Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

PPARγ agonist pioglitazone improves cerebellar dysfunction at pre-Aβ deposition stage in APPswe/PS1dE9 Alzheimer's disease model mice

(2016) Junya Toba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

(2016) Henrik H. Hansen et al.   BRAIN RESEARCH

A novel dual GLP-1 and GIP receptor agonist is neuroprotective in the MPTP mouse model of Parkinson′s disease by increasing expression of BNDF

(2016) Chenhui Ji et al.   BRAIN RESEARCH

Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

(2016) Masoumeh Asadbegi et al.   BRAIN RESEARCH BULLETIN

Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3β pathway in an amyloid β protein induced alzheimer disease mouse model

(2016) Liqin Qi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats

(2016) Yu-Wen Yu et al.   JOURNAL OF NEUROTRAUMA

Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-β peptide-induced impairment of spatial learning and memory in rats

(2016) Xiao-Tao Jia et al.   PHYSIOLOGY & BEHAVIOR

Neural effects of gut- and brain-derived glucagon-like peptide-1 and its receptor agonist

(2016) Kenichi Katsurada et al.   Journal of Diabetes Investigation

Type 3 Diabetes: Cross Talk between Differentially Regulated Proteins of Type 2 Diabetes Mellitus and Alzheimer’s Disease

(2016) Khyati Mittal et al.   Scientific Reports

Persistent hyperactivity and distinctive strategy features in the Morris water maze in 3xTg-AD mice at advanced stages of disease.

(2015) Raquel Baeta-Corral et al.   BEHAVIORAL NEUROSCIENCE

Prophylactic liraglutide treatment prevents amyloid plaque deposition, chronic inflammation and memory impairment in APP/PS1 mice

(2015) Paula L. McClean et al.   BEHAVIOURAL BRAIN RESEARCH

Reference and working memory deficits in the 3xTg-AD mouse between 2 and 15-months of age: A cross-sectional study

(2015) Leanne M. Stevens et al.   BEHAVIOURAL BRAIN RESEARCH

Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease

(2015) Kurt R. Stover et al.   BEHAVIOURAL BRAIN RESEARCH

DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

(2015) MingJie Ma et al.   Cardiovascular Diabetology

Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer’s Disease and Other Neurodegenerative Diseases

(2015) Valeria Calsolaro et al.   CNS DRUGS

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Mechanisms of Neurodegeration in Type 2 Diabetes and the Neuroprotective Potential of Dipeptidyl Peptidase 4 Inhibitors

(2015) E. Matteucci et al.   CURRENT MEDICINAL CHEMISTRY

Protective Effects of Liraglutide and Linagliptin in C. elegans as a New Model for Glucose-Induced Neurodegeneration

(2015) K. Wongchai et al.   HORMONE AND METABOLIC RESEARCH

Systemic Central Nervous System (CNS)-targeted Delivery of Neuropeptide Y (NPY) Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer Disease

(2015) Brian Spencer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A review on Alzheimer's disease pathophysiology and its management: an update

(2015) Anil Kumar et al.   Pharmacological Reports

Neuroprotective effect of selective DPP-4 inhibitor in experimental vascular dementia

(2015) Swati Jain et al.   PHYSIOLOGY & BEHAVIOR

Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 Diabetes Mellitus: A meta-analysis

(2015) Xiaoyan Song et al.   Scientific Reports

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice

(2015) Behrooz H Yousefi et al.   EJNMMI Research

A DPP-4 Inhibitor Suppresses Fibrosis and Inflammation on Experimental Autoimmune Myocarditis in Mice

(2015) Hiroyuki Hirakawa et al.   PLoS One

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer’s disease

(2014) Francesco Angelucci et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Administration of a selective β2 adrenergic receptor antagonist exacerbates neuropathology and cognitive deficits in a mouse model of Alzheimer's disease

(2014) Caterina Branca et al.   NEUROBIOLOGY OF AGING

Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease

(2014) Syed Faraz Kazim et al.   NEUROBIOLOGY OF DISEASE

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

(2014) Paula L. McClean et al.   NEUROPHARMACOLOGY

DPP-4 Inhibition and Neuroprotection: Do Mechanisms Matter?

(2013) R. P. Shannon   DIABETES

DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

(2013) Hiranya Pintana et al.   JOURNAL OF ENDOCRINOLOGY

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

(2013) Paula L. McClean et al.   NEUROPHARMACOLOGY

Stromal cell-derived factor 1α decreases β-amyloid deposition in Alzheimer's disease mouse model

(2012) Qi Wang et al.   BRAIN RESEARCH

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride

(2012) V. Darsalia et al.   DIABETES

The Diabetes Drug Liraglutide Ameliorates Aberrant Insulin Receptor Localisation and Signalling in Parallel with Decreasing Both Amyloid-β Plaque and Glial Pathology in a Mouse Model of Alzheimer’s Disease

(2012) Caitriona M. Long-Smith et al.   NEUROMOLECULAR MEDICINE

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

(2012) A.M. Duffy et al.   NEUROSCIENCE

Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer’s disease by exendin-4

(2011) Song Chen et al.   AGE

Long-Term Dipeptidyl-Peptidase 4 Inhibition Reduces Atherosclerosis and Inflammation via Effects on Monocyte Recruitment and Chemotaxis

(2011) Zubair Shah et al.   CIRCULATION

Effects of acute and chronic administration of GIP analogues on cognition, synaptic plasticity and neurogenesis in mice

(2011) Emilie Faivre et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis

(2011) Emilie Faivre et al.   JOURNAL OF NEUROPHYSIOLOGY

Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review

(2010) C. F. Deacon   DIABETES OBESITY & METABOLISM

Relationship Between Tau Pathology and Neuroinflammation in Alzheimer's Disease

(2010) Maria Jose Metcalfe et al.   MOUNT SINAI JOURNAL OF MEDICINE

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

(2009) Talib Abbas et al.   BEHAVIOURAL BRAIN RESEARCH

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: A link between diabetes and Alzheimer's disease

(2009) Paula L. McClean et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer’s prone mice

(2009) Michele D’Amico et al.   EXPERIMENTAL GERONTOLOGY

Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model

(2008) Chiho Hirata-Fukae et al.   BRAIN RESEARCH

Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-β peptide (1–42)

(2008) Zhenxia Qin et al.   NEUROSCIENCE LETTERS