Review
Medicine, General & Internal
Suncica Kapor, Juan F. Santibanez
Summary: This review discusses the main features of MDSCs and MSCs in myeloid malignancies, revealing that MDSCs are elevated in numbers and exhibit strong immunosuppressive capabilities, while MSCs not only have immunosuppressive properties but also regulate the growth, apoptosis, and chemotherapy resistance of myeloid leukemia cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Aenne Harberts, Constantin Schmidt, Joanna Schmid, Daniel Reimers, Friedrich Koch-Nolte, Hans-Willi Mittruecker, Friederike Raczkowski
Summary: IRF4 is essential for the activation and reactivation of CD8(+) memory T cells, but does not affect their overall survival. However, the formation and maintenance of CD8(+) tissue-resident memory T cells appears to depend on IRF4.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Xiaoping Xie, Lele Zhu, Zuliang Jie, Yanchuan Li, Meidi Gu, Xiaofei Zhou, Hui Wang, Jae-Hoon Chang, Chun-Jung Ko, Xuhong Cheng, Shao-Cong Sun
Summary: TRAF2 maintains a survival signaling axis in effector and memory CD8 T cells, required for immune responses against infections, by controlling the activation of Tpl2 and its downstream kinase ERK through NIK and degradation of the proapoptotic factor Bim. Uncontrolled NIK activation due to loss of TRAF2 leads to severe defects in ERK activation and CD8 T cell survival, affecting protective immunity.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Lorenz Kretschmer, Noemie Fuchs, Dirk H. Busch, Veit R. Buchholz
Summary: Clonal expansion and development of immunological memory are two hallmarks of adaptive immune responses. Resolving the intricate pathways that regulate cell cycle activity and lead to the generation of diverse effector and memory T cell subsets is essential for improving our understanding of protective T cell immunity. A deeper knowledge of cell cycle regulation in T cells also has translational implications for adoptive cell therapies and vaccinations against infectious diseases.
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2023)
Article
Biology
Tomonori Iyoda, Kanako Shimizu, Takaho Endo, Takashi Watanabe, Ichiro Taniuchi, Honoka Aoshima, Mikiko Satoh, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii
Summary: This study reveals that Zeb2 plays a crucial role in the differentiation and maintenance of iNKT cells, and regulates the formation of memory iNKT cells by preventing apoptosis of Klrg1+ long-lived iNKT cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yuen Ping Chong, Evelyn Priya Peter, Feon Jia Ming Lee, Chu Mun Chan, Shereen Chai, Lorni Poh Chou Ling, Eng Lai Tan, Sook Han Ng, Atsushi Masamune, Siti Aisyah Abd Ghafar, Norsharina Ismail, Ket Li Ho
Summary: Pancreatic cancer cells and pancreatic stellate cells together form the immunosuppressive tumor microenvironment of pancreatic cancer. This study found that co-culture of these two cell types resulted in a reduction in lymphocyte population. Proteomic analysis revealed differentially expressed proteins in two different stages of tumor-derived PCC lines. Additionally, it was found that the conditioned medium containing proteins secreted by PCC and/or PSC enhanced the viability of lymphocyte subtypes, while CM-induced MDSCs decreased the viability of certain T cells.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Sarah L. Bevington, Remi Fiancette, Dominika W. Gajdasik, Peter Keane, Jake K. Soley, Claire M. Willis, Daniel J. L. Coleman, David R. Withers, Peter N. Cockerill
Summary: Research reveals that T cell immunological memory is established within 7 days post-infection, with epigenetic programs playing a crucial role in Th differentiation and memory T cell formation. Memory T cell-specific regulatory elements contribute to enhanced inducible responses during secondary antigen exposures.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Patrick J. Woida, Karla J. F. Satchell
Summary: The host immune response plays a crucial role in detecting and eliminating bacterial pathogens. Bacteria often coordinate virulence factors to manipulate the host response during infection. This review discusses the surveillance and signaling systems in the intestine that detect bacteria, as well as the toxins and effectors that bypass these signaling pathways. These factors not only promote infection and disease progression, but can also be repurposed as tools or therapeutics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biology
Marie Strickland, Salanne Lee, Shi Yong Neo, Akhila Balachander, Ivy Low, Seri Mustafah, Wah Ing Goh, Graham D. D. Wright, Anis Larbi, Sylvia L. F. Pender
Summary: The study focuses on investigating the impact of mitochondrial dysfunction on immune responses to infection and vaccination in the elderly population. Specifically, it examines the metabolic responses and mitochondrial dynamics of CD4+ TEMRA cells and other CD4+ memory T cell subtypes. The results show that CD4+ TEMRA cells exhibit altered mitochondrial dynamics, increased glucose uptake, and higher mitochondrial mass, which may contribute to impaired responses to infection and vaccination.
Article
Endocrinology & Metabolism
Kirsten I. M. Looman, Susana Santos, Henriette A. Moll, Charlotte W. E. Leijten, Christina Grosserichter-Wagener, Trudy Voortman, Vincent V. W. Jaddoe, Menno C. van Zelm, Jessica C. Kiefte-de Jong
Summary: The study found significant associations between child adiposity measures and specific immune cell subsets, particularly with visceral fat index. Excessive fat in children may already indicate the presence of adiposity-related inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Julian L. Goggi, Shivashankar Khanapur, Siddesh Hartimath, Boominathan Ramasamy, Peter Cheng, Hui-Xian Chin, Jun-Rong Tang, You-Yi Hwang, Edward G. Robins
Summary: This study explored a novel PET imaging biomarker that can be used to evaluate lasting immune responses induced by specific combination therapies. The results showed that this radiopharmaceutical could reliably differentiate tumors with immune memory responses from non-responding tumors, and it could be used to measure the impact of combination therapy on T-effector memory cells responsible for durable immune memory responses.
Review
Medicine, Research & Experimental
Yuying Qu, Dongmei Li, Huabao Xiong, Dongmei Shi
Summary: Psoriasis is an inflammatory disease characterized by scaly erythematous plaques on the skin. The immunopathology of psoriasis suggests that T helper cells are primarily responsible for the inflammatory reaction. These Th cells differentiate into subsets such as Th1, Th2, Th17, and Treg, which play important roles in the pathogenesis of psoriasis. Modulating the expression of transcription factors for each Th subset could be a potential therapeutic target for psoriasis. This review focuses on the transcriptional regulation of Th cells in psoriasis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Immunology
Yuki Kagoya
Summary: Our understanding of T-cell exhaustion has been improved by studying exhausted T cells at the molecular level. We have discovered a subset of precursor exhausted T cells and found a way to evaluate the quality of exhausted T cells. Additionally, new therapeutic approaches to re-invigorate exhausted T cells have been explored.
INTERNATIONAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chih-Wei Lin, Yu-Jen Wang, Ting-Yen Lai, Tsui-Ling Hsu, Shin-Ying Han, Han-Chung Wu, Chia-Ning Shen, Van Dang, Ming-Wei Chen, Lan-Bo Chen, Chi-Huey Wong
Summary: The study reveals that SSEA-4 is overexpressed in pancreatic cancer cells and associated with survival rates; targeting SSEA-4 with antibodies or CAR-T cells shows promise in inhibiting cancer growth and could be a potential immunotherapy target for pancreatic disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Oncology
Julie E. Stein, Evan J. Lipson, Tricia R. Cottrell, Patrick M. Forde, Robert A. Anders, Ashley Cimino-Mathews, Elizabeth D. Thompson, Mohamad E. Allaf, Mark Yarchoan, Josephine Feliciano, Hao Wang, Elizabeth M. Jaffee, Drew M. Pardoll, Suzanne L. Topalian, Janis M. Taube
CLINICAL CANCER RESEARCH
(2020)
Editorial Material
Medicine, Research & Experimental
Won Jin Ho, Elizabeth M. Jaffee
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Letter
Behavioral Sciences
Yoshihiro Matsumoto, Nobutaka Ayani, Yoshinari Abe, Chikara Nakayama, Takahiro Tsujikawa, Masaya Oda, Jin Narumoto
Article
Oncology
Nitya Nair, Shih-Yu Chen, Ed Lemmens, Serena Chang, Dung T. Le, Elizabeth M. Jaffee, Aimee Murphy, Chan Whiting, Thomas Mueller, Dirk G. Brockstedt
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
Hanwen Wang, Richard J. Sove, Mohammad Jafarnejad, Sondra Rahmeh, Elizabeth M. Jaffee, Vered Stearns, Evanthia T. Roussos Torres, Roisin M. Connolly, Aleksander S. Popel
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Preethi Korangath, James D. Barnett, Anirudh Sharma, Elizabeth T. Henderson, Jacqueline Stewart, Shu-Han Yu, Sri Kamal Kandala, Chun-Ting Yang, Julia S. Caserto, Mohammad Hedayati, Todd D. Armstrong, Elizabeth Jaffee, Cordula Gruettner, Xian C. Zhou, Wei Fu, Chen Hu, Saraswati Sukumar, Brian W. Simons, Robert Ivkov
Article
Oncology
Won Jin Ho, Ludmila Danilova, Su Jin Lim, Rohan Verma, Stephanie Xavier, James M. Leatherman, Marcelo B. Sztein, Elana J. Fertig, Hao Wang, Elizabeth Jaffee, Mark Yarchoan
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Cell Biology
Isaac S. Chan, Hildur Knutsdottir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Matthew Dunworth, Hao Zhang, Elizabeth M. Jaffee, Joel S. Bader, Andrew Josef Ewald
JOURNAL OF CELL BIOLOGY
(2020)
Article
Medicine, Research & Experimental
Mark Yarchoan, Won Jin Ho, Aditya Mohan, Yajas Shah, Teena Vithayathil, James Leatherman, Lauren Dennison, Neeha Zaidi, Sudipto Ganguly, Skylar Woolman, Kayla Cruz, Todd D. Armstrong, Elizabeth M. Jaffee
Article
Oncology
Evanthia T. Roussos Torres, Christine Rafie, Chenguang Wang, David Lim, Adam Brufsky, Patricia LoRusso, Joseph Paul Eder, Vincent Chung, Melinda Downs, Molly Geare, Richard Piekarz, Howard Streicher, Leslie Anforth, Michelle A. Rudek, Qingfeng Zhu, Sepideh Besharati, Ashley Cimino-Mathews, Robert A. Anders, Vered Stearns, Elizabeth M. Jaffee, Roisin M. Connolly
Summary: This study investigated the efficacy and safety of combining the histone deacetylase inhibitor entinostat with nivolumab +/- ipilimumab in advanced solid tumors. The results showed that this combination therapy had promising clinical efficacy, with a significant increase in CD8/FoxP3 ratio, indicating potential for further research. The study concluded that the combination was safe and well tolerated, supporting the need for further investigation into both clinical efficacy and immune modulation.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Dimitrios N. Sidiropoulos, Christine I. Rafie, Julie K. Jang, Sofi Castanon, Aaron G. Baugh, Edgar Gonzalez, Brian J. Christmas, Valerie H. Narumi, Emily F. Davis-Marcisak, Gaurav Sharma, Emma Bigelow, Ajay Vaghasia, Anuj Gupta, Alyza Skaist, Michael Considine, Sarah J. Wheelan, Sathish Kumar Ganesan, Min Yu, Srinivasan Yegnasubramanian, Vered Stearns, Roisin M. Connolly, Daria A. Gaykalova, Luciane T. Kagohara, Elizabeth M. Jaffee, Elana J. Fertig, Evanthia T. Roussos Torres
Summary: This study comprehensively characterized the changes in the tumor microenvironment (TME) induced by entinostat, an oral histone deacetylase inhibitor, using single-cell RNA sequencing. The results showed that entinostat shifted the TME from a protumor to an antitumor signature, mainly through changes in myeloid cells. This study suggests that entinostat-induced alterations in myeloid cell types reduce immunosuppression and increase antitumor responses, thus improving the sensitivity to immune checkpoint inhibitors (ICIs).
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Adam C. Mirando, Akash Patil, Christine I. Rafie, Brian J. Christmas, Niranjan B. Pandey, Vered Stearns, Elizabeth M. Jaffee, Evanthia T. Roussos Torres, Aleksander S. Popel
Article
Oncology
Eric S. Christenson, Elizabeth Jaffee, Nilofer S. Azad
Meeting Abstract
Oncology
Rahul R. Suresh, David J. Barakat, Theresa Barberi, Lei Zheng, Elizabeth M. Jaffee, Kenneth J. Pienta, Alan D. Friedman
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Medicine, Research & Experimental
Won Jin Ho, Mark Yarchoan, Soren Charmsaz, Rebecca M. Munday, Ludmila Danilova, Marcelo B. Sztein, Elana J. Fertig, Elizabeth M. Jaffee