- Home
- Publications
- Publication Search
- Publication Details
Title
Structural Insights into TOR Signaling
Authors
Keywords
-
Journal
Genes
Volume 11, Issue 8, Pages 885
Publisher
MDPI AG
Online
2020-08-04
DOI
10.3390/genes11080885
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTOR at the nexus of nutrition, growth, ageing and disease
- (2020) Grace Y. Liu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structures and regulations of ATM and ATR, master kinases in genome integrity
- (2020) Rhys M Williams et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Prevention of premature death and seizures in a Depdc5 mouse epilepsy model through inhibition of mTORC1
- (2020) Lindsay K Klofas et al. HUMAN MOLECULAR GENETICS
- The flipside of the TOR coin – TORC2 and plasma membrane homeostasis at a glance
- (2020) Margot Riggi et al. JOURNAL OF CELL SCIENCE
- Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
- (2020) Lukas M Langer et al. eLife
- Structure of the TSC2 GAP Domain: Mechanistic Insight into Catalysis and Pathogenic Mutations
- (2020) Patrick Hansmann et al. STRUCTURE
- Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
- (2019) Kuang Shen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural and functional analysis of the role of the chaperonin CCT in mTOR complex assembly
- (2019) Jorge Cuéllar et al. Nature Communications
- Weak membrane interactions allow rheb to activate mTORC1 signaling without major lysosome enrichment
- (2019) Brittany Angarola et al. MOLECULAR BIOLOGY OF THE CELL
- Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth
- (2019) Sathish K. R. Padi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Advances in Cryo-Correlative Light and Electron Microscopy: Applications for Studying Molecular and Cellular Events
- (2019) Sangmi Jun et al. PROTEIN JOURNAL
- Structural insights into the EGO-TC–mediated membrane tethering of the TORC1-regulatory Rag GTPases
- (2019) Tianlong Zhang et al. Science Advances
- Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex
- (2019) Kuang Shen et al. CELL
- Architecture of human Rag GTPase heterodimers and their complex with mTORC1
- (2019) Madhanagopal Anandapadamanaban et al. SCIENCE
- Structural basis for the docking of mTORC1 on the lysosomal surface
- (2019) Kacper B. Rogala et al. SCIENCE
- Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex
- (2019) Rosalie E. Lawrence et al. SCIENCE
- Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations
- (2019) Luke A. Yates et al. STRUCTURE
- InsP6 binding to PIKK kinases revealed by the cryo-EM structure of an SMG1–SMG8–SMG9 complex
- (2019) Yair Gat et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cryo-EM structure of human mTOR complex 2
- (2018) Xizi Chen et al. CELL RESEARCH
- Architecture and activation of phosphatidylinositol 3-kinase related kinases
- (2018) Stefan Imseng et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome
- (2018) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
- (2018) Kuang Shen et al. NATURE
- Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
- (2018) Hsiang-Ting Lei et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Crystal structure of arginine-bound lysosomal transporter SLC38A9 in the cytosol-open state
- (2018) Hsiang-Ting Lei et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Architecture of the human mTORC2 core complex
- (2018) Edward Stuttfeld et al. eLife
- Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2
- (2018) Margot Riggi et al. NATURE CELL BIOLOGY
- Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states
- (2018) Yanxia Zhou et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- PIKKing a way to regulate inflammation
- (2017) Hazel Quek et al. IMMUNOLOGY AND CELL BIOLOGY
- Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
- (2017) Kuang Shen et al. MOLECULAR CELL
- Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
- (2017) Ming-Yuan Su et al. MOLECULAR CELL
- TORC1 organized in inhibited domains (TOROIDs) regulate TORC1 activity
- (2017) Manoël Prouteau et al. NATURE
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
- (2017) Haijuan Yang et al. NATURE
- KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
- (2017) Rachel L. Wolfson et al. NATURE
- Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
- (2017) Mariana E. G. de Araujo et al. SCIENCE
- 3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP
- (2017) Xuejuan Wang et al. SCIENCE
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
- (2017) Bancinyane L. Sibanda et al. SCIENCE
- Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex
- (2017) Brian M. Castellano et al. SCIENCE
- Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2
- (2017) Manikandan Karuppasamy et al. Nature Communications
- Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit
- (2017) Hisashi Tatebe et al. eLife
- Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution
- (2017) Luis Miguel Díaz-Santín et al. eLife
- Rag GTPase in amino acid signaling
- (2016) Joungmok Kim et al. AMINO ACIDS
- Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis
- (2016) Reinhard Zech et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanistically distinct cancer-associated mTOR activation clusters predict sensitivity to rapamycin
- (2016) Jianing Xu et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanism of arginine sensing by CASTOR1 upstream of mTORC1
- (2016) Robert A. Saxton et al. NATURE
- mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
- (2016) I. Ben-Sahra et al. SCIENCE
- The apo-structure of the leucine sensor Sestrin2 is still elusive
- (2016) Robert A. Saxton et al. Science Signaling
- TOR Complexes and the Maintenance of Cellular Homeostasis
- (2016) Sandra Eltschinger et al. TRENDS IN CELL BIOLOGY
- Lysosomal recruitment of TSC2 is a universal response to cellular stress
- (2016) Constantinos Demetriades et al. Nature Communications
- Tor forms a dimer through an N-terminal helical solenoid with a complex topology
- (2016) Domagoj Baretić et al. Nature Communications
- Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration
- (2016) Alba Diz-Muñoz et al. PLOS BIOLOGY
- 4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1
- (2016) Huirong Yang et al. Protein & Cell
- The apo-structure of the leucine sensor Sestrin2 is still elusive
- (2016) Robert A. Saxton et al. Science Signaling
- SEA you later alli-GATOR - a dynamic regulator of the TORC1 stress response pathway
- (2015) S. Dokudovskaya et al. JOURNAL OF CELL SCIENCE
- Molecular Basis of the Rapamycin Insensitivity of Target Of Rapamycin Complex 2
- (2015) Christl Gaubitz et al. MOLECULAR CELL
- Architecture of human mTOR complex 1
- (2015) C. H. S. Aylett et al. SCIENCE
- Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
- (2015) R. A. Saxton et al. SCIENCE
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex
- (2015) P. Liu et al. Cancer Discovery
- Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
- (2015) Marie-Pierre Péli-Gulli et al. Cell Reports
- Reciprocal conversion of Gtr1 and Gtr2 nucleotide-binding states by Npr2-Npr3 inactivates TORC1 and induces autophagy
- (2014) Shintaro Kira et al. Autophagy
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
- (2014) Constantinos Demetriades et al. CELL
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity
- (2014) B. C. Grabiner et al. Cancer Discovery
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- mTOR kinase structure, mechanism and regulation
- (2013) Haijuan Yang et al. NATURE
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
- (2013) N. Panchaud et al. Science Signaling
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- Crystal Structure of the Gtr1pGTP-Gtr2pGDPProtein Complex Reveals Large Structural Rearrangements Triggered by GTP-to-GDP Conversion
- (2012) Jae-Hee Jeong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Vam6 and Gtr1-Gtr2 pathway activates TORC1 in response to amino acids in fission yeast
- (2012) N. Valbuena et al. JOURNAL OF CELL SCIENCE
- TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1
- (2012) Christian C. Dibble et al. MOLECULAR CELL
- Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
- (2012) Sang Gyun Kim et al. MOLECULAR CELL
- Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
- (2012) Doris Berchtold et al. NATURE CELL BIOLOGY
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Structure-Function Relationships of the G Domain, a Canonical Switch Motif
- (2011) Alfred Wittinghofer et al. Annual Review of Biochemistry
- The R2TP complex: Discovery and functions
- (2011) Yoshito Kakihara et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
- (2011) Timothy R. Peterson et al. CELL
- Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
- (2011) R. Gong et al. GENES & DEVELOPMENT
- Target of Rapamycin Complex 2 Signals to Downstream Effector Yeast Protein Kinase 2 (Ypk2) through Adheres-Voraciously-to-Target-of-Rapamycin-2 Protein 1 (Avo1) inSaccharomyces cerevisiae
- (2011) Hsien-Ching Liao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes
- (2010) H. Takai et al. GENES & DEVELOPMENT
- Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly
- (2010) Takeshi Kaizuka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability
- (2010) Zuzana Hořejší et al. MOLECULAR CELL
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- AAA+ Proteins RUVBL1 and RUVBL2 Coordinate PIKK Activity and Function in Nonsense-Mediated mRNA Decay
- (2010) N. Izumi et al. Science Signaling
- mTORC1 signalling and mRNA translation: Figure 1
- (2009) Christopher G. Proud BIOCHEMICAL SOCIETY TRANSACTIONS
- DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival
- (2009) Timothy R. Peterson et al. CELL
- The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK–ERK pathway to late endosomes
- (2009) Shigeyki Nada et al. EMBO JOURNAL
- Enhancing mTOR-targeted cancer therapy
- (2009) Xuerong Wang et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- The Vam6 GEF Controls TORC1 by Activating the EGO Complex
- (2009) Matteo Binda et al. MOLECULAR CELL
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
- (2008) Tsuneo Ikenoue et al. EMBO JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started