Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Francisco Javier Godoy-Navarrete, Jose Manuel Lisbona-Montanez, Rocio Redondo-Rodriguez, Sara Manrique-Arija, Jose Rioja, Arkaitz Mucientes, Patricia Ruiz-Limon, Aimara Garcia-Studer, Fernando Ortiz-Marquez, Begona Oliver-Martos, Laura Cano-Garcia, Antonio Fernandez-Nebro
Summary: This study aimed to identify inflammatory factors and soluble cytokines that act as biomarkers in the diagnosis and prognosis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The study found that patients with RA-ILD had higher inflammatory activity and certain cytokines were associated with both diagnosis and poorer prognosis in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yerin Kim, Hyung-In Yang, Kyoung-Soo Kim
Summary: This review summarizes and analyzes the etiology and pathogenesis of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The incidence of RA-ILD increases with age and is higher in men, and is also associated with lifestyle factors such as smoking and exposure to pollutants. The presence of anti-cyclic citrullinated peptide antibody, high RA disease activity, and rheumatoid factor positivity increase the risk of RA-ILD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Hideaki Yamakawa, Takashi Ogura, Hideto Kameda, Tomoo Kishaba, Tae Iwasawa, Tamiko Takemura, Kazuyoshi Kuwano
Summary: RA is a common autoimmune arthritis, with ILD being the most important comorbidity. The acute form should be promptly treated with high-dose corticosteroids and antimicrobial agents, while the chronic form requires stabilization of RA followed by ILD management. Identification of UIP pattern and consideration of anti-fibrotic agents are crucial in patient care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Scott M. Matson, Misbah Baqir, Teng Moua, Michael Marll, Jessica Kent, Nicholas S. Iannazzo, Ryan D. Boente, John M. Donatelli, Junqiang Dai, Francisco J. Diaz, M. Kristen Demoruelle, Mark B. Hamblin, Susan K. Mathai, Jay H. Ryu, Kristen Pope, Christopher M. Walker, Joyce S. Lee
Summary: This study aims to investigate the impact of immunosuppression on pulmonary function trajectory in patients with rheumatoid arthritis-associated interstitial lung disease (ILD). The results showed that treatment with immunosuppressive agents improved lung function after 12 months. The radiologic pattern of ILD and choice of immunosuppressive agent did not significantly affect pulmonary function trajectory.
Review
Biochemistry & Molecular Biology
Alesandra Florescu, Florin Liviu Gherghina, Anca Emanuela Musetescu, Vlad Padureanu, Anca Rosu, Mirela Marinela Florescu, Cristina Criveanu, Lucian-Mihai Florescu, Anca Bobirca
Summary: This review discusses interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA), including its patterns, molecular mechanisms, and therapeutic challenges. Biomarkers have been found to be useful in identifying high-risk patients and guiding personalized treatment.
Review
Immunology
Mitsuhiro Akiyama, Yuko Kaneko
Summary: Rheumatoid arthritis is an autoimmune disease that primarily affects the joints but can also lead to interstitial lung disease. Understanding the pathogenesis and clinical features of this condition is crucial for better management and improved prognosis. Currently, there is no established treatment strategy specifically for RA-ILD.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Anthony J. Esposito, Jeffrey A. Sparks, Ritu R. Gill, Hiroto Hatabu, Eric J. Schmidlin, Partha Hota, Sergio Poli, Elaine A. Fletcher, Wesley Xiong, Michelle L. Frits, Christine K. Iannaccone, Maria Prado, Alessandra Zaccardelli, Allison Marshall, Paul F. Dellaripa, Michael E. Weinblatt, Nancy A. Shadick, Ivan O. Rosas, Tracy J. Doyle
Summary: Pulmonary disease is a common manifestation of RA, associated with increased morbidity and mortality. This study found a high prevalence of undiagnosed parenchymal lung disease in RA patients, primarily manifested as preclinical emphysema. High resolution CT scans may be the most effective screening modality for detecting lung abnormalities in RA patients.
Article
Medicine, Research & Experimental
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Carmen Maria Romero-Barco, Myriam Gandia-Martinez, Nair Perez-Gomez, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Aimara Garcia-Studer, Jerusalem Calvo-Gutierrez, Clara Fuego Varela, Pilar Morales-Garrido, Patricia Castro Perez, Coral Mourino-Rodriguez, Isabel Anon-Onate, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Rocio Redondo, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Maria Luisa Velloso-Feijoo, Antonio Fernandez-Nebro
Summary: The study aimed to describe comorbid conditions in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and analyze factors associated with multimorbidity. The results showed that comorbid conditions were more frequent in RA-ILD patients compared to those with RA but not ILD. Age, inflammatory markers, and lung function were found to be associated with multimorbidity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Ted R. Mikuls, Rohit Gaurav, Geoffrey M. Thiele, Bryant R. England, Madison G. Wolfe, Brianna P. Shaw, Kristina L. Bailey, Todd A. Wyatt, Amy J. Nelson, Michael J. Duryee, Carlos D. Hunter, Dong Wang, Debra J. Romberger, Dana P. Ascherman, Jill A. Poole
Summary: Airborne biohazards, such as LPS, can exacerbate rheumatoid arthritis and contribute to associated lung diseases. Patients exposed to LPS may be more susceptible to developing interstitial lung diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Goushi Matama, Masaki Okamoto, Kiminori Fujimoto, Takeshi Johkoh, Masaki Tominaga, Hiroshi Mukae, Noriho Sakamoto, Kosaku Komiya, Kenji Umeki, Masamichi Komatsu, Yasuo Shimizu, Koichiro Takahashi, Saeko Tokisawa, Yoshiaki Zaizen, Norikazu Matsuo, Takashi Nouno, Shinjiro Kaieda, Hiroaki Ida, Kenji Izuhara, Tomoaki Hoshino, Marco Sebastiani
Summary: This study investigated the potential of Periostin as a biomarker for rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that all biomarkers were higher in RA-ILD patients compared to healthy controls and RA patients without ILD. KL-6 accurately detected ILD in RA patients, while SP-D and Periostin moderately detected ILD. Periostin levels were correlated with lung fibrosis but not inflammatory areas. Additionally, Periostin was higher in RA-ILD patients with a typical usual interstitial pneumonia pattern. Immunohistochemical analyses showed that Periostin was expressed in fibroblastic foci. These findings suggest that Periostin can be used as a biomarker for diagnosis, evaluating fibrosis, and deciding therapeutic strategies for RA-ILD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Natalia Mena-Vazquez, Marta Rojas-Gimenez, Clara Fuego-Varela, Aimara Garcia-Studer, Nair Perez-Gomez, Carmen Maria Romero-Barco, Francisco Javier Godoy-Navarrete, Sara Manrique-Arija, Myriam Gandia-Martinez, Jerusalem Calvo-Gutierrez, Pilar Morales-Garrido, Coral Mourino-Rodriguez, Patricia Castro-Perez, Isabel Anon-Onate, Francisco Espildora, Maria Carmen Aguilar-Hurtado, Ana Hidalgo Conde, Rocio Arnedo Diez de los Rios, Eva Cabrera Cesar, Rocio Redondo-Rodriguez, Maria Luisa Velloso-Feijoo, Antonio Fernandez-Nebro
Summary: The study aims to evaluate the safety and efficacy profile of abatacept in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that abatacept can stabilize pulmonary function and joint inflammation in most patients, and it has a favorable safety profile.
Article
Rheumatology
Ning Chen, Chao-Yue Diao, Jie Gao, Dong-Bao Zhao
Summary: This study aims to explore the impact of clinical characteristics, new biomarkers, and treatment options on the prognosis of RA-ILD patients. The results suggest that male, UIP pattern, and increased RF-IgA may be potential predicting factors for poor prognosis of RA-ILD patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Xiaoxia Shen, Fei Wang
Summary: This study aimed to explore the additional treatment value of intravenous immunoglobulin injections for interstitial lung disease caused by rheumatoid arthritis (RA). The results showed that compared to traditional treatment methods, patients in the immunoglobulin group had significant improvements in lung function and quality of life after treatment, with no additional adverse effects.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jeffrey A. Sparks, Yinzhu Jin, Soo-Kyung Cho, Seanna Vine, Rishi Desai, Tracy J. Doyle, Seoyoung C. Kim
Summary: This study investigated the prevalence, incidence, and cause-specific mortality of RA-associated interstitial lung disease (RA-ILD) among older US patients with RA. The results showed that RA-ILD was present or developed in nearly 5% of patients, and RA-ILD was associated with excess total, respiratory, and cancer mortality compared with RA without ILD.
Article
Respiratory System
Jieun Kang, Woo Jung Seo, Eun Young Lee, Sung Hae Chang, Jooae Choe, Seokchan Hong, Jin Woo Song
Summary: This study investigated the prevalence and clinical implications of coexistent pleuroparenchymal fibroelastosis (PPFE) in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The results showed that PPFE was not rare in patients with RA-ILD and was significantly associated with an increased risk of pneumothorax and greater decline in lung function, although there was no significant association with mortality.
RESPIRATORY RESEARCH
(2022)