The role of adipose tissue immune cells in obesity and low-grade inflammation

Perspectives on the therapeutic potential of short-chain fatty acid receptors

(2014) Sunhong Kim et al.   BMB Reports

Pathways in Microbe-Induced Obesity

(2013) Laura M. Cox et al.   Cell Metabolism

The immune cells in adipose tissue

(2013) A. W. Ferrante   DIABETES OBESITY & METABOLISM

Metagenome and metabolism: the tissue microbiota hypothesis

(2013) Rémy Burcelin et al.   DIABETES OBESITY & METABOLISM

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Laparoscopic sleeve gastrectomy ameliorates mRNA expression of inflammation-related genes in subcutaneous adipose tissue but not in peripheral monocytes of obese patients

(2013) P. Trachta et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic adipose tissue inflammation: all immune cells on the stage

(2013) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

(2012) Shengyi Sun et al.   Annual Review of Nutrition

Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver

(2012) M. Stefanovic-Racic et al.   DIABETES

Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients

(2012) A. Bertola et al.   DIABETES

Adipose Tissue Invariant NKT Cells Protect against Diet-Induced Obesity and Metabolic Disorder through Regulatory Cytokine Production

(2012) Lydia Lynch et al.   IMMUNITY

Natural killer T cells in adipose tissue prevent insulin resistance

(2012) Henk S. Schipper et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-17 contributes to cardiovascular diseases

(2012) Hua-Sheng Ding et al.   MOLECULAR BIOLOGY REPORTS

Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans

(2012) Gijs H. Goossens et al.   MOLECULAR IMMUNOLOGY

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

(2012) Saswata Talukdar et al.   NATURE MEDICINE

The cellular and signaling networks linking the immune system and metabolism in disease

(2012) Olivia Osborn et al.   NATURE MEDICINE

Type II NKT Cells Stimulate Diet-Induced Obesity by Mediating Adipose Tissue Inflammation, Steatohepatitis and Insulin Resistance

(2012) Masashi Satoh et al.   PLoS One

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

(2012) L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipose tissue-resident immune cells: key players in immunometabolism

(2012) Henk S. Schipper et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice

(2011) Xavier Prieur et al.   DIABETES

Deficiency in Interferon-γ Results in Reduced Body Weight and Better Glucose Tolerance in Mice

(2011) Nicole Wong et al.   ENDOCRINOLOGY

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

(2011) Sa’ad Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Dendritic Cell and Macrophage Heterogeneity In Vivo

(2011) Daigo Hashimoto et al.   IMMUNITY

CD8+ T Cells: Foot Soldiers of the Immune System

(2011) Nu Zhang et al.   IMMUNITY

The Effect of Very-Low-Calorie Diet on mRNA Expression of Inflammation-Related Genes in Subcutaneous Adipose Tissue and Peripheral Monocytes of Obese Patients with Type 2 Diabetes Mellitus

(2011) M. Mraz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils

(2011) Stephen J Galli et al.   NATURE IMMUNOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Visceral Adipose Inflammation in Obesity Is Associated with Critical Alterations in Tregulatory Cell Numbers

(2011) Jeffrey Deiuliis et al.   PLoS One

Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity

(2011) Benjamin S. Mantell et al.   PLoS One

Impact of CD1d Deficiency on Metabolism

(2011) Maya E. Kotas et al.   PLoS One

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

(2010) Kees Meijer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet-Induced Obesity in Mice

(2010) M. E. Shaul et al.   DIABETES

Increased Toll-Like Receptor (TLR) Activation and TLR Ligands in Recently Diagnosed Type 2 Diabetic Subjects

(2010) M. R. Dasu et al.   DIABETES CARE

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Eosinophils and Th2 immunity: contemporary insights

(2010) Lisa A Spencer et al.   IMMUNOLOGY AND CELL BIOLOGY

Functional Heterogeneity of CD11c-positive Adipose Tissue Macrophages in Diet-induced Obese Mice

(2010) Pingping Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes

(2010) M. Jagannathan-Bogdan et al.   JOURNAL OF IMMUNOLOGY

IL-17 Regulates Adipogenesis, Glucose Homeostasis, and Obesity

(2010) L. A. Zuniga et al.   JOURNAL OF IMMUNOLOGY

IL-17R activation of human periodontal ligament fibroblasts induces IL-23 p19 production: Differential involvement of NF-κB versus JNK/AP-1 pathways

(2010) Lingxin Zhu et al.   MOLECULAR IMMUNOLOGY

IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity

(2010) R. R. Ricardo-Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of inflammation and macrophage accumulation in the development of obesity-induced type 2 diabetes mellitus and the possible therapeutic effects of long-chain n-3 PUFA

(2010) Elizabeth Oliver et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation

(2010) A. Jäger et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

(2009) Kazue Ohmura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity

(2009) Carine Duffaut et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

(2009) S. Fujisaka et al.   DIABETES

Invariant NKT cells and CD1d+cells amass in human omentum and are depleted in patients with cancer and obesity

(2009) Lydia Lynch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Adipose Tissue Dysfunction in Obesity

(2009) M. Blüher   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

(2009) Koji Ohashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

(2009) E. Maury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease

(2009) Tomas Roubicek et al.   NUTRITION

Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute Inflammation

(2009) Jeroen Nijhuis et al.   Obesity

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

(2008) Caroline M. Apovian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

B lymphocytes: how they develop and function

(2008) T. W. LeBien et al.   BLOOD

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Remodeling Phenotype of Human Subcutaneous Adipose Tissue Macrophages

(2008) V. Bourlier et al.   CIRCULATION

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

(2008) Viviane Zorzanelli Rocha et al.   CIRCULATION RESEARCH

Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity

(2008) Leonie Heilbronn et al.   CURRENT PHARMACEUTICAL DESIGN

Dendritic Cells In Vivo: A Key Target for a New Vaccine Science

(2008) Ralph M. Steinman   IMMUNITY

Peroxisome Proliferator-activated Receptor γ Activation Promotes Infiltration of Alternatively Activated Macrophages into Adipose Tissue

(2008) Rinke Stienstra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity

(2008) Joakim Huber et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding

(2008) Vered Elgazar-Carmon et al.   JOURNAL OF LIPID RESEARCH

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Inducible Toll-like Receptor and NF-κB Regulatory Pathway Expression in Human Adipose Tissue

(2008) Olga I. Vitseva et al.   Obesity