The controversial role of mast cells in fibrosis

Bile duct ligation-induced biliary hyperplasia, hepatic injury, and fibrosis are reduced in mast cell-deficient KitW-sh mice

(2017) Laura Hargrove et al.   HEPATOLOGY

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Less contribution of mast cells to the progression of renal fibrosis in Rat kidneys with chronic renal failure

(2017) Asuka Baba et al.   NEPHROLOGY

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

(2017) Katherine N. Cahill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress promotes myocardial fibrosis by upregulating KCa3.1 channel expression in AGT-REN double transgenic hypertensive mice

(2017) Li-Ping Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease

(2017) Latha Paka et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mast cells in asthma - state of the art

(2016) P. Bradding et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Inhibition of mast cell-secreted histamine decreases biliary proliferation and fibrosis in primary sclerosing cholangitis Mdr2−/−mice

(2016) Hannah Jones et al.   HEPATOLOGY

Protective role of ACE2-Ang-(1–7)-Mas in myocardial fibrosis by downregulating KCa3.1 channel via ERK1/2 pathway

(2016) Li-Ping Wang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

The immune network in thyroid cancer

(2016) Maria Rosaria Galdiero et al.   OncoImmunology

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis

(2016) Taiki Kida et al.   PLoS One

Histamine inhibits differentiation of skin fibroblasts into myofibroblasts

(2015) Lin Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Orai/CRACM1 and KCa3.1 ion channels interact in the human lung mast cell plasma membrane

(2015) S. Mark Duffy et al.   Cell Communication and Signaling

Blockade of KCa3.1 Attenuates Left Ventricular Remodeling after Experimental Myocardial Infarction

(2015) Chen-Hui Ju et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis

(2015) Djuro Kosanovic et al.   EUROPEAN RESPIRATORY JOURNAL

Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis

(2015) Lutz Wollin et al.   EUROPEAN RESPIRATORY JOURNAL

Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

(2015) Shunya Mashiko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2Adrenoceptors

(2015) Rebecca J. Lewis et al.   JOURNAL OF IMMUNOLOGY

β2-Adrenoceptor Activation Modulates Skin Wound Healing Processes to Reduce Scarring

(2015) Gabrielle S. Le Provost et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mast cells in renal inflammation and fibrosis: Lessons learnt from animal studies

(2015) Lydia Celia Madjene et al.   MOLECULAR IMMUNOLOGY

The role of KCa3.1 channels in cardiac fibrosis induced by pressure overload in rats

(2015) Li-Mei Zhao et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

(2015) Régis Joulia et al.   Nature Communications

KCa3.1 K+ Channel Expression and Function in Human Bronchial Epithelial Cells

(2015) Greer K. Arthur et al.   PLoS One

Soluble CD14 is essential for lipopolysaccharide-dependent activation of human intestinal mast cells from macroscopically normal as well as Crohn's disease tissue

(2014) Sibylle A. Brenner et al.   IMMUNOLOGY

Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cells

(2014) Jing Lu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Mast Cells Promote Airway Smooth Muscle Cell Differentiation via Autocrine Up-Regulation of TGF- 1

(2014) L. Woodman et al.   JOURNAL OF IMMUNOLOGY

Human Airway Smooth Muscle Promotes Human Lung Mast Cell Survival, Proliferation, and Constitutive Activation: Cooperative Roles for CADM1, Stem Cell Factor, and IL-6

(2014) F. Hollins et al.   JOURNAL OF IMMUNOLOGY

Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca2+-Activated K+ Channel KCa3.1

(2014) E. Shumilina et al.   JOURNAL OF IMMUNOLOGY

Mast Cells Contribute to Bleomycin-Induced Lung Inflammation and Injury in Mice through a Chymase/Mast Cell Protease 4-Dependent Mechanism

(2014) L. L. Reber et al.   JOURNAL OF IMMUNOLOGY

Genetic Ablation of Mast Cells Redefines the Role of Mast Cells in Skin Wound Healing and Bleomycin-Induced Fibrosis

(2014) Sebastian Willenborg et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

K+-channel inhibition reduces portal perfusion pressure in fibrotic rats and fibrosis associated characteristics of hepatic stellate cells

(2014) Christian Freise et al.   LIVER INTERNATIONAL

Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis

(2014) Luca Richeldi et al.   NEW ENGLAND JOURNAL OF MEDICINE

The K+ Channel KCa3.1 as a Novel Target for Idiopathic Pulmonary Fibrosis

(2014) Katy Morgan Roach et al.   PLoS One

CADM1 Controls Actin Cytoskeleton Assembly and Regulates Extracellular Matrix Adhesion in Human Mast Cells

(2014) Elena P. Moiseeva et al.   PLoS One

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cells and Fibroblasts Work in Concert to Aggravate Pulmonary Fibrosis

(2013) Malgorzata Wygrecka et al.   AMERICAN JOURNAL OF PATHOLOGY

Involvement of mast cells in adipose tissue fibrosis

(2013) Shizuka Hirai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The pathogenesis of cardiac fibrosis

(2013) Ping Kong et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Blockade of KCa3.1 Ameliorates Renal Fibrosis Through the TGF-β1/Smad Pathway in Diabetic Mice

(2013) Chunling Huang et al.   DIABETES

Mast Cells: A Pivotal Role in Pulmonary Fibrosis

(2013) Arul Veerappan et al.   DNA AND CELL BIOLOGY

Intercellular interactions between mast cells and fibroblasts promote pro-inflammatory signaling

(2013) R. Termei et al.   EXPERIMENTAL CELL RESEARCH

T cell–derived microvesicles induce mast cell production of IL-24: Relevance to inflammatory skin diseases

(2013) Irit Shefler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Mast Cell-Restricted, Tetramer-Forming Tryptases Induce Aggrecanolysis in Articular Cartilage by Activating Matrix Metalloproteinase-3 and -13 Zymogens

(2013) N. J. Magarinos et al.   JOURNAL OF IMMUNOLOGY

Prostaglandin D2 Inhibits Collagen Secretion From Lung Fibroblasts by Activating the DP Receptor

(2013) Shinya Ayabe et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction

(2013) Walid Beghdadi et al.   KIDNEY INTERNATIONAL

KCa3.1 mediates activation of fibroblasts in diabetic renal interstitial fibrosis

(2013) C. Huang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

CADM1 Is a Key Receptor Mediating Human Mast Cell Adhesion to Human Lung Fibroblasts and Airway Smooth Muscle Cells

(2013) Elena P. Moiseeva et al.   PLoS One

Leukotriene C4aggravates bleomycin-induced pulmonary fibrosis in mice

(2013) Hirokuni Hirata et al.   RESPIROLOGY

Cell-to-cell contact of activated mast cells with fibroblasts and lymphocytes in systemic sclerosis

(2012) Thomas Hügle et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis

(2012) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion

(2012) Elena P. Moiseeva et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human intestinal mast cells are a potent source of multiple chemokines

(2012) Katrin Feuser et al.   CYTOKINE

Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet

(2012) Shinsuke Masubuchi et al.   HEPATOLOGY RESEARCH

Widespread Immunological Functions of Mast Cells: Fact or Fiction?

(2012) Hans-Reimer Rodewald et al.   IMMUNITY

Central role of IL-6 and MMP-1 for cross talk between human intestinal mast cells and human intestinal fibroblasts

(2012) Yves Montier et al.   IMMUNOBIOLOGY

Orbit-Infiltrating Mast Cells, Monocytes, and Macrophages Produce PDGF Isoforms that Orchestrate Orbital Fibroblast Activation in Graves' Ophthalmopathy

(2012) L. van Steensel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction

(2012) Shaun A. Summers et al.   KIDNEY INTERNATIONAL

Evidence questioning cromolyn’s effectiveness and selectivity as a ‘mast cell stabilizer’ in mice

(2012) Tatsuya Oka et al.   LABORATORY INVESTIGATION

CADM1 is expressed as multiple alternatively spliced functional and dysfunctional isoforms in human mast cells

(2012) Elena P. Moiseeva et al.   MOLECULAR IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels

(2012) Li-Mei Zhao et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

RNA Sensors Enable Human Mast Cell Anti-Viral Chemokine Production and IFN-Mediated Protection in Response to Antibody-Enhanced Dengue Virus Infection

(2012) Michael G. Brown et al.   PLoS One

Genomic and genome-wide association of susceptibility to radiation-induced fibrotic lung disease in mice

(2012) Alexandra Paun et al.   RADIOTHERAPY AND ONCOLOGY

Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters

(2012) Yasutaka Maeda et al.   Journal of Diabetes Investigation

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials

(2011) Paul T. Thevenot et al.   BIOMATERIALS

The Development of Myocardial Fibrosis in Transgenic Mice With Targeted Overexpression of Tumor Necrosis Factor Requires Mast Cell–Fibroblast Interactions

(2011) Weili Zhang et al.   CIRCULATION

Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines

(2011) Gyi Aung et al.   IMMUNOLOGY

The mast cell stabilizer ketotifen reduces joint capsule fibrosis in a rabbit model of post-traumatic joint contractures

(2011) Michael J. Monument et al.   INFLAMMATION RESEARCH

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

(2011) Aarti Shikotra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interaction of Nectin-like Molecule 2 with Integrin α6β4and Inhibition of Disassembly of Integrin α6β4from Hemidesmosomes

(2011) Kiyohito Mizutani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

(2011) Mitsuteru Akahoshi et al.   JOURNAL OF CLINICAL INVESTIGATION

Idiopathic pulmonary fibrosis

(2011) Talmadge E King et al.   LANCET

Pirfenidone in patients with idiopathic pulmonary fibrosis (CAPACITY): two randomised trials

(2011) Paul W Noble et al.   LANCET

Immunoglobulin Free Light Chains Are Increased in Hypersensitivity Pneumonitis and Idiopathic Pulmonary Fibrosis

(2011) Tom Groot Kormelink et al.   PLoS One

The rising incidence of idiopathic pulmonary fibrosis in the UK

(2011) V. Navaratnam et al.   THORAX

Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium

(2011) Jolien Suurmond et al.   ARTHRITIS RESEARCH & THERAPY

Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro

(2010) M. Elishmereni et al.   ALLERGY

Physiology and pathophysiology of matrix metalloproteases

(2010) T. Klein et al.   AMINO ACIDS

Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling

(2010) Norifumi Sawamukai et al.   ARTHRITIS AND RHEUMATISM

Mast cells are a source of transforming growth factor β in systemic sclerosis

(2010) Thomas Hügle et al.   ARTHRITIS AND RHEUMATISM

Overexpression of transforming growth factor- 1 in fetal monkey lung results in prenatal pulmonary fibrosis

(2010) A. F. Tarantal et al.   EUROPEAN RESPIRATORY JOURNAL

The specific chymase inhibitor TY-51469 suppresses the accumulation of neutrophils in the lung and reduces silica-induced pulmonary fibrosis in mice

(2010) Hazuki Takato et al.   EXPERIMENTAL LUNG RESEARCH

Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters

(2010) Koji Komeda et al.   HEPATOLOGY RESEARCH

CADM1 Interacts with Tiam1 and Promotes Invasive Phenotype of Human T-cell Leukemia Virus Type I-transformed Cells and Adult T-cell Leukemia Cells

(2010) Mari Masuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mast cell chymase limits the cardiac efficacy of Ang I–converting enzyme inhibitor therapy in rodents

(2010) Chih-Chang Wei et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Lung Mast Cells Mediate Pneumococcal Cell Death in Response to Activation by Pneumolysin

(2010) G. Cruse et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mast Cells Express IL-17A in Rheumatoid Arthritis Synovium

(2010) A. J. Hueber et al.   JOURNAL OF IMMUNOLOGY

Mouse Mast Cell Protease-4 Deteriorates Renal Function by Contributing to Inflammation and Fibrosis in Immune Complex-Mediated Glomerulonephritis

(2010) L. Scandiuzzi et al.   JOURNAL OF IMMUNOLOGY

The Inflammatory Response after an Epidermal Burn Depends on the Activities of Mouse Mast Cell Proteases 4 and 5

(2010) G. Younan et al.   JOURNAL OF IMMUNOLOGY

Human Cord Blood-Derived Mast Cells Are Activated by the Nod1 Agonist M-TriDAP to Release Pro-Inflammatory Cytokines and Chemokines

(2010) Mattias Enoksson et al.   Journal of Innate Immunity

Mast Cell Infiltration Is Involved in Renal Interstitial Fibrosis in a Rat Model of Protein-Overload Nephropathy

(2010) Ying Li et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Captopril reduces collagen and mast cell and eosinophil accumulation in pig serum-induced rat liver fibrosis

(2010) Simone G. Ramos et al.   PATHOLOGY INTERNATIONAL

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

(2010) T. C. Theoharides et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eotaxin/CCL11 Levels Correlate With Myocardial Fibrosis and Mast Cell Density in Native and Transplanted Rat Hearts

(2010) M. Zweifel et al.   TRANSPLANTATION PROCEEDINGS

Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM1

(2010) E Fujita et al.   Cell Death & Disease

Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics

(2009) M. Humbert et al.   ALLERGY

Tumor suppressor CADM1 is involved in epithelial cell structure

(2009) Mika Sakurai-Yageta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of integrin-mediated TGFβ activation in the pathogenesis of pulmonary fibrosis

(2009) Amanda Goodwin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cell adhesion molecule 1: a novel risk factor for venous thrombosis

(2009) S. J. Hasstedt et al.   BLOOD

Recent Advances in Molecular Targets and Treatment of Idiopathic Pulmonary Fibrosis: Focus on TGFβ Signaling and the Myofibroblast

(2009) M. Gharaee-Kermani et al.   CURRENT MEDICINAL CHEMISTRY

Fc RI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells

(2009) Y. Okayama et al.   EUROPEAN RESPIRATORY JOURNAL

Cardiac Mast Cells Mediate Left Ventricular Fibrosis in the Hypertensive Rat Heart

(2009) Scott P. Levick et al.   HYPERTENSION

Tissue remodeling induced by hypersecreted epidermal growth factor and amphiregulin in the airway after an acute asthma attack

(2009) Yukinori Enomoto et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor

(2009) Glenn Cruse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts

(2009) Chien-hui Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

Dexamethasone and FK506 Inhibit Expression of Distinct Subsets of Chemokines in Human Mast Cells

(2009) A. Kato et al.   JOURNAL OF IMMUNOLOGY

Mast Cell-Dependent Contraction of Human Airway Smooth Muscle Cell-Containing Collagen Gels: Influence of Cytokines, Matrix Metalloproteases, and Serine Proteases

(2009) A. Margulis et al.   JOURNAL OF IMMUNOLOGY

Contribution of Chymase-Dependent Angiotensin II Formation to the Progression of Tubulointerstitial Fibrosis in Obstructed Kidneys in Hamsters

(2009) Yu-Yan Fan et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mast cells decrease renal fibrosis in unilateral ureteral obstruction

(2009) Duk Hoon Kim et al.   KIDNEY INTERNATIONAL

Novel site-specific mast cell subpopulations in the human lung

(2009) C K Andersson et al.   THORAX

Nerve growth factor localization in the nasal mucosa of patients with persistent allergic rhinitis

(2008) M. Bresciani et al.   ALLERGY

Local Delivery of the K Ca 3.1 Blocker, TRAM-34, Prevents Acute Angioplasty-Induced Coronary Smooth Muscle Phenotypic Modulation and Limits Stenosis

(2008) D.L. Tharp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Tryptase activates TGFβ in human airway smooth muscle cells via direct proteolysis

(2008) Amanda L. Tatler et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mutations in the gene encoding CADM1 are associated with autism spectrum disorder

(2008) Yu Zhiling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effects of co-culture of fibroblasts on mast cell exocytotic release characteristics as evaluated by carbon-fiber microelectrode amperometry

(2008) Bryce J. Marquis et al.   BIOPHYSICAL CHEMISTRY

IgE alone promotes human lung mast cell survival through the autocrine production of IL-6

(2008) Glenn Cruse et al.   BMC IMMUNOLOGY

Engagement of the EP2 prostanoid receptor closes the K+ channel KCa3.1 in human lung mast cells and attenuates their migration

(2008) S. Mark Duffy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs

(2008) Corrie L. Gallant-Behm et al.   WOUND REPAIR AND REGENERATION

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY