T-cell selection in the thymus: a spatial and temporal perspective

A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes

(2015) Charles Sinclair et al.   IMMUNOLOGY AND CELL BIOLOGY

T Cell Adolescence: Maturation Events Beyond Positive Selection

(2015) Kristin A. Hogquist et al.   JOURNAL OF IMMUNOLOGY

Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition

(2015) Brian M Weist et al.   NATURE IMMUNOLOGY

Elevated T Cell Receptor Signaling Identifies a Thymic Precursor to the TCRαβ+CD4−CD8β− Intraepithelial Lymphocyte Lineage

(2014) Benjamin D. McDonald et al.   IMMUNITY

αβT Cell Receptors Expressed by CD4−CD8αβ− Intraepithelial T Cells Drive Their Fate into a Unique Lineage with Unusual MHC Reactivities

(2014) Sofia Mayans et al.   IMMUNITY

The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development

(2014) Christoph S.N. Klose et al.   IMMUNITY

Thymocyte-Dendritic Cell Interactions near Sources of CCR7 Ligands in the Thymic Cortex

(2014) E. Ladi et al.   JOURNAL OF IMMUNOLOGY

Overlapping and Asymmetric Functions of TCR Signaling during Thymic Selection of CD4 and CD8 Lineages

(2014) C. Sinclair et al.   JOURNAL OF IMMUNOLOGY

Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development

(2014) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

(2014) Guangwei Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct phases in the positive selection of CD8+ T cells distinguished by intrathymic migration and T-cell receptor signaling patterns

(2014) J. O. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Opposing chemokine gradients control human thymocyte migration in situ

(2013) Joanna Halkias et al.   JOURNAL OF CLINICAL INVESTIGATION

The thymic medulla is required for Foxp3+regulatory but not conventional CD4+thymocyte development

(2013) Jennifer E. Cowan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helios marks strongly autoreactive CD4+T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB

(2013) Stephen R. Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Themis sets the signal threshold for positive and negative selection in T-cell development

(2013) Guo Fu et al.   NATURE

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

(2013) R. S. Paiva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine thymic selection quantified using a unique method to capture deleted T cells

(2013) G. L. Stritesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system

(2013) C. Sinclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Temporal Patterns of T Cell Receptor Signaling During Positive Versus Negative Selection in Situ

(2013) H. J. Melichar et al.   Science Signaling

Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection

(2013) Ivan Lilyanov Dzhagalov et al.   PLOS BIOLOGY

Selection of Self-Reactive T Cells in the Thymus

(2012) Gretta L. Stritesky et al.   Annual Review of Immunology

β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+ T cells

(2012) Yousuke Takahama et al.   CURRENT OPINION IN IMMUNOLOGY

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

(2012) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

Thymic epithelial cells: working class heroes for T cell development and repertoire selection

(2012) Graham Anderson et al.   TRENDS IN IMMUNOLOGY

Regulation of Zap70 Expression During Thymocyte Development Enables Temporal Separation of CD4 and CD8 Repertoire Selection at Different Signaling Thresholds

(2010) M. Saini et al.   Science Signaling

Spatial Mapping of Thymic Stromal Microenvironments Reveals Unique Features Influencing T Lymphoid Differentiation

(2009) Ann V. Griffith et al.   IMMUNITY

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The impact of negative selection on thymocyte migration in the medulla

(2009) Marie Le Borgne et al.   NATURE IMMUNOLOGY

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

(2009) G. Wirnsberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Differentiation of regulatory Foxp3+ T cells in the thymic cortex

(2008) A. Liston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA