Anti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma

Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients

(2018) Jiayi Yu et al.   Journal of Hematology & Oncology

Antitumor activity of EGFR-specific CAR T cells against non-small-cell lung cancer cells in vitro and in mice

(2018) He Li et al.   Cell Death & Disease

Redirecting T Cells to Glypican-3 with 4-1BB Zeta Chimeric Antigen Receptors Results in Th1 Polarization and Potent Antitumor Activity

(2017) Wenpeng Li et al.   HUMAN GENE THERAPY

Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial

(2017) Hussein A Tawbi et al.   LANCET ONCOLOGY

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Development of CAR T cells designed to improve antitumor efficacy and safety

(2017) Janneke E. Jaspers et al.   PHARMACOLOGY & THERAPEUTICS

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

(2017) Marie-Françoise Heymann et al.   CELLULAR IMMUNOLOGY

Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets

(2016) Guang-Ning Yan et al.   CANCER LETTERS

Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor

(2016) Xuemei Jiang et al.   Frontiers in Immunology

Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial

(2015) Stefan S. Bielack et al.   JOURNAL OF CLINICAL ONCOLOGY

Osteosarcoma: Current Treatment and a Collaborative Pathway to Success

(2015) Michael S. Isakoff et al.   JOURNAL OF CLINICAL ONCOLOGY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma

(2015) Danielle M Lussier et al.   Journal for ImmunoTherapy of Cancer

Cellular Immunotherapy for Carcinoma Using Genetically Modified EGFR-Specific T Lymphocytes

(2015) Xikun Zhou et al.   NEOPLASIA

Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-κB pathway

(2013) Zhiqiang Zhao et al.   CANCER LETTERS

The Weal and Woe of Costimulation in the Adoptive Therapy of Cancer with Chimeric Antigen Receptor (CAR)-Redirected T Cells

(2013) A. Hombach et al.   CURRENT MOLECULAR MEDICINE

Human placental trophoblasts express the immunosuppressive cytokine IL-35

(2013) Haiting Mao et al.   HUMAN IMMUNOLOGY

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD19-Targeted T Cells Rapidly Induce Molecular Remissions in Adults with Chemotherapy-Refractory Acute Lymphoblastic Leukemia

(2013) R. J. Brentjens et al.   Science Translational Medicine

New targets and approaches in osteosarcoma

(2012) Jonathan Gill et al.   PHARMACOLOGY & THERAPEUTICS

Depending on Its Nano-Spacing, ALCAM Promotes Cell Attachment and Axon Growth

(2012) Karsten Thelen et al.   PLoS One

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Genetically Modified T cells Targeting Interleukin-11 Receptor  -Chain Kill Human Osteosarcoma Cells and Induce the Regression of Established Osteosarcoma Lung Metastases

(2011) G. Huang et al.   CANCER RESEARCH

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

Sensitization of human osteosarcoma cells to Vγ9Vδ2 T-cell-mediated cytotoxicity by zoledronate

(2011) Zhaoxu Li et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Immunotherapy for Osteosarcoma: Genetic Modification of T cells Overcomes Low Levels of Tumor Antigen Expression

(2009) Nabil Ahmed et al.   MOLECULAR THERAPY

Activated leukocyte cell adhesion molecule: a new paradox in cancer

(2007) Solomon F. Ofori-Acquah et al.   Translational Research