Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
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Title
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-06-03
DOI
10.3389/fcell.2020.00402
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- (2020) Tao Li et al. INVESTIGATIONAL NEW DRUGS
- Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors
- (2020) Enli Liu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oncolytic Virus Encoding a Master Pro-Inflammatory Cytokine Interleukin 12 in Cancer Immunotherapy
- (2020) Hong-My Nguyen et al. Cells
- High-Dose Ipilimumab and High-Dose Interleukin-2 for Patients With Advanced Melanoma
- (2020) Ann W. Silk et al. Frontiers in Oncology
- Interferon-α2b enhances survival and modulates transcriptional profiles and the immune response in melanoma patients treated with dendritic cell vaccines
- (2020) Liuxue Sheng et al. BIOMEDICINE & PHARMACOTHERAPY
- Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
- (2019) Karin M. Knudson et al. Journal for ImmunoTherapy of Cancer
- Therapy with high-dose Interleukin-2 (HD IL-2) in metastatic melanoma and renal cell carcinoma following PD1 or PDL1 inhibition
- (2019) Elizabeth I. Buchbinder et al. Journal for ImmunoTherapy of Cancer
- Eradication of glioblastoma by immuno-virotherapy with a retargeted oncolytic HSV in a preclinical model
- (2019) Francesco Alessandrini et al. ONCOGENE
- A phase I/II trial of cetuximab in combination with interleukin-12 administered to patients with unresectable primary or recurrent head and neck squamous cell carcinoma
- (2019) Elizabeth L McMichael et al. CLINICAL CANCER RESEARCH
- Initial safety analysis of a randomized phase II trial of nelipepimut-S + GM-CSF and trastuzumab compared to trastuzumab alone to prevent recurrence in breast cancer patients with HER2 low-expressing tumors
- (2019) G. Travis Clifton et al. CLINICAL IMMUNOLOGY
- Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
- (2019) Yitian Wang et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated macrophages in vitro
- (2019) Brooke Benner et al. Journal for ImmunoTherapy of Cancer
- Randomized phase II trial of survivin 2B peptide vaccination for patients with HLA ‐A24‐positive pancreatic adenocarcinoma
- (2019) Hiroaki Shima et al. CANCER SCIENCE
- Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
- (2019) Chunwan Lu et al. Journal for ImmunoTherapy of Cancer
- A phase II study of the L19IL2 immunocytokine in combination with dacarbazine in advanced metastatic melanoma patients
- (2019) Benjamin Weide et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial
- (2019) E. Antonio Chiocca et al. Science Translational Medicine
- Phase III Study of Adjuvant Ipilimumab (3 or 10 mg/kg) Versus High-Dose Interferon Alfa-2b for Resected High-Risk Melanoma: North American Intergroup E1609
- (2019) Ahmad A. Tarhini et al. JOURNAL OF CLINICAL ONCOLOGY
- Non-conventional Inhibitory CD4 + Foxp3 − PD-1 hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
- (2018) Roberta Zappasodi et al. CANCER CELL
- Haploidentical IL-15/41BBL activated and expanded natural killer cell infusion therapy after salvage chemotherapy in children with relapsed and refractory leukemia
- (2018) M. Vela et al. CANCER LETTERS
- Pembrolizumab Plus Pegylated Interferon alfa-2b or Ipilimumab for Advanced Melanoma or Renal Cell Carcinoma: Dose-Finding Results from the Phase Ib KEYNOTE-029 Study
- (2018) Michael B. Atkins et al. CLINICAL CANCER RESEARCH
- CAR T-cell Therapy: A New Era in Cancer Immunotherapy
- (2018) Miliotou N. Androulla et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- The function and dysfunction of memory CD8+ T cells in tumor immunity
- (2018) James L. Reading et al. IMMUNOLOGICAL REVIEWS
- Role of Human Macrophage Polarization in Inflammation during Infectious Diseases
- (2018) Chiraz Atri et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma
- (2018) Toshihiko Wakabayashi et al. JOURNAL OF NEURO-ONCOLOGY
- Plasmacytoid dendritic cell in immunity and cancer
- (2018) Dana Mitchell et al. JOURNAL OF NEUROIMMUNOLOGY
- ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomised, open-label, phase 1b trial
- (2018) John M Wrangle et al. LANCET ONCOLOGY
- Evaluation of effectiveness of granulocyte-macrophage colony-stimulating factor therapy to cancer patients after chemotherapy: a meta-analysis
- (2018) Wen-Liang Yu et al. Oncotarget
- Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy
- (2018) Prajakta Shinde et al. Scientific Reports
- Prospects of IL-2 in Cancer Immunotherapy
- (2018) Hani Choudhry et al. Biomed Research International
- Application of Mesenchymal Stem Cells for Therapeutic Agent Delivery in Anti-tumor Treatment
- (2018) Daria S. Chulpanova et al. Frontiers in Pharmacology
- SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion
- (2018) Audrey Brenot et al. Oncogenesis
- Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment
- (2018) Daria S. Chulpanova et al. Frontiers in Immunology
- Randomized phase II trial of autologous dendritic cell vaccines versus autologous tumor cell vaccines in metastatic melanoma: 5-year follow up and additional analyses
- (2018) Robert O. Dillman et al. Journal for ImmunoTherapy of Cancer
- A phase I/randomized phase II study of GM.CD40L vaccine in combination with CCL21 in patients with advanced lung adenocarcinoma
- (2018) Jhanelle E. Gray et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Follicular helper T cells promote the effector functions of CD8+ T cells via the provision of IL-21, which is downregulated due to PD-1/PD-L1-mediated suppression in colorectal cancer
- (2018) Weiwei Shi et al. EXPERIMENTAL CELL RESEARCH
- Tumor Resident Memory T Cells: New Players in Immune Surveillance and Therapy
- (2018) Nina Dumauthioz et al. Frontiers in Immunology
- Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance
- (2018) Megha Budhwani et al. Frontiers in Oncology
- NCI 8628: A randomized phase 2 study of ziv-aflibercept and high-dose interleukin 2 or high-dose interleukin 2 alone for inoperable stage III or IV melanoma
- (2018) Ahmad A. Tarhini et al. CANCER
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- (2018) Anandaroop Mukhopadhyay et al. GENE THERAPY
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- (2018) M. Raza Zaidi JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- T lymphocyte subsets in cancer immunity: Friends or foes
- (2018) Dounia Chraa et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Interleukin 2 with anti-GD2 antibody ch14.18/CHO (dinutuximab beta) in patients with high-risk neuroblastoma (HR-NBL1/SIOPEN): a multicentre, randomised, phase 3 trial
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- (2017) Ting-ting Wang et al. GUT
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- (2017) Tanya O. Robinson et al. IMMUNOLOGY LETTERS
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- (2017) Julia A. Wagner, Maximillian Rosario, Rizwan Romee, Melissa M. Berrien-Elliott, Stephanie E. Schneider, Jeffrey W. Leong, Ryan P. Sullivan, Brea A. Jewell, Michelle Becker-Hapak, Timothy Schappe, Sara Abdel-Latif, Aaron R. Ireland, Devika Jaishankar, Justin A. King, Ravi Vij, Dennis Clement, Jodie Goodridge, Karl-Johan Malmberg, Hing C. Wong, Todd A. Fehniger JOURNAL OF CLINICAL INVESTIGATION
- Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells
- (2017) Masashi Watanabe et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Dendritic cells combined with tumor cells and α-galactosylceramide induce a potent, therapeutic and NK-cell dependent antitumor immunity in B cell lymphoma
- (2017) Laura Escribà-Garcia et al. Journal of Translational Medicine
- Neutrophils in cancer: prognostic role and therapeutic strategies
- (2017) Alberto Ocana et al. Molecular Cancer
- Comparison of morphology, phenotypes and function between cultured human IL-4-DC and IFN-DC
- (2017) Zhiliang Jin et al. Molecular Medicine Reports
- Cytokines in Cancer Immunotherapy
- (2017) Thomas A. Waldmann Cold Spring Harbor Perspectives in Biology
- Regulatory B cell-myeloma cell interaction confers immunosuppression and promotes their survival in the bone marrow milieu
- (2017) L Zhang et al. Blood Cancer Journal
- CD163 as a marker of M2 macrophage, contribute to predict aggressiveness and prognosis of Kazakh esophageal squamous cell carcinoma
- (2017) Jian Ming Hu et al. Oncotarget
- IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56 bright NK Cells and Increases NK-Cell Cytokine Release Capabilities
- (2017) Sigrid Dubois et al. Cancer Immunology Research
- Antigen-Presenting Intratumoral B Cells Affect CD4 + TIL Phenotypes in Non–Small Cell Lung Cancer Patients
- (2017) Tullia C. Bruno et al. Cancer Immunology Research
- Role of Distinct Natural Killer Cell Subsets in Anticancer Response
- (2017) Helena Stabile et al. Frontiers in Immunology
- Type I Interferons and Natural Killer Cell Regulation in Cancer
- (2017) Lena Müller et al. Frontiers in Immunology
- Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective
- (2017) Amrendra Kumar et al. Frontiers in Immunology
- CD163+CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma
- (2017) Keigo Kubota et al. Scientific Reports
- Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis
- (2017) Francesca R. Bertani et al. Scientific Reports
- IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells
- (2017) Lei Li et al. Scientific Reports
- Patterns of Clinical Response with Talimogene Laherparepvec (T-VEC) in Patients with Melanoma Treated in the OPTiM Phase III Clinical Trial
- (2016) Robert H. I. Andtbacka et al. ANNALS OF SURGICAL ONCOLOGY
- Transcriptional Control of Dendritic Cell Development
- (2016) Theresa L. Murphy et al. Annual Review of Immunology
- Interleukin-12 activated CD8 + T cells induces apoptosis in breast cancer cells and reduces tumor growth
- (2016) Shi-Xin Yang et al. BIOMEDICINE & PHARMACOTHERAPY
- Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma
- (2016) Edward W. Roberts et al. CANCER CELL
- A phase I/IIa clinical trial in stage IV melanoma of an autologous tumor–dendritic cell fusion (dendritoma) vaccine with low dose interleukin-2
- (2016) Julia M. Greene et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- A phase I study of recombinant (r) vaccinia-CEA(6D)-TRICOM and rFowlpox-CEA(6D)-TRICOM vaccines with GM-CSF and IFN-α-2b in patients with CEA-expressing carcinomas
- (2016) Megan C. Duggan et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Combined treatment with ipilimumab and intratumoral interleukin-2 in pretreated patients with stage IV melanoma—safety and efficacy in a phase II study
- (2016) Benjamin Weide et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- The Emerging Role of B Cells in Tumor Immunity
- (2016) Peiling Tsou et al. CANCER RESEARCH
- A Randomized Phase II/III Study of Naptumomab Estafenatox + IFN versus IFN in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis
- (2016) R. E. Hawkins et al. CLINICAL CANCER RESEARCH
- Identification of neutrophil surface marker changes in health and inflammation using high-throughput screening flow cytometry
- (2016) Flavia S. Lakschevitz et al. EXPERIMENTAL CELL RESEARCH
- Type II NKT cells: a distinct CD1d-restricted immune regulatory NKT cell subset
- (2016) Suryasarathi Dasgupta et al. IMMUNOGENETICS
- Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal
- (2016) Kelly L. Singel et al. IMMUNOLOGICAL REVIEWS
- T-cell selection in the thymus: a spatial and temporal perspective
- (2016) Nadia Kurd et al. IMMUNOLOGICAL REVIEWS
- Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli
- (2016) Yishan Chuang et al. Innate Immunity
- IL17 producing γδT cells induce angiogenesis and are associated with poor survival in gallbladder cancer patients
- (2016) Rushikesh Sudam Patil et al. INTERNATIONAL JOURNAL OF CANCER
- Combined IL-21–primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient
- (2016) Aude G. Chapuis et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage
- (2016) Irina Ushach et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Immune Cells in Cancer Therapy and Drug Delivery
- (2016) Ceren Eyileten et al. MEDIATORS OF INFLAMMATION
- The inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach
- (2016) Frederick O. Cope et al. NUCLEAR MEDICINE AND BIOLOGY
- Novel Strategy for Phenotypic Characterization of Human B Lymphocytes from Precursors to Effector Cells by Flow Cytometry
- (2016) Giovanna Clavarino et al. PLoS One
- TH9 cells in anti-tumor immunity
- (2016) Thaiz Rivera Vargas et al. Seminars in Immunopathology
- Dendritic Cells and Cancer Immunity
- (2016) Alycia Gardner et al. TRENDS IN IMMUNOLOGY
- A phase I study of intratumoral ipilimumab and interleukin-2 in patients with advanced melanoma
- (2016) Abhijit Ray et al. Oncotarget
- Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages
- (2016) Hideyuki Takahashi et al. Oncotarget
- γδ T cells in cancer immunotherapy
- (2016) Chang Zou et al. Oncotarget
- Cellular Adjuvant Properties, Direct Cytotoxicity of Re-differentiated Vα24 Invariant NKT-like Cells from Human Induced Pluripotent Stem Cells
- (2016) Shuichi Kitayama et al. Stem Cell Reports
- Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma
- (2016) Daxa M. Patel et al. Human Gene Therapy Clinical Development
- Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp 70 Derived 14-Mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors on Peripheral Blood T Cells, B Cells and NKT Cells
- (2016) Ilona Hromadnikova et al. PLoS One
- RECORD-2: phase II randomized study of everolimus and bevacizumab versus interferon α-2a and bevacizumab as first-line therapy in patients with metastatic renal cell carcinoma
- (2015) A. Ravaud et al. ANNALS OF ONCOLOGY
- A phase I trial combining carboplatin/doxorubicin with tocilizumab, an anti-IL-6R monoclonal antibody, and interferon-α2b in patients with recurrent epithelial ovarian cancer
- (2015) E. M. Dijkgraaf et al. ANNALS OF ONCOLOGY
- Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells
- (2015) M Ricciardi et al. BRITISH JOURNAL OF CANCER
- Interleukin-12 enhances the function and anti-tumor activity in murine and human CD8+ T cells
- (2015) Mark P. Rubinstein et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Thymosin alpha1 enhanced cytotoxicity of iNKT cells against colon cancer via upregulating CD1d expression
- (2015) Chao Ni et al. CANCER LETTERS
- Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma
- (2015) L. Zhang et al. CLINICAL CANCER RESEARCH
- GM-CSF: An immune modulatory cytokine that can suppress autoimmunity
- (2015) Palash Bhattacharya et al. CYTOKINE
- T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
- (2015) Itay Raphael et al. CYTOKINE
- A phase I/II trial of interleukin-15–stimulated natural killer cell infusion after haplo-identical stem cell transplantation for pediatric refractory solid tumors
- (2015) Antonio Pérez-Martínez et al. CYTOTHERAPY
- Regulatory B Cells: Origin, Phenotype, and Function
- (2015) Elizabeth C. Rosser et al. IMMUNITY
- The evolution of natural killer cell receptors
- (2015) Paola Carrillo-Bustamante et al. IMMUNOGENETICS
- Practical NK cell phenotyping and variability in healthy adults
- (2015) Laura S. Angelo et al. IMMUNOLOGIC RESEARCH
- Redistribution, Hyperproliferation, Activation of Natural Killer Cells and CD8 T Cells, and Cytokine Production During First-in-Human Clinical Trial of Recombinant Human Interleukin-15 in Patients With Cancer
- (2015) Kevin C. Conlon et al. JOURNAL OF CLINICAL ONCOLOGY
- IL-9 inhibits HTB-72 melanoma cell growth through upregulation of p21 and TRAIL
- (2015) Yujiang Fang et al. JOURNAL OF SURGICAL ONCOLOGY
- NHS-IL2 combined with radiotherapy: preclinical rationale and phase Ib trial results in metastatic non-small cell lung cancer following first-line chemotherapy
- (2015) Michel M van den Heuvel et al. Journal of Translational Medicine
- Favorable in vitro effects of combined IL-12 and IL-18 treatment on NK cell cytotoxicity and CD25 receptor expression in metastatic melanoma patients
- (2015) Katarina Mirjačić Martinović et al. Journal of Translational Medicine
- Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial
- (2015) Encouse B Golden et al. LANCET ONCOLOGY
- Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire
- (2015) Tanya Dimova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients
- (2015) Xin Wei et al. TUMOR BIOLOGY
- Characterization of tumor infiltrating natural killer cell subset
- (2015) Inbar Levi et al. Oncotarget
- Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α
- (2015) Eyad Elkord et al. Oncotarget
- CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients
- (2015) Li Yang et al. Oncotarget
- Monocyte-Derived Dendritic Cells Are Essential for CD8+ T Cell Activation and Antitumor Responses After Local Immunotherapy
- (2015) Sabine Kuhn et al. Frontiers in Immunology
- Impaired Function of CD4+ T Follicular Helper (Tfh) Cells Associated with Hepatocellular Carcinoma Progression
- (2015) Yiqiong Jia et al. PLoS One
- The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer
- (2015) Antonino Bruno et al. NEOPLASIA
- Phase II clinical trial of ex vivo-expanded cytokine-induced killer cells therapy in advanced pancreatic cancer
- (2014) Moon Jae Chung et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Interleukin 12: still a promising candidate for tumor immunotherapy?
- (2014) Witold Lasek et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Therapeutic DC vaccination with IL-2 as a consolidation therapy for ovarian cancer patients: a phase I/II trial
- (2014) Soyoung Baek et al. Cellular & Molecular Immunology
- Plasmacytoid dendritic cells, a role in neoplastic prevention and progression
- (2014) Vincent C. Lombardi et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- γδT17 Cells Promote the Accumulation and Expansion of Myeloid-Derived Suppressor Cells in Human Colorectal Cancer
- (2014) Pin Wu et al. IMMUNITY
- Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties
- (2014) Marc Descatoire et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Human Thymocytes Are Functionally Immature and Differentiate into Cytotoxic Type 1 Effector T Cells upon IL-2/IL-15 Signaling
- (2014) J. C. Ribot et al. JOURNAL OF IMMUNOLOGY
- CD56brightPerforinlow Noncytotoxic Human NK Cells Are Abundant in Both Healthy and Neoplastic Solid Tissues and Recirculate to Secondary Lymphoid Organs via Afferent Lymph
- (2014) P. Carrega et al. JOURNAL OF IMMUNOLOGY
- GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis
- (2014) H.-J. Ko et al. JOURNAL OF IMMUNOLOGY
- Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with high-dose Interleukin-2: evaluation of biomarkers of immunologic and therapeutic response
- (2014) Laura Ridolfi et al. Journal of Translational Medicine
- Clinical use of dendritic cells for cancer therapy
- (2014) Sébastien Anguille et al. LANCET ONCOLOGY
- Decreased expression of NKG2D, NKp46, DNAM-1 receptors, and intracellular perforin and STAT-1 effector molecules in NK cells and their dim and bright subsets in metastatic melanoma patients
- (2014) Katarina M. Mirjačić Martinović et al. MELANOMA RESEARCH
- Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model
- (2014) Tobias Brodbeck et al. Molecular Cancer
- The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells
- (2014) Frédérique Végran et al. NATURE IMMUNOLOGY
- IL-12 Directs Further Maturation of Ex Vivo Differentiated NK Cells with Improved Therapeutic Potential
- (2014) Dorit Lehmann et al. PLoS One
- Enrichment of CD56dimKIR+CD57+ highly cytotoxic NK cells in tumour-infiltrated lymph nodes of melanoma patients
- (2014) Talib Hassan Ali et al. Nature Communications
- Interferon-γ and celecoxib inhibit lung-tumor growth through modulating M2/M1 macrophage ratio in the tumor microenvironment
- (2014) Lunxu Liu et al. Drug Design Development and Therapy
- CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful
- (2014) H.-J. Kim et al. Cancer Immunology Research
- Plasticity of Human CD4 T Cell Subsets
- (2014) Jens Geginat et al. Frontiers in Immunology
- Type II natural killer T cells foster the antitumor activity of CpG-oligodeoxynucleotides
- (2014) Jie Zhao et al. OncoImmunology
- Recombinant interleukin-21 plus sorafenib for metastatic renal cell carcinoma: a phase 1/2 study
- (2014) Shailender Bhatia et al. Journal for ImmunoTherapy of Cancer
- IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells
- (2013) M. F. Pascutti et al. BLOOD
- Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1–Cα1 germline transcription in epithelial cancer cells
- (2013) Zhi Duan et al. Cellular & Molecular Immunology
- CD137 as a Biomarker for Tumor-Reactive T Cells: Finding Gold in the Desert
- (2013) Y. Zhu et al. CLINICAL CANCER RESEARCH
- CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor
- (2013) Q. Ye et al. CLINICAL CANCER RESEARCH
- Lineage relationship of effector and memory T cells
- (2013) Nicholas P Restifo et al. CURRENT OPINION IN IMMUNOLOGY
- The who's who of T-cell differentiation: Human memory T-cell subsets
- (2013) Yolanda D. Mahnke et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Phase I trial of a formulated IL-12 plasmid in combination with carboplatin and docetaxel chemotherapy in the treatment of platinum-sensitive recurrent ovarian cancer
- (2013) Khursheed Anwer et al. GYNECOLOGIC ONCOLOGY
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- (2013) Elodie Segura et al. IMMUNITY
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- (2013) Erin E. West et al. JOURNAL OF CLINICAL INVESTIGATION
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- (2013) B. B. Ding et al. JOURNAL OF IMMUNOLOGY
- Distinct Chemokine Receptor Axes Regulate Th9 Cell Trafficking to Allergic and Autoimmune Inflammatory Sites
- (2013) E. E. Kara et al. JOURNAL OF IMMUNOLOGY
- Multiplex and Genome-Wide Analyses Reveal Distinctive Properties of KIR+ and CD56+ T Cells in Human Blood
- (2013) W. K. Chan et al. JOURNAL OF IMMUNOLOGY
- OX40L/Jagged1 Cosignaling by GM-CSF-Induced Bone Marrow-Derived Dendritic Cells Is Required for the Expansion of Functional Regulatory T Cells
- (2013) A. Gopisetty et al. JOURNAL OF IMMUNOLOGY
- Comprehensive analysis of the percentage of surface receptors and cytotoxic granules positive natural killer cells in patients with pancreatic cancer, gastric cancer, and colorectal cancer
- (2013) Yun-Peng Peng et al. Journal of Translational Medicine
- Macrophage biology in development, homeostasis and disease
- (2013) Thomas A. Wynn et al. NATURE
- Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model
- (2013) T. A. Cheema et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
- (2013) S. Malchow et al. SCIENCE
- CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation
- (2013) F. Flores-Borja et al. Science Translational Medicine
- Inflammatory dendritic cells in mice and humans
- (2013) Elodie Segura et al. TRENDS IN IMMUNOLOGY
- IL-21 in cancer immunotherapy
- (2013) Saskia JAM Santegoets et al. OncoImmunology
- The Tumor Microenvironment: A Pitch for Multiple Players
- (2013) Giovanna Schiavoni et al. Frontiers in Oncology
- GM-CSF promotes inflammatory dendritic cell formation but does not contribute to disease progression in experimental autoimmune myocarditis
- (2012) Przemyslaw Blyszczuk et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities
- (2012) J. Tel et al. BLOOD
- IL-21 inhibits T cell IL-2 production and impairs Treg homeostasis
- (2012) K. Attridge et al. BLOOD
- A phase 1 trial of recombinant human IL-21 in combination with cetuximab in patients with metastatic colorectal cancer
- (2012) N Steele et al. BRITISH JOURNAL OF CANCER
- A Phase I Dose-Finding Trial of Recombinant Interleukin-21 and Rituximab in Relapsed and Refractory Low Grade B-cell Lymphoproliferative Disorders
- (2012) J. M. Timmerman et al. CLINICAL CANCER RESEARCH
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- (2012) Dick J. Pang et al. IMMUNOLOGY
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- (2012) Wei Li et al. INFECTION AND IMMUNITY
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- (2012) Zhaoyang Li et al. INTERNATIONAL JOURNAL OF CANCER
- Cancer immunoediting by the innate immune system in the absence of adaptive immunity
- (2012) Timothy O’Sullivan et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cancer and Innate Immune System Interactions
- (2012) Yanan Liu et al. JOURNAL OF IMMUNOTHERAPY
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- (2012) Nina Linde et al. JOURNAL OF PATHOLOGY
- Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
- (2012) Ayumi Yoshizaki et al. NATURE
- Robust tumor immunity to melanoma mediated by interleukin-9–producing T cells
- (2012) Rahul Purwar et al. NATURE MEDICINE
- Activation of Invariant NKT Cells with Glycolipid Ligand α-Galactosylceramide Ameliorates Glucose-6-Phosphate Isomerase Peptide-Induced Arthritis
- (2012) Masanobu Horikoshi et al. PLoS One
- Human Th17 cells in patients with cancer
- (2012) Tim F. Greten et al. OncoImmunology
- Plasmacytoid dendritic cells deficient in IFNα production promote the amplification of FOXP3+regulatory T cells and are associated with poor prognosis in breast cancer patients
- (2012) Vanja Sisirak et al. OncoImmunology
- Sulfatide-activated type II NKT cells prevent allergic airway inflammation by inhibiting type I NKT cell function in a mouse model of asthma
- (2011) Guqin Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung
- (2011) Zvi Granot et al. CANCER CELL
- Alternative activation of tumor-associated macrophages by IL-4
- (2011) Hao-Wei Wang et al. CELL CYCLE
- Anti-γδ TCR antibody-expanded γδ T cells: a better choice for the adoptive immunotherapy of lymphoid malignancies
- (2011) Jianhua Zhou et al. Cellular & Molecular Immunology
- Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis
- (2011) Alon Y. Hershko et al. IMMUNITY
- IL-12 inhibits the TGF-β-dependent T cell developmental programs and skews the TGF-β-induced differentiation into a Th1-like direction
- (2011) Jana Prochazkova et al. IMMUNOBIOLOGY
- Structure/function of human killer cell immunoglobulin-like receptors: lessons from polymorphisms, evolution, crystal structures and mutations
- (2011) Kerry S. Campbell et al. IMMUNOLOGY
- The regulation and role of T follicular helper cells in immunity
- (2011) Elissa K. Deenick et al. IMMUNOLOGY
- Regulation of effector and memory T-cell functions by type I interferon
- (2011) Jonathan P. Huber et al. IMMUNOLOGY
- Type I interferon is selectively required by dendritic cells for immune rejection of tumors
- (2011) Mark S. Diamond et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Proliferating Cell Nuclear Antigen Is a Novel Inhibitory Ligand for the Natural Cytotoxicity Receptor NKp44
- (2011) B. Rosental et al. JOURNAL OF IMMUNOLOGY
- Merkel cell carcinoma induces lymphatic microvessel formation
- (2011) Siegfried Werchau et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Characterization of intratumoral follicular helper T cells in follicular lymphoma: role in the survival of malignant B cells
- (2011) P Amé-Thomas et al. LEUKEMIA
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- The Accumulation and Prognosis Value of Tumor Infiltrating IL-17 Producing Cells in Esophageal Squamous Cell Carcinoma
- (2011) Lin Lv et al. PLoS One
- A phase II study of the cancer vaccine TG4010 alone and in combination with cytokines in patients with metastatic renal clear-cell carcinoma: clinical and immunological findings
- (2010) Stéphane Oudard et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
- (2010) S. P. Kerkar et al. CANCER RESEARCH
- Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8+ T cells
- (2010) Sandra Hervas-Stubbs et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- IL-10 produced by activated human B cells regulates CD4+ T-cell activation in vitro
- (2010) Jean-David Bouaziz et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
- (2010) V. Gocheva et al. GENES & DEVELOPMENT
- Overview of the immune response
- (2010) David D. Chaplin JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model
- (2010) Jadwiga Jablonska et al. JOURNAL OF CLINICAL INVESTIGATION
- Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells
- (2010) Lionel Franz Poulin et al. JOURNAL OF EXPERIMENTAL MEDICINE
- IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism
- (2010) Dimitra Zotos et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cutting Edge: Type I IFN Reverses Human Th2 Commitment and Stability by Suppressing GATA3
- (2010) J. P. Huber et al. JOURNAL OF IMMUNOLOGY
- GM-CSF Is an Essential Regulator of T Cell Activation Competence in Uterine Dendritic Cells during Early Pregnancy in Mice
- (2010) L. M. Moldenhauer et al. JOURNAL OF IMMUNOLOGY
- IFN- Inhibits Dendritic Cell Migration through STAT-1-Mediated Transcriptional Suppression of CCR7 and Matrix Metalloproteinase 9
- (2010) J.-H. Yen et al. JOURNAL OF IMMUNOLOGY
- B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
- (2010) Massimo Ammirante et al. NATURE
- Regulation of IL-9 expression by IL-25 signaling
- (2010) Pornpimon Angkasekwinai et al. NATURE IMMUNOLOGY
- Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
- (2010) J. D. Shields et al. SCIENCE
- GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF- converting enzyme (TACE)
- (2009) M. Hiasa et al. BLOOD
- Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
- (2009) Zvi G. Fridlender et al. CANCER CELL
- Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages
- (2009) T. D. Eubank et al. CANCER RESEARCH
- Clinical and Biological Efficacy of Recombinant Human Interleukin-21 in Patients with Stage IV Malignant Melanoma without Prior Treatment: A Phase IIa Trial
- (2009) I. D. Davis et al. CLINICAL CANCER RESEARCH
- Clinical and Immunologic Effects of Intranodal Autologous Tumor Lysate-Dendritic Cell Vaccine with Aldesleukin (Interleukin 2) and IFN- 2a Therapy in Metastatic Renal Cell Carcinoma Patients
- (2009) T. Schwaab et al. CLINICAL CANCER RESEARCH
- Prognostic implications of circulating anti-p53 antibodies in lung cancer - a review
- (2009) S. KUMAR et al. EUROPEAN JOURNAL OF CANCER CARE
- Multiple tissue-specific isoforms of sulfatide activate CD1d-restricted type II NKT cells
- (2009) Maria Blomqvist et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling
- (2009) Yeonseok Chung et al. IMMUNITY
- Activated CD8+ T-Effector/Memory Cells Eliminate CD4+ CD25+ Foxp3+ T-Suppressor Cells from Tumors via FasL Mediated Apoptosis
- (2009) M. O. Kilinc et al. JOURNAL OF IMMUNOLOGY
- IFN- Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity
- (2009) A. G. Sikora et al. JOURNAL OF IMMUNOLOGY
- IL-21 Mediates Suppressive Effects via Its Induction of IL-10
- (2009) R. Spolski et al. JOURNAL OF IMMUNOLOGY
- Efficient Killing of Human Colon Cancer Stem Cells by T Lymphocytes
- (2009) M. Todaro et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: TGF- 1 and IL-15 Induce FOXP3+ Regulatory T Cells in the Presence of Antigen Stimulation
- (2009) R. Casetti et al. JOURNAL OF IMMUNOLOGY
- Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
- (2009) M. Balsamo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy
- (2008) C. S. Hinrichs et al. BLOOD
- Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells
- (2008) S. Agaugue et al. BLOOD
- Inflammation-associated lysophospholipids as ligands for CD1d-restricted T cells in human cancer
- (2008) D. H. Chang et al. BLOOD
- B lymphocytes: how they develop and function
- (2008) T. W. LeBien et al. BLOOD
- Human natural killer cells
- (2008) M. A. Caligiuri BLOOD
- Restoration of Tumor Immunosurveillance via Targeting of Interleukin-13 Receptor- 2
- (2008) S. Fichtner-Feigl et al. CANCER RESEARCH
- Relationship between CD107a expression and cytotoxic activity
- (2008) Esin Aktas et al. CELLULAR IMMUNOLOGY
- Isopentenyl Pyrophosphate-Activated CD56+ T Lymphocytes Display Potent Antitumor Activity toward Human Squamous Cell Carcinoma
- (2008) A. A.Z. Alexander et al. CLINICAL CANCER RESEARCH
- A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells
- (2008) Alexis Vogelzang et al. IMMUNITY
- CD56brightnatural killer (NK) cells: an important NK cell subset
- (2008) Aurélie Poli et al. IMMUNOLOGY
- Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma
- (2008) John A. Thompson et al. JOURNAL OF CLINICAL ONCOLOGY
- Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset
- (2008) Marc Veldhoen et al. NATURE IMMUNOLOGY
- Interleukin-21 activates human natural killer cells and modulates their surface receptor expression
- (2007) Kresten Skak et al. IMMUNOLOGY
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