Preclinical Development of Orally Inhaled Drugs (OIDs)—Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?

Inhalation therapy devices for the treatment of obstructive lung diseases: the history of inhalers towards the ideal inhaler

(2020) Claudio Sorino et al.   European Journal of Internal Medicine

Innovative preclinical models for pulmonary drug delivery research

(2020) Stephan Ehrmann et al.   Expert Opinion on Drug Delivery

Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccines

(2020) Francois Busquet et al.   ARCHIVES OF TOXICOLOGY

Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture

(2020) Julia A. Gindele et al.   Scientific Reports

Organoids as a Powerful Model for Respiratory Diseases

(2020) Yu Li et al.   Stem Cells International

In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective

(2020) Dania Movia et al.   Frontiers in Bioengineering and Biotechnology

Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips

(2019) Veronika Sedláková et al.   DRUG DISCOVERY TODAY

Delivery Technologies for Orally Inhaled Products: an Update

(2019) Chaeho Moon et al.   AAPS PHARMSCITECH

Recent advances in aerosolised drug delivery

(2019) Akshay Chandel et al.   BIOMEDICINE & PHARMACOTHERAPY

Biomimetic human lung-on-a-chip for modeling disease investigation

(2019) Kaiyan Li et al.   Biomicrofluidics

In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration

(2019) Thomas Sécher et al.   JOURNAL OF CONTROLLED RELEASE

Biological Obstacles for Identifying In Vitro-In Vivo Correlations of Orally Inhaled Formulations

(2019) Eleonore Fröhlich   Pharmaceutics

Understanding Dry Powder Inhalers: Key Technical and Patient Preference Attributes

(2019) Mark L. Levy et al.   ADVANCES IN THERAPY

ALI multilayered co-cultures mimic biochemical mechanisms of the cancer cell-fibroblast cross-talk involved in NSCLC MultiDrug Resistance

(2019) Dania Movia et al.   BMC CANCER

Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development

(2019) Paula G. Miller et al.   BIOTECHNOLOGY AND BIOENGINEERING

Altered generation of ciliated cells in chronic obstructive pulmonary disease

(2019) Sophie Gohy et al.   Scientific Reports

Inhalation of Immuno-Therapeutics/-Prophylactics to Fight Respiratory Tract Infections: An Appropriate Drug at the Right Place!

(2019) Thomas Sécher et al.   Frontiers in Immunology

Inhalers: to switch or not to switch? That is the question

(2019) Anna Claire Murphy   THORAX

Matching Inhaler Devices with Patients: The Role of the Primary Care Physician

(2018) Alan Kaplan et al.   Canadian Respiratory Journal

Inhaled Therapy in Respiratory Disease: The Complex Interplay of Pulmonary Kinetic Processes

(2018) Jens Markus Borghardt et al.   Canadian Respiratory Journal

The Rationale and Evidence for Use of Inhaled Antibiotics to Control Pseudomonas aeruginosa Infection in Non-cystic Fibrosis Bronchiectasis

(2018) Rajiv Dhand   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Use of porous membranes in tissue barrier and co-culture models

(2018) Henry H. Chung et al.   LAB ON A CHIP

Modelling Cryptosporidium infection in human small intestinal and lung organoids

(2018) Inha Heo et al.   Nature Microbiology

A Drosophila model of cigarette smoke induced COPD identifies Nrf2 signaling as an expedient target for intervention

(2018) Ruben Prange et al.   Aging-US

Amikacin Liposome Inhalation Suspension for Treatment-Refractory Lung Disease Caused by Mycobacterium avium Complex (CONVERT): A Prospective, Open-Label, Randomized Study

(2018) David E Griffith et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Use of 3D organoids and lung-on-a-chip methods to study lung development, regeneration and disease

(2018) Konstantinos Gkatzis et al.   EUROPEAN RESPIRATORY JOURNAL

Multilayered Cultures of NSCLC cells grown at the Air-Liquid Interface allow the efficacy testing of inhaled anti-cancer drugs

(2018) Dania Movia et al.   Scientific Reports

A 3D human lung-on-a-chip model for nanotoxicity testing

(2018) Min Zhang et al.   Toxicology Research

Models of deposition, pharmacokinetics, and intersubject variability in respiratory drug delivery

(2018) Andrew R. Martin et al.   Expert Opinion on Drug Delivery

Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis

(2018) Stefano Castellani et al.   Analytical Cellular Pathology

Tissue-informed engineering strategies for modeling human pulmonary diseases

(2018) Kolene E. Bailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke

(2017) Gimano D. Amatngalim et al.   Journal of Innate Immunity

A three-dimensional model of human lung development and disease from pluripotent stem cells

(2017) Ya-Wen Chen et al.   NATURE CELL BIOLOGY

Optimizing drug delivery in COPD: The role of inhaler devices

(2017) Paola Rogliani et al.   RESPIRATORY MEDICINE

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Inhalation devices, delivery systems, and patient technique

(2016) Harold S. Nelson   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Organoids as a model system for studying human lung development and disease

(2016) Rohan R. Nadkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhalation devices: from basic science to practical use, innovative vs generic products

(2016) Michal Pirozynski et al.   Expert Opinion on Drug Delivery

Will pulmonary drug delivery for systemic application ever fulfill its rich promise?

(2016) David Cipolla   Expert Opinion on Drug Delivery

Bridging the Gap Between Science and Clinical Efficacy: Physiology, Imaging, and Modeling of Aerosols in the Lung

(2016) Chantal Darquenne et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Microengineered cancer-on-a-chip platforms to study the metastatic microenvironment

(2016) R. Portillo-Lara et al.   LAB ON A CHIP

Measurements of Deposition, Lung Surface Area and Lung Fluid for Simulation of Inhaled Compounds

(2016) Eleonore Fröhlich et al.   Frontiers in Pharmacology

Irregular and Ineffective: A Quantitative Observational Study of the Time and Technique of Inhaler Use

(2016) Imran Sulaiman et al.   Journal of Allergy and Clinical Immunology-In Practice

“Trying, But Failing” — The Role of Inhaler Technique and Mode of Delivery in Respiratory Medication Adherence

(2016) Fulvio Braido et al.   Journal of Allergy and Clinical Immunology-In Practice

Development of Liposomal Ciprofloxacin to Treat Lung Infections

(2016) David Cipolla et al.   Pharmaceutics

In Vitro Testing for Orally Inhaled Products: Developments in Science-Based Regulatory Approaches

(2015) Ben Forbes et al.   AAPS Journal

Pharmacometric Models for Characterizing the Pharmacokinetics of Orally Inhaled Drugs

(2015) Jens Markus Borghardt et al.   AAPS Journal

Translational models of lung disease

(2015) Paul F. Mercer et al.   CLINICAL SCIENCE

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

Global incidence and mortality of idiopathic pulmonary fibrosis: a systematic review

(2015) John Hutchinson et al.   EUROPEAN RESPIRATORY JOURNAL

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Patient Education and Adherence to Aerosol Therapy

(2015) A. Ari   Respiratory Care

Human tissue models for a human disease: what are the barriers?

(2015) J. Edwards et al.   THORAX

In vitro generation of human pluripotent stem cell derived lung organoids

(2015) Briana R Dye et al.   eLife

Adapting the Electrospinning Process to Provide Three Unique Environments for a Tri-layered In Vitro Model of the Airway Wall

(2015) Jack C. Bridge et al.   Jove-Journal of Visualized Experiments

Developing Ways to Evaluate in the Laboratory How Inhalation Devices Will Be Used by Patients and Care-Givers: The Need for Clinically Appropriate Testing

(2014) Jolyon P. Mitchell et al.   AAPS PHARMSCITECH

Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses

(2014) Ben Forbes et al.   ADVANCED DRUG DELIVERY REVIEWS

Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration

(2014) Darcy E. Wagner et al.   BIOMATERIALS

Modeling the lung: Design and development of tissue engineered macro- and micro-physiologic lung models for research use

(2014) Joan E Nichols et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A novel electrospun biphasic scaffold provides optimal three-dimensional topography forin vitroco-culture of airway epithelial and fibroblast cells

(2014) G E Morris et al.   Biofabrication

In vitro, in vivo and ex vivo models for studying particle deposition and drug absorption of inhaled pharmaceuticals

(2013) Kamrun Nahar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The impact of pulmonary diseases on the fate of inhaled medicines—A review

(2013) Yi-Bo Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Validation of a General In Vitro Approach for Prediction of Total Lung Deposition in Healthy Adults for Pharmaceutical Inhalation Products

(2013) Bo Olsson et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges

(2013) Christian A Ruge et al.   Lancet Respiratory Medicine

Inhaler competence in asthma: Common errors, barriers to use and recommended solutions

(2012) D. Price et al.   RESPIRATORY MEDICINE

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

(2012) Dongeun Huh et al.   Science Translational Medicine

Animal models of asthma: value, limitations and opportunities for alternative approaches

(2011) Anthony M. Holmes et al.   DRUG DISCOVERY TODAY

Cytochrome P450–Mediated Pulmonary Metabolism of Carcinogens

(2010) Sisko Anttila et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Modeling human diseases in Caenorhabditis elegans

(2010) Maria Markaki et al.   Biotechnology Journal

C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes

(2010) Shahid S. Siddiqui et al.   CANCER BIOLOGY & THERAPY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

What can Dictyostelium bring to the study of Pseudomonas infections?

(2010) Wanessa C. Lima et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Drosophilain Asthma Research

(2009) Thomas Roeder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Usingin vivozebrafish models to understand the biochemical basis of neutrophilic respiratory disease

(2009) Jane S. Martin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes

(2009) A. C. Kirby et al.   JOURNAL OF IMMUNOLOGY

Association of Inhalation Toxicologists (AIT) Working Party Recommendation for Standard Delivered Dose Calculation and Expression in Non-Clinical Aerosol Inhalation Toxicology Studies with Pharmaceuticals

(2008) David J. Alexander et al.   INHALATION TOXICOLOGY

Modeling Molecular and Cellular Aspects of Human Disease Using the Nematode Caenorhabditis elegans

(2008) Gary A Silverman et al.   PEDIATRIC RESEARCH