Lycopene Attenuates Colistin-Induced Nephrotoxicity in Mice via Activation of the Nrf2/HO-1 Pathway

Colistin-Induced Nephrotoxicity in Mice Involves the Mitochondrial, Death Receptor, and Endoplasmic Reticulum Pathways

(2014) Chongshan Dai et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of Lycopene Against Cisplatin-Induced Acute Renal Injury in Rats: Organic Anion and Cation Transporters Evaluation

(2014) Fazilet Erman et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Evaluation of efficacy of natural astaxanthin and vitamin E in prevention of colistin-induced nephrotoxicity in the rat model

(2014) Zohra Ghlissi et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Oxaliplatin activates the Keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs

(2014) Xiu Jun Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Delayed treatment with oleanolic acid attenuates tubulointerstitial fibrosis in chronic cyclosporine nephropathy through Nrf2/HO-1 signaling

(2014) Yu Hong et al.   Journal of Translational Medicine

Activation of the Nrf2/HO-1 Antioxidant Pathway Contributes to the Protective Effects of Lycium Barbarum Polysaccharides in the Rodent Retina after Ischemia-Reperfusion-Induced Damage

(2014) Meihua He et al.   PLoS One

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway

(2014) Juan Wu et al.   TOXICOLOGY

How Does Colistin-Induced Nephropathy Develop and Can It Be Treated?

(2013) Gulsum Ozkan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxin B Induces Apoptosis in Kidney Proximal Tubular Cells

(2013) Mohammad A. K. Azad et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens

(2013) Ana M. Sandri et al.   CLINICAL INFECTIOUS DISEASES

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Higher Incidence of Acute Kidney Injury With Intravenous Colistimethate Sodium Compared With Polymyxin B in Critically Ill Patients at a Tertiary Care Medical Center

(2013) Darowan S. Akajagbor et al.   CLINICAL INFECTIOUS DISEASES

In vitro toxicity of colistin on primary chick cortex neurons and its potential mechanism

(2013) Chongshan Dai et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

New insight in colistin induced neurotoxicity with the mitochondrial dysfunction in mice central nervous tissues

(2013) Chongshan Dai et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Protective effects of 6-hydroxy-1-methylindole-3-acetonitrile on cisplatin-induced oxidative nephrotoxicity via Nrf2 inactivation

(2013) Ji Hee Moon et al.   FOOD AND CHEMICAL TOXICOLOGY

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Olmesartan protects against oxidative stress possibly through the Nrf2 signaling pathway and inhibits inflammation in daunorubicin-induced nephrotoxicity in rats

(2013) Vengadeshprabhu Karuppa Gounder et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Autophagy and apoptosis in tubular cells following unilateral ureteral obstruction are associated with mitochondrial oxidative stress

(2013) YANFANG XU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Activation of renal haeme oxygenase-1 alleviates gentamicin-induced acute nephrotoxicity in rats

(2013) Ashraf Taye et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A Dose-Response Study on the Effects of Purified Lycopene Supplementation on Biomarkers of Oxidative Stress

(2013) Sridevi Devaraj et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Role of Nrf2 in protection against acute kidney injury

(2013) Luke M. Shelton et al.   KIDNEY INTERNATIONAL

The Nrf2 pathway in the progression of renal disease

(2013) C. Zoja et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway

(2013) Ulkan Kilic et al.   Nutrition & Metabolism

Early Prediction of Polymyxin-Induced Nephrotoxicity With Next-Generation Urinary Kidney Injury Biomarkers

(2013) Natalie D. Keirstead et al.   TOXICOLOGICAL SCIENCES

Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells

(2013) Min Tan et al.   TOXICOLOGY LETTERS

Ascorbic acid protects against colistin sulfate-induced neurotoxicity in PC12 cells

(2013) Yang Liu et al.   TOXICOLOGY MECHANISMS AND METHODS

Non-Alcoholic Steatohepatitis and Hepatocellular Carcinoma: Implications for Lycopene Intervention

(2013) Blanche Ip et al.   Nutrients

Role of Heme Oxygenase-1 in Polymyxin B-Induced Nephrotoxicity in Rats

(2012) Cassiane Dezoti Fonseca et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of Polymyxin B-Induced Nephrotoxicity: Implications for Dosing Regimen Design

(2012) Kamilia Abdelraouf et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and pharmacodynamics of ‘old’ polymyxins: what is new?

