Molecular Mechanisms of Colistin-Induced Nephrotoxicity

Curcumin alleviates colistin-induced nephrotoxicity and neurotoxicity in rats via attenuation of oxidative stress, inflammation and apoptosis

(2018) Nagah E. Edrees et al.   CHEMICO-BIOLOGICAL INTERACTIONS

N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions

(2018) Bahadir Ceylan et al.   RENAL FAILURE

The nephroprotective properties of taurine in colistin-treated mice is mediated through the regulation of mitochondrial function and mitigation of oxidative stress

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

Baicalein acts as a nephroprotectant that ameliorates colistin-induced nephrotoxicity by activating the antioxidant defence mechanism of the kidneys and down-regulating the inflammatory response

(2017) Chongshan Dai et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Megalin Blockade with Cilastatin Suppresses Drug-Induced Nephrotoxicity

(2017) Yoshihisa Hori et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Possible protective role of silybin against polymyxin E-induced toxic effect in rat kidneys: A biochemical approach

(2017) Sherif S. Hassan et al.   NEUROUROLOGY AND URODYNAMICS

The 6R’s of drug induced nephrotoxicity

(2017) Linda Awdishu et al.   BMC Nephrology

Defining the incidence and risk factors of colistin-induced acute kidney injury by KDIGO criteria

(2017) Ryan K. Shields et al.   PLoS One

Organic Cation Transporter 2 Overexpression May Confer an Increased Risk of Gentamicin-Induced Nephrotoxicity

(2016) Zhibo Gai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Membrane permeabilization of colistin toward pan-drug resistant Gram-negative isolates

(2016) Yasmine Fathy Mohamed et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Type II NADH:quinone oxidoreductase family: phylogenetic distribution, structural diversity and evolutionary divergences

(2016) Bruno C. Marreiros et al.   ENVIRONMENTAL MICROBIOLOGY

Luteolin ameliorates colistin-induced nephrotoxicity in the rat models

(2016) Birsen Yigit Arslan et al.   RENAL FAILURE

Characterization of urinary metabolites as biomarkers of colistin-induced nephrotoxicity in rats by a liquid chromatography/mass spectrometry-based metabolomics approach

(2016) Eun Sook Jeong et al.   TOXICOLOGY LETTERS

Preliminary Clinical Study of the Effect of Ascorbic Acid on Colistin-Associated Nephrotoxicity

(2015) Rujipas Sirijatuphat et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Editorial Commentary:Optimal Usage of Colistin: Are We Any Closer?

(2015) Jason M. Pogue et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study

(2015) Eric A. J. Hoste et al.   INTENSIVE CARE MEDICINE

Incidence and Risk Factors for Colistin-Associated Nephrotoxicity

(2015) Fatih Temocin et al.   JAPANESE JOURNAL OF INFECTIOUS DISEASES

Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins

(2015) Xiaoxi Lu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Apoptosis-inducing Factor (AIF) and Its Family Member Protein, AMID, Are Rotenone-sensitive NADH:Ubiquinone Oxidoreductases (NDH-2)

(2015) Mahmoud M. Elguindy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antibacterial Mechanisms of Polymyxin and Bacterial Resistance

(2015) Zhiliang Yu et al.   Biomed Research International

Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model

(2014) Zohra Ghlissi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Imaging the distribution of polymyxins in the kidney

(2014) B. Yun et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for Acute Kidney Injury

(2013) Paul M. Palevsky et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Megalin Contributes to Kidney Accumulation and Nephrotoxicity of Colistin

(2013) Takahiro Suzuki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

How Does Colistin-Induced Nephropathy Develop and Can It Be Treated?

(2013) Gulsum Ozkan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

(2013) Zakuan Z Deris et al.   JOURNAL OF ANTIBIOTICS

Evaluation of colistin nephrotoxicity administered at different doses in the rat model

(2013) Zohra Ghlissi et al.   RENAL FAILURE

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

(2013) Natalie D. Keirstead et al.   TOXICOLOGICAL SCIENCES

Incidence and Predictors of Nephrotoxicity Associated with Intravenous Colistin in Overweight and Obese Patients

(2012) Timothy P. Gauthier et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

(2012) Ikumi Tamai   BIOPHARMACEUTICS & DRUG DISPOSITION

What Is the Efficacy and Safety of Colistin for the Treatment of Ventilator-Associated Pneumonia? A Systematic Review and Meta-Regression

(2012) D. F. Florescu et al.   CLINICAL INFECTIOUS DISEASES

Melatonin Attenuates Colistin-Induced Nephrotoxicity in Rats

(2011) Jumana M. Yousef et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Acute Kidney Injury and Increasing Nephrotoxic-Medication Exposure in Noncritically-Ill Children

(2011) B. S. Moffett et al.   Clinical Journal of the American Society of Nephrology

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

(2011) J. M. Yousef et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Aerosolized plus Intravenous Colistin versus Intravenous Colistin Alone for the Treatment of Ventilator‐Associated Pneumonia: A Matched Case‐Control Study

(2010) Diamantis P. Kofteridis et al.   CLINICAL INFECTIOUS DISEASES

Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine?

(2010) Ezgi Ozyilmaz et al.   INTENSIVE CARE MEDICINE

Elucidation of the Pharmacokinetic/Pharmacodynamic Determinant of Colistin Activity against Pseudomonas aeruginosa in Murine Thigh and Lung Infection Models

(2009) R. V. Dudhani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Early Diagnosis of Acute Kidney Injury: The Promise of Novel Biomarkers

(2009) Sachin S. Soni et al.   BLOOD PURIFICATION

Nephrotoxicity Associated with Intravenous Colistin (Colistimethate Sodium) Treatment at a Tertiary Care Medical Center

(2009) Joshua D. Hartzell et al.   CLINICAL INFECTIOUS DISEASES

Nephrotoxicity of Colistin: New Insight into an Old Antibiotic

(2009) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

Clinical characteristics and risk factors of colistin-induced nephrotoxicity

(2009) Jieun Kim et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Polymyxin B Identified as an Inhibitor of Alternative NADH Dehydrogenase and Malate: Quinone Oxidoreductase from the Gram-positive Bacterium Mycobacterium smegmatis

(2009) T. Mogi et al.   JOURNAL OF BIOCHEMISTRY

Receptor-mediated endocytosis in renal proximal tubule

(2009) Erik Ilsø Christensen et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Identification of new inhibitors for alternative NADH dehydrogenase (NDH-II)

(2008) Tatsushi Mogi et al.   FEMS MICROBIOLOGY LETTERS

Biomarkers of nephrotoxic acute kidney injury

(2008) Michael A. Ferguson et al.   TOXICOLOGY