Article
Radiology, Nuclear Medicine & Medical Imaging
Junghoan Park, Julip Jung, Soon Ho Yoon, Helen Hong, Hyungjin Kim, Heekyung Kim, Jeong-Hwa Yoon, Jin Mo Goo
Summary: The Gaussian curvatures of fibrosis boundaries in idiopathic pulmonary fibrosis (IPF) become more heterogeneous as the disease progresses, and this heterogeneity is negatively associated with survival. By analyzing Gaussian curvature, disease severity can be evaluated and survival rate can be predicted in IPF patients.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju Gang Nam, Yunhee Choi, Sang-Min Lee, Soon Ho Yoon, Jin Mo Goo, Hyungjin Kim
Summary: The prognostic value of DL-driven CT fibrosis quantification in IPF was investigated. CT-Norm% and CT-Fib% showed significant correlations with FVC and D-LCO. Both CT-Norm% and CT-Fib% were independent prognostic factors for overall survival in IPF when adjusted for various variables. Substituting CT-Norm% for D-LCO showed comparable discrimination to the original GAP index.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Medicinal
Barbara Ruaro, Ilaria Gandin, Riccardo Pozzan, Stefano Tavano, Chiara Bozzi, Michael Hughes, Metka Kodric, Rossella Cifaldi, Selene Lerda, Marco Confalonieri, Elisa Baratella, Paola Confalonieri, Francesco Salton
Summary: This study examines the safety and efficacy of Nintedanib in treating IPF in a real-life setting. The results show that NTD may stabilize FVC values in IPF patients, but frequent gastrointestinal side effects and dose adjustments may be necessary. The study also confirms the safety of NTD in patients treated with anticoagulant drugs.
Article
Medicine, General & Internal
Jonathan H. Chung, Ayodeji Adegunsoye, Brenna Cannon, Rekha Vij, Justin M. Oldham, Christopher King, Steven M. Montner, Prahasit Thirkateh, Scott Barnett, Ronald Karwoski, Brian J. Bartholmai, Mary Strek, Steven D. Nathan
Summary: A study comparing quantitative imaging data between IPF and CTD-ILD in a UIP setting found that VRS was higher in IPF patients. VRS showed an inverse correlation with DLCO%, while the total volume of normal lung was associated with both DLCO% and FVC% in multivariable analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physiology
Jiwoong Choi, Kum Ju Chae, Gong Yong Jin, Ching-Long Lin, Archana T. Laroia, Eric A. Hoffman, Chang Hyun Lee
Summary: This study used quantitative CT image matching to assess lung motion in idiopathic interstitial lung diseases (UIP and NSIP) and found different characteristics between UIP and NSIP.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Respiratory System
Nicholas D. Weatherley, James A. Eaden, Paul J. C. Hughes, Matthew Austin, Laurie Smith, Jody Bray, Helen Marshall, Stephen Renshaw, Stephen M. Bianchi, Jim M. Wild
Summary: The study found correlations between DCE-MRI first pass perfusion and existing physiological gas exchange metrics in IPF patients, suggesting that capillary perfusion deficit may contribute to gas exchange limitation. The FWHMmean metric showed a significant increase over a 6-month period and may serve as a quantitative biomarker for pulmonary vascular disease progression in IPF.
Article
Respiratory System
Jonathan Keow, Matthew J. Cecchini, Nathashi Jayawardena, Maurizio Zompatori, Mariamma G. Joseph, Marco Mura
Summary: This study found that p16-positive foci can be used to diagnose idiopathic pulmonary fibrosis and are not related to radiographic patterns. High p16 expression is associated with shorter survival time, while antifibrotic therapy has a significant protective effect. Digital spatial profiling showed that fibroblastic foci have distinct gene expression compared to normal and fibrotic areas.
RESPIRATORY RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haishuang Sun, Xiaoyan Yang, Xuebiao Sun, Xiapei Meng, Han Kang, Rongguo Zhang, Haoyue Zhang, Min Liu, Huaping Dai, Chen Wang
Summary: The elastic registration technique can assess the morphological deterioration of lung shrinkage in idiopathic pulmonary fibrosis (IPF), and the log_jac values are significantly correlated with pulmonary function tests (PFTs).
EUROPEAN RADIOLOGY
(2023)
Article
Critical Care Medicine
Joseph L. Barnett, Toby M. Maher, Jennifer K. Quint, Alex Adamson, Zhe Wu, David J. F. Smith, Bhavin Rawal, Arjun Nair, Simon L. F. Walsh, Sujal R. Desai, Peter M. George, Maria Kokosi, Gisli Jenkins, Vasilis Kouranos, Elisabetta A. Renzoni, Alex Rice, Andrew G. Nicholson, Felix Chua, Athol U. Wells, Philip L. Molyneaux, Anand Devaraj
Summary: This study found that increased BAL lymphocyte proportion is rare in patients with extensive fibrosis or a UIP pattern on CT, and in patients without extensive fibrosis or a non-UIP pattern, an increased BAL lymphocyte proportion is associated with a lower likelihood of disease progression.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junya Tominaga, Tae Iwasawa, Makiko Murota, Hiroaki Arakawa, Takeshi Johkoh, Yasuhiko Yamano, Yoshiaki Zaizen, Kazuya Ichikado, Mikiko Hashisako, Yasuhiro Kondoh, Kensuke Kataoka, Masaki Okamoto, Kiminori Fujimoto, Junya Fukuoka
Summary: The study evaluated CT findings and found characteristic differences in airspace consolidation between current I-NSIP and previous CTD-NSIP.
JAPANESE JOURNAL OF RADIOLOGY
(2021)
Review
Chemistry, Medicinal
Barbara Ruaro, Riccardo Pozzan, Paola Confalonieri, Stefano Tavano, Michael Hughes, Marco Matucci Cerinic, Elisa Baratella, Elisabetta Zanatta, Selene Lerda, Pietro Geri, Marco Confalonieri, Francesco Salton
Summary: This review study confirms the hypothesized association between gastro-esophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF), indicating increased acid exposure, risk of gastric aspiration, and elevated bile acid levels in IPF patients. However, further research is needed to explore treatment strategies for GERD-IPF.
Article
Medicine, General & Internal
Elisa Baratella, Barbara Ruaro, Fabiola Giudici, Barbara Wade, Mario Santagiuliana, Francesco Salton, Paola Confalonieri, Michele Simbolo, Aldo Scarpa, Saverio Tollot, Cristina Marrocchio, Maria Assunta Cova, Marco Confalonieri
Summary: This study found significant differences in HRCT patterns at diagnosis between familial and sporadic IPF patients, with familial patients showing a slight increase in typical UIP pattern at two years. Genetic factors play a key role in IPF development, but further studies are needed to clarify their impact on clinical treatment decisions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sarah C. Scharm, Jens Vogel-Claussen, Cornelia Schaefer-Prokop, Sabine Dettmer, Lars Knudsen, Danny Jonigk, Jan Fuge, Rosa-Marie Apel, Tobias Welte, Frank Wacker, Antje Prasse, Hoen-oh Shin
Summary: The study found that CT-derived functional parameters of regional ventilation and parenchymal late enhancement may serve as early imaging markers for idiopathic pulmonary fibrosis progression.
EUROPEAN RADIOLOGY
(2021)
Article
Medicine, General & Internal
Lauren C. Testa, Yvon Jule, Linnea Lundh, Karine Bertotti, Melissa A. Merideth, Kevin J. O'Brien, Steven D. Nathan, Drew C. Venuto, Souheil El-Chemaly, May Christine V. Malicdan, Bernadette R. Gochuico
Summary: Automated computerized imaging analysis has been shown to provide accurate and reader-independent quantification of pulmonary fibrosis in human histopathology samples. Fibrosis, collagen content, and immune-stained cells can be automatically and individually quantified from serial sections, enhancing the tools available for studying fibrotic lung disease. This analysis method allows for continuous measurement of fibrosis in lung tissue, with potential applications for both research and clinical diagnosis.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilyes Benlala, Agnes Albat, Elodie Blanchard, Julie Macey, Chantal Raherison, Thomas Benkert, Patrick Berger, Francois Laurent, Gael Dournes
Summary: This study assessed the feasibility of quantifying T-2 interstitial lung disease signal-intensity volume using a semi-automated method and found that T-2-ISIV was significantly correlated with disease severity in IPF patients and higher in IPF patients compared to controls.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)