Src Tyrosine Kinase Inhibitors: New Perspectives on Their Immune, Antiviral, and Senotherapeutic Potential

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

The tyrosine kinase inhibitor dasatinib acts as a pharmacologic on/off switch for CAR T cells

(2019) Katrin Mestermann et al.   Science Translational Medicine

Early Reconstitution of NK and γδ T Cells and Its Implication for the Design of Post-Transplant Immunotherapy

(2018) Moniek A. de Witte et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

p53 isoforms regulate premature aging in human cells

(2018) Natalia von Muhlinen et al.   ONCOGENE

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Chemical screen identifies a geroprotective role of quercetin in premature aging

(2018) Lingling Geng et al.   Protein & Cell

Electrocardiographic Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome

(2018) David Filgueiras-Rama et al.   JAMA Cardiology

Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer

(2018) Kristina Kovacovicova et al.   Frontiers in Oncology

Tyrosine kinase inhibitors: potential use and safety considerations in HIV-1 infection

(2017) Mayte Coiras et al.   Expert Opinion On Drug Safety

Prospects for immunotherapy of acute myeloid leukemia using γδ T cells

(2017) Leena Halim et al.   Immunotherapy

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

(2017) Keith Wheaton et al.   MOLECULAR AND CELLULAR BIOLOGY

Long‑lasting memory of cellular immunity in a chronic myeloid leukemia patient maintains molecular response 5 after cessation of dasatinib

(2017) Tatsuro Jo et al.   Oncology Letters

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

c-SRC protein tyrosine kinase regulates early HIV-1 infection post-entry

(2016) Stephen D.S. McCarthy et al.   AIDS

Dasatinib inhibits HIV-1 replication through the interference of SAMHD1 phosphorylation in CD4+ T cells

(2016) Mercedes Bermejo et al.   BIOCHEMICAL PHARMACOLOGY

Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis

(2016) Chengguo Wei et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

European LeukemiaNet recommendations for the management and avoidance of adverse events of treatment in chronic myeloid leukaemia

(2016) J L Steegmann et al.   LEUKEMIA

Cardiac electrical defects in progeroid mice and Hutchinson–Gilford progeria syndrome patients with nuclear lamina alterations

(2016) José Rivera-Torres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1

(2016) Gi Uk Jeong et al.   VIROLOGY

Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells

(2016) Jharna R Das et al.   PLoS One

Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle

(2016) Andreas F. R. Sommer et al.   Scientific Reports

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

   T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-  +/CD19+ lymphocytes

(2015) I. Airoldi et al.   BLOOD

DNA repair defects and genome instability in Hutchinson–Gilford Progeria Syndrome

(2015) Susana Gonzalo et al.   CURRENT OPINION IN CELL BIOLOGY

Clinical strategies and animal models for developing senolytic agents

(2015) James L. Kirkland et al.   EXPERIMENTAL GERONTOLOGY

Inhibition of c-Src/p38 MAPK pathway ameliorates renal tubular epithelial cells apoptosis in db/db mice

(2015) Haijiang Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors

(2015) Robert Roskoski   PHARMACOLOGICAL RESEARCH

SAMHD1: At the Crossroads of Cell Proliferation, Immune Responses, and Virus Restriction

(2015) Ester Ballana et al.   TRENDS IN MICROBIOLOGY

Profile of nintedanib in the treatment of solid tumors: the evidence to date

(2015) Niranjan Awasthi et al.   OncoTargets and Therapy

Inhibition of Hepatitis B virus replication by SAMHD1

(2014) Zhangming Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C

(2014) Fei Xiao et al.   GUT

γδ T cells for cancer immunotherapy

(2014) Jonathan PH Fisher et al.   OncoImmunology

Large granular lymphocytosis during dasatinib therapy

(2013) Zhi-Yuan Qiu et al.   CANCER BIOLOGY & THERAPY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment

(2013) Ricardo Villa-Bellosta et al.   CIRCULATION

Inhibition of Src Kinase Blocks High Glucose-Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice

(2013) K. Taniguchi et al.   DIABETES

Identification of mitochondrial dysfunction in Hutchinson–Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture

(2013) José Rivera-Torres et al.   Journal of Proteomics

SAMHD1 Restricts Herpes Simplex Virus 1 in Macrophages by Limiting DNA Replication

(2013) Eui Tae Kim et al.   JOURNAL OF VIROLOGY

The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase

(2013) M. de Wispelaere et al.   JOURNAL OF VIROLOGY

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

(2013) Baohua Liu et al.   Nature Communications

Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

(2013) Joseph A. Hollenbaugh et al.   PLoS Pathogens

Multifunctional γδ T cells and their receptors for targeted anticancer immunotherapy

(2013) Wouter Scheper et al.   OncoImmunology

Rapid and sustained increase of large granular lymphocytes and rare cytomegalovirus reactivation during dasatinib treatment in chronic myelogenous leukemia patients

(2012) Hideo Tanaka et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Dasatinib as a Bone-Modifying Agent: Anabolic and Anti-Resorptive Effects

(2012) Antonio Garcia-Gomez et al.   PLoS One

Retrospective multicenter study on the development of peripheral lymphocytosis following second-line dasatinib therapy for chronic myeloid leukemia

(2011) Su Jin Lee et al.   AMERICAN JOURNAL OF HEMATOLOGY

c-Src inactivation reduces renal epithelial cell-matrix adhesion, proliferation, and cyst formation

(2011) Justine Elliott et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Expansion of highly differentiated CD8+ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation

(2011) A Kreutzman et al.   LEUKEMIA

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Activation of Src Mediates PDGF-Induced Smad1 Phosphorylation and Contributes to the Progression of Glomerulosclerosis in Glomerulonephritis

(2011) Akira Mima et al.   PLoS One

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy

(2010) A. Kreutzman et al.   BLOOD

Clinical features of dasatinib-induced large granular lymphocytosis and pleural effusion

(2010) Yasunobu Nagata et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step

(2010) Brooke Harmon et al.   PLoS Pathogens

Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily

(2009) C. Sillaber et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Effects of the Src kinase inhibitor saracatinib (AZD0530) on bone turnover in healthy men: A randomized, double-blind, placebo-controlled, multiple-ascending-dose phase I trial

(2009) Rosemary A Hannon et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy

(2009) S Mustjoki et al.   LEUKEMIA

Pleural effusions in patients with chronic myeloid leukaemia treated with dasatinib may have an immune-mediated pathogenesis

(2008) Hugues de Lavallade et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sprycel for Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Resistant to or Intolerant of Imatinib Mesylate

(2008) M. Brave et al.   CLINICAL CANCER RESEARCH

Profound Inhibition of Antigen-Specific T-Cell Effector Functions by Dasatinib

(2008) R. Weichsel et al.   CLINICAL CANCER RESEARCH

The Src/ABL kinase inhibitor dasatinib (BMS-354825) inhibits function of normal human T-lymphocytes in vitro

(2008) Stephen Blake et al.   CLINICAL IMMUNOLOGY

Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia

(2008) D. H. Kim et al.   HAEMATOLOGICA

Src Inhibition Ameliorates Polycystic Kidney Disease

(2008) W. E. Sweeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY