Autophagy and amino acid metabolism in the brain: implications for epilepsy

Autophagic neuron death in neonatal brain ischemia/hypoxia

(2014) Yasuo Uchiyama et al.   Autophagy

Involvement of autophagy in hypoxic-excitotoxic neuronal death

(2014) Vanessa Ginet et al.   Autophagy

mTOR and autophagy in normal brain aging and caloric restriction ameliorating age-related cognition deficits

(2014) Fengying Yang et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Two Novel Mutations in theBCKDK(Branched-Chain Keto-Acid Dehydrogenase Kinase) Gene Are Responsible for a Neurobehavioral Deficit in Two Pediatric Unrelated Patients

(2014) Angels García-Cazorla et al.   HUMAN MUTATION

Connexins modulate autophagosome biogenesis

(2014) Eloy Bejarano et al.   NATURE CELL BIOLOGY

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Long-distance mechanism of neurotransmitter recycling mediated by glial network facilitates visual function in Drosophila

(2014) R. Chaturvedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle

(2014) A. B. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TORC1-dependent epilepsy caused by acute biallelicTsc1deletion in adult mice

(2013) Elisabeth Abs et al.   ANNALS OF NEUROLOGY

Glutamate dehydrogenase contributes to leucine sensing in the regulation of autophagy

(2013) Séverine Lorin et al.   Autophagy

Differential Contribution of Insulin and Amino Acids to the mTORC1-Autophagy Pathway in the Liver and Muscle

(2013) Takako Naito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the mTOR signaling pathway in epilepsy

(2013) Xiang-Fei Meng et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Measurement of autophagy flux in the nervous system in vivo

(2013) K Castillo et al.   Cell Death & Disease

Large neutral amino acids: dietary effects on brain neurochemistry and function

(2012) John D. Fernstrom   AMINO ACIDS

Autophagy

(2012) Tsung-Chin Lin et al.   Autophagy

Exercise induces autophagy in peripheral tissues and in the brain

(2012) Congcong He et al.   Autophagy

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Central Leucine Sensing in the Control of Energy Homeostasis

(2012) Gary J. Schwartz   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Harnessing the power of metabolism for seizure prevention: Focus on dietary treatments

(2012) Adam L. Hartman et al.   EPILEPSY & BEHAVIOR

Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

(2012) J. McMahon et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial

(2012) David Neal Franz et al.   LANCET

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

(2012) Eloy Bejarano et al.   MOLECULAR BIOLOGY OF THE CELL

Glutaminolysis Activates Rag-mTORC1 Signaling

(2012) Raúl V. Durán et al.   MOLECULAR CELL

Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy

(2012) Kristan E. van der Vos et al.   NATURE CELL BIOLOGY

Inhibitory effect of dietary lipids on chaperone-mediated autophagy

(2012) J. A. Rodriguez-Navarro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR

(2011) Dan Egan et al.   Autophagy

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway

(2011) Sharon S. McDaniel et al.   EPILEPSIA

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2011) Olga Criado et al.   HUMAN MOLECULAR GENETICS

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy: a pathway that contributes to connexin degradation

(2011) A. Lichtenstein et al.   JOURNAL OF CELL SCIENCE

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The monoamine neurotransmitter disorders: an expanding range of neurological syndromes

(2011) Manju A Kurian et al.   LANCET NEUROLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease

(2011) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

(2011) Emmanuel Raffo et al.   NEUROBIOLOGY OF DISEASE

Glutamate dehydrogenase in brain mitochondria: Do lipid modifications and transient metabolon formation influence enzyme activity?

(2011) Mary C. McKenna   NEUROCHEMISTRY INTERNATIONAL

The Role of Glutamate Dehydrogenase in Mammalian Ammonia Metabolism

(2011) Cleanthe Spanaki et al.   NEUROTOXICITY RESEARCH

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Short-term fasting induces profound neuronal autophagy

(2010) Mehrdad Alirezaei et al.   Autophagy

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): A double-edged sword?

(2010) Ling-Hui Zeng et al.   CELL CYCLE

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

(2010) H. W. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Network organization of the human autophagy system

(2010) Christian Behrends et al.   NATURE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

The Association of AMPK with ULK1 Regulates Autophagy

(2010) Jong Woo Lee et al.   PLoS One

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Autophagy and lipids: tightening the knot

(2010) Jose Antonio Rodriguez-Navarro et al.   Seminars in Immunopathology

Branched-chain 2-oxoacid transamination increases GABA-shunt metabolism and insulin secretion in isolated islets

(2009) Javier Pizarro-Delgado et al.   BIOCHEMICAL JOURNAL

Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

(2009) Paul Nicklin et al.   CELL

Mediobasal Hypothalamic Leucine Sensing Regulates Food Intake through Activation of a Hypothalamus-Brainstem Circuit

(2009) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

(2008) Ling-Hui Zeng et al.   ANNALS OF NEUROLOGY

Ketosis and brain handling of glutamate, glutamine, and GABA

(2008) Marc Yudkoff et al.   EPILEPSIA

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

A ketogenic diet rescues the murine succinic semialdehyde dehydrogenase deficient phenotype

(2007) Kirk Nylen et al.   EXPERIMENTAL NEUROLOGY