphamide: a phase II pilot study

(2014) Paolo Fraticelli et al.   ARTHRITIS RESEARCH & THERAPY

Advances in the Evaluation and Management of Esophageal Disease of Systemic Sclerosis

(2014) Dustin A. Carlson et al.   Current Rheumatology Reports

Review: Interstitial Lung Disease Associated With Systemic Sclerosis and Idiopathic Pulmonary Fibrosis: How Similar and Distinct?

(2014) Erica L. Herzog et al.   Arthritis & Rheumatology

An Official American Thoracic Society/European Respiratory Society Statement: Update of the International Multidisciplinary Classification of the Idiopathic Interstitial Pneumonias

(2013) William D. Travis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Association Between the MUC5B Promoter Polymorphism and Survival in Patients With Idiopathic Pulmonary Fibrosis

(2013) Anna L. Peljto et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Serum Interleukin 6 Is Predictive of Early Functional Decline and Mortality in Interstitial Lung Disease Associated with Systemic Sclerosis

(2013) A. De Lauretis et al.   JOURNAL OF RHEUMATOLOGY

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Alveolar Fibrocytes in Idiopathic Pulmonary Fibrosis and Systemic Sclerosis

(2013) Raphael Borie et al.   PLoS One

A Novel Telomerase Activator Suppresses Lung Damage in a Murine Model of Idiopathic Pulmonary Fibrosis

(2013) Claude Jourdan Le Saux et al.   PLoS One

The MUC5B Variant Is Associated with Idiopathic Pulmonary Fibrosis but Not with Systemic Sclerosis Interstitial Lung Disease in the European Caucasian Population

(2013) Raphael Borie et al.   PLoS One

Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants

(2013) Simon L F Walsh et al.   THORAX

Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis

(2013) Carmel J Stock et al.   THORAX

Short-term and long-term outcomes of interstitial lung disease in polymyositis and dermatomyositis: A series of 107 patients

(2011) I. Marie et al.   ARTHRITIS AND RHEUMATISM

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis

(2011) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

A CommonMUC5BPromoter Polymorphism and Pulmonary Fibrosis

(2011) Max A. Seibold et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Impairment of CD4+CD25+FOXP3+Regulatory T Cells in Idiopathic Pulmonary Fibrosis

(2009) Ioannis Kotsianidis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease

(2009) E. J. Kim et al.   EUROPEAN RESPIRATORY JOURNAL

Host–Environment Interactions in Exposure-Related Diffuse Lung Diseases

(2009) David Brass et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Antifibrotic action of pirfenidone and prednisolone: Different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis

(2008) Hisashi Oku et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A novel therapeutic approach to the treatment of scleroderma-associated pulmonary complications: safety and efficacy of combination therapy with imatinib and cyclophosphamide

(2008) I. Sabnani et al.   RHEUMATOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY