The Role of MicroRNAs in Repair Processes in Multiple Sclerosis

Differential Expression of miRNAs and Behavioral Change in the Cuprizone-Induced Demyelination Mouse Model

(2020) Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

(2020) Iñaki Osorio-Querejeta et al.   Pharmaceutics

In vivo silencing of miR‐125a‐3p promotes myelin repair in models of white matter demyelination

(2020) Davide Marangon et al.   GLIA

Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury

(2020) Tuo Yang et al.   Frontiers in Cellular Neuroscience

Expression of disease‐related mi RNA s in white‐matter lesions of progressive multiple sclerosis brains

(2019) Ajai Tripathi et al.   Annals of Clinical and Translational Neurology

A critical role for miR-184 in the fate determination of oligodendrocytes

(2019) Negin Afrang et al.   Stem Cell Research & Therapy

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Transplantation of miR‐219 overexpressed human endometrial stem cells encapsulated in fibrin hydrogel in spinal cord injury

(2019) Marzie Jalali Monfared et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Low frequency pulsed electromagnetic field promotes differentiation of oligodendrocyte precursor cells through upregulation of miR-219-5p in vitro

(2019) Fei Yao et al.   LIFE SCIENCES

MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis

(2019) Jing Zhang et al.   NEUROBIOLOGY OF DISEASE

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Nanomodulation of Macrophages in Multiple Sclerosis

(2019) Frances K. Nally et al.   Cells

MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis

(2019) Barbara Morquette et al.   BRAIN

Down-regulation of taurine-up-regulated gene 1 attenuates inflammation by sponging miR-9-5p via targeting NF-κB1/p50 in multiple sclerosis

(2019) Peijian Yue et al.   LIFE SCIENCES

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

(2019) Simon Faissner et al.   NATURE REVIEWS DRUG DISCOVERY

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

(2019)   SCIENCE

MiR-125a-5p Regulates Vitamin D Receptor Expression in a Mouse Model of Experimental Autoimmune Encephalomyelitis

(2019) Han-Chun Long et al.   Neuroscience Bulletin

Astrocytes in the Pathogenesis of Multiple Sclerosis: An In Situ MicroRNA Study

(2019) Vijayaraghava T S Rao et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Astrocytes in myelination and remyelination

(2019) Irene Molina-Gonzalez et al.   NEUROSCIENCE LETTERS

miRNAs as Therapeutic Targets in Inflammatory Disease

(2019) Qianjin Lu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination

(2019) Ajai Tripathi et al.   Cell Reports

MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration

(2019) Paweł Piatek et al.   Cells

Oligodendrocytes in Development, Myelin Generation and Beyond

(2019) Sarah Kuhn et al.   Cells

From OPC to Oligodendrocyte: An Epigenetic Journey

(2019) Assia Tiane et al.   Cells

Intranasal Administration of miR-146a Agomir Rescued the Pathological Process and Cognitive Impairment in an AD Mouse Model

(2019) Hui Mai et al.   Molecular Therapy-Nucleic Acids

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

(2018) Ilaria Prada et al.   ACTA NEUROPATHOLOGICA

Exosomal cargo-loading and synthetic exosome-mimics as potential therapeutic tools

(2018) Song-pei Li et al.   ACTA PHARMACOLOGICA SINICA

Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR-136-5p and long non-coding RNA HOTAIR in cuprizone-induced demyelination

(2018) Chenfan Duan et al.   BIOCHEMICAL PHARMACOLOGY

Human miR-26a-5p regulates the glutamate transporter SLC1A1 (EAAT3) expression. Relevance in multiple sclerosis

(2018) Nicoletta Potenza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Analysis of the expression of mir-34a, mir-199a, mir-30c and mir-19a in peripheral blood CD4+T lymphocytes of relapsing-remitting multiple sclerosis patients

(2018) Nooshin Ghadiri et al.   GENE

Animal models of multiple sclerosis: Focus on experimental autoimmune encephalomyelitis

(2018) Ivana Bjelobaba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Multiple sclerosis

(2018) Alan J Thompson et al.   LANCET

Clinical use of lentiviral vectors

(2018) Michael C. Milone et al.   LEUKEMIA

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Microglia-Astrocyte Crosstalk: An Intimate Molecular Conversation

(2018) Mithilesh Kumar Jha et al.   NEUROSCIENTIST

MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer

(2018) Hui-Ming Lin et al.   Scientific Reports

The Role of Astrocytes in Multiple Sclerosis

(2018) Gerald Ponath et al.   Frontiers in Immunology

Experimental Demyelination and Axonal Loss Are Reduced in MicroRNA-146a Deficient Mice

(2018) Nellie A. Martin et al.   Frontiers in Immunology

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

(2018) Yan Li et al.   Autophagy

The First Dose of Fingolimod Affects Circulating Extracellular Vesicles in Multiple Sclerosis Patients

(2018) Matías Sáenz-Cuesta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis

(2018) Camille A. Juźwik et al.   Scientific Reports

The formation of a glial scar does not prohibit remyelination in an animal model of multiple sclerosis

(2018) Michaela Tanja Haindl et al.   GLIA

miR‐223 promotes regenerative myeloid cell phenotype and function in the demyelinated central nervous system

(2018) Dylan A. Galloway et al.   GLIA

Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

(2018) Ulla Milbreta et al.   MOLECULAR THERAPY

Regenerating CNS myelin: Emerging roles of regulatory T cells and CCN proteins

(2018) Nira de la Vega Gallardo et al.   NEUROCHEMISTRY INTERNATIONAL

Microglia in Central Nervous System Inflammation and Multiple Sclerosis Pathology

(2018) Sofie Voet et al.   TRENDS IN MOLECULAR MEDICINE

Therapeutic Potential of Extracellular Vesicles for Demyelinating Diseases; Challenges and Opportunities

(2018) Iñaki Osorio-Querejeta et al.   Frontiers in Molecular Neuroscience

miR-219 attenuates demyelination in cuprizone-induced demyelinated mice by regulating monocarboxylate transporter 1

(2017) Sihan Liu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Splitting the “Unsplittable”: Dissecting Resident and Infiltrating Macrophages in Experimental Autoimmune Encephalomyelitis

(2017) Tobias Koeniger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development of Novel Therapeutic Agents by Inhibition of Oncogenic MicroRNAs

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biodegradable and biocompatible cationic polymer delivering microRNA-221/222 promotes nerve regeneration after sciatic nerve crush

(2017) Jialin Song et al.   International Journal of Nanomedicine

Excessive expression of miR-27 impairs Treg-mediated immunological tolerance

(2017) Leilani O. Cruz et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity

(2017) Bo Li et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo conversion of astrocytes to myelinating cells by miR-302/367 and valproate to enhance myelin repair

(2017) Maryam Ghasemi-Kasman et al.   Journal of Tissue Engineering and Regenerative Medicine

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

MiR-146a promotes remyelination in a cuprizone model of demyelinating injury

(2017) Jing Zhang et al.   NEUROSCIENCE

Multiple sclerosis: Pathology, diagnosis and treatments

(2017) Wen-Juan Huang et al.   Experimental and Therapeutic Medicine

MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis

(2017) Xue Fang et al.   Neuroscience Bulletin

Transplanted miR-219-overexpressing oligodendrocyte precursor cells promoted remyelination and improved functional recovery in a chronic demyelinated model

(2017) Hong-Bin Fan et al.   Scientific Reports

MicroRNA-181 Variants Regulate T Cell Phenotype in the Context of Autoimmune Neuroinflammation

(2017) Samira Ghorbani et al.   Frontiers in Immunology

Beyond immunomodulation: The regenerative role for regulatory T cells in central nervous system remyelination

(2017) Veronique E. Miron   Journal of Cell Communication and Signaling

Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation

(2017) Dylan A. Galloway et al.   Annals of Clinical and Translational Neurology

Long-term evolution of multiple sclerosis disability in the treatment era

(2016) et al.   ANNALS OF NEUROLOGY

Environmental Enrichment Stimulates Immune Cell Secretion of Exosomes that Promote CNS Myelination and May Regulate Inflammation

(2016) Kae M. Pusic et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Delivery of Therapeutic Proteins via Extracellular Vesicles: Review and Potential Treatments for Parkinson’s Disease, Glioma, and Schwannoma

(2016) Justin Hall et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

In vitro and ex vivo models of multiple sclerosis

(2016) Martin Madill et al.   DRUG DISCOVERY TODAY

The regenerative effects of electromagnetic field on spinal cord injury

(2016) Christina L. Ross et al.   ELECTROMAGNETIC BIOLOGY AND MEDICINE

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

Remyelinating Oligodendrocyte Precursor Cell miRNAs from the Sfmbt2 Cluster Promote Cell Cycle Arrest and Differentiation

(2016) Nicholas J. Kuypers et al.   JOURNAL OF NEUROSCIENCE

Circulating microRNAs as biomarkers in progressive multiple sclerosis

(2016) Julia Vistbakka et al.   Multiple Sclerosis Journal

Circulating microRNAs as biomarkers in progressive multiple sclerosis

(2016) Julia Vistbakka et al.   Multiple Sclerosis Journal

Gene Expression Analysis of Neurons and Astrocytes Isolated by Laser Capture Microdissection from Frozen Human Brain Tissues

(2016) Lidia Tagliafierro et al.   Frontiers in Molecular Neuroscience

MiR-125a-3p timely inhibits oligodendroglial maturation and is pathologically up-regulated in human multiple sclerosis

(2016) Davide Lecca et al.   Scientific Reports

Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development

(2015) Hua Jia Diao et al.   BIOMATERIALS

Animal models of Multiple Sclerosis

(2015) Claudio Procaccini et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nanofiber-mediated microRNA delivery to enhance differentiation and maturation of oligodendroglial precursor cells

(2015) Hua Jia Diao et al.   JOURNAL OF CONTROLLED RELEASE

Phasic Treatment with Interferon Gamma Stimulates Release of Exosomes that Protect Against Spreading Depression

(2015) Aya D. Pusic et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination

(2015) P. Lewkowicz et al.   JOURNAL OF NEUROSCIENCE

Enhanced remyelination following lysolecithin-induced demyelination in mice under treatment with fingolimod (FTY720)

(2015) A. Yazdi et al.   NEUROSCIENCE

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b

(2015) Jens Ingwersen et al.   Annals of Clinical and Translational Neurology

Biogenesis and secretion of exosomes

(2014) Joanna Kowal et al.   CURRENT OPINION IN CELL BIOLOGY

What are exosomes and how can they be used in multiple sclerosis therapy?

(2014) Aya D Pusic et al.   Expert Review of Neurotherapeutics

CNS Repair Requires Both Effector and Regulatory T Cells with Distinct Temporal and Spatial Profiles

(2014) C. Raposo et al.   JOURNAL OF NEUROSCIENCE

Decreased Dicer expression is linked to increased expression of co-stimulatory molecule CD80 on B cells in multiple sclerosis

(2014) Latt Latt Aung et al.   Multiple Sclerosis Journal

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Remyelination after spinal cord injury: Is it a target for repair?

(2014) Jason R. Plemel et al.   PROGRESS IN NEUROBIOLOGY

Extracellular Vesicles in Multiple Sclerosis: What are They Telling Us?

(2014) Matías Sáenz-Cuesta et al.   Frontiers in Cellular Neuroscience

Heterogeneity of oligodendrocyte progenitor cells in adult human brain

(2014) Soo Yuen Leong et al.   Annals of Clinical and Translational Neurology

The essential role of t cells in multiple sclerosis: A reappraisal

(2014) CrisS Constantinescu et al.   Biomedical Journal

miR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization

(2013) Craig S. Moore et al.   ANNALS OF NEUROLOGY

Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors

(2013) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

(2013) A. Reijerkerk et al.   JOURNAL OF NEUROSCIENCE

Differential microRNA expression in blood in multiple sclerosis

(2013) Helle Bach Søndergaard et al.   Multiple Sclerosis Journal

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

(2013) Matthew J. Haney et al.   PLoS One

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia

(2013) Robert W. Freilich et al.   PLoS One

Aryl hydrocarbon receptor-mediated induction of the microRNA-132/212 cluster promotes interleukin-17-producing T-helper cell differentiation

(2013) T. Nakahama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sample sizes for lesion magnetisation transfer ratio outcomes in remyelination trials for multiple sclerosis

(2013) D.R. Altmann et al.   Multiple Sclerosis and Related Disorders

Regulation of serum response factor by miRNA-200 and miRNA-9 modulates oligodendrocyte progenitor cell differentiation

(2012) Benjamin Buller et al.   GLIA

Iron Efflux from Astrocytes Plays a Role in Remyelination

(2012) K. Schulz et al.   JOURNAL OF NEUROSCIENCE

Panglial Gap Junctional Communication is Essential for Maintenance of Myelin in the CNS

(2012) O. Tress et al.   JOURNAL OF NEUROSCIENCE

Specification and maintenance of oligodendrocyte precursor cells from neural progenitor cells: involvement of microRNA-7a

(2012) Xianghui Zhao et al.   MOLECULAR BIOLOGY OF THE CELL

Circulating microRNAs involved in multiple sclerosis

(2012) Sue Rutherford Siegel et al.   MOLECULAR BIOLOGY REPORTS

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

(2012) Reuben Saba et al.   PLoS One

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

(2012) Tatiana Veremeyko et al.   Jove-Journal of Visualized Experiments

Impaired neurosteroid synthesis in multiple sclerosis

(2011) Farshid Noorbakhsh et al.   BRAIN

Mediators of oligodendrocyte differentiation during remyelination

(2011) Jigisha R. Patel et al.   FEBS LETTERS

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

(2011) Ivana Nikić et al.   NATURE MEDICINE

Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis

(2011) Chiara Fenoglio et al.   NEUROSCIENCE LETTERS

Glatiramer Acetate Treatment Normalizes Deregulated microRNA Expression in Relapsing Remitting Multiple Sclerosis

(2011) Anne Waschbisch et al.   PLoS One

Fingolimod (FTY720) Enhances Remyelination Following Demyelination of Organotypic Cerebellar Slices

(2010) Veronique E. Miron et al.   AMERICAN JOURNAL OF PATHOLOGY

Demyelination causes synaptic alterations in hippocampi from multiple sclerosis patients

(2010) Ranjan Dutta et al.   ANNALS OF NEUROLOGY

Cells of the oligodendroglial lineage, myelination, and remyelination

(2010) Veronique E. Miron et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Control of oligodendroglial cell number by the miR-17-92 cluster

(2010) H. Budde et al.   DEVELOPMENT

Altered miRNA expression in T regulatory cells in course of multiple sclerosis

(2010) Giuseppe De Santis et al.   JOURNAL OF NEUROIMMUNOLOGY

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

The widespread regulation of microRNA biogenesis, function and decay

(2010) Jacek Krol et al.   NATURE REVIEWS GENETICS

Dicer1 and miR-219 Are Required for Normal Oligodendrocyte Differentiation and Myelination

(2010) Jason C. Dugas et al.   NEURON

MicroRNA-Mediated Control of Oligodendrocyte Differentiation

(2010) Xianghui Zhao et al.   NEURON

MicroRNA Expression Profiling of Oligodendrocyte Differentiation from Human Embryonic Stem Cells

(2010) Brian S. Letzen et al.   PLoS One

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Dicerablation in oligodendrocytes provokes neuronal impairment in mice

(2009) Daesung Shin et al.   ANNALS OF NEUROLOGY

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

miR-23 regulation of lamin B1 is crucial for oligodendrocyte development and myelination

(2009) S.-T. Lin et al.   Disease Models & Mechanisms

FTY720 (fingolimod) for relapsing multiple sclerosis

(2008) Alejandro Horga et al.   Expert Review of Neurotherapeutics

Identification of Dynamically Regulated MicroRNA and mRNA Networks in Developing Oligodendrocytes

(2008) P. Lau et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation

(2008) Ulf Andersson Ørom et al.   MOLECULAR CELL

MicroRNA-373 induces expression of genes with complementary promoter sequences

(2008) R. F. Place et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA