Potential therapeutic uses of BDNF in neurological and psychiatric disorders

Increase of BDNF Serum Concentration in Lithium Treated Patients with Early Alzheimer's Disease

(2017) Thomas Leyhe et al.   JOURNAL OF ALZHEIMERS DISEASE

Fine-mapping of the brain-derived neurotrophic factor (BDNF) gene supports an association of the Val66Met polymorphism with episodic memory

(2010) Flurin Cathomas et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents

(2010) Stephen M. Massa et al.   JOURNAL OF CLINICAL INVESTIGATION

Global Deprivation of Brain-Derived Neurotrophic Factor in the CNS Reveals an Area-Specific Requirement for Dendritic Growth

(2010) S. Rauskolb et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

(2010) K. I. Erickson et al.   JOURNAL OF NEUROSCIENCE

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Real-time MR Imaging With Gadoteridol Predicts Distribution of Transgenes After Convection-enhanced Delivery of AAV2 Vectors

(2010) Xiaomin Su et al.   MOLECULAR THERAPY

Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC

(2010) Piotr Hadaczek et al.   MOLECULAR THERAPY

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

Long-Distance Control of Synapse Assembly by Target-Derived NGF

(2010) Nikhil Sharma et al.   NEURON

Novel Insights into Lithium’s Mechanism of Action: Neurotrophic and Neuroprotective Effects

(2010) Jorge A. Quiroz et al.   NEUROPSYCHOBIOLOGY

Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons

(2010) Hisatsugu Koshimizu et al.   NEUROSCIENCE LETTERS

Exercise improves cognition and hippocampal plasticity in APOE ε4 mice

(2009) Kathryn Nichol et al.   Alzheimers & Dementia

Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene

(2009) Tania L. Roth et al.   BIOLOGICAL PSYCHIATRY

Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies

(2009) Łukasz R. Drzyzga et al.   BRAIN RESEARCH BULLETIN

Review of Lithium Effects on Brain and Blood

(2009) Wise Young   CELL TRANSPLANTATION

Molecular therapy of obesity and diabetes by a physiological autoregulatory approach

(2009) Lei Cao et al.   NATURE MEDICINE

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury

(2009) Laura Taylor Alto et al.   NATURE NEUROSCIENCE

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease

(2009) C. W. Christine et al.   NEUROLOGY

EXPRESSION, BIOACTIVITY, AND SAFETY 1 YEAR AFTER ADENO-ASSOCIATED VIRAL VECTOR TYPE 2–MEDIATED DELIVERY OF NEURTURIN TO THE MONKEY NIGROSTRIATAL SYSTEM SUPPORT CERE-120 FOR PARKINSON'S DISEASE

(2009) Christopher D. Herzog et al.   NEUROSURGERY

Amyotrophic lateral sclerosis

(2009) Lokesh C Wijesekera et al.   Orphanet Journal of Rare Diseases

Induction of corticospinal regeneration by lentiviral trkB-induced Erk activation

(2009) E. R. Hollis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease

(2009) M. Blurton-Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice

(2009) D. A. Simmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

(2008) Srijan Sen et al.   BIOLOGICAL PSYCHIATRY

Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance

(2008) Aya Fujinami et al.   CLINICAL BIOCHEMISTRY

Dietary restriction started after spinal cord injury improves functional recovery

(2008) Ward T. Plunet et al.   EXPERIMENTAL NEUROLOGY

AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment

(2008) A P Kells et al.   GENE THERAPY

Treatment of Late Infantile Neuronal Ceroid Lipofuscinosis by CNS Administration of a Serotype 2 Adeno-Associated Virus Expressing CLN2 cDNA

(2008) Stefan Worgall et al.   HUMAN GENE THERAPY

A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression

(2008) André Russowsky Brunoni et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Clathrin-dependent Endocytosis Is Required for TrkB-dependent Akt-mediated Neuronal Protection and Dendritic Growth

(2008) Jing Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

(2008) F. D. Lubin et al.   JOURNAL OF NEUROSCIENCE

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder

(2008) M Kato et al.   MOLECULAR PSYCHIATRY

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Real-time MR imaging of adeno-associated viral vector delivery to the primate brain

(2008) Massimo S. Fiandaca et al.   NEUROIMAGE

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

BDNF–exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats

(2008) Z. Ying et al.   NEUROSCIENCE

BDNFgene: functional Val66Met polymorphism in mood disorders and schizophrenia

(2008) Janusz K Rybakowski   PHARMACOGENOMICS

Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines

(2008) J.-i. Tanaka et al.   SCIENCE

Brain-Derived Neurotrophic Factor But Not Forced Arm Use Improves Long-Term Outcome After Photothrombotic Stroke and Transiently Upregulates Binding Densities of Excitatory Glutamate Receptors in the Rat Brain

(2008) Harald D. Müller et al.   STROKE

Spinal cord injury: plasticity, regeneration and the challenge of translational drug development

(2008) Armin Blesch et al.   TRENDS IN NEUROSCIENCES