Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease

Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer’s Disease, Diabetes, and Obesity

(2019) Giulia Rigotto et al.   Oxidative Medicine and Cellular Longevity

Inflammation and cerebral small vessel disease: A systematic review

(2019) Audrey Low et al.   AGEING RESEARCH REVIEWS

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

High Fat Diet Causes Mitochondrial Dysfunction as a Result of Impaired ADP Sensitivity

(2018) Paula M Miotto et al.   DIABETES

Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer’s disease

(2018) P Hemachandra Reddy et al.   HUMAN MOLECULAR GENETICS

The State of US Health, 1990-2016

(2018) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums

(2018) Steven E. Arnold et al.   Nature Reviews Neurology

Mediterranean diet and 3-year Alzheimer brain biomarker changes in middle-aged adults

(2018) Valentina Berti et al.   NEUROLOGY

Cerebral Small Vessel Disease

(2018) Qian Li et al.   CELL TRANSPLANTATION

Mediterranean diet adherence and rate of cerebral Aβ-amyloid accumulation: Data from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing

(2018) Stephanie R. Rainey-Smith et al.   Translational Psychiatry

C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance

(2017) Xia Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurological consequences of obesity

(2017) Phillipe D O'Brien et al.   LANCET NEUROLOGY

Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

(2017) Rosa Casas et al.   MEDIATORS OF INFLAMMATION

Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort

(2017) Michelle Luciano et al.   NEUROLOGY

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Alzheimer's disease and metabolic syndrome: A link from oxidative stress and inflammation to neurodegeneration

(2017) Eduardo Rojas-Gutierrez et al.   SYNAPSE

Mitochondrial homeostasis in adipose tissue remodeling

(2017) Svetlana Altshuler-Keylin et al.   Science Signaling

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

(2017) Andrew Kneynsberg et al.   Frontiers in Neuroscience

Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

(2017) Sayad Kocahan et al.   Clinical Psychopharmacology and Neuroscience

The Effects of a High-Energy Diet on Hippocampal Function and Blood-Brain Barrier Integrity in the Rat

(2017) Scott E. Kanoski et al.   JOURNAL OF ALZHEIMERS DISEASE

MEDITERRANEAN DIET IS ASSOCIATED WITH SLOWER RATE OF HIPPOCAMPAL ATROPHY: A LONGITUDINAL STUDY IN COGNITIVELY NORMAL OLDER ADULTS

(2016) Yian Gu et al.   Alzheimers & Dementia

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Changes in insulin and insulin signaling in Alzheimer’s disease: cause or consequence?

(2016) Molly Stanley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Long-Term Immunomodulatory Effects of a Mediterranean Diet in Adults at High Risk of Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Randomized Controlled Trial

(2016) Rosa Casas et al.   JOURNAL OF NUTRITION

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

(2016) Dongsheng Cai et al.   Aging-US

Metabolic Syndrome and Alzheimer's Disease: A Link to a Vascular Hypothesis?

(2016) Haralampos J. Milionis et al.   CNS SPECTRUMS

Age and amyloid effects on human central nervous system amyloid-beta kinetics

(2015) Bruce W. Patterson et al.   ANNALS OF NEUROLOGY

Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly

(2015) Prashanthi Vemuri et al.   BRAIN

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Impaired Mitochondrial Biogenesis in Adipose Tissue in Acquired Obesity

(2015) Sini Heinonen et al.   DIABETES

Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation

(2015) Farhana Naznin et al.   JOURNAL OF ENDOCRINOLOGY

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity

(2015) Danielle N. Doll et al.   JOURNAL OF NEUROCHEMISTRY

The contribution of neuroinflammation to amyloid toxicity in Alzheimer's disease

(2015) Myles R. Minter et al.   JOURNAL OF NEUROCHEMISTRY

Insulin resistance by TNF-α is associated with mitochondrial dysfunction in 3T3-L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist

(2015) S.S. Anusree et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Total MRI load of cerebral small vessel disease and cognitive ability in older people

(2015) Julie Staals et al.   NEUROBIOLOGY OF AGING

The role of type 2 diabetes in neurodegeneration

(2015) Giuseppe Verdile et al.   NEUROBIOLOGY OF DISEASE

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

BMI and risk of dementia in two million people over two decades: a retrospective cohort study

(2015) Nawab Qizilbash et al.   Lancet Diabetes & Endocrinology

The role of inflammasome in Alzheimer's disease

(2014) Li Liu et al.   AGEING RESEARCH REVIEWS

Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics

(2014) Wendy S. Hahn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Obesity and neuroinflammation: A pathway to cognitive impairment

(2014) Alyson A. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

(2014) Teresa Valero   CURRENT PHARMACEUTICAL DESIGN

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

Effect of one month duration ketogenic and non-ketogenic high fat diets on mouse brain bioenergetic infrastructure

(2014) J. Eva Selfridge et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The role of adipose tissue immune cells in obesity and low-grade inflammation

(2014) Milos Mraz et al.   JOURNAL OF ENDOCRINOLOGY

Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife

(2014) A. Singh-Manoux et al.   NEUROLOGY

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden

(2014) J. Staals et al.   NEUROLOGY

Human cognitive function and the obesogenic environment

(2014) Ashley A. Martin et al.   PHYSIOLOGY & BEHAVIOR

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

The longer-term impacts of Western diet on human cognition and the brain

(2013) Heather Francis et al.   APPETITE

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES)

(2013) J. Benito-León et al.   EUROPEAN JOURNAL OF NEUROLOGY

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

(2013) Joanna M Wardlaw et al.   LANCET NEUROLOGY

Regulation of mitochondrial biogenesis and PGC-1α under cellular stress

(2013) Tina Wenz   MITOCHONDRION

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

(2013) Linnea R. Freeman et al.   NUTRITIONAL NEUROSCIENCE

Predicting the effects of a high-energy diet on fatty liver and hippocampal-dependent memory in male rats

(2013) J.N. Darling et al.   Obesity

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

(2013) Morihiro Matsuda et al.   Obesity Research & Clinical Practice

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

The Early Involvement of the Innate Immunity in the Pathogenesis of Lateonset Alzheimers Disease: Neuropathological, Epidemiological and Genetic Evidence

(2012) P. Eikelenboom et al.   Current Alzheimer Research

Finding a pathological diagnosis for Alzheimer's disease: Are inflammatory molecules the answer?

(2012) Manraj S. Bhamra et al.   ELECTROPHORESIS

Axonal Transport and Mitochondrial Dysfunction in Alzheimer's Disease

(2012) Jan Riemer et al.   Neurodegenerative Diseases

Circulating IL-6 and CRP are associated with MRI findings in the elderly: The 3C-Dijon Study

(2012) C. L. Satizabal et al.   NEUROLOGY

Insulin resistance in the nervous system

(2012) Bhumsoo Kim et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Alzheimer’s Disease: A Clinical Practice-Oriented Review

(2012) Luísa Alves et al.   Frontiers in Neurology

IL-6 regulation on skeletal muscle mitochondrial remodeling during cancer cachexia in the ApcMin/+ mouse

(2012) James P White et al.   Skeletal Muscle

Astrocytes: Implications for Neuroinflammatory Pathogenesis of Alzheimers Disease

(2011) Chuanyu Li et al.   Current Alzheimer Research

The Mitochondrial Dynamics of Alzheimers Disease and Parkinsons Disease Offer Important Opportunities for Therapeutic Intervention

(2011) David J. Bonda et al.   CURRENT PHARMACEUTICAL DESIGN

Inflammation, Oxidative Stress, and Obesity

(2011) Alba Fernández-Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice

(2011) Stephanos Kyrkanides et al.   Journal of Neuroinflammation

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals

(2011) Michal Schnaider Beeri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Mitochondrial dysfunction in obesity

(2011) Juan C Bournat et al.   Current Opinion in Endocrinology Diabetes and Obesity

Biochemical Study of Oxidative Stress Markers in the Liver, Kidney and Heart of High Fat Diet Induced Obesity in Rats

(2011) Saad A Noeman et al.   Diabetology & Metabolic Syndrome

Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages

(2010) Morihiko Nakamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Meta-Analysis of Cytokines in Alzheimer's Disease

(2010) Walter Swardfager et al.   BIOLOGICAL PSYCHIATRY

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

(2010) Scott E. Kanoski et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling

(2010) Christopher D. Morrison et al.   JOURNAL OF NEUROCHEMISTRY

TNF-α induces mitochondrial dysfunction in 3T3-L1 adipocytes

(2010) Xiao-Hui Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes

(2010) Chun-Lin Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?

(2010) G MacQueen et al.   MOLECULAR PSYCHIATRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Dietary ketosis enhances memory in mild cognitive impairment

(2010) Robert Krikorian et al.   NEUROBIOLOGY OF AGING

Nitric oxide and neuronal death

(2010) Guy C. Brown   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations

(2009) Aurélia De Pauw et al.   AMERICAN JOURNAL OF PATHOLOGY

Nutrition, Inflammation, and Cognitive Function

(2009) Julia Wärnberg et al.   Annals of the New York Academy of Sciences

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Midlife and Late-Life Obesity and the Risk of Dementia

(2009) Annette L. Fitzpatrick et al.   ARCHIVES OF NEUROLOGY

Amyloid β and APP as biomarkers for Alzheimer’s disease

(2009) Henrik Zetterberg et al.   EXPERIMENTAL GERONTOLOGY

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

Overweight in midlife and risk of dementia: a 40-year follow-up study

(2009) L B Hassing et al.   INTERNATIONAL JOURNAL OF OBESITY

TNF-α-mediated reduction in PGC-1α may impair skeletal muscle function after cigarette smoke exposure

(2009) Kechun Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cognitive impairment following high fat diet consumption is associated with brain inflammation

(2009) Paul J. Pistell et al.   JOURNAL OF NEUROIMMUNOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease

(2009) Velandai Srikanth et al.   NEUROBIOLOGY OF AGING

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats

(2009) Kamal A Amin et al.   Diabetology & Metabolic Syndrome

Diet-induced metabolic disturbances as modulators of brain homeostasis

(2008) Le Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

(2008) Xavier Palomer et al.   CARDIOVASCULAR RESEARCH

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain

(2008) M. C. Déniz-Naranjo et al.   EUROPEAN JOURNAL OF NEUROLOGY

Mitochondrial dynamics and apoptosis

(2008) D.-F. Suen et al.   GENES & DEVELOPMENT

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

(2008) Elisabete Ferreiro et al.   NEUROBIOLOGY OF DISEASE

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE