SRC Kinase in Glioblastoma: News from an Old Acquaintance

Role of STAT3 signaling pathway in breast cancer

(2020) Jia-hui Ma et al.   Cell Communication and Signaling

Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance

(2019) Ruilong Liu et al.   Nature Communications

Inflammatory regulatory network mediated by the joint action of NF-kB, STAT3, and AP-1 factors is involved in many human cancers

(2019) Zhe Ji et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma

(2019) Yufeng Shi et al.   NATURE

Modulating the antibody density changes the uptake and transport at the blood-brain barrier of both transferrin receptor-targeted gold nanoparticles and liposomal cargo

(2019) Kasper Bendix Johnsen et al.   JOURNAL OF CONTROLLED RELEASE

Intertumoral heterogeneity in patient-specific drug sensitivities in treatment-naïve glioblastoma

(2019) Erlend Skaga et al.   BMC CANCER

A phase 1 and randomized, placebo‐controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

(2019) Evanthia Galanis et al.   CANCER

A New Strategy for Glioblastoma Treatment: In Vitro and In Vivo Preclinical Characterization of Si306, a Pyrazolo[3,4-d]Pyrimidine Dual Src/P-Glycoprotein Inhibitor

(2019) Anna Lucia Fallacara et al.   Cancers

Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model

(2019) Rupa Juthani et al.   CLINICAL CANCER RESEARCH

Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line

(2019) Francesco P Cammarata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in�vitro and in�vivo

(2019) Qingjun Liu et al.   Molecular Medicine Reports

Lusianthridin targeting of lung cancer stem cells via Src-STAT3 suppression

(2019) Narumol Bhummaphan et al.   PHYTOMEDICINE

Phase II trial of ponatinib in patients with bevacizumab‐refractory glioblastoma

(2019) Eudocia Q. Lee et al.   Cancer Medicine

Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

(2019) José Rivera-Torres et al.   Frontiers in Pharmacology

Metabolic Abnormalities in Glioblastoma and Metabolic Strategies to Overcome Treatment Resistance

(2019) Weihua Zhou et al.   Cancers

Inhibition of motility by NEO100 through the calpain-1/RhoA pathway

(2019) Nagore I. Marín-Ramos et al.   JOURNAL OF NEUROSURGERY

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches

(2019) Karen G. de la Cruz-López et al.   Frontiers in Oncology

Glucose-6 Phosphate, a Central Hub for Liver Carbohydrate Metabolism

(2019) Fabienne Rajas et al.   Metabolites

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells

(2019) Marie-Ange Djeungoue-Petga et al.   Cell Death & Disease

Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma

(2018) Elena Battistello et al.   BLOOD

Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells

(2018) Sung Yeon Park et al.   BMC CANCER

Hexokinase 2 and nuclear factor erythroid 2–related factor 2 transcriptionally coactivate xanthine oxidoreductase expression in stressed glioma cells

(2018) Touseef Sheikh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)

(2018) Michael P. Smolinski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting tumour microenvironment by tyrosine kinase inhibitor

(2018) Hor-Yue Tan et al.   Molecular Cancer

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

SLIT2/ROBO1 axis contributes to the Warburg effect in osteosarcoma through activation of SRC/ERK/c-MYC/PFKFB2 pathway

(2018) Shu-Jie Zhao et al.   Cell Death & Disease

Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer–Drug Microarrays

(2018) Monica Sanna et al.   ACS Medicinal Chemistry Letters

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten -Null Cells

(2018) Adam Naguib et al.   Cell Reports

Improved Brain Penetration and Antitumor Efficacy of Temozolomide by Inhibition of ABCB1 and ABCG2

(2018) Mark C. de Gooijer et al.   NEOPLASIA

Glioblastoma Chemoresistance: The Double Play by Microenvironment and Blood-Brain Barrier

(2018) Martina Da Ros et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

KX2-361: a novel orally bioavailable small molecule dual Src/tubulin inhibitor that provides long term survival in a murine model of glioblastoma

(2018) Michael J. Ciesielski et al.   JOURNAL OF NEURO-ONCOLOGY

Microglia/Astrocytes–Glioblastoma Crosstalk: Crucial Molecular Mechanisms and Microenvironmental Factors

(2018) Diana Matias et al.   Frontiers in Cellular Neuroscience

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

(2018) Giulia Fianco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glioblastoma: Microenvironment and Niche Concept

(2018) Davide Schiffer et al.   Cancers

Radiation-Induced Alterations in the Recurrent Glioblastoma Microenvironment: Therapeutic Implications

(2018) Kshama Gupta et al.   Frontiers in Oncology

Heterogeneous Binding and Central Nervous System Distribution of the Multitargeted Kinase Inhibitor Ponatinib Restrict Orthotopic Efficacy in a Patient-Derived Xenograft Model of Glioblastoma

(2017) Janice K. Laramy et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

(2017) Shunsuke Shibao et al.   NEURO-ONCOLOGY

Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells

(2017) Nicole Colwell et al.   NEURO-ONCOLOGY

Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data

(2017) Jann N Sarkaria et al.   NEURO-ONCOLOGY

c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis

(2017) Jia Zhang et al.   Nature Communications

Melanoma Therapeutic Strategies that Select against Resistance by Exploiting MYC-Driven Evolutionary Convergence

(2017) Katherine R. Singleton et al.   Cell Reports

Caspase-8 contributes to angiogenesis and chemotherapy resistance in glioblastoma

(2017) Giulia Fianco et al.   eLife

Metabolic exchanges within tumor microenvironment

(2016) Paola Chiarugi et al.   CANCER LETTERS

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

(2016) Daniel R. Wahl et al.   CANCER RESEARCH

Myc-Driven Glycolysis Is a Therapeutic Target in Glioblastoma

(2016) K. Tateishi et al.   CLINICAL CANCER RESEARCH

Caspase-8 expression and its Src-dependent phosphorylation on Tyr380 promote cancer cell neoplastic transformation and resistance to anoikis

(2016) G. Fianco et al.   EXPERIMENTAL CELL RESEARCH

Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

(2016) Alessia Calgani et al.   MOLECULAR CANCER THERAPEUTICS

Epidermal growth factor receptor targeting and challenges in glioblastoma

(2016) Amy Haseley Thorne et al.   NEURO-ONCOLOGY

Glycolysis and the pentose phosphate pathway are differentially associated with the dichotomous regulation of glioblastoma cell migration versus proliferation

(2016) Annegret Kathagen-Buhmann et al.   NEURO-ONCOLOGY

Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma

(2016) F Ahmad et al.   Cell Death & Disease

Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation

(2016) Yue Jin et al.   Oncotarget

The Effect of Chemoradiotherapy with SRC Tyrosine Kinase Inhibitor, PP2 and Temozolomide on Malignant Glioma Cells In Vitro and In Vivo

(2016) Keun-Yong Eom et al.   Cancer Research and Treatment

HSPB1 Enhances SIRT2-Mediated G6PD Activation and Promotes Glioma Cell Proliferation

(2016) Hongxing Ye et al.   PLoS One

Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer

(2015) S. Jain et al.   CANCER RESEARCH

Mitochondrial Src tyrosine kinase plays a role in the cardioprotective effect of ischemic preconditioning by modulating complex I activity and mitochondrial ROS generation

(2015) H. Ge et al.   FREE RADICAL RESEARCH

SRC Family Kinase Inhibition Through a New Pyrazolo[3,4-d]Pyrimidine Derivative as a Feasible Approach for Glioblastoma Treatment

(2015) Elisa Ceccherini et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Src family kinases differentially influence glioma growth and motility

(2015) Laura J. Lewis-Tuffin et al.   Molecular Oncology

Dasatinib in recurrent glioblastoma: failure as a teacher

(2015) David Schiff et al.   NEURO-ONCOLOGY

Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)

(2015) Andrew B. Lassman et al.   NEURO-ONCOLOGY

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

(2015) Sean J. Humphrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

ABCB1, ABCG2, and PTEN Determine the Response of Glioblastoma to Temozolomide and ABT-888 Therapy

(2014) F. Lin et al.   CLINICAL CANCER RESEARCH

The role of Src family kinases in growth and migration of glioma stem cells

(2014) XIAOSI HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma

(2014) Cristina Tintori et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phase 2 study of bosutinib, a Src inhibitor, in adults with recurrent glioblastoma

(2014) Jennie W. Taylor et al.   JOURNAL OF NEURO-ONCOLOGY

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

The effects of ponatinib, a multi-targeted tyrosine kinase inhibitor, against human U87 malignant glioblastoma cells

(2014) Lingfei Kong et al.   OncoTargets and Therapy

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

Src as the link between inflammation and cancer

(2014) Sandy T. Liu et al.   Frontiers in Physiology

Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells

(2013) Annegret Kathagen et al.   ACTA NEUROPATHOLOGICA

Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect

(2013) K. K. Velpula et al.   CANCER RESEARCH

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Src and CXCR4 are involved in the invasiveness of breast cancer cells with acquired resistance to lapatinib

(2013) Antonella De Luca et al.   CELL CYCLE

Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategies

(2013) Atique U Ahmed et al.   Expert Review of Neurotherapeutics

Cytokine Patterns in Brain Tumour Progression

(2013) Radu Albulescu et al.   MEDIATORS OF INFLAMMATION

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

(2013) Deborah Huveldt et al.   PLoS One

Opposing Effect of EGFRWT on EGFRvIII-Mediated NF-κB Activation with RIP1 as a Cell Death Switch

(2013) Vineshkumar Thidil Puliyappadamba et al.   Cell Reports

Glioblastoma cancer stem cells: Role of the microenvironment and therapeutic targeting

(2012) Luca Persano et al.   BIOCHEMICAL PHARMACOLOGY

Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10

(2012) Etienne Hebert-Chatelain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Interleukins in glioblastoma pathophysiology: implications for therapy

(2012) YT Yeung et al.   BRITISH JOURNAL OF PHARMACOLOGY

Emerging insights into the molecular and cellular basis of glioblastoma

(2012) G. P. Dunn et al.   GENES & DEVELOPMENT

Active Efflux of Dasatinib from the Brain Limits Efficacy against Murine Glioblastoma: Broad Implications for the Clinical Use of Molecularly Targeted Agents

(2012) S. Agarwal et al.   MOLECULAR CANCER THERAPEUTICS

Ponatinib in Refractory Philadelphia Chromosome–Positive Leukemias

(2012) Jorge E. Cortes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of STAT3 in Transformation and Drug Resistance in CML

(2012) Rajesh R. Nair et al.   Frontiers in Oncology

The brain tumor microenvironment

(2011) Nikki A. Charles et al.   GLIA

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism

(2011) Anna N. Cvrljevic et al.   JOURNAL OF CELL SCIENCE

Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy

(2011) Sumitra Ananda et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway

(2011) R Bonavia et al.   ONCOGENE

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

Inflammation-mediated promotion of invasion and metastasis

(2010) Graziella Solinas et al.   CANCER AND METASTASIS REVIEWS

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies

(2010) Manmeet S. Ahluwalia et al.   CANCER LETTERS

NF-κB and STAT3 signaling in glioma: targets for future therapies

(2010) George P Atkinson et al.   Expert Review of Neurotherapeutics

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

(2010) M.-d.-M. Inda et al.   GENES & DEVELOPMENT

The Pathobiology of Glioma Tumors

(2009) Candece L. Gladson et al.   Annual Review of Pathology-Mechanisms of Disease

Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors

(2009) S. Soverini et al.   BLOOD

Epidermal Growth Factor Receptor Translocation to the Mitochondria

(2009) Michelle L. Demory et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P-glycoprotein and Breast Cancer Resistance Protein Influence Brain Distribution of Dasatinib

(2009) Y. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma

(2009) V. Milano et al.   MOLECULAR CANCER THERAPEUTICS

Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts

(2009) J. Graeme Hodgson et al.   NEURO-ONCOLOGY

The Role of Src in Solid Tumors

(2009) D. L. Wheeler et al.   ONCOLOGIST

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

CNS Delivery Via Adsorptive Transcytosis

(2008) Françoise Hervé et al.   AAPS Journal

Myc increases self-renewal in neural progenitor cells through Miz-1

(2008) L. Kerosuo et al.   JOURNAL OF CELL SCIENCE

Src-Tyrosine kinases are major agents in mitochondrial tyrosine phosphorylation

(2008) Elena Tibaldi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Cancer-related inflammation

(2008) Alberto Mantovani et al.   NATURE

Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

(2008) Jinyan Du et al.   NATURE BIOTECHNOLOGY

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530

(2008) Y-M Chang et al.   ONCOGENE