Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes

Critical Role of Beclin1 in HIV Tat and Morphine-Induced Inflammation and Calcium Release in Glial Cells from Autophagy Deficient Mouse

(2018) Jessica Lapierre et al.   Journal of Neuroimmune Pharmacology

Expression profiling of chromatin-modifying enzymes and global DNA methylation in CD4+ T cells from patients with chronic HIV infection at different HIV control and progression states

(2018) Roberta Nicoleta Bogoi et al.   Clinical Epigenetics

Importance of Autophagy in Mediating Human Immunodeficiency Virus (HIV) and Morphine-Induced Metabolic Dysfunction and Inflammation in Human Astrocytes

(2017) Myosotys Rodriguez et al.   Viruses-Basel

Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs

(2017) Justin Cohen et al.   Frontiers in Aging Neuroscience

HIV-1 envelope glycoprotein stimulates viral transcription and increases the infectivity of the progeny virus through the manipulation of cellular machinery

(2017) Xiaozhuo Ran et al.   Scientific Reports

Immunoassay and molecular methods to investigate DNA methylation changes in peripheral blood mononuclear cells in HIV infected patients on cART

(2016) Adelina Rosca et al.   JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY

Neurotoxicity in the Post-HAART Era: Caution for the Antiretroviral Therapeutics

(2016) Ankit Shah et al.   NEUROTOXICITY RESEARCH

Modeling the Effects of Morphine on Simian Immunodeficiency Virus Dynamics

(2016) Naveen K. Vaidya et al.   PLoS Computational Biology

Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals

(2016) Kateřina Trejbalová et al.   Clinical Epigenetics

Protein Quality Control and Metabolism: Bidirectional Control in the Heart

(2015) Zhao V. Wang et al.   Cell Metabolism

Central Nervous System Penetration of Antiretroviral Drugs: Pharmacokinetic, Pharmacodynamic and Pharmacogenomic Considerations

(2015) Eric H. Decloedt et al.   CLINICAL PHARMACOKINETICS

Cerebrospinal fluid concentrations of tenofovir and emtricitabine in the setting of HIV-1 protease inhibitor-based regimens

(2015) Cecile D. Lahiri et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Opioid and chemokine receptor crosstalk: a promising target for pain therapy?

(2015) Stéphane Mélik Parsadaniantz et al.   NATURE REVIEWS NEUROSCIENCE

Multiple Protein Kinases via Activation of Transcription Factors NF-κB, AP-1 and C/EBP-δ Regulate the IL-6/IL-8 Production by HIV-1 Vpr in Astrocytes

(2015) Mohitkumar R. Gangwani et al.   PLoS One

Viruses and the autophagy pathway

(2015) William T. Jackson   VIROLOGY

Epigenetic control of HIV-1 post integration latency: implications for therapy

(2015) Amit Kumar et al.   Clinical Epigenetics

Differing roles of autophagy in HIV-associated neurocognitive impairment and encephalitis with implications for morphine co-exposure

(2015) Seth M. Dever et al.   Frontiers in Microbiology

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

(2014) Cagla Akay et al.   JOURNAL OF NEUROVIROLOGY

HIV-1 and Morphine Regulation of Autophagy in Microglia: Limited Interactions in the Context of HIV-1 Infection and Opioid Abuse

(2014) Nazira El-Hage et al.   JOURNAL OF VIROLOGY

Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages

(2014) Xiaoxuan Zhang et al.   PLoS One

HIV and Aging: Effects on the Central Nervous System

(2014) Silvia Cañizares et al.   SEMINARS IN NEUROLOGY

Viral and cellular factors underlying neuropathogenesis in HIV associated neurocognitive disorders (HAND)

(2014) Vasudev R Rao et al.   AIDS Research and Therapy

Closing the Gap: Increases in Life Expectancy among Treated HIV-Positive Individuals in the United States and Canada

(2013) Hasina Samji et al.   PLoS One

HIV-1 and HIV-2 infections induce autophagy in Jurkat and CD4+ T cells

(2012) Xue Wang et al.   CELLULAR SIGNALLING

Differential expression and HIV-1 regulation of μ-opioid receptor splice variants across human central nervous system cell types

(2012) Seth M. Dever et al.   JOURNAL OF NEUROVIROLOGY

Antiretroviral neurotoxicity

(2012) Kevin Robertson et al.   JOURNAL OF NEUROVIROLOGY

Persistence of HIV-associated cognitive impairment, inflammation, and neuronal injury in era of highly active antiretroviral treatment

(2011) Jarek Harezlak et al.   AIDS

Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival-promoting autophagy

(2011) Nadezda Apostolova et al.   HEPATOLOGY

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

(2011) Won-Seok Choi et al.   JOURNAL OF CELL BIOLOGY

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

(2011) Yanqi Chang et al.   NUCLEIC ACIDS RESEARCH

Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

(2011) Giuseppe Fiume et al.   NUCLEIC ACIDS RESEARCH

Innate Antiviral Response: Role in HIV-1 Infection

(2011) Paula M. Pitha   Viruses-Basel

Antiretroviral medications disrupt microglial phagocytosis of β-amyloid and increase its production by neurons: Implications for HIV-associated neurocognitive disorders

(2011) Brian Giunta et al.   Molecular Brain

Morphine induces Beclin 1- and ATG5-dependent autophagy in human neuroblastoma SH-SY5Y cells and in the rat hippocampus

(2010) Lixia Zhao et al.   Autophagy

Cytoprotective roles for autophagy

(2010) Kevin Moreau et al.   CURRENT OPINION IN CELL BIOLOGY

Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood–brain barrier endothelial cells

(2010) Kalyan Reddy Manda et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells

(2010) Ana Blas-García et al.   HEPATOLOGY

HIV-1-Specific Interleukin-21+ CD4+ T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8+ T Cell Function

(2010) M. F. Chevalier et al.   JOURNAL OF VIROLOGY

Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

(2010) Dan Levy et al.   NATURE IMMUNOLOGY

Neurocognitive effects of treatment interruption in stable HIV-positive patients in an observational cohort

(2010) K. R. Robertson et al.   NEUROLOGY

Human immunodeficiency virus type-1 infection inhibits autophagy

(2009) Dejiang Zhou et al.   AIDS

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

HIV protease inhibitor lopinavir-induced TNF-α and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages

(2009) Li Chen et al.   BIOCHEMICAL PHARMACOLOGY

HIV-1 Protease Inhibitor Induced Oxidative Stress Suppresses Glucose Stimulated Insulin Release: Protection with Thymoquinone

(2009) Surabhi Chandra et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease

(2009) Yifeng Du et al.   NEUROBIOLOGY OF DISEASE

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Long-Term Exposure to AZT, but not d4T, Increases Endothelial Cell Oxidative Stress and Mitochondrial Dysfunction

(2008) Erik R. Kline et al.   Cardiovascular Toxicology

Low-level viremia persists for at least 7 years in patients on suppressive antiretroviral therapy

(2008) S. Palmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR

(2008) Rachel Van Duyne et al.   Retrovirology