(2012) Phillip J. Bergen et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Ginsenoside Rg3 enhances the chemosensitivity of tumors to cisplatin by reducing the basal level of nuclear factor erythroid 2-related factor 2-mediated heme oxygenase-1/NAD(P)H quinone oxidoreductase-1 and prevents normal tissue damage by scavenging cisplatin-induced intracellular reactive oxygen species

(2012) Chang Ki Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Incidence and predictors of acute kidney injury associated with intravenous polymyxin B therapy

(2012) Christine J. Kubin et al.   JOURNAL OF INFECTION

Inhibition of NF-κB nuclear translocation via HO-1 activation underlies α-tocopheryl succinate toxicity

(2012) Ilaria Bellezza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Tomato juice intake suppressed serum concentration of 8-oxodG after extensive physical activity

(2012) Mats Harms-Ringdahl et al.   Nutrition Journal

Lycopene Protects against Hypoxia/Reoxygenation-Induced Apoptosis by Preventing Mitochondrial Dysfunction in Primary Neonatal Mouse Cardiomyocytes

(2012) Rongchuan Yue et al.   PLoS One

Melatonin Attenuates Colistin-Induced Nephrotoxicity in Rats

(2011) Jumana M. Yousef et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

(2011) S. M. Garonzik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

(2011) J. M. Yousef et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Nrf2/HO-1 pathway activation by manganese is associated with reactive oxygen species and ubiquitin-proteasome pathway, not MAPKs signaling

(2011) Huangyuan Li et al.   JOURNAL OF APPLIED TOXICOLOGY

Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway

(2011) Mingyue Qu et al.   NEUROCHEMISTRY INTERNATIONAL

A Tomato Lycopene Complex Protects the Kidney From Cisplatin-Induced Injury via Affecting Oxidative Stress as Well as Bax, Bcl-2, and HSPs Expression

(2011) Ayhan Dogukan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARγ Signalling in Cigarette Smoke–Stimulated Macrophages

(2011) Rossella E. Simone et al.   PLoS One

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene

(2010) Kazim Sahin et al.   FOOD AND CHEMICAL TOXICOLOGY

Could nephrotoxicity due to colistin be ameliorated with the use of N-acetylcysteine?

(2010) Ezgi Ozyilmaz et al.   INTENSIVE CARE MEDICINE

New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view

(2010) Jose M. Lopez-Novoa et al.   KIDNEY INTERNATIONAL

Early Acute Kidney Injury Is a Risk Factor That Predicts Mortality in Patients Treated with Colistin

(2010) Hee ja Ko et al.   NEPHRON CLINICAL PRACTICE

Lycopene and Chemotherapy Toxicity

(2010) Kazim Sahin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Nephrotoxicity Associated with Intravenous Colistin (Colistimethate Sodium) Treatment at a Tertiary Care Medical Center

(2009) Joshua D. Hartzell et al.   CLINICAL INFECTIOUS DISEASES

Diallyl sulfide enhances antioxidants and inhibits inflammation through the activation of Nrf2 against gentamicin-induced nephrotoxicity in Wistar rats

(2009) Srinivasan Kalayarasan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-κB in macrophages

(2009) Dan Feng et al.   INFLAMMATION RESEARCH

Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity

(2009) Puneet Kumar et al.   LIFE SCIENCES

Polymyxins Revisited

(2008) D. Landman et al.   CLINICAL MICROBIOLOGY REVIEWS

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL