Neutrophilia and NETopathy as Key Pathologic Drivers of Progressive Lung Impairment in Patients With COVID-19

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China

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Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle

(2020) Hongzhou Lu et al.   JOURNAL OF MEDICAL VIROLOGY

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

(2020) Joseph T Wu et al.   LANCET

Pathological findings of COVID-19 associated with acute respiratory distress syndrome

(2020) Zhe Xu et al.   Lancet Respiratory Medicine

Histopathologic Changes and SARS-CoV-2 Immunostaining in the Lung of a Patient With COVID-19

(2020) Huilan Zhang et al.   ANNALS OF INTERNAL MEDICINE

CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity

(2020) Álvaro Teijeira et al.   IMMUNITY

SARS-CoV-2: a storm is raging

(2020) Savannah F. Pedersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting potential drivers of COVID-19: Neutrophil extracellular traps

(2020) Betsy J. Barnes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Understanding epidemic data and statistics: A case study of COVID‐19

(2020) Amirhoshang Hoseinpour Dehkordi et al.   JOURNAL OF MEDICAL VIROLOGY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

(2020) Neeltje van Doremalen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effective treatment of severe COVID-19 patients with tocilizumab

(2020) Xiaoling Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

(2020) Chaomin Wu et al.   JAMA Internal Medicine

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow-up

(2020) Jiao Zhang et al.   BioScience Trends

Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza

(2019) Anuradha Madan et al.   Open Forum Infectious Diseases

Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza

(2019) Grace Roberts et al.   Open Forum Infectious Diseases

Neutrophils-related host factors associated with severe disease and fatality in patients with influenza infection

(2019) Benjamin M. Tang et al.   Nature Communications

Neutrophil Extracellular Traps Initiate Gallstone Formation

(2019) Luis E. Muñoz et al.   IMMUNITY

Treatment with DNases rescues hidden neutrophil elastase from aggregated NETs

(2019) Malgorzata J. Podolska et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Role of Extracellular Histones in Influenza Virus Pathogenesis

(2018) Harshini K. Ashar et al.   AMERICAN JOURNAL OF PATHOLOGY

Application of extracorporeal membrane oxygenation in patients with severe acute respiratory distress syndrome induced by avian influenza A (H7N9) viral pneumonia: national data from the Chinese multicentre collaboration

(2018) Linna Huang et al.   BMC INFECTIOUS DISEASES

Inhibition of peptidylarginine deiminase alleviates LPS-induced pulmonary dysfunction and improves survival in a mouse model of lethal endotoxemia

(2018) Yingjian Liang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neutrophil extracellular trap formation is regulated by CXCR2 in COPD neutrophils

(2018) Frauke Pedersen et al.   EUROPEAN RESPIRATORY JOURNAL

High Level of Neutrophil Extracellular Traps Correlates With Poor Prognosis of Severe Influenza A Infection

(2018) Liuluan Zhu et al.   JOURNAL OF INFECTIOUS DISEASES

Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

(2018) Jake Dunning et al.   NATURE IMMUNOLOGY

Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms

(2018) Ofir Wolach et al.   Science Translational Medicine

Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways

(2018) Olga Tatsiy et al.   Frontiers in Immunology

The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis

(2018) Mykolas Bendorius et al.   Frontiers in Immunology

Neutrophil extracellular trap production contributes to pathogenesis in SIV-infected nonhuman primates

(2018) Ranjit Sivanandham et al.   JOURNAL OF CLINICAL INVESTIGATION

Host DNases prevent vascular occlusion by neutrophil extracellular traps

(2017) Miguel Jiménez-Alcázar et al.   SCIENCE

Local dornase alfa treatment reduces NETs-induced airway obstruction during severe RSV infection

(2017) Bart Cortjens et al.   THORAX

Neutrophil stunning by metoprolol reduces infarct size

(2017) Jaime García-Prieto et al.   Nature Communications

Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR4

(2017) Haosi Li et al.   Biomed Research International

Neutrophil Extracellular Traps Open the Pandora’s Box in Severe Malaria

(2017) Sebastian Boeltz et al.   Frontiers in Immunology

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates

(2016) Mohib Uddin et al.   HAEMATOLOGICA

Clinical Progression and Cytokine Profiles of Middle East Respiratory Syndrome Coronavirus Infection

(2016) Eu Suk Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus

(2016) Sylviane Muller et al.   NATURE MEDICINE

The chemokine CXCR2 antagonist (AZD5069) preserves neutrophil-mediated host immunity in non-human primates

(2016) Mohib Uddin et al.   HAEMATOLOGICA

Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial

(2016) Paul M O'Byrne et al.   Lancet Respiratory Medicine

Mechanical Ventilation Induces Neutrophil Extracellular Trap Formation

(2015) Christopher Yildiz et al.   ANESTHESIOLOGY

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions

(2015) Stipo Jurcevic et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

(2015) Franz von Nussbaum et al.   ChemMedChem

1918 pandemic influenza virus andStreptococcus pneumoniaeco-infection results in activation of coagulation and widespread pulmonary thrombosis in mice and humans

(2015) Kathie-Anne Walters et al.   JOURNAL OF PATHOLOGY

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates

(2014) Sigrun Lange et al.   JOURNAL OF NEUROCHEMISTRY

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps

(2014) N. Maugeri et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines

(2014) Christine Schauer et al.   NATURE MEDICINE

Pharmacokinetics and safety of AZD9668, an oral neutrophil elastase inhibitor, in healthy volunteers and patients with COPD

(2013) Kulasiri A. Gunawardena et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Circulating Histones Are Mediators of Trauma-associated Lung Injury

(2012) Simon T. Abrams et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Proteinase 3 Contributes to Transendothelial Migration of NB1-Positive Neutrophils

(2012) C. J. Kuckleburg et al.   JOURNAL OF IMMUNOLOGY

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Critical findings of severe influenza A (H1N1) pneumonia in children

(2011) Hidetoshi Ishigaki et al.   PEDIATRICS INTERNATIONAL

Biologic and pharmacologic therapies in clinical development for the inflammatory response in COPD

(2010) Jaymin B. Morjaria et al.   DRUG DISCOVERY TODAY

Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats

(2010) Sumiko Yoshikawa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute Lung Injury with Alveolar Hemorrhage Due to a Novel Swine-Origin Influenza A (H1N1) Virus

(2010) Toshiki Yokoyama et al.   INTERNAL MEDICINE

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

(2009) O. Holz et al.   EUROPEAN RESPIRATORY JOURNAL

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

SIVELESTAT (SELECTIVE NEUTROPHIL ELASTASE INHIBITOR) IMPROVES THE MORTALITY RATE OF SEPSIS ASSOCIATED WITH BOTH ACUTE RESPIRATORY DISTRESS SYNDROME AND DISSEMINATED INTRAVASCULAR COAGULATION PATIENTS

(2009) Mineji Hayakawa et al.   SHOCK

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES