Protein aggregation, misfolding and consequential human neurodegenerative diseases

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis

(2016) Kevin S. Chen et al.   ANNALS OF NEUROLOGY

Delineating the relationship between amyotrophic lateral sclerosis and frontotemporal dementia: Sequence and structure-based predictions

(2016) Vijay Kumar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Smooth muscle titin forms in vitro amyloid aggregates

(2016) A. G. Bobylev et al.   BIOSCIENCE REPORTS

Induced pluripotent stem cells and Parkinson's disease: modelling and treatment

(2016) Xiaoyun Xu et al.   CELL PROLIFERATION

Insulin and Lispro Insulin: What is Common and Different in their Behavior?

(2016) Olga Selivanova et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?

(2016) Nazem Atassi et al.   CYTOTHERAPY

Protein aggregation and neurodegenerative diseases: From theory to therapy

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Current updates on computer aided protein modeling and designing

(2016) Faez Iqbal Khan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Development of stem cell-based therapies for Parkinson's disease

(2016) Bangfu Zhu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) Proteinopathies

(2016) Roberta Cascella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

One of the possible mechanisms of amyloid fibrils formation based on the sizes of primary and secondary folding nuclei of Aβ40 and Aβ42

(2016) Nikita V. Dovidchenko et al.   JOURNAL OF STRUCTURAL BIOLOGY

Current Perspective of Stem Cell Therapy in Neurodegenerative and Metabolic Diseases

(2016) Ajay Kumar et al.   MOLECULAR NEUROBIOLOGY

Structural insight into C9orf72 hexanucleotide repeat expansions: Towards new therapeutic targets in FTD-ALS

(2016) Vijay Kumar et al.   NEUROCHEMISTRY INTERNATIONAL

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

The HET-S/s Prion Motif in the Control of Programmed Cell Death

(2016) Roland Riek et al.   Cold Spring Harbor Perspectives in Biology

A Compendium of Preparation and Application of Stem Cells in Parkinson's Disease: Current Status and Future Prospects

(2016) Yan Shen et al.   Frontiers in Aging Neuroscience

Are Stem Cell-Based Therapies for Parkinson’s Disease Ready for the Clinic in 2016?

(2016) Roger A. Barker et al.   Journal of Parkinsons Disease

Functional and Clinical Consequences of Novel α-Galactosidase A Mutations in Fabry Disease

(2015) Jan Lukas et al.   HUMAN MUTATION

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repeats are one of the main characteristics of RNA-binding proteins with prion-like domains

(2015) Oxana V. Galzitskaya   Molecular BioSystems

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Targeting protein aggregation for the treatment of degenerative diseases

(2015) Yvonne S. Eisele et al.   NATURE REVIEWS DRUG DISCOVERY

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Developing stem cell therapies for juvenile and adult-onset Huntington's disease

(2015) Kyle D Fink et al.   Regenerative Medicine

Gene therapy for neurodegenerative diseases

(2015) Deirdre M. O’Connor et al.   TRENDS IN MOLECULAR MEDICINE

Neural and mesenchymal stem cells in animal models of Huntington’s disease: past experiences and future challenges

(2015) Irina Kerkis et al.   Stem Cell Research & Therapy

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

(2014) Shane Grealish et al.   Cell Stem Cell

Chaperones and Cardiac Misfolding Protein Diseases

(2014) Elisabeth S. Christians et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation

(2014) Alexander K. Buell et al.   Essays in Biochemistry

The past, present and future of stem cell clinical trials for ALS

(2014) Gretchen M. Thomsen et al.   EXPERIMENTAL NEUROLOGY

How to Determine the Size of Folding Nuclei of Protofibrils from the Concentration Dependence of the Rate and Lag-Time of Aggregation. I. Modeling the Amyloid Protofibril Formation

(2014) Nikita V. Dovidchenko et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

(2014) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transplantation of Induced Pluripotent Stem Cells Improves Functional Recovery in Huntington's Disease Rat Model

(2014) Shuhua Mu et al.   PLoS One

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

The nature of protein folding pathways

(2014) S. Walter Englander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like aggregation of mutant p53 in cancer

(2014) Jerson L. Silva et al.   TRENDS IN BIOCHEMICAL SCIENCES

Recent developments in targeting protein misfolding diseases

(2013) Rajiah Aldrin Denny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of key residues in structure, function, and stability of cytochrome-c

(2013) Sobia Zaidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Bone Marrow-Derived Mesenchymal Stem Cells Contribute to the Reduction of Amyloid-β Deposits and the Improvement of Synaptic Transmission in a Mouse Model of Pre-Dementia Alzheimer’s Disease

(2013) Jae-sung Bae et al.   Current Alzheimer Research

Elucidating the role of cofactors in mammalian prion propagation

(2013) Surachai Supattapone   Prion

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frontotemporal Dementia

(2013) Bruce Miller et al.   SEMINARS IN NEUROLOGY

Human umbilical cord mesenchymal stem cell-derived neuron-like cells rescue memory deficits and reduce amyloid-beta deposition in an AβPP/PS1 transgenic mouse model

(2013) Hui Yang et al.   Stem Cell Research & Therapy

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

(2013) Y. Ihara et al.   Cold Spring Harbor Perspectives in Medicine

Long-term Clinical Outcome of Fetal Cell Transplantation for Parkinson Disease

(2013) Zinovia Kefalopoulou et al.   JAMA Neurology

The genetics and neuropathology of frontotemporal lobar degeneration

(2012) Anne Sieben et al.   ACTA NEUROPATHOLOGICA

Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects

(2012) Glenda Halliday et al.   ACTA NEUROPATHOLOGICA

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons

(2012) A. D. Carri et al.   DEVELOPMENT

Producing striatal phenotypes for transplantation in Huntington's disease

(2012) Sophie V Precious et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mutant p53 Aggregates into Prion-like Amyloid Oligomers and Fibrils

(2012) Ana P. D. Ano Bom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From Macroscopic Measurements to Microscopic Mechanisms of Protein Aggregation

(2012) Samuel I.A. Cohen et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

(2012) Carolin Seuring et al.   PLOS BIOLOGY

Stem cell technology for neurodegenerative diseases

(2011) J. Simon Lunn et al.   ANNALS OF NEUROLOGY

Atomic Structures Suggest Determinants of Transmission Barriers in Mammalian Prion Disease

(2011) Marcin I. Apostol et al.   BIOCHEMISTRY

RNAi: a potential new class of therapeutic for human genetic disease

(2011) Attila A. Seyhan   HUMAN GENETICS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Small-molecule conversion of toxic oligomers to nontoxic β-sheet–rich amyloid fibrils

(2011) Jan Bieschke et al.   Nature Chemical Biology

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Allopregnanolone restores hippocampal-dependent learning and memory and neural progenitor survival in aging 3xTgAD and nonTg mice

(2011) Chanpreet Singh et al.   NEUROBIOLOGY OF AGING

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Misfolded protein aggregates: Mechanisms, structures and potential for disease transmission

(2011) Ines Moreno-Gonzalez et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Combined Effects of Hematopoietic Progenitor Cell Mobilization from Bone Marrow by Granulocyte Colony Stimulating Factor and AMD3100 and Chemotaxis into the Brain Using Stromal Cell-Derived Factor-1α in an Alzheimer's Disease Mouse Model

(2011) Ji-Woong Shin et al.   STEM CELLS

Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

(2011) M. Vendruscolo et al.   Cold Spring Harbor Perspectives in Biology

Cellular Strategies of Protein Quality Control

(2011) B. Chen et al.   Cold Spring Harbor Perspectives in Biology

Structure and Intermolecular Dynamics of Aggregates Populated during Amyloid Fibril Formation Studied by Hydrogen/Deuterium Exchange

(2010) Natàlia Carulla et al.   ACCOUNTS OF CHEMICAL RESEARCH

Multidimensional Structure-Activity Relationship of a Protein in Its Aggregated States

(2010) Lei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Intravenous Immunoglobulins as a Treatment for Alzheimerʼs Disease

(2010) Richard Dodel et al.   DRUGS

Immunotherapy for Alzheimer’s disease

(2010) D. Morgan   JOURNAL OF INTERNAL MEDICINE

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies

(2010) Felix Geser et al.   NEUROPATHOLOGY

Biology of Amyloid: Structure, Function, and Regulation

(2010) Jason Greenwald et al.   STRUCTURE

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Crowded Cell-like Environment Accelerates the Nucleation Step of Amyloidogenic Protein Misfolding

(2009) Zheng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The emerging concept of functional amyloid

(2009) C. P. J. Maury   JOURNAL OF INTERNAL MEDICINE

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules

(2009) S. K. Maji et al.   SCIENCE

Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease

(2009) Shin-Ichi Muramatsu et al.   SYNAPSE

Amyloidogenesis in its biological environment: challenging a fundamental issue in protein misfolding diseases

(2008) Vittorio Bellotti et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE