Understanding glioma stem cells: rationale, clinical relevance and therapeutic strategies

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

(2012) D. Friedmann-Morvinski et al.   SCIENCE

Glioma-Initiating Cell Elimination by Metformin Activation of FOXO3 via AMPK

(2012) Atsushi Sato et al.   Stem Cells Translational Medicine

The role of microRNAs in glioma initiation and progression

(2011) Ying Zhang   Frontiers in Bioscience-Landmark

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(2011) Ilya Ulasov et al.   MOLECULAR MEDICINE

Cells of origin in cancer

(2011) Jane E. Visvader   NATURE

The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas

(2011) Kyung-Jung Kim et al.   NEUROPATHOLOGY

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

(2011) C. L. Chaffer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MEK-ERK Signaling Dictates DNA-Repair Gene MGMT Expression and Temozolomide Resistance of Stem-Like Glioblastoma Cells via the MDM2-p53 Axis

(2011) Atsushi Sato et al.   STEM CELLS

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Integrin Alpha 6 Regulates Glioblastoma Stem Cells

(2010) Justin D. Lathia et al.   Cell Stem Cell

HER2-Specific T Cells Target Primary Glioblastoma Stem Cells and Induce Regression of Autologous Experimental Tumors

(2010) N. Ahmed et al.   CLINICAL CANCER RESEARCH

Immunobiological Characterization of Cancer Stem Cells Isolated from Glioblastoma Patients

(2010) T. Di Tomaso et al.   CLINICAL CANCER RESEARCH

Induction of cytotoxic T lymphocytes against ovarian cancer-initiating cells

(2010) Desheng Weng et al.   INTERNATIONAL JOURNAL OF CANCER

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice

(2010) Mitomu Kioi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cancer stem cells: problems for therapy?

(2010) Malcolm R Alison et al.   JOURNAL OF PATHOLOGY

Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma

(2010) Zeshaan A. Rasheed et al.   JNCI-Journal of the National Cancer Institute

Sensitivity to temozolomide in brain tumor initiating cells

(2010) M. D. Blough et al.   NEURO-ONCOLOGY

The paradoxical effect of bevacizumab in the therapy of malignant gliomas

(2010) E. M. Thompson et al.   NEUROLOGY

Association of stem cell marker CD133 expression with dissemination of glioblastomas

(2010) Atsushi Sato et al.   NEUROSURGICAL REVIEW

A Role of Canonical Transient Receptor Potential 5 Channel in Neuronal Differentiation from A2B5 Neural Progenitor Cells

(2010) Hye Young Shin et al.   PLoS One

Aldehyde dehydrogenase 1 is a putative marker for cancer stem cells in head and neck squamous cancer

(2009) Yu-Chih Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Concerns about anti-angiogenic treatment in patients with glioblastoma multiforme

(2009) Joost JC Verhoeff et al.   BMC CANCER

Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model

(2009) Yuan Wang et al.   CANCER CELL

Malignant Astrocytomas Originate from Neural Stem/Progenitor Cells in a Somatic Tumor Suppressor Mouse Model

(2009) Sheila Alcantara Llaguno et al.   CANCER CELL

Identification of CD15 as a Marker for Tumor-Propagating Cells in a Mouse Model of Medulloblastoma

(2009) Tracy-Ann Read et al.   CANCER CELL

Prognostic Significance of the Cancer Stem Cell Markers CD133, CD44, and CD166 in Colorectal Cancer

(2009) David Horst et al.   CANCER INVESTIGATION

Recognition and Killing of Brain Tumor Stem-Like Initiating Cells by CD8+ Cytolytic T Cells

(2009) C. E. Brown et al.   CANCER RESEARCH

Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1

(2009) C. Folkins et al.   CANCER RESEARCH

MicroRNA-34a Inhibits Glioblastoma Growth by Targeting Multiple Oncogenes

(2009) Y. Li et al.   CANCER RESEARCH

Stem cell marker aldehyde dehydrogenase 1-positive breast cancers are characterized by negative estrogen receptor, positive human epidermal growth factor receptor type 2, and high Ki67 expression

(2009) Koji Morimoto et al.   CANCER SCIENCE

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma

(2009) Myung Jin Son et al.   Cell Stem Cell

PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells

(2009) Anne-Marie Bleau et al.   Cell Stem Cell

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes

(2009) Thomas S Jacques et al.   EMBO JOURNAL

Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma

(2009) Henry S. Friedman et al.   JOURNAL OF CLINICAL ONCOLOGY

A chimeric adenovirus with an Ad 3 fiber knob modification augments glioma virotherapy

(2009) Suvobroto Nandi et al.   JOURNAL OF GENE MEDICINE

Cancer stem cells: mirage or reality?

(2009) Piyush B Gupta et al.   NATURE MEDICINE

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

In Vivo and Ex Vivo Evaluation of L-Type Calcium Channel Blockers on Acid β-Glucosidase in Gaucher Disease Mouse Models

(2009) Ying Sun et al.   PLoS One

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

(2009) Dan R. Laks et al.   STEM CELLS

CD133 as a Marker for Cancer Stem Cells: Progresses and Concerns

(2009) Yaojiong Wu et al.   STEM CELLS AND DEVELOPMENT

A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients

(2008) M. Schaich et al.   ANNALS OF ONCOLOGY

MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells

(2008) Hilah Gal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tissue-Specific Promoters Active in CD44+CD24-/low Breast Cancer Cells

(2008) G. J. Bauerschmitz et al.   CANCER RESEARCH

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

Brain Tumor Stem Cells: Bringing Order to the Chaos of Brain Cancer

(2008) Peter B. Dirks   JOURNAL OF CLINICAL ONCOLOGY

Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients

(2008) Mingyu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Oncolytic HSV-1 Infection of Tumors Induces Angiogenesis and Upregulates CYR61

(2008) Kazuhiko Kurozumi et al.   MOLECULAR THERAPY

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

(2008) Gaspar J. Kitange et al.   NEURO-ONCOLOGY

IDENTIFICATION OF A2B5+CD133− TUMOR-INITIATING CELLS IN ADULT HUMAN GLIOMAS

(2008) Alfred T. Ogden et al.   NEUROSURGERY

Human Embryonic Stem Cells Have Enhanced Repair of Multiple Forms of DNA Damage

(2008) Scott Maynard et al.   STEM CELLS