Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging

Genomic footprints of activated telomere maintenance mechanisms in cancer

(2020) Lina Sieverling et al.   Nature Communications

Autophagy, Cellular Aging and Age-related Human Diseases

(2020) So Yeong Cheon et al.   Experimental Neurobiology

Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

(2019) Jun Liu et al.   Cells

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

(2019) Miguel C. Coelho et al.   NATURE

Protein Quality Control of the Endoplasmic Reticulum and Ubiquitin–Proteasome-Triggered Degradation of Aberrant Proteins: Yeast Pioneers the Path

(2018) Nicole Berner et al.   Annual Review of Biochemistry

TFE-induced local unfolding and fibrillation of SOD1: bridging the experiment and simulation studies

(2018) Vijay Kumar et al.   BIOCHEMICAL JOURNAL

Comparative analysis of thermal unfolding simulations of RNA recognition motifs (RRMs) of TAR DNA-binding protein 43 (TDP-43)

(2018) Amresh Prakash et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Mitochondrial dysfunction reduces yeast replicative lifespan by elevating RAS-dependent ROS production by the ER-localized NADPH oxidase Yno1

(2018) Dae-Gwan Yi et al.   PLoS One

Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

(2018) Kurt A. Escobar et al.   AGING CELL

Keeping ribosomal DNA intact: a repeating challenge

(2018) Daniël O. Warmerdam et al.   CHROMOSOME RESEARCH

Genome Instability Induced by Low Levels of Replicative DNA Polymerases in Yeast

(2018) Dao-Qiong Zheng et al.   Genes

Protein aggregation, misfolding and consequential human neurodegenerative diseases

(2017) Neha Sami et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Solvent sensitivity of protein aggregation in Cu, Zn superoxide dismutase: a molecular dynamics simulation study

(2017) Amresh Prakash et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

DNA methylation changes at TREM2 intron 1 and TREM2 mRNA expression in patients with Alzheimer's disease

(2017) Yuki Ozaki et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Role of DNA methylation in human age prediction

(2017) Neelam Goel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Business of Anti-Aging Science

(2017) João Pedro de Magalhães et al.   TRENDS IN BIOTECHNOLOGY

Caloric restriction improves health and survival of rhesus monkeys

(2017) Julie A. Mattison et al.   Nature Communications

The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan

(2017) Nitish Mittal et al.   Nature Communications

Pharmacologic Targeting of S6K1 in PTEN-Deficient Neoplasia

(2017) Hongqi Liu et al.   Cell Reports

Mutations that Allow SIR2 Orthologs to Function in a NAD + -Depleted Environment

(2017) Caitlin R. Ondracek et al.   Cell Reports

Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations

(2017) Vijay Kumar et al.   Scientific Reports

Age-dependent expression ofDNMT1andDNMT3Bin PBMCs from a large European population enrolled in the MARK-AGE study

(2016) Fabio Ciccarone et al.   AGING CELL

Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options

(2016) Wilbert P. Vermeij et al.   Annual Review of Pharmacology and Toxicology

Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice

(2016) Michael Shum et al.   DIABETOLOGIA

Protein aggregation and neurodegenerative diseases: From theory to therapy

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification of the Target of the Retrograde Response that Mediates Replicative Lifespan Extension in Saccharomyces cerevisiae

(2016) J. C. Jiang et al.   GENETICS

The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging

(2016) Kanad Ghosh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

(2016) Vanessa S. Rodrik-Outmezguine et al.   NATURE

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural insight into C9orf72 hexanucleotide repeat expansions: Towards new therapeutic targets in FTD-ALS

(2016) Vijay Kumar et al.   NEUROCHEMISTRY INTERNATIONAL

Epigenome Editing: State of the Art, Concepts, and Perspectives

(2016) Goran Kungulovski et al.   TRENDS IN GENETICS

Sirtuin functions and modulation: from chemistry to the clinic

(2016) Vincenzo Carafa et al.   Clinical Epigenetics

Structure and function of the telomeric CST complex

(2016) Cory Rice et al.   Computational and Structural Biotechnology Journal

The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

(2016) Gino Heeren et al.   Aging-US

Conserved role of Ras-GEFs in promoting aging: from yeast to mice

(2016) Mario G. Mirisola et al.   Aging-US

Aging and DNA methylation

(2015) Marc Jung et al.   BMC BIOLOGY

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

(2015) Zhengwei Xie et al.   CELL

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

First-in-Human Pharmacokinetic and Pharmacodynamic Study of the Dual m-TORC 1/2 Inhibitor AZD2014

(2015) B. Basu et al.   CLINICAL CANCER RESEARCH

Affected chromosome homeostasis and genomic instability of clonal yeast cultures

(2015) Jagoda Adamczyk et al.   CURRENT GENETICS

20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegans

(2015) Niki Chondrogianni et al.   FASEB JOURNAL

Altering nuclear pore complex function impacts longevity and mitochondrial function inS. cerevisiae

(2015) Christopher L. Lord et al.   JOURNAL OF CELL BIOLOGY

Essential role for autophagy in life span extension

(2015) Frank Madeo et al.   JOURNAL OF CLINICAL INVESTIGATION

Measuring Biological Age via Metabonomics: The Metabolic Age Score

(2015) Johannes Hertel et al.   JOURNAL OF PROTEOME RESEARCH

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

SIRTain regulators of premature senescence and accelerated aging

(2015) Shrestha Ghosh et al.   Protein & Cell

Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast

(2015) Woo Kyu Kang et al.   eLife

AMPK at the Nexus of Energetics and Aging

(2014) Kristopher Burkewitz et al.   Cell Metabolism

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

Nucleosome loss leads to global transcriptional up-regulation and genomic instability during yeast aging

(2014) Z. Hu et al.   GENES & DEVELOPMENT

Proteostasis and the Aging Proteome in Health and Disease

(2014) R. I. Morimoto et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

(2014) Sarah J. Mitchell et al.   Cell Reports

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

The SAGA Histone Deubiquitinase Module Controls Yeast Replicative Lifespan via Sir2 Interaction

(2014) Mark A. McCormick et al.   Cell Reports

Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan

(2013) Jun Liu et al.   AGING CELL

Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

(2013) Massimo Bogliolo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Yeast sirtuins and the regulation of aging

(2013) Margaret B. Wierman et al.   FEMS YEAST RESEARCH

A cascade leading to premature aging phenotypes including abnormal tumor profiles in Werner syndrome (Review)

(2013) MASANOBU SUGIMOTO   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Protein Level of PGC-1 , a Key Metabolic Regulator, Is Controlled by NADH-NQO1

(2013) Y. Adamovich et al.   MOLECULAR AND CELLULAR BIOLOGY

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Chromatin Modifications as Determinants of Muscle Stem Cell Quiescence and Chronological Aging

(2013) Ling Liu et al.   Cell Reports

The mouse as a model organism in aging research: Usefulness, pitfalls and possibilities

(2012) Valerie Vanhooren et al.   AGEING RESEARCH REVIEWS

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

The caloric restriction paradigm: Implications for healthy human aging

(2012) Rozalyn M. Anderson et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Yeast as a model to understand the interaction between genotype and the response to calorie restriction

(2012) Jennifer Schleit et al.   FEBS LETTERS

Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome

(2012) R. P. McCord et al.   GENOME RESEARCH

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Human Telomeres Are Tethered to the Nuclear Envelope during Postmitotic Nuclear Assembly

(2012) Laure Crabbe et al.   Cell Reports

Sirtuins as Regulators of the Yeast Metabolic Network

(2012) Markus Ralser et al.   Frontiers in Pharmacology

Loss of Mitochondrial Membrane Potential Triggers the Retrograde Response Extending Yeast Replicative Lifespan

(2012) Michael V. Miceli et al.   Frontiers in Genetics

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin

(2011) Mariano Oppikofer et al.   EMBO JOURNAL

Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast

(2011) Jeremy J. R. Benjamin et al.   MOLECULAR BIOLOGY OF THE CELL

Absence of Mitochondrial Translation Control Proteins Extends Life Span by Activating Sirtuin-Dependent Silencing

(2011) Antonio Caballero et al.   MOLECULAR CELL

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

(2011) V. Krishnan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Elevated Proteasome Capacity Extends Replicative Lifespan in Saccharomyces cerevisiae

(2011) Undine Kruegel et al.   PLoS Genetics

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats

(2010) Claudio Guetg et al.   EMBO JOURNAL

γH2AX as a molecular marker of aging and disease

(2010) Li-Jeen Mah et al.   Epigenetics

Gene regulatory changes in yeast during life extension by nutrient limitation

(2010) Jinqing Wang et al.   EXPERIMENTAL GERONTOLOGY

Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

(2010) V. K. Rakyan et al.   GENOME RESEARCH

Design and Conduct of the CALERIE Study: Comprehensive Assessment of the Long-term Effects of Reducing Intake of Energy

(2010) James Rochon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice

(2010) Satoru Hayashida et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Elevated Histone Expression Promotes Life Span Extension

(2010) Jason Feser et al.   MOLECULAR CELL

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(2010) Eric L. Greer et al.   NATURE

Lessons on longevity from budding yeast

(2010) Matt Kaeberlein   NATURE

Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice

(2010) S. Peleg et al.   SCIENCE

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

(2009) María Jiménez-Hidalgo et al.   AGING CELL

Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?

(2009) Pamela Boon Li Pun et al.   BIOGERONTOLOGY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Cohesinopathy mutations disrupt the subnuclear organization of chromatin

(2009) Scarlett Gard et al.   JOURNAL OF CELL BIOLOGY

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

The DNA damage response at eroded telomeres and tethering to the nuclear pore complex

(2009) Basheer Khadaroo et al.   NATURE CELL BIOLOGY

A two-step model for senescence triggered by a single critically short telomere

(2009) Pauline Abdallah et al.   NATURE CELL BIOLOGY

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

Telomere Diseases

(2009) Rodrigo T. Calado et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruption of Protein Kinase A in Mice Enhances Healthy Aging

(2009) Linda C. Enns et al.   PLoS One

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Septins: molecular partitioning and the generation of cellular asymmetry

(2009) Michael A McMurray et al.   Cell Division

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

A mechanism for asymmetric segregation of age during yeast budding

(2008) Zhanna Shcheprova et al.   NATURE

Histone H3 Modifications Associated With Differentiation and Long-Term Culture of Mesenchymal Adipose Stem Cells

(2008) Agate Noer et al.   STEM CELLS AND DEVELOPMENT