Polymyxins–Curcumin Combination Antimicrobial Therapy: Safety Implications and Efficacy for Infection Treatment

7-Hydroxycoumarin protects against cisplatin-induced acute kidney injury by inhibiting necroptosis and promoting Sox9-mediated tubular epithelial cell proliferation

(2020) Wei-Feng Wu et al.   PHYTOMEDICINE

Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice

(2020) Chongshan Dai et al.   ACS Infectious Diseases

Curcumin as a Therapeutic Option in Retinal Diseases

(2020) Daniel López-Malo et al.   Antioxidants

Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity

(2020) Chongshan Dai et al.   ACS Infectious Diseases

The aqueous extract of aged black garlic ameliorates colistin-induced acute kidney injury in rats

(2019) Tae Won Lee et al.   RENAL FAILURE

Drug combinations: a strategy to extend the life of antibiotics in the 21st century

(2019) Mike Tyers et al.   NATURE REVIEWS MICROBIOLOGY

Molecular Mechanisms of Colistin-Induced Nephrotoxicity

(2019) Zhibo Gai et al.   MOLECULES

Colistin induced peripheral neurotoxicity involves mitochondrial dysfunction and oxidative stress in mice

(2019) Chongshan Dai et al.   MOLECULAR BIOLOGY REPORTS

Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death

(2019) Melania Guerrero-Hue et al.   FASEB JOURNAL

Anti-infective Properties of the Golden Spice Curcumin

(2019) Dimas Praditya et al.   Frontiers in Microbiology

Bacterial viability after antimicrobial photodynamic therapy with curcumin on multiresistant Staphylococcus aureus

(2019) Mirian AA Freitas et al.   Future Microbiology

Curcumin Combination Chemotherapy: The Implication and Efficacy in Cancer

(2019) Bee Ling Tan et al.   MOLECULES

Curcumin-mediated photodynamic inactivation (PDI) against DH5α contaminated in oysters and cellular toxicological evaluation of PDI-treated oysters

(2019) Yuan Gao et al.   Photodiagnosis and Photodynamic Therapy

Curcumin Mitigates Immune-Induced Epithelial Barrier Dysfunction by Campylobacter jejuni

(2019) Fábia Daniela Lobo de Sá et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Polymyxin B causes DNA damage in HK-2 cells and mice

(2018) B. Yun et al.   ARCHIVES OF TOXICOLOGY

Curcumin Inhibits Lipopolysaccharide-Induced Mucin 5AC Hypersecretion and Airway Inflammation via Nuclear Factor Erythroid 2-Related Factor 2

(2018) Yi-Ming Zeng et al.   CHINESE MEDICAL JOURNAL

Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin

(2018) Lorraine M. Deck et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cytochrome C suppresses renal accumulation and nephrotoxicity of polymyxin B

(2018) Z-D Li et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

TGF-β-mediated NADPH oxidase 4-dependent oxidative stress promotes colistin-induced acute kidney injury

(2018) Bo Young Jeong et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of imipenem/relebactam against Gram-negative ESKAPE pathogens isolated in 17 European countries: 2015 SMART surveillance programme

(2018) James A Karlowsky et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

(2018) Haipeng Yin et al.   JOURNAL OF IMMUNOLOGY

Antifungal activity, main active components and mechanism of Curcuma longa extract against Fusarium graminearum

(2018) Ciqiong Chen et al.   PLoS One

Curcumin alleviates persistence of Acinetobacter baumannii against colistin

(2018) Amanjot Kaur et al.   Scientific Reports

Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage

(2018) Fulya Benzer et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Curcumin alleviates colistin-induced nephrotoxicity and neurotoxicity in rats via attenuation of oxidative stress, inflammation and apoptosis

(2018) Nagah E. Edrees et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Opportunities for plant natural products in infection control

(2018) Akram M Salam et al.   CURRENT OPINION IN MICROBIOLOGY

Curcumin prevents potassium dichromate (K2Cr2O7)-induced renal hypoxia

(2018) Sabino H. Avila-Rojas et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention

(2018) Chongshan Dai et al.   ACS Chemical Neuroscience

Preventive effects of nerve growth factor against colistin-induced autophagy and apoptosis in PC12 cells

(2018) Erjie Tian et al.   TOXICOLOGY MECHANISMS AND METHODS

Curcumin prevents cisplatin-induced renal alterations in mitochondrial bioenergetics and dynamic

(2017) Bibiana Ortega-Domínguez et al.   FOOD AND CHEMICAL TOXICOLOGY

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

(2017) Chongshan Dai et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Minocycline attenuates colistin-induced neurotoxicity via suppression of apoptosis, mitochondrial dysfunction and oxidative stress

(2017) Chongshan Dai et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Modes of antibacterial action of curcumin under dark and light conditions: A toxicoproteomics approach

(2017) Ilya Shlar et al.   Journal of Proteomics

Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity

(2017) Yoshihisa Hori et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oxidative stress, protein damage and repair in bacteria

(2017) Benjamin Ezraty et al.   NATURE REVIEWS MICROBIOLOGY

The Role of Reactive Oxygen Species in Antibiotic-Mediated Killing of Bacteria

(2017) Heleen Van Acker et al.   TRENDS IN MICROBIOLOGY

Effect of curcumin on glycerol-induced acute kidney injury in rats

(2017) Jindao Wu et al.   Scientific Reports

A Dual Role of P53 in Regulating Colistin-Induced Autophagy in PC-12 Cells

(2017) Ziyin Lu et al.   Frontiers in Pharmacology

Curcumin inhibits lipopolysaccharide (LPS)-induced endotoxemia and airway inflammation through modulation of sequential release of inflammatory mediators (TNF-α and TGF-β1) in murine model

(2017) Asha Kumari et al.   INFLAMMOPHARMACOLOGY

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

The nephroprotection exerted by curcumin in maleate-induced renal damage is associated with decreased mitochondrial fission and autophagy

(2016) Eduardo Molina-Jijón et al.   BIOFACTORS

Dosing guidance for intravenous colistin in critically-ill patients

(2016) Roger L Nation et al.   CLINICAL INFECTIOUS DISEASES

Curcumin attenuates quinocetone induced apoptosis and inflammation via the opposite modulation of Nrf2/HO-1 and NF-kB pathway in human hepatocyte L02 cells

(2016) Chongshan Dai et al.   FOOD AND CHEMICAL TOXICOLOGY

Curcumin inhibits placental inflammation to ameliorate LPS-induced adverse pregnancy outcomes in mice via upregulation of phosphorylated Akt

(2016) Jianjun Zhou et al.   INFLAMMATION RESEARCH

In Vitro Antibacterial Activity of Curcumin–Polymyxin B Combinations against Multidrug-Resistant Bacteria Associated with Traumatic Wound Infections

(2016) Jonathan W. Betts et al.   JOURNAL OF NATURAL PRODUCTS

Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study

(2016) Yi-Yun Liu et al.   LANCET INFECTIOUS DISEASES

Curcumin Attenuates Colistin-Induced Neurotoxicity in N2a Cells via Anti-inflammatory Activity, Suppression of Oxidative Stress, and Apoptosis

(2016) Chongshan Dai et al.   MOLECULAR NEUROBIOLOGY

Effects of colistin on amino acid neurotransmitters and blood-brain barrier in the mouse brain

(2016) Jian Wang et al.   NEUROTOXICOLOGY AND TERATOLOGY

Lycium barbarumPolysaccharides Protect against Trimethyltin Chloride-Induced Apoptosis via Sonic Hedgehog and PI3K/Akt Signaling Pathways in Mouse Neuro-2a Cells

(2016) Wanyun Zhao et al.   Oxidative Medicine and Cellular Longevity

Curcumin enhances human macrophage control ofMycobacterium tuberculosisinfection

(2016) Xiyuan Bai et al.   RESPIROLOGY

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

(2016) Tony Velkov et al.   ACS Infectious Diseases

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

(2015) Mohammad A. K. Azad et al.   ANALYTICAL CHEMISTRY

Major Pathways of Polymyxin-Induced Apoptosis in Rat Kidney Proximal Tubular Cells

(2015) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Autophagy Regulates Colistin-Induced Apoptosis in PC-12 Cells

(2015) Ling Zhang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Polymyxin B Biodistribution and Disposition in an Animal Model

