Article
Oncology
Yanze Yin, Huijuan Dai, Xicheng Sun, Zhifeng Xi, Jiang Zhang, Yixiao Pan, Yongxin Huang, Xueyun Ma, Qiang Xia, Kang He
Summary: This study reveals that liver cancer promotes tumor lung metastasis by regulating neutrophil recruitment and NETs formation in the metastatic microenvironment through reducing HRG secretion. The findings of this study will contribute to the development of possible strategies for treating metastases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Instruments & Instrumentation
Emeka B. Okeke, Cameron Louttit, Caitlin M. Snyder, James J. Moon
Summary: Neutrophils and NETs play significant roles in cancer progression and metastasis and are associated with adverse patient outcomes. New drug delivery approaches targeting and modulating neutrophils and NETs have become a research focus in cancer therapeutics.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Cell Biology
Yiming Shao, Linbin Li, Lu Liu, Yunxi Yang, Jiamin Huang, Dongdong Ji, Yuying Zhou, Yi Chen, Zhechen Zhu, Bingwei Sun
Summary: Delayed 'targeted nuclear degranulation' after neutrophil activation is found to be a key mechanism of NET formation. The process is mediated by the CD44/ERM/F-actin complex.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Parasitology
Ran Wei, Xin Li, Xiaocen Wang, Yuru Wang, Xu Zhang, Nan Zhang, Jingsen Wang, Ju Yang, Xichen Zhang, Pengtao Gong, Jianhua Li
Summary: This study is the first report of T. evansi-induced NETs formation. NETs can reduce parasite motility without affecting viability, and their formation is dose and time-dependent with accompanying ROS production. The role of MPO, NE, and ERK1/2 signaling pathway is crucial in T. evansi-induced NETs formation, while NADPH oxidase and SOCE are not involved, and LDH activity does not significantly change during NETs formation.
VETERINARY PARASITOLOGY
(2021)
Article
Oncology
Simrit Safarulla, Ankit Madan, Fei Xing, Arvind Chandrasekaran
Summary: This study reveals the mechanisms by which CXCR2 affects neutrophils in brain metastasis of breast cancer. Activation of CXCR2 receptors by brain metastatic tumors promotes neutrophil migration to tumor sites and formation of NETs, thereby facilitating tumor progression. Inhibiting CXCR2 and NETs formation can limit the interaction between neutrophils and tumors, slowing down the development of brain metastatic breast cancer.
Article
Immunology
Kai Yang, Bin Wu, Wu Wei, Cuiyu Li, Lu Li, Zhukai Cong, Qian Xiang
Summary: This study investigated the effects of curdione, an active ingredient of Curcuma zedoary, on sepsis-induced lung injury. The results showed that curdione can alleviate tissue pathological changes, reduce inflammatory factors and protein concentrations, decrease oxidative stress responses, inhibit platelet activation, and reduce neutrophil infiltration and NET formation. Curdione has great therapeutic potential in sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sonia Aguila, Ascension M. de los Reyes-Garcia, Maria P. Fernandez-Perez, Laura Reguilon-Gallego, Laura Zapata-Martinez, Inmaculada Ruiz-Lorente, Vicente Vicente, Rocio Gonzalez-Conejero, Constantino Martinez
Summary: This article summarizes the formation mechanism and regulatory elements of Neutrophil extracellular traps (NETs), as well as the role of miRNAs associated with various inflammatory pathologies. miRNAs, as small non-coding RNAs, play important regulatory roles in various pathological processes and may become therapeutic targets for preventing inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhiyang Wu, Guotao Lu, Luyao Zhang, Lu Ke, Chenchen Yuan, Nan Ma, Xianqiang Yu, Xi Guo, Wei Zhao, Yingjie Wang, Sanyuan Hu, Dawei Wu, Weiqin Li
Summary: The study demonstrates that PD1 alleviates acute pancreatitis by reducing early neutrophil infiltration and neutrophil extracellular trap formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Takeshi Sugimoto, Hiroyuki Yamada, Naotoshi Wada, Shinichiro Motoyama, Makoto Saburi, Hiroshi Kubota, Daisuke Miyawaki, Noriyuki Wakana, Daisuke Kami, Takehiro Ogata, Masakazu Ibi, Satoaki Matoba
Summary: This study investigated the impact of repeated social defeat (RSD) on arterial thrombosis and found that RSD enhances the formation of fibrin-rich clots after arterial injury. These findings suggest that NET could be a new therapeutic target in depression-related cardiovascular disease.
Article
Medicine, General & Internal
Salti Talal, Khoury Mona, Awad Karem, Lerenthal Yaniv, Harari-Misgav Reut, Shemesh Ariel, Avraham-Kelbert Moran, Eitam Harel, Salvatore Campisi-Pinto, Abu-Amna Mahmoud, Colodner Raul, Tovbin David, Bar-Sela Gil, Cohen Idan
Summary: In this study, it was found that patients undergoing hemodialysis have impaired neutrophil functionality, leading to increased susceptibility to infections. Targeting NETosis may reduce the occurrence and mortality rate of infections in these patients.
Article
Immunology
Yifang Chen, Chenxu Zhao, Han Guo, Weilong Zou, Zhaoqi Zhang, Dong Wei, Hezhe Lu, Lianfeng Zhang, Yong Zhao
Summary: Inhibition of Wip1 enhances the formation of NETs, leading to accelerated abscess healing in a Staphylococcus aureus-induced abscess model. Wip1 interacts preferentially with phosphorylated Coro1a and Wip1 inhibitors promote NET formation in mouse and human neutrophils. This study identifies Coro1a as a novel substrate of Wip1 and shows that Wip1 negatively regulates NET formation during infection.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Immunology
Jakub Janko, Emil Becka, Katarina Kmetova, Leticia Hudecova, Barbora Konecna, Peter Celec, Mona Bajaj-Elliott, Michal Pastorek
Summary: Fever and hypothermia represent two opposite strategies for fighting systemic inflammation. Temperature was found to modulate the homeostasis of neutrophil extracellular traps (NETs) formation and clearance, with increased formation and degradation at higher temperatures, while temperatures of 35°C and 42°C attenuated this response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caren Linnemann, Filiz Sahin, Yangmengfan Chen, Karsten Falldorf, Michael Ronniger, Tina Histing, Andreas K. Nussler, Sabrina Ehnert
Summary: This study aimed to evaluate the effect of a 16 Hz extremely low-frequency pulsed electromagnetic field (ELF-PEMF) on neutrophil extracellular trap (NET) formation. The study found that ELF-PEMF exposure did not induce reactive oxygen species and Ca2+-influx in neutrophils, and it reduced the amount of NET release. Therefore, ELF-PEMF exposure can be started immediately after fracture treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Fei Han, Zi-fan Ding, Xiao-lei Shi, Qing-tian Zhu, Qin-hao Shen, Xing-meng Xu, Jun-xian Zhang, Wei-juan Gong, Wei-ming Xiao, Dan Wang, Wei-wei Chen, Liang-hao Hu, Guo-tao Lu
Summary: The newly discovered myokine irisin can inhibit neutrophil extracellular traps (NETs) formation and protect mice from pancreatic injury. This study further elucidates the protective effect of exercise on acute inflammatory injury.
Article
Cell Biology
Iwona Cichon, Weronika Ortmann, Michal Santocki, Malgorzata Opydo-Chanek, Elzbieta Kolaczkowska
Summary: Obese individuals have a higher survival rate during sepsis, but their white blood cell response in liver vasculature is suppressed; the study found that platelets in obese mice have a limited impact on neutrophil formation, suggesting that their dysfunctional state may affect immune responses.
Editorial Material
Oncology
Junji Uchino, Torsten Goldmann, Hideharu Kimura
FRONTIERS IN ONCOLOGY
(2022)
Article
Allergy
Mustafa Abdo, Frauke Pedersen, Anne-Marie Kirsten, Vera Veith, Heike Biller, Frederik Trinkmann, Erika von Mutius, Matthias Kopp, Gesine Hansen, Klaus F. Rabe, Thomas Bahmer, Henrik Watz
Summary: This study investigated the impact of airway inflammatory phenotypes on small airway dysfunction (SAD) and asthma outcomes. The results showed that patients with eosinophilic and mixed granulocytic asthma had worse lung function, higher exacerbation rates, and poorer symptom control compared to patients with paucigranulocytic asthma. Persistent mixed granulocytic asthma was associated with the worst SAD measures. Changes in sputum eosinophil counts were found to be an independent predictor for the longitudinal change in lung function.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Article
Respiratory System
Kathrin Kahnert, Carolina Fischer, Peter Alter, Franziska Trudzinski, Tobias Welte, Juergen Behr, Felix Herth, Hans-Ulrich Kauczor, Robert Bals, Henrik Watz, Klaus Rabe, Sandra Soehler, Inge Kokot, Claus Vogelmeier, Rudolf Joerres
Summary: COSYCONET 1 is the only large German COPD cohort that can be compared internationally. From 2010 to December 2013, a total of 2741 patients diagnosed with COPD were recruited and subsequently followed up. Various clinical questions were addressed using this comprehensive dataset, covering medication prescription, comorbidity analysis, biomarker assessment, radiological aspects, and health economic aspects. More than 60 publications of COSYCONET data are currently available internationally. This overview summarizes the obtained results, focusing on the relationships between different clinical and functional aspects and their potential practical consequences. Additionally, information on the follow-up study COSYCONET 2 is provided.
Article
Respiratory System
Lucia De Prado Gomez, Ian Pavord, William Busse, Christopher E. Brightling, Michael E. Wechsler, Klaus F. Rabe, Mei Zhang, Jun Xing, Juby A. Jacob-Nara, Paul J. Rowe
Summary: The ATLAS trial aims to evaluate the role of Dupilumab in preventing or slowing loss of lung function in patients with uncontrolled moderate-to-severe asthma. The trial will last for 3 years and compare the effects of Dupilumab and standard-of-care therapy on lung function decline. Outcome measures include exhaled nitric oxide fraction, exacerbations, asthma control, quality of life, and the utility of exhaled nitric oxide as a biomarker of lung function decline.
Article
Allergy
Klaus F. Rabe, Ian D. Pavord, William W. Busse, Geoffrey L. Chupp, Kenji Izuhara, Arman Altincatal, Rebecca Gall, Nami Pandit-Abid, Yamo Deniz, Paul J. Rowe, Juby A. Jacob-Nara, Amr Radwan
Summary: This study analyzed the efficacy of dupilumab in patients with or without evidence of allergic asthma and type 2 inflammation according to current GINA guidelines. The results showed that dupilumab reduced asthma exacerbation rates and improved lung function and asthma control, regardless of the presence of allergic asthma.
Review
Critical Care Medicine
Klaus F. Rabe, Stephen Rennard, Fernando J. Martinez, Bartolome R. Celli, Dave Singh, Alberto Papi, Mona Bafadhel, Jigna Heble, Amr Radwan, Xavier Soler, Juby A. Jacob Nara, Yamo Deniz, Paul J. Rowe
Summary: COPD is a complex inflammatory airway disease with different types of inflammation, requiring targeted therapies and biomarkers for better management. Current treatments have limitations and there is a need for new strategies to address specific pathophysiological issues.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Jonathan Corren, David J. Jackson, Thomas B. Casale, Larry Borish, Klaus F. Rabe, William W. Busse, Jorge F. Maspero, Daniel J. Jackson, Nadia Daizadeh, Arman Altincatal, Amr Radwan, Angela Khodzhayev, Michel Djandji, Juby A. Jacob-Nara, Paul J. Rowe, Yamo Deniz
Summary: In this study, Dupilumab demonstrated good efficacy by reducing asthma exacerbations and improving lung function in patients with uncontrolled, moderate-to-severe T2 asthma. Furthermore, Dupilumab showed similar effects in improving clinical outcomes and reducing biomarkers levels regardless of allergen sensitization status or number.
JOURNAL OF ASTHMA AND ALLERGY
(2023)
Article
Respiratory System
Kathrin Kahnert, Rudolf A. Joerres, Hans-Ulrich Kauczor, Peter Alter, Franziska C. Trudzinski, Felix Herth, Bertram Jobst, Oliver Weinheimer, Sebastian Nauck, Pontus Mertsch, Diego Kauffmann-Guerrero, Juergen Behr, Robert Bals, Henrik Watz, Klaus F. Rabe, Tobias Welte, Claus F. Vogelmeier, Juergen Biederer
Summary: This study aimed to evaluate the association of Pi10, a measure of standardized airway wall thickness on CT, with exacerbations, mortality, and response to triple therapy in patients with COPD. The results showed that Pi10 was associated with COPD severity, comorbidities, lung function, respiratory therapy, and mortality, and it had some predictive ability.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Article
Respiratory System
Peter Alter, Kathrin Kahnert, Franziska C. Trudzinski, Robert Bals, Henrik Watz, Tim Speicher, Sandra Soehler, Tobias Welte, Klaus F. Rabe, Emiel F. M. Wouters, Claus F. Vogelmeier, Rudolf A. Joerres
Summary: This study analyzed factors associated with the use of COPD drugs in non-interventional circumstances using data from the COSYCONET cohort. The results showed that the use of respiratory medication was related to the severity of COPD and GOLD grades.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2023)
Meeting Abstract
Respiratory System
A. Peck, N. Maison, A. Hose, J. Omony, B. Schaub, R. Grychtol, A. Dittrich, C. Nitsche, S. Foth, M. Weckmann, M. Abdo, T. Bahmer, K. F. Rabe, H. Renz, G. Hansen, M. Kopp, E. Von Mutius
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
T. Karp, A. Faiz, H. A. M. Kerstjens, I. M. Boudewijn, M. Kraft, J. M. Vonk, M. C. Nawijn, I. H. Heijink, L. M. Fabbri, K. F. Rabe, G. Nicolini, A. Papi, C. Brightling, D. Singh, T. Van der Molen, S. Siddiqui, S. Christenson, V Guryev, M. Van den Berge
EUROPEAN RESPIRATORY JOURNAL
(2022)
Meeting Abstract
Respiratory System
F. Trinkmann, A. Kirsten, M. Abdo, K. F. Rabe, F. J. Herth, H. Watz, M. Abdo
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Dave Singh, John R. Hurst, Fernando J. Martinez, Klaus F. Rabe, Mona Bafadhel, Martin Jenkins, Domingo Salazar, Paul Dorinsky, Patrick Darken
Summary: This study developed models to predict the rate of moderate/severe exacerbations in COPD patients based on baseline risk factors. Factors such as prior exacerbations, eosinophil count, and use of inhaled corticosteroids were found to be significant predictors of exacerbation risk. The models showed good fit and improved prediction metrics compared to a simplified model. These models can be useful for evaluating treatment decisions in individual COPD patients.
THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE
(2022)
Meeting Abstract
Critical Care Medicine
P. Berger, A. Menzies-Gow, A. Peters, P. Kuna, K. F. Rabe, A. Altincatal, B. Ortiz, M. Djandji, S. Siddiqui, Y. Deniz, J. Jacob-Nara, P. J. Rowe
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