(2015) Pooja Manchandani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Protective effects of curcumin on acute gentamicin-induced nephrotoxicity in rats

(2015) Liyu He et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update

(2015) Shatadal Ghosh et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural products as a source of drug leads to overcome drug resistance

(2015) Lynn L Silver   Future Microbiology

In vitro synergy of polymyxins with other antibiotics for Acinetobacter baumannii: A systematic review and meta-analysis

(2015) Wentao Ni et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

(2015) Xiaoxi Lu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy

(2015) Chongshan Dai et al.   MOLECULAR NEUROBIOLOGY

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

The emerging threat of multidrug-resistant Gram-negative bacteria in urology

(2015) Hosam M. Zowawi et al.   Nature Reviews Urology

P-Glycoprotein Induction Ameliorates Colistin Induced Nephrotoxicity in Cultured Human Proximal Tubular Cells

(2015) Sun-hyo Lee et al.   PLoS One

Trends of 9,416 multidrug-resistant Gram-negative bacteria

(2015) Viviane Decicera Colombo Oliveira et al.   Revista da Associacao Medica Brasileira

The effect of curcumin on liver fibrosis in the rat model of microsurgical cholestasis

(2015) Andrej Barta et al.   Food & Function

Curcumin Inhibits Gastric Inflammation Induced by Helicobacter Pylori Infection in a Mouse Model

(2015) António Santos et al.   Nutrients

Antibacterial Mechanisms of Polymyxin and Bacterial Resistance

(2015) Zhiliang Yu et al.   Biomed Research International

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

(2015) Kade D. Roberts et al.   ACS Infectious Diseases

Colistin Heteroresistance in Enterobacter cloacae Is Associated with Cross-Resistance to the Host Antimicrobial Lysozyme

(2014) Brooke A. Napier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effects of Colistin on the Sensory Nerve Conduction Velocity and F-wave in Mice

(2014) Chongshan Dai et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Colistin and Polymyxin B: Peas in a Pod, or Chalk and Cheese?

(2014) R. L. Nation et al.   CLINICAL INFECTIOUS DISEASES

Antibiotic-Resistant Gram-Negative Bacterial Infections in Patients With Cancer

(2014) Federico Perez et al.   CLINICAL INFECTIOUS DISEASES

Curcumin attenuatesstaphylococcus aureus-induced acute lung injury

(2014) Feng Xu et al.   Clinical Respiratory Journal

Protective effect of curcumin against heavy metals-induced liver damage

(2014) Wylly Ramsés García-Niño et al.   FOOD AND CHEMICAL TOXICOLOGY

Colistin-induced apoptosis in PC12 cells: Involvement of the mitochondrial apoptotic and death receptor pathways

(2014) HONG JIANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Imaging the distribution of polymyxins in the kidney

(2014) B. Yun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3β signaling

(2014) T Couroussé et al.   MOLECULAR PSYCHIATRY

Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria

(2014) Abiola O. Olaitan et al.   Frontiers in Microbiology

Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

(2013) Takahiro Suzuki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Species-Dependent Blood-Brain Barrier Disruption of Lipopolysaccharide: Amelioration by ColistinIn VitroandIn Vivo

(2013) Liang Jin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activities of Vancomycin-Containing Regimens against Colistin-Resistant Acinetobacter baumannii Clinical Strains

(2013) Jessica A. O'Hara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues

(2013) Chongshan Dai et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Fortifying the barrier: the impact of lipid A remodelling on bacterial pathogenesis

(2013) Brittany D. Needham et al.   NATURE REVIEWS MICROBIOLOGY

Cell cycle arrest in a model of colistin nephrotoxicity

(2013) Michael T. Eadon et al.   PHYSIOLOGICAL GENOMICS

Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus

(2013) Su-Hyun Mun et al.   PHYTOMEDICINE

Evaluation of colistin nephrotoxicity administered at different doses in the rat model

(2013) Zohra Ghlissi et al.   RENAL FAILURE

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

(2013) Natalie D. Keirstead et al.   TOXICOLOGICAL SCIENCES

Oral nanoparticulate curcumin combating arsenic-induced oxidative damage in kidney and brain of rats

(2013) Palanisamy Sankar et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Antibacterial effects of curcumin

(2013) Hayati Gunes et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Rapid Killing of Acinetobacter baumannii by Polymyxins Is Mediated by a Hydroxyl Radical Death Pathway

(2012) Timothy R. Sampson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats

(2012) Cassiane Dezoti Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Systemic Infection Induced by Pseudomonas aeruginosa on the Brain Uptake of Colistin in Mice

(2012) Liang Jin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

Epithelial Proinflammatory Response and Curcumin-Mediated Protection from Staphylococcal Toxic Shock Syndrome Toxin-1

(2012) Matthew M. Schaefers et al.   PLoS One

Electrophysiology and ultrastructural changes in mouse sciatic nerve associated with colistin sulfate exposure

(2012) Chongshan Dai et al.   TOXICOLOGY MECHANISMS AND METHODS

Effect of colistin exposure on calcium homeostasis and mitochondria functions in chick cortex neurons

(2012) Chongshan Dai et al.   TOXICOLOGY MECHANISMS AND METHODS

LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease

(2012) Carlos Spuch et al.   Frontiers in Physiology

Melatonin Attenuates Colistin-Induced Nephrotoxicity in Rats

(2011) Jumana M. Yousef et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

(2011) S. M. Garonzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Race against time to develop new antibiotics

(2011) . .   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Vascular anti-inflammatory effects of curcumin on HMGB1-mediated responses in vitro

(2011) Dong-Chan Kim et al.   INFLAMMATION RESEARCH

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

(2011) J. M. Yousef et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Curcumin is a potent modulator of microglial gene expression and migration

(2011) Marcus Karlstetter et al.   Journal of Neuroinflammation

Curcumin Alleviates Matrix Metalloproteinase-3 and -9 Activities during Eradication of Helicobacter pylori Infection in Cultured Cells and Mice

(2011) Parag Kundu et al.   PLoS One

Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice

(2010) Liang Jin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Neuronal Death and Oxidative Stress in the Developing Brain

(2010) Chrysanthy Ikonomidou et al.   ANTIOXIDANTS & REDOX SIGNALING

Aerosolized plus Intravenous Colistin versus Intravenous Colistin Alone for the Treatment of Ventilator‐Associated Pneumonia: A Matched Case‐Control Study

(2010) Diamantis P. Kofteridis et al.   CLINICAL INFECTIOUS DISEASES

Intravenous and Inhalational Colistin–Induced Respiratory Failure

(2010) Krista Wahby et al.   CLINICAL INFECTIOUS DISEASES

Neurotoxicity in patients treated with intravenous polymyxin B: Two case reports

(2009) L. Weinstein et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Antimicrobial Activity of Curcumin against Helicobacter pylori Isolates from India and during Infections in Mice

(2009) R. De et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Renal Disposition of Colistin in the Isolated Perfused Rat Kidney

(2009) Z. Ma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Brain Penetration of Colistin in Mice Assessed by a Novel High-Performance Liquid Chromatographic Technique

(2009) L. Jin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Reactive Oxygen Species Production in Excitable Cells: Modulators of Mitochondrial and Cell Function

(2009) David F. Stowe et al.   ANTIOXIDANTS & REDOX SIGNALING

Nephrotoxicity Associated with Intravenous Colistin (Colistimethate Sodium) Treatment at a Tertiary Care Medical Center

(2009) Joshua D. Hartzell et al.   CLINICAL INFECTIOUS DISEASES

Subacute Toxicity of Colistin Methanesulfonate in Rats: Comparison of Various Intravenous Dosage Regimens

(2008) S. J. Wallace et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity

(2008) Dipti Rai et al.   BIOCHEMICAL JOURNAL

Blood–brain barrier permeability considerations for CNS-targeted compound library design

(2008) Stephen A Hitchcock   CURRENT OPINION IN CHEMICAL BIOLOGY

Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases

(2008) Bharat B. Aggarwal et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Curcumin, a Known Phenolic from Curcuma longa, Attenuates the Virulence of Pseudomonas aeruginosa PAO1 in Whole Plant and Animal Pathogenicity Models

(2008) Thimmaraju Rudrappa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY